[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki40\/karl-fredrik-norrback-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki40\/karl-fredrik-norrback-wikipedia\/","headline":"Karl-Fredrik Norrback – Wikipedia","name":"Karl-Fredrik Norrback – Wikipedia","description":"From Wikipedia, the free encyclopedia Swedish medical doctor and researcher (born 1972) Karl-Fredrik Norrback (born 1972) is a Swedish medical","datePublished":"2018-11-16","dateModified":"2018-11-16","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki40\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki40\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki40\/karl-fredrik-norrback-wikipedia\/","wordCount":1925,"articleBody":"From Wikipedia, the free encyclopediaSwedish medical doctor and researcher (born 1972)Karl-Fredrik Norrback (born 1972) is a Swedish medical doctor and researcher. He is an associate Professor of Experimental Psychiatry and researcher at the department of Clinical Sciences, Unit of Psychiatry, Ume\u00e5 University, Sweden.[1]Table of ContentsEducation[edit]Research[edit]Telomerase and telomere biology[edit]Stress and stress dysregulation[edit]Psychosomatics[edit]References[edit]Education[edit]He received his PhD in Medicine at Ume\u00e5 University, Sweden at the Department of Medical Biosciences in 2000 and his MD at Ume\u00e5 University, Sweden in 2004.Research[edit]Norrback’s work has mostly been connected to the Betula project, a longitudinal multiple outcome research project, which in 2005 was appointed as one of the leading research environments in Sweden by the Swedish Research Council, and the Northern Sweden psychiatric multiple outcomes studies lead by Professor Rolf Adolfsson, Ume\u00e5 University.[2]Telomerase and telomere biology[edit]Norrback has performed research into the roles of telomerase activity and telomere length regulation in immune cells and its malignant counterparts.[3][4]He has worked on potential roles of telomerase activity and telomere length for the inflammatory process and for immunological memory which both are dependent on immune cell proliferation. More recently, he has been involved in evaluating the biomarker value of  telomere length with respect to structural and functional measures of the brain, particularly increased stress.[5] His work he has contributed to the body of research which  supports considering telomere length as a biomarker of increased levels of chronic stress,  as well as  containing information pertaining to the proliferative history and future proliferative potential of cells.[6]Stress and stress dysregulation[edit]Norrback also works on the causes and effects of stress and stress-dysregulation in the general population as well as in affective disorders, which are believed to be stress-related conditions. The research has  provided additional support for the  condition denoted hypocortisolism, which is characterized by a long-term lowering of the cortisol levels, believed to be induced through an increased stress load.[7][8][9]  Norrback\u2019s research has shown that there exist significant associations between hypocortisolism and affective disorders, accelerated cellular aging, psychosomatic conditions, pain and inflammatory symptoms and markers of inflammation.[10]Psychosomatics[edit]Norrback\u2019s research in this area has mainly concerned the functional gastrointestinal condition irritable bowel syndrome (IBS), but also spans different functional gastrointestinal symptoms as well as pain conditions and pain symptoms. He has tried to address the potential roles of stress- and mood-dysregulation for the etiology, expression and progression of pain and intestinal symptoms as well as conditions. The studies supported that both pain and gastrointestinal symptoms as well as conditions are significantly associated with affective disorders, depressive symptoms and hypocortisolism. The research hence shows support for both stress- and mood-dysregulation as being involved in intestinal and pain symptoms as well as conditions.[11]References[edit]^ “Karl-Fredrik Norrback – Ume\u00e5 University, Sweden”. Ume\u00e5 University.^ “Long telomeres can be linked to poorer memory”. ScienceDaily. Retrieved 20 September 2017.^ Norrback KF, Dahlenborg K, Carlsson R, Roos G. Telomerase activity in normal B lymphocytes and non-Hodgkin\u2019s lymphomas. Blood 1996 Jul 1;88(1):222-9.^ Norrback K-F, Enblad G, Erlanson M, Sundstr\u00f6m C, Roos G (1998) Telomerase activity in Hodgkin\u00b4s disease. Blood 92: 567-573.^ “Does depression contribute to the aging process?”. Medical Xpress. Retrieved 20 September 2017.^ “Depression and chronic stress accelerates aging”. ScienceDaily. Retrieved 20 September 2017.^ “D\u00e4rf\u00f6r tar hj\u00e4rtat ofta stryk hos bipol\u00e4ra och deprimerade”. Nyheter & Fakta (in Swedish). Retrieved 20 September 2017.^ Fries E, Hesse J, Hellhammer J, Hellhammer DH (2005), A new view on hypocortisolism. Psychoneuroendocrinology 30:1010-1016^ Heim C, Ehlert U, Hellhammer DH (2000), The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 25:1-35^ “Link between stress hormone and obesity in depressed and bipolar patients”. Medical Xpress. Retrieved 20 September 2017.^ “European research brings us a step closer to a better understanding of psychiatric disorders”. News-Medical.net. 15 March 2006. Retrieved 20 September 2017."},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki40\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki40\/karl-fredrik-norrback-wikipedia\/#breadcrumbitem","name":"Karl-Fredrik Norrback – Wikipedia"}}]}]