HIST1H1T – Wikipedia

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Protein-coding gene in the species Homo sapiens

H1-6
Identifiers
Aliases H1-6, H1FT, H1t, dJ221C16.2, H1.6, histone cluster 1, H1t, histone cluster 1 H1 family member t, HIST1H1T, H1.6 linker histone, cluster member
External IDs OMIM: 142712 MGI: 1888530 HomoloGene: 3889 GeneCards: H1-6
Wikidata

Histone H1t is a protein that in humans is encoded by the HIST1H1T gene.[5][6][7]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187475 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036211 – Ensembl, May 2017
  3. ^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Koppel DA, Wolfe SA, Fogelfeld LA, Merchant PS, Prouty L, Grimes SR (Jun 1994). “Primate testicular histone H1t genes are highly conserved and the human H1t gene is located on chromosome 6”. J Cell Biochem. 54 (2): 219–30. doi:10.1002/jcb.240540210. PMID 8175896. S2CID 13648109.
  6. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). “The human and mouse replication-dependent histone genes”. Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. ^ a b “Entrez Gene: HIST1H1T histone cluster 1, H1t”.

Further reading[edit]