[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki43\/sox17-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki43\/sox17-wikipedia\/","headline":"SOX17 – Wikipedia","name":"SOX17 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens SRY-box 17 is a protein that in humans","datePublished":"2018-04-10","dateModified":"2018-04-10","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki43\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki43\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki43\/sox17-wikipedia\/","wordCount":6906,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensSRY-box 17 is a protein that in humans is encoded by the SOX17 gene.[5]Table of ContentsRegulation at the human SOX17 locus[edit]Function in development[edit]References[edit]Further reading[edit]Regulation at the human SOX17 locus[edit]The gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, located on Chromosome 8 q11.23. It’s gene body is isolated within a CTCF loop domain.[6][7][8] Approximately 230 kb upstream of SOX17 it has been identified a tissue specific differentially (hypo-)methylated region (DMR), which consists of SOX17 regulatory elements.[9][10] The DMR in particular bears the most distal definitive endoderm specific enhancer at the SOX17 locus.[11]SOX17 itself has recently been defined as so called topologically insulated gene (TIG). TIGs per definition are single protein coding genes (PCGs) within CTCF loop domains, that are mainly enriched in developmental regulators and suggested to be very tightly controlled via their 3D loop-domain architecture.[12]Function in development[edit]SOX17 is involved in the regulation of vertebrate embryonic development and in the determination of the endodermal cell fate. The encoded protein acts downstream of TGF beta signaling (Activin) and canonical WNT signaling (Wnt3a).[13][14] Especially the correct phosphorylation of SMAD2\/3 within the respective cell cycle (early G1 phase) is crucial for the activation of cardinal endodermal genes (e.g. SOX17) to further enter the definitive endodermal lineage.[15] Besides that, perturbation of the SOX17 centromertic CTCF-boundary in early definitive endoderm differentiation, leads to massive developmental failure and a so called mes-endodermal like trapped cell-state, which can be rescued by ectopic SOX17 expression.[16] In Xenopus gastrulae it has been shown that SOX17 modifies Wnt responses, where genomic specificity of Wnt\/\u03b2-catenin transcription is determined through functional interactions between SOX17 and \u03b2-catenin\/Tcf transcriptional complexes.[17]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000164736 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025902 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Entrez Gene: SRY-box 17”. Retrieved 2017-09-07.^ Rao SS, Huang SC, Glenn St Hilaire B, Engreitz JM, Perez EM, Kieffer-Kwon KR,  et\u00a0al. (October 2017). “Cohesin Loss Eliminates All Loop Domains”. Cell. 171 (2): 305\u2013320.e24. doi:10.1016\/j.cell.2017.09.026. hdl:1721.1\/118942. PMC\u00a05846482. PMID\u00a028985562.^ Szabo Q, Bantignies F, Cavalli G (April 2019). “Principles of genome folding into topologically associating domains”. Science Advances. 5 (4): eaaw1668. Bibcode:2019SciA….5.1668S. doi:10.1126\/sciadv.aaw1668. PMC\u00a06457944. PMID\u00a030989119.^ Wu, Hua-Jun; Landshammer, Alexandro; Stamenova, Elena K.; Bolondi, Adriano; Kretzmer, Helene; Meissner, Alexander; Michor, Franziska (2021-08-12). “Topological isolation of developmental regulators in mammalian genomes”. Nature Communications. 12 (1): 4897. Bibcode:2021NatCo..12.4897W. doi:10.1038\/s41467-021-24951-7. ISSN\u00a02041-1723. PMC\u00a08361032. PMID\u00a034385432.^ Tsankov AM, Gu H, Akopian V, Ziller MJ, Donaghey J, Amit I,  et\u00a0al. (February 2015). “Transcription factor binding dynamics during human ES cell differentiation”. Nature. 518 (7539): 344\u20139. Bibcode:2015Natur.518..344T. doi:10.1038\/nature14233. PMC\u00a04499331. PMID\u00a025693565.^ Wu, Hua-Jun; Landshammer, Alexandro; Stamenova, Elena K.; Bolondi, Adriano; Kretzmer, Helene; Meissner, Alexander; Michor, Franziska (2021-08-12). “Topological isolation of developmental regulators in mammalian genomes”. Nature Communications. 12 (1): 4897. Bibcode:2021NatCo..12.4897W. doi:10.1038\/s41467-021-24951-7. ISSN\u00a02041-1723. PMC\u00a08361032. PMID\u00a034385432.^ Wu, Hua-Jun; Landshammer, Alexandro; Stamenova, Elena K.; Bolondi, Adriano; Kretzmer, Helene; Meissner, Alexander; Michor, Franziska (2021-08-12). “Topological isolation of developmental regulators in mammalian genomes”. Nature Communications. 12 (1): 4897. Bibcode:2021NatCo..12.4897W. doi:10.1038\/s41467-021-24951-7. ISSN\u00a02041-1723. PMC\u00a08361032. PMID\u00a034385432.^ Wu, Hua-Jun; Landshammer, Alexandro; Stamenova, Elena K.; Bolondi, Adriano; Kretzmer, Helene; Meissner, Alexander; Michor, Franziska (2021-08-12). “Topological isolation of developmental regulators in mammalian genomes”. Nature Communications. 12 (1): 4897. Bibcode:2021NatCo..12.4897W. doi:10.1038\/s41467-021-24951-7. ISSN\u00a02041-1723. PMC\u00a08361032. PMID\u00a034385432.^ Engert S, Burtscher I, Liao WP, Dulev S, Schotta G, Lickert H (August 2013). “Wnt\/\u03b2-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse”. Development. 140 (15): 3128\u201338. doi:10.1242\/dev.088765. PMID\u00a023824574.^ Mukherjee S, Chaturvedi P, Rankin SA, Fish MB, Wlizla M, Paraiso KD,  et\u00a0al. (September 2020).  LaBonne C, Morrisey EE (eds.). “Sox17 and \u03b2-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network”. eLife. 9: e58029. doi:10.7554\/eLife.58029. PMC\u00a07498262. PMID\u00a032894225.^ Pauklin S, Vallier L (September 2013). “The cell-cycle state of stem cells determines cell fate propensity”. Cell. 155 (1): 135\u201347. doi:10.1016\/j.cell.2013.08.031. PMC\u00a03898746. PMID\u00a024074866.^ Wu, Hua-Jun; Landshammer, Alexandro; Stamenova, Elena K.; Bolondi, Adriano; Kretzmer, Helene; Meissner, Alexander; Michor, Franziska (2021-08-12). “Topological isolation of developmental regulators in mammalian genomes”. Nature Communications. 12 (1): 4897. Bibcode:2021NatCo..12.4897W. doi:10.1038\/s41467-021-24951-7. ISSN\u00a02041-1723. PMC\u00a08361032. PMID\u00a034385432.^ Mukherjee, Shreyasi; Chaturvedi, Praneet; Rankin, Scott A; Fish, Margaret B; Wlizla, Marcin; Paraiso, Kitt D; MacDonald, Melissa; Chen, Xiaoting; Weirauch, Matthew T; Blitz, Ira L; Cho, Ken WY (2020-09-07).  LaBonne, Carole; Morrisey, Edward E (eds.). “Sox17 and \u03b2-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network”. eLife. 9: e58029. doi:10.7554\/eLife.58029. ISSN\u00a02050-084X. PMC\u00a07498262. PMID\u00a032894225.Further reading[edit]Zhang W, Gl\u00f6ckner SC, Guo M, Machida EO, Wang DH, Easwaran H,  et\u00a0al. (April 2008). “Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer”. Cancer Research. 68 (8): 2764\u201372. doi:10.1158\/0008-5472.CAN-07-6349. PMC\u00a02823123. PMID\u00a018413743.Patterson ES, Addis RC, Shamblott MJ, Gearhart JD (August 2008). “SOX17 directly activates Zfp202 transcription during in vitro endoderm differentiation”. Physiological Genomics. 34 (3): 277\u201384. doi:10.1152\/physiolgenomics.90236.2008. PMID\u00a018523156.Ferrell RE, Kimak MA, Lawrence EC, Finegold DN (2008). “Candidate gene analysis in primary lymphedema”. Lymphatic Research and Biology. 6 (2): 69\u201376. doi:10.1089\/lrb.2007.1022. PMID\u00a018564921.S\u00e9guin CA, Draper JS, Nagy A, Rossant J (August 2008). “Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells”. Cell Stem Cell. 3 (2): 182\u201395. doi:10.1016\/j.stem.2008.06.018. PMID\u00a018682240.Semb H (October 2008). “Expandable endodermal progenitors: new tools to explore endoderm and its derivatives”. Cell Stem Cell. 3 (4): 355\u20136. doi:10.1016\/j.stem.2008.09.010. PMID\u00a018940723.Fu DY, Wang ZM, Wang BL, Shen ZZ, Huang W, Shao ZM (February 2010). “Sox17, the canonical Wnt antagonist, is epigenetically inactivated by promoter methylation in human breast cancer”. Breast Cancer Research and Treatment. 119 (3): 601\u201312. doi:10.1007\/s10549-009-0339-8. PMID\u00a019301122. S2CID\u00a08614063.Nonaka D (May 2009). “Differential expression of SOX2 and SOX17 in testicular germ cell tumors”. American Journal of Clinical Pathology. 131 (5): 731\u20136. doi:10.1309\/AJCP7MNCNBCRN8NO. PMID\u00a019369635.Du YC, Oshima H, Oguma K, Kitamura T, Itadani H, Fujimura T,  et\u00a0al. (October 2009). “Induction and down-regulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis”. Gastroenterology. 137 (4): 1346\u201357. doi:10.1053\/j.gastro.2009.06.041. hdl:2297\/25144. PMID\u00a019549530. S2CID\u00a06296792.Stefanovic S, Abboud N, D\u00e9silets S, Nury D, Cowan C, Puc\u00e9at M (September 2009). “Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate”. The Journal of Cell Biology. 186 (5): 665\u201373. doi:10.1083\/jcb.200901040. PMC\u00a02742180. PMID\u00a019736317.MacCarthy CM, Malik V, Wu G,  et al., & Velychko S  (September 2022). “Enhancing Sox\/Oct cooperativity induces higher-grade developmental reset”. bioRxiv.  doi:10.1101\/2022.09.23.509242This article incorporates text from the United States National Library of Medicine, which is in the public domain."},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki43\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki43\/sox17-wikipedia\/#breadcrumbitem","name":"SOX17 – Wikipedia"}}]}]