[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki5\/atf1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki5\/atf1-wikipedia\/","headline":"ATF1 – Wikipedia","name":"ATF1 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Cyclic AMP-dependent transcription factor ATF-1 is a protein","datePublished":"2020-12-28","dateModified":"2020-12-28","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki5\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki5\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/11\/book.png","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/11\/book.png","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/a\/a7\/PDB_1dh3_EBI.jpg\/180px-PDB_1dh3_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/a\/a7\/PDB_1dh3_EBI.jpg\/180px-PDB_1dh3_EBI.jpg","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki5\/atf1-wikipedia\/","wordCount":6636,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensCyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine\/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I\/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.[5]Clinical significance[edit]Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.[5][6]See also[edit]Interactions[edit]ATF1 has been shown to interact with:References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000123268 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000080968 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b “Entrez Gene: ATF1 activating transcription factor 1”.^ Zucman J, Delattre O, Desmaze C, Epstein AL, Stenman G, Speleman F, Fletchers CD, Aurias A, Thomas G (November 1993). “EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts”. Nat Genet. 4 (4): 341\u20135. doi:10.1038\/ng0893-341. PMID\u00a08401579. S2CID\u00a010944105.^ Houvras Y, Benezra M, Zhang H, Manfredi JJ, Weber BL, Licht JD (November 2000). “BRCA1 physically and functionally interacts with ATF1”. J. Biol. Chem. 275 (46): 36230\u20137. doi:10.1074\/jbc.M002539200. PMID\u00a010945975.^ a b Yamaguchi Y, Wada T, Suzuki F, Takagi T, Hasegawa J, Handa H (August 1998). “Casein kinase II interacts with the bZIP domains of several transcription factors”. Nucleic Acids Res. 26 (16): 3854\u201361. doi:10.1093\/nar\/26.16.3854. PMC\u00a0147779. PMID\u00a09685505.^ Fujimura Y, Ohno T, Siddique H, Lee L, Rao VN, Reddy ES (January 1996). “The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activator”. Oncogene. 12 (1): 159\u201367. PMID\u00a08552387.Further reading[edit]Fujimura Y, Ohno T, Siddique H, Lee L, Rao VN, Reddy ES (January 1996). “The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activator”. Oncogene. 12 (1): 159\u201367. PMID\u00a08552387.Fujimura Y, Siddique H, Lee L, Rao VN, Reddy ES (October 2001). “EWS-ATF-1 chimeric protein in soft tissue clear cell sarcoma associates with CREB-binding protein and interferes with p53-mediated trans-activation function”. Oncogene. 20 (46): 6653\u20139. doi:10.1038\/sj.onc.1204684. PMID\u00a011709699.Rehfuss RP, Walton KM, Loriaux MM, Goodman RH (1991). “The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.” J. Biol. Chem. 266 (28): 18431\u20134. doi:10.1016\/S0021-9258(18)55078-X. PMID\u00a01655749.Yoshimura T, Fujisawa J, Yoshida M (1990). “Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain”. EMBO J. 9 (8): 2537\u201342. doi:10.1002\/j.1460-2075.1990.tb07434.x. PMC\u00a0552284. PMID\u00a02196176.Hai TW, Liu F, Coukos WJ, Green MR (1990). “Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers”. Genes Dev. 3 (12B): 2083\u201390. doi:10.1101\/gad.3.12b.2083. PMID\u00a02516827.Pongubala JM, Atchison ML (1995). “Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3′ enhancer”. J. Biol. Chem. 270 (17): 10304\u201313. doi:10.1074\/jbc.270.17.10304. PMID\u00a07730336.Liu F, Thompson MA, Wagner S,  et\u00a0al. (1993). “Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation”. J. Biol. Chem. 268 (9): 6714\u201320. doi:10.1016\/S0021-9258(18)53308-1. PMID\u00a08384217.Dorsey MJ, Tae HJ, Sollenberger KG,  et\u00a0al. (1996). “B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family”. Oncogene. 11 (11): 2255\u201365. PMID\u00a08570175.Sun P, Lou L, Maurer RA (1996). “Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+\/calmodulin-dependent protein kinases type I, II, and IV”. J. Biol. Chem. 271 (6): 3066\u201373. doi:10.1074\/jbc.271.6.3066. PMID\u00a08621702.Shimomura A, Ogawa Y, Kitani T,  et\u00a0al. (1996). “Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein”. J. Biol. Chem. 271 (30): 17957\u201360. doi:10.1074\/jbc.271.30.17957. PMID\u00a08663317.Bonaldo MF, Lennon G, Soares MB (1997). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791\u2013806. doi:10.1101\/gr.6.9.791. PMID\u00a08889548.Kobayashi M, Shimomura A, Hagiwara M, Kawakami K (1997). “Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na,K-ATPase alpha 1 subunit gene promoter”. Nucleic Acids Res. 25 (4): 877\u201382. doi:10.1093\/nar\/25.4.877. PMC\u00a0146500. PMID\u00a09016641.Soubt MK, Marksitzer R, Menoud PA, Nagamine Y (1998). “Role of tissue-specific transcription factor LFB3 in a cyclic AMP-responsive enhancer of the urokinase-type plasminogen activator gene in LLC-PK1 cells”. Mol. Cell. Biol. 18 (8): 4698\u2013706. doi:10.1128\/mcb.18.8.4698. PMC\u00a0109056. PMID\u00a09671480.Yamaguchi Y, Wada T, Suzuki F,  et\u00a0al. (1998). “Casein kinase II interacts with the bZIP domains of several transcription factors”. Nucleic Acids Res. 26 (16): 3854\u201361. doi:10.1093\/nar\/26.16.3854. PMC\u00a0147779. PMID\u00a09685505.Pell\u00edn A, Monteagudo C, L\u00f3pez-Gin\u00e9s C,  et\u00a0al. (1999). “New type of chimeric fusion product between the EWS and ATFI genes in clear cell sarcoma (malignant melanoma of soft parts)”. Genes Chromosomes Cancer. 23 (4): 358\u201360. doi:10.1002\/(SICI)1098-2264(199812)23:43.0.CO;2-3. PMID\u00a09824209. S2CID\u00a022927124.Kabe Y, Goto M, Shima D,  et\u00a0al. (1999). “The role of human MBF1 as a transcriptional coactivator”. J. Biol. Chem. 274 (48): 34196\u2013202. doi:10.1074\/jbc.274.48.34196. PMID\u00a010567391.Sawada J, Simizu N, Suzuki F,  et\u00a0al. (2000). “Synergistic transcriptional activation by hGABP and select members of the activation transcription factor\/cAMP response element-binding protein family”. J. Biol. Chem. 274 (50): 35475\u201382. doi:10.1074\/jbc.274.50.35475. PMID\u00a010585419.Houvras Y, Benezra M, Zhang H,  et\u00a0al. (2000). “BRCA1 physically and functionally interacts with ATF1”. J. Biol. Chem. 275 (46): 36230\u20137. doi:10.1074\/jbc.M002539200. PMID\u00a010945975.Kn\u00f6fler M, Saleh L, Bauer S,  et\u00a0al. (2000). “Promoter elements and transcription factors involved in differentiation-dependent human chorionic gonadotrophin-alpha messenger ribonucleic acid expression of term villous trophoblasts”. Endocrinology. 141 (10): 3737\u201348. doi:10.1210\/en.141.10.3737. PMID\u00a011014230.Arthur JS, Cohen P (2000). “MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells”. FEBS Lett. 482 (1\u20132): 44\u20138. doi:10.1016\/S0014-5793(00)02031-7. PMID\u00a011018520. S2CID\u00a030094202.Andreucci JJ, Grant D, Cox DM,  et\u00a0al. (2002). “Composition and function of AP-1 transcription complexes during muscle cell differentiation”. J. Biol. Chem. 277 (19): 16426\u201332. doi:10.1074\/jbc.M110891200. PMID\u00a011877423.External links[edit]PDB gallery1dh3: CRYSTAL STRUCTURE OF A CREB BZIP-CRE COMPLEX REVEALS THE BASIS FOR CREB FAIMLY SELECTIVE DIMERIZATION AND DNA BINDINGThis article incorporates text from the United States National Library of Medicine, which is in the public domain."},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki5\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki5\/atf1-wikipedia\/#breadcrumbitem","name":"ATF1 – Wikipedia"}}]}]