[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki5\/eif2c2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki5\/eif2c2-wikipedia\/","headline":"EIF2C2 – Wikipedia","name":"EIF2C2 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens AGO2 Available structures PDB Ortholog search:","datePublished":"2018-08-20","dateModified":"2018-08-20","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki5\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki5\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/c\/ce\/Protein_EIF2C2_PDB_3LUC.png\/250px-Protein_EIF2C2_PDB_3LUC.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/c\/ce\/Protein_EIF2C2_PDB_3LUC.png\/250px-Protein_EIF2C2_PDB_3LUC.png","height":"208","width":"250"},"url":"https:\/\/wiki.edu.vn\/en\/wiki5\/eif2c2-wikipedia\/","wordCount":7422,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensAGO2Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3LUC, 3LUD, 3LUG, 3LUH, 3LUJ, 3LUK, 3QX8, 3QX9, 4F3T, 4OLA, 4OLB, 4W5N, 4W5O, 4W5Q, 4W5R, 4W5T, 4Z4C, 4Z4D, 4Z4E, 4Z4F, 4Z4G, 4Z4H, 4Z4I, 5JS1, 5JS2       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4IdentifiersAliasesAGO2, EIF2C2, Q10, argonaute 2, RISC catalytic component, PPD, CASC7, LINC00980, argonaute RISC catalytic component 2, LESKRESExternal IDsOMIM: 606229 MGI: 2446632 HomoloGene: 81825 GeneCards: AGO2 WikidataProtein argonaute-2 is a protein that in humans is encoded by the EIF2C2 gene.[5][6][7]This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with Dicer1 and play a role in short-interfering-RNA-mediated gene silencing.[7]Interactions[edit]EIF2C2 has been shown to interact withReferences[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000123908 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036698 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Koesters R, Adams V, Betts D, Moos R, Schmid M, Siermann A, Hassam S, Weitz S, Lichter P, Heitz PU, von Knebel Doeberitz M, Briner J (Dec 1999). “Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression”. Genomics. 61 (2): 210\u20138. doi:10.1006\/geno.1999.5951. PMID\u00a010534406. S2CID\u00a024461432.^ Sasaki T, Shiohama A, Minoshima S, Shimizu N (Aug 2003). “Identification of eight members of the Argonaute family in the human genome small star, filled”. Genomics. 82 (3): 323\u201330. doi:10.1016\/S0888-7543(03)00129-0. PMID\u00a012906857.^ a b “Entrez Gene: EIF2C2 eukaryotic translation initiation factor 2C, 2”.^ Nelson PT, Hatzigeorgiou AG, Mourelatos Z (March 2004). “miRNP:mRNA association in polyribosomes in a human neuronal cell line”. RNA. 10 (3): 387\u201394. doi:10.1261\/rna.5181104. PMC\u00a01370934. PMID\u00a014970384.^ a b Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (March 2002). “miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs”. Genes Dev. 16 (6): 720\u20138. doi:10.1101\/gad.974702. PMC\u00a0155365. PMID\u00a011914277.^ Doi N, Zenno S, Ueda R, Ohki-Hamazaki H, Ui-Tei K, Saigo K (January 2003). “Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors”. Curr. Biol. 13 (1): 41\u20136. doi:10.1016\/S0960-9822(02)01394-5. PMID\u00a012526743. S2CID\u00a014650075.^ Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST (February 2004). “Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway”. Nat. Neurosci. 7 (2): 113\u20137. doi:10.1038\/nn1174. PMID\u00a014703574. S2CID\u00a01146182.^ Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). “A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain”. Nat. Struct. Mol. Biol. 14 (10): 897\u2013903. doi:10.1038\/nsmb1302. PMID\u00a017891150. S2CID\u00a08136380.Further reading[edit]Carmell MA, Xuan Z, Zhang MQ, Hannon GJ (2002). “The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis”. Genes Dev. 16 (21): 2733\u201342. doi:10.1101\/gad.1026102. PMID\u00a012414724.Mourelatos Z, Dostie J, Paushkin S,  et\u00a0al. (2002). “miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs”. Genes Dev. 16 (6): 720\u20138. doi:10.1101\/gad.974702. PMC\u00a0155365. PMID\u00a011914277.Martinez J, Patkaniowska A, Urlaub H,  et\u00a0al. (2003). “Single-stranded antisense siRNAs guide target RNA cleavage in RNAi”. Cell. 110 (5): 563\u201374. doi:10.1016\/S0092-8674(02)00908-X. hdl:11858\/00-001M-0000-0012-F2FD-2. PMID\u00a012230974. S2CID\u00a010616773.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Doi N, Zenno S, Ueda R,  et\u00a0al. (2003). “Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors”. Curr. Biol. 13 (1): 41\u20136. doi:10.1016\/S0960-9822(02)01394-5. PMID\u00a012526743. S2CID\u00a014650075.Tahbaz N, Kolb FA, Zhang H,  et\u00a0al. (2004). “Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer”. EMBO Rep. 5 (2): 189\u201394. doi:10.1038\/sj.embor.7400070. PMC\u00a01298981. PMID\u00a014749716.Nelson PT, Hatzigeorgiou AG, Mourelatos Z (2004). “miRNP:mRNA association in polyribosomes in a human neuronal cell line”. RNA. 10 (3): 387\u201394. doi:10.1261\/rna.5181104. PMC\u00a01370934. PMID\u00a014970384.Liu J, Carmell MA, Rivas FV,  et\u00a0al. (2004). “Argonaute2 is the catalytic engine of mammalian RNAi”. Science. 305 (5689): 1437\u201341. doi:10.1126\/science.1102513. PMID\u00a015284456. S2CID\u00a02778088.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Rivas FV, Tolia NH, Song JJ,  et\u00a0al. (2005). “Purified Argonaute2 and an siRNA form recombinant human RISC”. Nat. Struct. Mol. Biol. 12 (4): 340\u20139. doi:10.1038\/nsmb918. PMID\u00a015800637. S2CID\u00a02021813.Sen GL, Blau HM (2005). “Argonaute 2\/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies”. Nat. Cell Biol. 7 (6): 633\u20136. doi:10.1038\/ncb1265. PMID\u00a015908945. S2CID\u00a06085169.Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (2005). “MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies”. Nat. Cell Biol. 7 (7): 719\u201323. doi:10.1038\/ncb1274. PMC\u00a01855297. PMID\u00a015937477.Rual JF, Venkatesan K, Hao T,  et\u00a0al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173\u20138. Bibcode:2005Natur.437.1173R. doi:10.1038\/nature04209. PMID\u00a016189514. S2CID\u00a04427026.Kraynack BA, Baker BF (2006). “Small interfering RNAs containing full 2′-O-methylribonucleotide-modified sense strands display Argonaute2\/eIF2C2-dependent activity”. RNA. 12 (1): 163\u201376. doi:10.1261\/rna.2150806. PMC\u00a01370895. PMID\u00a016301602.Maniataki E, Mourelatos Z (2006). “A human, ATP-independent, RISC assembly machine fueled by pre-miRNA”. Genes Dev. 19 (24): 2979\u201390. doi:10.1101\/gad.1384005. PMC\u00a01315402. PMID\u00a016357216.Shi H, Tschudi C, Ullu E (2006). “Functional replacement of Trypanosoma brucei Argonaute by the human slicer Argonaute2”. RNA. 12 (6): 943\u20137. doi:10.1261\/rna.20806. PMC\u00a01464859. PMID\u00a016611939.Wichroski MJ, Robb GB, Rana TM (2006). “Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies”. PLOS Pathog. 2 (5): e41. doi:10.1371\/journal.ppat.0020041. PMC\u00a01458959. PMID\u00a016699599.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki5\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki5\/eif2c2-wikipedia\/#breadcrumbitem","name":"EIF2C2 – Wikipedia"}}]}]