[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki41\/megestrol-caproate-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki41\/megestrol-caproate-wikipedia\/","headline":"Megestrol caproate – Wikipedia","name":"Megestrol caproate – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Chemical compound Megestrol caproate Other names MGC; Megestrol hexanoate; Megestrol 17\u03b1-caproate; 17\u03b1-Hydroxy-6-dehydro-6-methylprogesterone 17\u03b1-caproate;","datePublished":"2014-05-25","dateModified":"2014-05-25","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki41\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki41\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/d\/d0\/Megestrol_caproate.svg\/250px-Megestrol_caproate.svg.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/d\/d0\/Megestrol_caproate.svg\/250px-Megestrol_caproate.svg.png","height":"127","width":"250"},"url":"https:\/\/wiki.edu.vn\/en\/wiki41\/megestrol-caproate-wikipedia\/","about":["Wiki"],"wordCount":2780,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Chemical compoundMegestrol caproateOther namesMGC; Megestrol hexanoate; Megestrol 17\u03b1-caproate; 17\u03b1-Hydroxy-6-dehydro-6-methylprogesterone 17\u03b1-caproate; 17\u03b1-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17\u03b1-caproateDrug classProgestin; Progestogen; Progestogen ester[(8R,9S,10R,13S,14S,17R)-17-Acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] hexanoatePubChem CIDChemSpiderFormulaC28H40O4Molar mass440.624\u00a0g\u00b7mol\u221213D model (JSmol)CCCCCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C=C(C4=CC(=O)CC[C@]34C)C)C)C(=O)C       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4InChI=1S\/C28H40O4\/c1-6-7-8-9-25(31)32-28(19(3)29)15-12-23-21-16-18(2)24-17-20(30)10-13-26(24,4)22(21)11-14-27(23,28)5\/h16-17,21-23H,6-15H2,1-5H3\/t21-,22+,23+,26-,27+,28+\/m1\/s1Key:XDVHIXRJLWUKRR-ORZTVLAMSA-NMegestrol caproate, abbreviated as MGC, is a progestin medication which was never marketed.[1][2] It was developed in Russia in 2002.[1] In animals, MGC shows 10-fold higher progestogenic activity compared to progesterone when both are administered via subcutaneous injection.[1] In addition, MGC has no androgenic, anabolic, or estrogenic activity.[1] The medication was suggested as a potential contraceptive and therapeutic agent.[1]Chemistry[edit]Megestrol caproate, also known as megestrol 17\u03b1-caproate, as well as 17\u03b1-hydroxy-6-dehydro-6-methylprogesterone 17\u03b1-caproate or as 17\u03b1-hydroxy-6-methylpregna-4,6-diene-3,20-dione 17\u03b1-caproate, is a synthetic pregnane steroid and a derivative of progesterone and 17\u03b1-hydroxyprogesterone.[1][2] It is the C17\u03b1 caproate (hexanoate) ester of megestrol.[1][2] Closely related medications include megestrol acetate (MGA; megestrol 17\u03b1-acetate), acetomepregenol (megestrol 3\u03b2,17\u03b1-diacetate), and cymegesolate (megestrol 17\u03b1-acetate 3\u03b2-cypionate).[3][4][5][6] In addition to MGA, analogues of MGC include chlormadinone caproate, gestonorone caproate, hydroxyprogesterone caproate, medroxyprogesterone caproate, and methenmadinone caproate.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4References[edit]^ a b c d e f g Pirzada OL (June 2002). “Effect of megestrol caproate on the reproductive function of laboratory animals”. Bull. Exp. Biol. Med. 133 (6): 574\u20136. doi:10.1023\/A:1020233925626. PMID\u00a012447469. S2CID\u00a024115315.^ a b c Grinenko, G. S.; Kadatskii, G. M.; Korkhov, V. V.; Boikova, V. V. (1981). “Preparation of 6-methylpregna-4,6-diene-3?,17?-diol-20-one 17-caproate and its influence on the reproductive function in rats”. Pharmaceutical Chemistry Journal. 15 (10): 718\u2013720. doi:10.1007\/BF00765383. ISSN\u00a00091-150X. S2CID\u00a046676531.^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp.\u00a0595, 664, 657. ISBN\u00a0978-1-4757-2085-3.^ Grinenko, G. S.; Popova, E. V.; Korkhov, V. V.; Lesik, E. A.; Petrosyan, M. A.; Topil’skaya, N. I. (March 2000). “Synthesis and biological activity of 17\u03b1-acetoxy-3\u03b2-phenylpropionyloxy-6-methylpregna-4,6-dien-20-one”. Pharmaceutical Chemistry Journal. 34 (3): 113\u2013114. doi:10.1007\/BF02524577. ISSN\u00a01573-9031. S2CID\u00a044235508. Note that 3,17-diacetoxy-6-methylpregna-4,6-dien-20-one (1b), a structural analog of compound 1a, is certified in Russia under the trade name acetomepregnol and recommended for therapeutic purposes in gynecological practice and as a contraceptive preparation in combination with estrogens [4].^ De-Wei Z (1982). “Research activities in the field of oral contraceptives in the People’s Republic of China”. Acta Obstet Gynecol Scand Suppl. 105: 51\u201360. doi:10.3109\/00016348209155319. PMID\u00a06952745. S2CID\u00a044858028.^ Yang, Yi-chien; Gu, Xi-gen; Li, Shu-xiang (1982). Proteins and Steroids in Early Pregnancy. pp.\u00a0335\u2013342. doi:10.1007\/978-3-642-67890-5_22. ISBN\u00a0978-3-642-67892-9.PRAgonistsTestosterone derivatives: Progestins: 6,6-Difluoronorethisterone6,6-Difluoronorethisterone acetate17\u03b1-Allyl-19-nortestosteroneAllylestrenolAltrenogestChloroethynylnorgestrelCingestolDanazolDesogestrelDienogestEthinylandrostenediolEthisteroneEthyneroneEtonogestrelEtynodiolEtynodiol diacetateGestodeneGestrinoneLevonorgestrelLevonorgestrel esters (e.g., levonorgestrel butanoate)LynestrenolLynestrenol phenylpropionateMetynodiolMetynodiol diacetateNorelgestrominNorethisterone (norethindrone)Norethisterone esters (e.g., norethisterone acetate, norethisterone enanthate)NoretynodrelNorgesteroneNorgestimateNorgestrelNorgestrienoneNorvinisteroneOxendoloneQuingestanolQuingestanol acetateTiboloneTigestolTosagestin; Anabolic\u2013androgenic steroids: 11\u03b2-Methyl-19-nortestosterone11\u03b2-Methyl-19-nortestosterone dodecylcarbonate19-Nor-5-androstenediol19-Nor-5-androstenedione19-NordehydroepiandrosteroneBolandiolBolandiol dipropionateBolandioneDimethisteroneDienedioneDienoloneDimethandroloneDimethandrolone buciclateDimethandrolone dodecylcarbonateDimethandrolone undecanoateDimethyldienoloneDimethyltrienoloneEthyldienoloneEthylestrenol (ethylnandrol)MethyldienoloneMetribolone (R-1881)Methoxydienone (methoxygonadiene)MiboleroneNandroloneNandrolone esters (e.g., nandrolone decanoate, nandrolone phenylpropionate)NorethandroloneNormethandrone (methylestrenolone, normethandrolone, normethisterone)RU-2309TetrahydrogestrinoneTrenbolone (trienolone)Trenbolone esters (e.g., trenbolone acetate, trenbolone enanthate)TrendioneTrestoloneTrestolone acetateMixed(SPRMs)AntagonistsmPR(PAQR)     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki41\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki41\/megestrol-caproate-wikipedia\/#breadcrumbitem","name":"Megestrol caproate – Wikipedia"}}]}]