[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/cotl1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki6\/cotl1-wikipedia\/","headline":"COTL1 – Wikipedia","name":"COTL1 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Coactosin-like protein (COTL1 or CLP) is a protein","datePublished":"2017-01-29","dateModified":"2017-01-29","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki6\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/54\/PDB_1t2l_EBI.jpg\/180px-PDB_1t2l_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/54\/PDB_1t2l_EBI.jpg\/180px-PDB_1t2l_EBI.jpg","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki6\/cotl1-wikipedia\/","wordCount":5794,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensCoactosin-like protein (COTL1 or CLP) is a protein that in humans is encoded by the COTL1 gene.[5][6][7][8]Function[edit]This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with and thereby stabilizes 5-lipoxygenase (ALOX5). Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.[8]Interactions[edit]COTL1 has been shown to interact with ALOX5.[9]  ALOX5 is the first committed enzyme in the metabolism of arachidonic acid to an array of biologically important cell signaling agents: a) the pro-inflammatory mediator, leukotriene B4 (LTB4); b) the airways constrictors, LTC4, LTD4, and LTE4; c) the 5-hydroxyeicosatetraenoic acid family of pro-inflammatory and pro-allergic reactions mediators, 5-HETE and 5-oxo-eicosatetraenoic acid. ALOX5 also contributes to the metabolism of arachidonic acid and other polyunsaturated fatty acids to agents which act block inflammation and allergic reactions, the specialized pro-resolving mediators of the lipoxin and resolvin subclasses. Based on in vitro studies, COTL1 serves to stabilize ALOX5, acting as a chaperone or scaffold, to avert the enzyme’s inactivation and thereby to promote its metabolic activity.[10]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000103187 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031827 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Provost P, Samuelsson B, R\u00e5dmark O (Apr 1999). “Interaction of 5-lipoxygenase with cellular proteins”. Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1881\u20135. Bibcode:1999PNAS…96.1881P. doi:10.1073\/pnas.96.5.1881. PMC\u00a026705. PMID\u00a010051563.^ Chen KS, Manian P, Koeuth T, Potocki L, Zhao Q, Chinault AC, Lee CC, Lupski JR (Nov 1997). “Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome”. Nat. Genet. 17 (2): 154\u201363. doi:10.1038\/ng1097-154. PMID\u00a09326934. S2CID\u00a027742511.^ Rakonjac M, Fischer L, Provost P, Werz O, Steinhilber D, Samuelsson B, R\u00e5dmark O (Sep 2006). “Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production”. Proc. Natl. Acad. Sci. U.S.A. 103 (35): 13150\u20135. Bibcode:2006PNAS..10313150R. doi:10.1073\/pnas.0605150103. PMC\u00a01559768. PMID\u00a016924104.^ a b “Entrez Gene: COTL1 coactosin-like 1 (Dictyostelium)”.^ Provost P, Doucet J, Hammarberg T, Gerisch G, Samuelsson B, Radmark O (May 2001). “5-Lipoxygenase interacts with coactosin-like protein”. J. Biol. Chem. 276 (19): 16520\u20137. doi:10.1074\/jbc.M011205200. PMID\u00a011297527.^ Anwar Y, Sabir JS, Qureshi MI, Saini KS (2014). “5-lipoxygenase: a promising drug target against inflammatory diseases-biochemical and pharmacological regulation”. Current Drug Targets. 15 (4): 410\u201322. doi:10.2174\/1389450114666131209110745. PMID\u00a024313690.External links[edit]Further reading[edit]Wu C, Friedlander P, Lamoureux C, Zannis-Hadjopoulos M, Price GB (1993). “cDNA clones contain autonomous replication activity”. Biochim. Biophys. Acta. 1174 (3): 241\u201357. doi:10.1016\/0167-4781(93)90193-h. PMID\u00a07690594.Provost P, Doucet J, Hammarberg T, Gerisch G, Samuelsson B, Radmark O (2001). “5-Lipoxygenase interacts with coactosin-like protein”. J. Biol. Chem. 276 (19): 16520\u20137. doi:10.1074\/jbc.M011205200. PMID\u00a011297527.Provost P, Doucet J, Stock A, Gerisch G, Samuelsson B, R\u00e5dmark O (2001). “Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75”. Biochem. J. 359 (Pt 2): 255\u201363. doi:10.1042\/0264-6021:3590255. PMC\u00a01222143. PMID\u00a011583571.Nakatsura T, Senju S, Ito M, Nishimura Y, Itoh K (2002). “Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method”. Eur. J. Immunol. 32 (3): 826\u201336. doi:10.1002\/1521-4141(200203)32:33.0.CO;2-Y. PMID\u00a011870627. S2CID\u00a021684580.Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). “Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides”. Nat. Biotechnol. 21 (5): 566\u20139. doi:10.1038\/nbt810. PMID\u00a012665801. S2CID\u00a023783563.Dai H, Wu J, Xu Y, Yajun T, Husheng D, Shi Y (2004). “1H, 13C and 15N resonance assignments and the secondary structures of human coactosin like protein (hCLP) D123N”. J. Biomol. NMR. 29 (3): 455\u20136. doi:10.1023\/B:JNMR.0000032550.18424.aa. PMID\u00a015213466. S2CID\u00a027858479.Liu L, Wang Y, Zhang P, Cheng Z, Wan M, Zhou Z, Gong W (2004). “Expression, purification and preliminary crystallographic studies of human coactosin-like protein”. Acta Crystallogr. D. 60 (Pt 9): 1651\u20133. doi:10.1107\/S0907444904016701. PMID\u00a015333945.Li X, Liu X, Lou Z, Duan X, Wu H, Liu Y, Rao Z (2004). “Crystal structure of human coactosin-like protein at 1.9 A resolution”. Protein Sci. 13 (11): 2845\u201351. doi:10.1110\/ps.04937304. PMC\u00a02286586. PMID\u00a015459340.Li X, Liu X, Zhao Q, Liu Y, Duan X, Rao Z (2004). “Crystallization and preliminary crystallographic studies of human coactosin-like protein (CLP)”. Acta Crystallogr. D. 60 (Pt 12 Pt 2): 2387\u20138. doi:10.1107\/S0907444904028112. PMID\u00a015583396.Gevaert K, Staes A, Van Damme J, De Groot S, Hugelier K, Demol H, Martens L, Goethals M, Vandekerckhove J (2005). “Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC”. Proteomics. 5 (14): 3589\u201399. doi:10.1002\/pmic.200401217. PMID\u00a016097034. S2CID\u00a0895879.Dai H, Huang W, Xu J, Yao B, Xiong S, Ding H, Tang Y, Liu H, Wu J, Shi Y (2006). “Binding model of human coactosin-like protein with filament actin revealed by mutagenesis”. Biochim. Biophys. Acta. 1764 (11): 1688\u2013700. doi:10.1016\/j.bbapap.2006.06.017. PMID\u00a017070122.PDB gallery1t2l: Three Crystal Structures of Human Coactosin-like Protein1t3x: Three Crystal Structures of Human Coactosin-like Protein1t3y: Three Crystal Structures of Human Coactosin-like Protein1tmw: Solution structure of Human Coactosin Like Protein D123N1udm: Solution structure of Coactosin-like protein (Cofilin family) from Mus Musculus1vfq: The Crystal Structure of Human Coactosin-like Protein at 1.9 A Resolution1wm4: Solution structure of mouse coactosin, an actin filament binding protein1wnj: NMR structure of human coactosin-like protein"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/cotl1-wikipedia\/#breadcrumbitem","name":"COTL1 – Wikipedia"}}]}]