FOXN1 – Wikipedia

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Protein-coding gene in the species Homo sapiens

Forkhead box protein N1 is a protein that in humans is encoded by the FOXN1 gene.[5][6]


Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5′ UTR of this gene has been observed.[6] In the chick embryo, the FOXN1 gene is expressed in the developing thymus, claws and feathers. The expression of FOXN1 in feathers and claws indicates that it may regulate the feather outgrowth. In feather and claws, FOXN1 can potentially regulate expression of keratins similar to mammalian orthologs. [7] In thymic epithelial cells, FOXN1 has been shown to bind to and regulate genes involved in T-cell maturation and antigen presentation.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109101 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002057 – Ensembl, May 2017
  3. ^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schorpp M, Hofmann M, Dear TN, Boehm T (Dec 1997). “Characterization of mouse and human nude genes”. Immunogenetics. 46 (6): 509–15. doi:10.1007/s002510050312. PMID 9321431. S2CID 32175138.
  6. ^ a b “Entrez Gene: FOXN1 forkhead box N1”.
  7. ^ Darnell DK, Zhang LS, Hannenhalli S, Yaklichkin SY (Dec 2014). “Developmental expression of chicken FOXN1 and putative target genes during feather development”. The International Journal of Developmental Biology. 58 (1): 57–64. doi:10.1387/ijdb.130023sy. PMID 24860996.
  8. ^ Žuklys S, Handel A, Zhanybekova S, Govani F, Keller M, Maio S, Mayer CE, Teh HY, Hafen K, Gallone G, Barthlott T, Ponting CP, Holländer GA (Aug 2016). “Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells”. Nature Immunology. 17 (10): 1206–15. doi:10.1038/ni.3537. PMC 5033077. PMID 27548434.

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