[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki41\/chromosome-20-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki41\/chromosome-20-wikipedia\/","headline":"Chromosome 20 – Wikipedia","name":"Chromosome 20 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia Human chromosome Chromosome 20 is one of the 23 pairs of chromosomes in humans.","datePublished":"2018-06-25","dateModified":"2018-06-25","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki41\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki41\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/4\/48\/Human_chromosome_20_ideogram_vertical.svg\/134px-Human_chromosome_20_ideogram_vertical.svg.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/4\/48\/Human_chromosome_20_ideogram_vertical.svg\/134px-Human_chromosome_20_ideogram_vertical.svg.png","height":"698","width":"134"},"url":"https:\/\/wiki.edu.vn\/en\/wiki41\/chromosome-20-wikipedia\/","wordCount":5818,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopediaHuman chromosomeChromosome 20 is one of the 23 pairs of chromosomes in humans. Chromosome 20 spans around 66 million base pairs (the building material of DNA) and represents between 2 and 2.5 percent of the total DNA in cells. Chromosome 20 was fully sequenced in 2001 and was reported to contain over 59 million base pairs.[4]  Since then, due to sequencing improvements and fixes, the length of chromosome 20 has been updated to just over 66 million base pairs.[5]Table of ContentsNumber of genes[edit]Gene list[edit]Diseases and disorders[edit]Cytogenetic band[edit]References[edit]External links[edit]Number of genes[edit]The following are some of the gene count estimates of human chromosome 20. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS’s gene number prediction represents a lower bound on the total number of human protein-coding genes.[6]Gene list[edit]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4The following is a partial list of genes on human chromosome 20. For complete list, see the link in the infobox on the right.ADA: Adenosine Deaminase (Adenosine Deaminase Deficiency)ANDP: encoding protein Activity-dependent neuroprotector homeoboxAHCY: S-adenosylhomocysteine hydrolaseAPMAP: encoding protein Adipocyte plasma membrane-associated proteinARFGEF2: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)BCAS1: Breast carcinoma-amplified sequence 1BLCAP: Bladder cancer associated proteinBMP2: Bone Morphogenetic Protein 2 (osteoblast differentiation)BPIFA1: encoding protein BPI fold containing family A, member 1BPIFA2: encoding protein BPI fold containing family A, member 2BPIFA3: encoding protein BPI fold containing family A, member 3BPIFA4P: non-coding pseudogene of the BPI fold containing family A, member 4PBPIFB1: encoding protein BPI fold containing family B, member 1BPIFB2: encoding protein BPI fold containing family B, member 2BPIFB3: encoding protein BPI fold containing family B, member 3BPIFB4: encoding protein BPI fold containing family B, member 4BPIFB5P: non-coding pseudogene of the BPI fold containing family B, member 5PBPIFB6: encoding protein BPI fold containing family B, member 6BPIFB9P: non-coding pseudogene of the BPI fold containing family B, member 9PC20orf27: encoding protein UPF0687 protein C20orf27CSRP2BP: encoding protein CSRP2 binding proteinCST9L: Cystatin-9-likeCSTL1: Cystatin-like 1CTCFL: CCCTC-binding factor-likeCTNNBL1: Beta-catenin-like protein 1DBNDD2: Dysbindin domain-containing protein 2DDX27: DEAD box polypeptide 27DEFB118, DEFB119, DEFB126, DEFB127, DEFB129: Beta-defensin genesDLGAP4: Disks large-associated protein 4DNAJC5: Cysteine string proteinEDEM2: ER degradation-enhancing alpha-mannosidase-like 2EDN3: endothelin 3ENTPD6: Ectonucleoside triphosphate diphosphohydrolase 6ESF1: ESF1 nucleolar pre-rRNA processing protein homologFAM210B: encoding protein FAM210BFASTKD5: encoding protein FAST kinase domain-containing protein 5 (FASTKD5)FITM2: encoding protein Fat storage-inducing transmembrane protein 2GZF1: encoding protein GDNF-inducible zinc finger protein 1GMEB2: Glucocorticoid modulatory element-binding protein 2GNAS1: Gs alpha subunit (membrane G-protein)GSS: glutathione synthetaseITPA: encoding enzyme Inosine triphosphate pyrophosphataseJAG1: jagged 1 (Alagille syndrome)JPH2: encoding protein Junctophilin 2KIZ: encoding protein Kizuna centrosomal proteinKua-UEV:LIME1: encoding protein Lck-interacting transmembrane adapter 1LZTS3: encoding protein Leucine zipper, putative tumor suppressor family member 3MROH8: encoding protein maestro heat like repeat family member 8NAPB: encoding protein Beta-soluble NSF attachment proteinNDUFAF5: encoding protein NADH:ubiquinone oxidoreductase complex assembly factor 5Nnat: encoding protein NeuronatinNOL5A: encoding protein Nucleolar protein 56NRSN2: encoding protein Neurensin-2OTOR: encoding protein OtoraplinPANK2: pantothenate kinase 2 (pantothenate kinase-associated neurodegeneration)PKIG: encoding protein cAMP-dependent protein kinase inhibitor gammaPLAGL2: encoding protein Zinc finger protein PLAGL2POLR3F: encoding enzyme DNA-directed RNA polymerase III subunit RPC6PRIC285:PRNP: prion protein (p27-30) (Creutzfeldt\u2013Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)PXMP4: encoding protein Peroxisomal membrane protein 4R3HDML: encoding protein R3H domain containing-likeRTF2: encoding protein RTF2 homologSALL4: sal-like 4 (Drosophila)SERINC3: encoding protein Serine incorporator 3SHLD1: encoding protein Shieldin complex subunit 1SLC17A9: encoding protein Solute carrier family 17 member 9SLC2A4RG: encoding protein SLC2A4 regulatorSLX4IP: encoding protein SLX4 interacting proteinSPATA2: encoding protein Spermatogenesis-associated protein 2SPEF1: encoding protein Sperm flagellar protein 1SRXN1: encoding protein Sulfiredoxin-1STAU1: encoding protein Double-stranded RNA-binding protein Staufen homolog 1STK35L1: encoding protein STK35L1SUN5: encoding protein SUN domain-containing protein 5TASP1: encoding enzyme Threonine aspartase 1tTG: tissue transglutaminase (auto antigen of Celiac disease)TMEPAI: encoding protein Transmembrane prostate androgen-induced proteinTTPAL: encoding protein Tocopherol (alpha) transfer protein-likeUCKL1: encoding enzyme Uridine-cytidine kinase-like 1UQCC: encoding enzyme Ubiquinol-cytochrome c reductase complex chaperone CBP3 homologVAPB: VAMP (vesicle-associated membrane protein)-associated protein B and CYTHDF1: encoding protein YTH domain family, member 1ZFP64 encoding protein Zinc finger protein 64 homolog, isoforms 1 and 2ZGPAT: encoding protein Zinc finger CCCH-type with G patch domain-containing proteinZHX3: encoding protein Zinc fingers and homeoboxes protein 3ZNF334: encoding protein Zinc finger protein 334ZNF343: encoding protein Zinc finger protein 343 ZSWIM3: encoding protein Zinc finger SWIM-type containing 3ZMYND8: encoding enzyme Protein kinase C-binding protein 1ZNF133: encoding protein Zinc finger protein 133Diseases and disorders[edit]The following diseases are some of those related to genes on chromosome 20:[13]Cytogenetic band[edit]G-banding ideogram of human chromosome 20 in resolution 850 bphs. Band length in this diagram is proportional to base-pair length. This type of ideogram is generally used in genome browsers (e.g. Ensembl, UCSC Genome Browser).G-banding patterns of human chromosome 20 in three different resolutions (400,[14] 550[15] and 850[3]). Band length in this diagram is based on the ideograms from ISCN (2013).[16] This type of ideogram represents actual relative band length observed under a microscope at the different moments during the mitotic process.[17]G-bands of human chromosome 20 in resolution 850 bphs[18]Chr.Arm[19]Band[20]ISCNstart[21]ISCNstop[21]BasepairstartBasepairstopStain[22]Density20p13033315,100,000gneg20p12.33335135,100,0019,200,000gpos7520p12.25136249,200,00112,000,000gneg20p12.162491512,000,00117,900,000gpos7520p11.23915116417,900,00121,300,000gneg20p11.221164127521,300,00122,300,000gpos2520p11.211275144122,300,00125,700,000gneg20p11.11441160825,700,00128,100,000acen20q11.11608177428,100,00130,400,000acen20q11.211774192730,400,00133,500,000gneg20q11.221927205133,500,00135,800,000gpos2520q11.232051223235,800,00139,000,000gneg20q122232243939,000,00143,100,000gpos7520q13.112439257843,100,00143,500,000gneg20q13.122578275843,500,00147,800,000gpos2520q13.132758307747,800,00151,200,000gneg20q13.23077329951,200,00156,400,000gpos7520q13.313299338256,400,00157,800,000gneg20q13.323382349357,800,00159,700,000gpos5020q13.333493377059,700,00164,444,167gnegReferences[edit]^ a b “Search results – 20[CHR] AND “Homo sapiens”[Organism] AND (“has ccds”[Properties] AND alive[prop]) – Gene”. NCBI. CCDS Release 20 for Homo sapiens. 2016-09-08. Retrieved 2017-05-28.^ Tom Strachan; Andrew Read (2 April 2010). Human Molecular Genetics. Garland Science. p.\u00a045. ISBN\u00a0978-1-136-84407-2.^ a b Genome Decoration Page, NCBI.   Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.^ Deloukas P;  et\u00a0al. (2001). “The DNA sequence and comparative analysis of human chromosome 20”. Nature. 414 (6866): 865\u2013871. Bibcode:2001Natur.414..865D. doi:10.1038\/414865a. PMID\u00a011780052.^ “Homo sapiens chromosome 20, GRCh37.p13 Primary Assembly”. National Center for Biotechnology Information. Retrieved October 17, 2013.^ Pertea M, Salzberg SL (2010). “Between a chicken and a grape: estimating the number of human genes”. Genome Biol. 11 (5): 206. doi:10.1186\/gb-2010-11-5-206. PMC\u00a02898077. PMID\u00a020441615. ^ “Statistics & Downloads for chromosome 20”. HUGO Gene Nomenclature Committee. 2017-05-12. Retrieved 2017-05-19.^ “Chromosome 20: Chromosome summary – Homo sapiens”. Ensembl Release 88. 2017-03-29. Retrieved 2017-05-19.^ “Human chromosome 20: entries, gene names and cross-references to MIM”. UniProt. 2018-02-28. Retrieved 2018-03-16.^ “Search results – 20[CHR] AND “Homo sapiens”[Organism] AND (“genetype protein coding”[Properties] AND alive[prop]) – Gene”. NCBI. 2017-05-19. Retrieved 2017-05-20.^ “Search results – 20[CHR] AND “Homo sapiens”[Organism] AND ( (“genetype miscrna”[Properties] OR “genetype ncrna”[Properties] OR “genetype rrna”[Properties] OR “genetype trna”[Properties] OR “genetype scrna”[Properties] OR “genetype snrna”[Properties] OR “genetype snorna”[Properties]) NOT “genetype protein coding”[Properties] AND alive[prop]) – Gene”. NCBI. 2017-05-19. Retrieved 2017-05-20.^ “Search results – 20[CHR] AND “Homo sapiens”[Organism] AND (“genetype pseudo”[Properties] AND alive[prop]) – Gene”. NCBI. 2017-05-19. Retrieved 2017-05-20.^ Gilbert F (1997). “Disease genes and chromosomes: disease maps of the human genome”. Genet Test. 1 (3): 225\u2013229. doi:10.1089\/gte.1997.1.225. PMID\u00a010464650.^ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (400 bphs, Assembly GRCh38.p3). Last update 2014-03-04. Retrieved 2017-04-26.^ Genome Decoration Page, NCBI.   Ideogram data for Homo sapience (550 bphs, Assembly GRCh38.p3). Last update 2015-08-11. Retrieved 2017-04-26.^ International Standing Committee on Human Cytogenetic Nomenclature (2013). ISCN 2013: An International System for Human Cytogenetic Nomenclature (2013). Karger Medical and Scientific Publishers. ISBN\u00a0978-3-318-02253-7.^ Sethakulvichai, W.; Manitpornsut, S.; Wiboonrat, M.; Lilakiatsakun, W.; Assawamakin, A.; Tongsima, S. (2012). “Estimation of band level resolutions of human chromosome images”. In Computer Science and Software Engineering (JCSSE), 2012 International Joint Conference on: 276\u2013282. doi:10.1109\/JCSSE.2012.6261965. ISBN\u00a0978-1-4673-1921-8. S2CID\u00a016666470.^ Genome Decoration Page, NCBI.   Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.^ “p“: Short arm; “q“: Long arm.^ For cytogenetic banding nomenclature, see article locus.^ a b These values (ISCN start\/stop) are based on the length of bands\/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit.^ gpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk.External links[edit]National Institutes of Health. “Chromosome 20”. Genetics Home Reference. Archived from the original on August 3, 2004. Retrieved 2017-05-06.“Chromosome 20”. Human Genome Project Information Archive 1990\u20132003. Retrieved 2017-05-06.     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki41\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki41\/chromosome-20-wikipedia\/#breadcrumbitem","name":"Chromosome 20 – Wikipedia"}}]}]