[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki5\/cdkn2b-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki5\/cdkn2b-wikipedia\/","headline":"CDKN2B – Wikipedia","name":"CDKN2B – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Cyclin-dependent kinase 4 inhibitor B also known as","datePublished":"2018-08-12","dateModified":"2018-08-12","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki5\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki5\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki5\/cdkn2b-wikipedia\/","about":["Wiki"],"wordCount":7374,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensCyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4b is a protein that is encoded by the CDKN2B gene in humans.[5][6]Table of ContentsFunction[edit]Interactions[edit]References[edit]Further reading[edit]External links[edit]Function[edit]This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated, deleted, or disregulated in a wide variety of cancer.[7][8][9] This gene encodes a cyclin-dependent kinase inhibitor, also known as p15Ink4b protein, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases by cyclin D, thus the encoded protein functions as a cell growth regulator that inhibits cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcripts of this gene encode proteins that share the N-terminal sequence but completely differ in the C-terminus.[6]Interactions[edit]CDKN2B tumor suppressor gene product p15 has been shown to interact with cyclin-dependent kinase 4.[10][11]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000147883 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073802 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Hannon GJ, Beach D (September 1994). “p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest”. Nature. 371 (6494): 257\u201361. Bibcode:1994Natur.371..257H. doi:10.1038\/371257a0. PMID\u00a08078588. S2CID\u00a04268054.^ a b “Entrez Gene: CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)”.^ Tu Q, Hao J, Zhou X, Yan L, Dai H, Sun B,  et\u00a0al. (January 2018). “CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A”. Oncogene. 37 (1): 128\u2013138. doi:10.1038\/onc.2017.316. PMC\u00a05759028. PMID\u00a028892048.^ Jafri M, Wake NC, Ascher DB, Pires DE, Gentle D, Morris MR,  et\u00a0al. (July 2015). “Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma”. Cancer Discovery. 5 (7): 723\u20139. doi:10.1158\/2159-8290.CD-14-1096. PMID\u00a025873077.^ Yu W, Gius D, Onyango P, Muldoon-Jacobs K, Karp J, Feinberg AP, Cui H (January 2008). “Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA”. Nature. 451 (7175): 202\u20136. Bibcode:2008Natur.451..202Y. doi:10.1038\/nature06468. PMC\u00a02743558. PMID\u00a018185590.^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N,  et\u00a0al. (October 2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173\u20138. Bibcode:2005Natur.437.1173R. doi:10.1038\/nature04209. PMID\u00a016189514. S2CID\u00a04427026.^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H,  et\u00a0al. (September 2005). “A human protein-protein interaction network: a resource for annotating the proteome”. Cell. 122 (6): 957\u201368. doi:10.1016\/j.cell.2005.08.029. hdl:11858\/00-001M-0000-0010-8592-0. PMID\u00a016169070. S2CID\u00a08235923.Further reading[edit]Hall M, Bates S, Peters G (October 1995). “Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins”. Oncogene. 11 (8): 1581\u20138. PMID\u00a07478582.Stone S, Dayananth P, Jiang P, Weaver-Feldhaus JM, Tavtigian SV, Cannon-Albright L, Kamb A (September 1995). “Genomic structure, expression and mutational analysis of the P15 (MTS2) gene”. Oncogene. 11 (5): 987\u201391. PMID\u00a07675459.Okamoto A, Hussain SP, Hagiwara K, Spillare EA, Rusin MR, Demetrick DJ,  et\u00a0al. (April 1995). “Mutations in the p16INK4\/MTS1\/CDKN2, p15INK4B\/MTS2, and p18 genes in primary and metastatic lung cancer”. Cancer Research. 55 (7): 1448\u201351. PMID\u00a07882351.Jen J, Harper JW, Bigner SH, Bigner DD, Papadopoulos N, Markowitz S,  et\u00a0al. (December 1994). “Deletion of p16 and p15 genes in brain tumors”. Cancer Research. 54 (24): 6353\u20138. PMID\u00a07987828.Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O’Keefe CL,  et\u00a0al. (December 1994). “Growth suppression by p18, a p16INK4\/MTS1- and p14INK4B\/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function”. Genes & Development. 8 (24): 2939\u201352. doi:10.1101\/gad.8.24.2939. PMID\u00a08001816.Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV,  et\u00a0al. (April 1994). “A cell cycle regulator potentially involved in genesis of many tumor types”. Science. 264 (5157): 436\u201340. Bibcode:1994Sci…264..436K. doi:10.1126\/science.8153634. PMID\u00a08153634.Reynisd\u00f3ttir I, Massagu\u00e9 J (February 1997). “The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2”. Genes & Development. 11 (4): 492\u2013503. doi:10.1101\/gad.11.4.492. PMID\u00a09042862.Sandhu C, Garbe J, Bhattacharya N, Daksis J, Pan CH, Yaswen P,  et\u00a0al. (May 1997). “Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells”. Molecular and Cellular Biology. 17 (5): 2458\u201367. doi:10.1128\/MCB.17.5.2458. PMC\u00a0232094. PMID\u00a09111314.Iavarone A, Massagu\u00e9 J (May 1997). “Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15”. Nature. 387 (6631): 417\u201322. Bibcode:1997Natur.387..417L. doi:10.1038\/387417a0. PMID\u00a09163429. S2CID\u00a01040022.Tsubari M, Tiihonen E, Laiho M (July 1997). “Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor”. Cancer Research. 57 (14): 2966\u201373. PMID\u00a09230210.Rich JN, Zhang M, Datto MB, Bigner DD, Wang XF (December 1999). “Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines”. The Journal of Biological Chemistry. 274 (49): 35053\u20138. doi:10.1074\/jbc.274.49.35053. PMID\u00a010574984.Yuan C, Selby TL, Li J, Byeon IJ, Tsai MD (June 2000). “Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data”. Protein Science. 9 (6): 1120\u20138. doi:10.1110\/ps.9.6.1120. PMC\u00a02144649. PMID\u00a010892805.Hartley JL, Temple GF, Brasch MA (November 2000). “DNA cloning using in vitro site-specific recombination”. Genome Research. 10 (11): 1788\u201395. doi:10.1101\/gr.143000. PMC\u00a0310948. PMID\u00a011076863.Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H,  et\u00a0al. (April 2001). “Repression of p15INK4b expression by Myc through association with Miz-1”. Nature Cell Biology. 3 (4): 392\u20139. doi:10.1038\/35070076. PMID\u00a011283613. S2CID\u00a012696178.Orlow I, Cordon-Cardo C (2002). “Evaluation of alterations in the tumor suppressor genes INK4A and INK4B in human bladder tumors”. Gene Probes. Methods Mol. Biol. Vol.\u00a0179. pp.\u00a043\u201359. doi:10.1385\/1-59259-238-4:043. ISBN\u00a01-59259-238-4. PMID\u00a011692873.Agiostratidou G, Derventzi A, Gonos ES (2002). “Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1\/WAF1 genes mediate growth arrest in human osteosarcoma cell lines”. In Vivo. 15 (5): 443\u20136. PMID\u00a011695244.Simon M, Park TW, K\u00f6ster G, Mahlberg R, Hackenbroch M, Bostr\u00f6m J,  et\u00a0al. (December 2001). “Alterations of INK4a(p16-p14ARF)\/INK4b(p15) expression and telomerase activation in meningioma progression”. Journal of Neuro-Oncology. 55 (3): 149\u201358. doi:10.1023\/A:1013863630293. PMID\u00a011859969. S2CID\u00a019711721.Scarisbrick JJ, Woolford AJ, Calonje E, Photiou A, Ferreira S, Orchard G,  et\u00a0al. (March 2002). “Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and sezary syndrome”. The Journal of Investigative Dermatology. 118 (3): 493\u20139. doi:10.1046\/j.0022-202x.2001.01682.x. PMID\u00a011874489.Kudoh K, Ichikawa Y, Yoshida S, Hirai M, Kikuchi Y, Nagata I,  et\u00a0al. (June 2002). “Inactivation of p16\/CDKN2 and p15\/MTS2 is associated with prognosis and response to chemotherapy in ovarian cancer”. International Journal of Cancer. 99 (4): 579\u201382. doi:10.1002\/ijc.10331. PMID\u00a011992549. S2CID\u00a081974.Yang W, Zhang A, Han Y, Su X, Chen Y, Zhao W (2021). “Cyclin-Dependent Kinase Inhibitor 2b Controls Fibrosis and Functional Changes in Ischemia-Induced Heart Failure via the BMI1-p15-Rb Signalling Pathway”. Canadian Journal of Cardiology. 37 (4): 655\u2013664. doi:10.1016\/j.cjca.2020.05.016. PMID\u00a032428618. S2CID\u00a0218756624.External links[edit]"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki5\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki5\/cdkn2b-wikipedia\/#breadcrumbitem","name":"CDKN2B – Wikipedia"}}]}]