[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/hla-dqa2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki6\/hla-dqa2-wikipedia\/","headline":"HLA-DQA2 – Wikipedia","name":"HLA-DQA2 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens HLA class II histocompatibility antigen, DQ(6)","datePublished":"2022-05-16","dateModified":"2022-05-16","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki6\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki6\/hla-dqa2-wikipedia\/","wordCount":4934,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensHLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the HLA-DQA2 gene. Also known as HLA-DXA or DAAP-381D23.2, it is part of the human leucocyte antigen system.[3]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4The protein encoded by this gene is expressed, but unlike HLA-DQA1, it apparently unable to heterodimerize with HLA class II beta chain paralogues.[4] The low level of HLA-DQA2 expression is apparently due to impaired transcription factor binding to the HLA-DQA2 gene promoter.[5]References[edit]^ a b c ENSG00000206301, ENSG00000257473, ENSG00000231526, ENSG00000225103, ENSG00000237541, ENSG00000223793, ENSG00000233192 GRCh38: Ensembl release 89: ENSG00000231823, ENSG00000206301, ENSG00000257473, ENSG00000231526, ENSG00000225103, ENSG00000237541, ENSG00000223793, ENSG00000233192 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Entrez Gene: HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2”.^ Rudy GB, Lew AM (March 1997). “The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells”. J. Immunol. 158 (5): 2116\u201325. PMID\u00a09036956.^ Indovina P, Megiorni F, Fontemaggi G, Coni P, Mora B, Mazzilli MC (May 2001). “Absence of in vivo DNA-protein interactions in the DQA2 and DQB2 promoter regions”. Hum. Immunol. 62 (5): 504\u20138. doi:10.1016\/S0198-8859(01)00236-1. PMID\u00a011334674.Further reading[edit]Marsh SG, Bodmer JG (1993). “HLA class II nucleotide sequences, 1992”. Tissue Antigens. 40 (5): 229\u201343. doi:10.1111\/j.1399-0039.1992.tb02050.x. PMID\u00a01362295.Kenter M, Otting N, Anholts J,  et\u00a0al. (1992). “Evolutionary relationships among the primate Mhc-DQA1 and DQA2 alleles”. Immunogenetics. 36 (2): 71\u20138. doi:10.1007\/BF00215282. PMID\u00a01612647. S2CID\u00a043642526.Piatier-Tonneau D, Gastinel LN, Amblard F,  et\u00a0al. (1991). “Interaction of CD4 with HLA class II antigens and HIV gp120”. Immunogenetics. 34 (2): 121\u20138. doi:10.1007\/BF00211424. PMID\u00a01869305. S2CID\u00a010116507.Rosenstein Y, Burakoff SJ, Herrmann SH (1990). “HIV-gp120 can block CD4-class II MHC-mediated adhesion”. J. Immunol. 144 (2): 526\u201331. PMID\u00a01967269.Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). “Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules”. Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052\u20136. doi:10.1073\/pnas.87.22.9052. PMC\u00a055099. PMID\u00a01978941.Gyllensten UB, Erlich HA (1990). “Ancient roots for polymorphism at the HLA-DQ alpha locus in primates”. Proc. Natl. Acad. Sci. U.S.A. 86 (24): 9986\u201390. doi:10.1073\/pnas.86.24.9986. PMC\u00a0298627. PMID\u00a02513578.Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). “Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding”. Nature. 339 (6225): 548\u201351. Bibcode:1989Natur.339..548C. doi:10.1038\/339548a0. PMID\u00a02543930. S2CID\u00a04246781.Diamond DC, Sleckman BP, Gregory T,  et\u00a0al. (1988). “Inhibition of CD4+ T cell function by the HIV envelope protein, gp120”. J. Immunol. 141 (11): 3715\u20137. PMID\u00a02846691.Jonsson AK, Hyldig-Nielsen JJ, Servenius B,  et\u00a0al. (1987). “Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes”. J. Biol. Chem. 262 (18): 8767\u201377. doi:10.1016\/S0021-9258(18)47482-0. PMID\u00a03036828.Horn GT, Bugawan TL, Long CM,  et\u00a0al. (1988). “Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals”. Hum. Immunol. 21 (4): 249\u201363. doi:10.1016\/0198-8859(88)90034-1. PMID\u00a03372263.Andrieu JM, Even P, Venet A (1986). “AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications”. AIDS Research. 2 (3): 163\u201374. doi:10.1089\/aid.1.1986.2.163. PMID\u00a03489470.Auffray C, Lillie JW, Korman AJ,  et\u00a0al. (1987). “Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector”. Immunogenetics. 26 (1\u20132): 63\u201373. doi:10.1007\/bf00345456. PMID\u00a03610256. S2CID\u00a019758795.Trowsdale J, Lee J, Carey J,  et\u00a0al. (1983). “Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes”. Proc. Natl. Acad. Sci. U.S.A. 80 (7): 1972\u20136. Bibcode:1983PNAS…80.1972T. doi:10.1073\/pnas.80.7.1972. PMC\u00a0393734. PMID\u00a06300884.Auffray C, Lillie JW, Arnot D,  et\u00a0al. (1984). “Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes”. Nature. 308 (5957): 327\u201333. Bibcode:1984Natur.308..327A. doi:10.1038\/308327a0. PMID\u00a06584734. S2CID\u00a04358124.Houlgatte R, Scarmato P, el Marhomy S,  et\u00a0al. (1994). “HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4”. J. Immunol. 152 (9): 4475\u201388. PMID\u00a07512597.Chirmule N, McCloskey TW, Hu R,  et\u00a0al. (1995). “HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)”. J. Immunol. 155 (2): 917\u201324. PMID\u00a07541827.Rowell JF, Stanhope PE, Siliciano RF (1995). “Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC”. J. Immunol. 155 (1): 473\u201388. PMID\u00a07602119.Rudy G, Lew AM (1994). “Limited polymorphism of the HLA-DQA2 promoter and identification of a variant octamer”. Hum. Immunol. 39 (3): 225\u20139. doi:10.1016\/0198-8859(94)90264-X. PMID\u00a08026991.Chen YH, B\u00f6ck G, Vornhagen R,  et\u00a0al. (1994). “HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41”. Mol. Immunol. 31 (13): 977\u201382. doi:10.1016\/0161-5890(94)90092-2. PMID\u00a08084338.Chirmule N, Wang XP, Hu R,  et\u00a0al. (1994). “Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help”. Cell. Immunol. 155 (1): 169\u201382. doi:10.1006\/cimm.1994.1110. PMID\u00a08168144.     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