[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki41\/mixed-lineage-kinase-domain-like-pseudokinase\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki41\/mixed-lineage-kinase-domain-like-pseudokinase\/","headline":"Mixed lineage kinase domain like pseudokinase","name":"Mixed lineage kinase domain like pseudokinase","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Mixed lineage kinase domain like pseudokinase","datePublished":"2021-08-15","dateModified":"2021-08-15","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki41\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki41\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki41\/mixed-lineage-kinase-domain-like-pseudokinase\/","about":["Wiki"],"wordCount":3727,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensMixed lineage kinase domain like pseudokinase (MLKL) is a protein that in humans is encoded by the MLKL gene.[5]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Influence in diseases[edit]See also[edit]References[edit]Further reading[edit]Function[edit]This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis.Influence in diseases[edit]High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]. Some reports have linked it to unusual variants of multiple sclerosis[6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000168404 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000012519 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Entrez Gene: Mixed lineage kinase domain like pseudokinase”. Retrieved 2017-12-31.^ Faergeman, S.L., Evans, H., Attfield, K.E. et al. A novel neurodegenerative spectrum disorder in patients with MLKL deficiency. Cell Death Dis 11, 303 (2020). https:\/\/doi.org\/10.1038\/s41419-020-2494-0Further reading[edit]Dastani Z, Pajukanta P, Marcil M, Rudzicz N, Ruel I, Bailey SD, Lee JC, Lemire M, Faith J, Platko J, Rioux J, Hudson TJ, Gaudet D, Engert JC, Genest J (2010). “Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects”. Eur. J. Hum. Genet. 18 (3): 342\u20137. doi:10.1038\/ejhg.2009.157. PMC\u00a02824775. PMID\u00a019844255.Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, Wang X (2012). “Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase”. Cell. 148 (1\u20132): 213\u201327. doi:10.1016\/j.cell.2011.11.031. PMID\u00a022265413. S2CID\u00a017832872.Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J, Liu ZG (2012). “Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis”. Proc. Natl. Acad. Sci. U.S.A. 109 (14): 5322\u20137. Bibcode:2012PNAS..109.5322Z. doi:10.1073\/pnas.1200012109. PMC\u00a03325682. PMID\u00a022421439.Chen W, Zhou Z, Li L, Zhong CQ, Zheng X, Wu X, Zhang Y, Ma H, Huang D, Li W, Xia Z, Han J (2013). “Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling”. J. Biol. Chem. 288 (23): 16247\u201361. doi:10.1074\/jbc.M112.435545. PMC\u00a03675564. PMID\u00a023612963.Colbert LE, Fisher SB, Hardy CW, Hall WA, Saka B, Shelton JW, Petrova AV, Warren MD, Pantazides BG, Gandhi K, Kowalski J, Kooby DA, El-Rayes BF, Staley CA, Adsay NV, Curran WJ, Landry JC, Maithel SK, Yu DS (2013). “Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma”. Cancer. 119 (17): 3148\u201355. doi:10.1002\/cncr.28144. PMC\u00a04389890. PMID\u00a023720157.Murphy JM, Lucet IS, Hildebrand JM, Tanzer MC, Young SN, Sharma P, Lessene G, Alexander WS, Babon JJ, Silke J, Czabotar PE (2014). “Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL”. Biochem. J. 457 (3): 369\u201377. doi:10.1042\/BJ20131270. PMID\u00a024219132.Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG (2014). “Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis”. Nat. Cell Biol. 16 (1): 55\u201365. doi:10.1038\/ncb2883. PMC\u00a08369836. PMID\u00a024316671. S2CID\u00a027124722.Pierdomenico M, Negroni A, Stronati L, Vitali R, Prete E, Bertin J, Gough PJ, Aloi M, Cucchiara S (2014). “Necroptosis is active in children with inflammatory bowel disease and contributes to heighten intestinal inflammation”. Am. J. Gastroenterol. 109 (2): 279\u201387. doi:10.1038\/ajg.2013.403. PMID\u00a024322838. S2CID\u00a025540582.Wang H, Sun L, Su L, Rizo J, Liu L, Wang LF, Wang FS, Wang X (2014). “Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3”. Mol. Cell. 54 (1): 133\u2013146. doi:10.1016\/j.molcel.2014.03.003. PMID\u00a024703947.This article incorporates text from the United States National Library of Medicine, which is in the public domain.     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki41\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki41\/mixed-lineage-kinase-domain-like-pseudokinase\/#breadcrumbitem","name":"Mixed lineage kinase domain like pseudokinase"}}]}]