[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/ncoa6-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki6\/ncoa6-wikipedia\/","headline":"NCOA6 – Wikipedia","name":"NCOA6 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Nuclear receptor coactivator 6 is a","datePublished":"2014-01-13","dateModified":"2014-01-13","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki6\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki6\/ncoa6-wikipedia\/","wordCount":9678,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensNuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.[3][4][5]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Interactions[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Function[edit]The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.[5]Interactions[edit]NCOA6 has been shown to interact with:       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4ASCL2[6] andActivating transcription factor 2,[7]Androgen receptor,[8]CREB-binding protein,[9][10]DNA-PKcs,[11]E2F1,[12]EP300,[11]Estrogen receptor alpha,[9][13]Estrogen receptor beta,[10][13]HBXIP,[14]HIST2H3C,[6]HSF1,[15]Ku70,[11][16]Ku80,[11][16]Liver X receptor beta,[10]MLL3,[6]RBBP5,[6]Retinoblastoma protein,[8]Retinoic acid receptor alpha,[9][10][11]Retinoid X receptor alpha,[9][10][13][14]Src,[6][9][10][17]TGS1,[18][19]TUBA4A,[6]TUBB,[6]Thyroid hormone receptor alpha,[9][17]  andThyroid hormone receptor beta.[9][10][11][13]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000198646 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (November 1996). “Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1”. DNA Res. 3 (1): 17\u201324. doi:10.1093\/dnares\/3.1.17. PMID\u00a08724849.^ Estey A, Kemp M, Allison S, Lamb C (January 1994). “Evaluation of a patient information booklet”. J Nurs Staff Dev. 9 (6): 278\u201382. PMID\u00a08263591.^ a b “Entrez Gene: NCOA6 nuclear receptor coactivator 6”.^ a b c d e f g Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (January 2003). “Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins”. Mol. Cell. Biol. 23 (1): 140\u20139. doi:10.1128\/mcb.23.1.140-149.2003. PMC\u00a0140670. PMID\u00a012482968.^ Hong S, Choi HM, Park MJ, Kim YH, Choi YH, Kim HH, Choi YH, Cheong J (April 2004). “Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid”. J. Biol. Chem. 279 (17): 16996\u20137003. doi:10.1074\/jbc.M311752200. PMID\u00a014734562.^ a b Goo YH, Na SY, Zhang H, Xu J, Hong S, Cheong J, Lee SK, Lee JW (February 2004). “Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation”. J. Biol. Chem. 279 (8): 7131\u20135. doi:10.1074\/jbc.M312563200. PMID\u00a014645241.^ a b c d e f g Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (November 1999). “A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo”. J. Biol. Chem. 274 (48): 34283\u201393. doi:10.1074\/jbc.274.48.34283. PMID\u00a010567404.^ a b c d e f g Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (February 2001). “Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2”. Mol. Endocrinol. 15 (2): 241\u201354. doi:10.1210\/mend.15.2.0595. PMID\u00a011158331.^ a b c d e f Ko L, Cardona GR, Chin WW (May 2000). “Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator”. Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212\u20137. Bibcode:2000PNAS…97.6212K. doi:10.1073\/pnas.97.11.6212. PMC\u00a018584. PMID\u00a010823961.^ Kong HJ, Yu HJ, Hong S, Park MJ, Choi YH, An WG, Lee JW, Cheong J (November 2003). “Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation”. Mol. Cancer Res. 1 (13): 948\u201358. PMID\u00a014638867.^ a b c d Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW (January 2002). “Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs”. Mol. Endocrinol. 16 (1): 128\u201340. doi:10.1210\/mend.16.1.0755. PMID\u00a011773444.^ a b Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J (November 2003). “Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2”. Hepatology. 38 (5): 1258\u201366. doi:10.1053\/jhep.2003.50451. PMID\u00a014578865. S2CID\u00a029349615.^ Hong S, Kim SH, Heo MA, Choi YH, Park MJ, Yoo MA, Kim HD, Kang HS, Cheong J (February 2004). “Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock”. FEBS Lett. 559 (1\u20133): 165\u201370. doi:10.1016\/S0014-5793(04)00028-6. PMID\u00a014960326. S2CID\u00a022383479.^ a b Ko L, Chin WW (March 2003). “Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase”. J. Biol. Chem. 278 (13): 11471\u20139. doi:10.1074\/jbc.M209723200. PMID\u00a012519782.^ a b Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW (June 2000). “Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2”. Mol. Endocrinol. 14 (6): 915\u201325. doi:10.1210\/mend.14.6.0471. PMID\u00a010847592.^ Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK (May 2002). “Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation”. J. Biol. Chem. 277 (22): 20011\u20139. doi:10.1074\/jbc.M201739200. PMID\u00a011912212.^ Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK (August 2001). “Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function”. Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10380\u20135. Bibcode:2001PNAS…9810380Z. doi:10.1073\/pnas.181347498. PMC\u00a056969. PMID\u00a011517327.Further reading[edit]Mahajan MA, Samuels HH (July 2000). “A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein”. Mol. Cell. Biol. 20 (14): 5048\u201363. doi:10.1128\/MCB.20.14.5048-5063.2000. PMC\u00a085955. PMID\u00a010866662.Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones”. DNA Res. 9 (3): 99\u2013106. doi:10.1093\/dnares\/9.3.99. PMID\u00a012168954.Carney JP, McKnight C, VanEpps S, Kelley MR (1995). “Random rapid amplification of cDNA ends (RRACE) allows for cloning of multiple novel human cDNA fragments containing (CAG)n repeats”. Gene. 155 (2): 289\u201392. doi:10.1016\/0378-1119(94)00758-K. PMID\u00a07536696.Guan XY, Xu J, Anzick SL, Zhang H, Trent JM, Meltzer PS (1996). “Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer”. Cancer Res. 56 (15): 3446\u201350. PMID\u00a08758910.Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (1999). “A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo”. J. Biol. Chem. 274 (48): 34283\u201393. doi:10.1074\/jbc.274.48.34283. PMID\u00a010567404.Caira F, Antonson P, Pelto-Huikko M, Treuter E, Gustafsson JA (2000). “Cloning and characterization of RAP250, a novel nuclear receptor coactivator”. J. Biol. Chem. 275 (8): 5308\u201317. doi:10.1074\/jbc.275.8.5308. PMID\u00a010681503.Zhu Y, Kan L, Qi C, Kanwar YS, Yeldandi AV, Rao MS, Reddy JK (2000). “Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR”. J. Biol. Chem. 275 (18): 13510\u20136. doi:10.1074\/jbc.275.18.13510. PMID\u00a010788465.Ko L, Cardona GR, Chin WW (2000). “Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator”. Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212\u20137. Bibcode:2000PNAS…97.6212K. doi:10.1073\/pnas.97.11.6212. PMC\u00a018584. PMID\u00a010823961.Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW (2000). “Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2”. Mol. Endocrinol. 14 (6): 915\u201325. doi:10.1210\/mend.14.6.0471. PMID\u00a010847592.Mahajan MA, Samuels HH (2000). “A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein”. Mol. Cell. Biol. 20 (14): 5048\u201363. doi:10.1128\/MCB.20.14.5048-5063.2000. PMC\u00a085955. PMID\u00a010866662.Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (2001). “Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2”. Mol. Endocrinol. 15 (2): 241\u201354. doi:10.1210\/mend.15.2.0595. PMID\u00a011158331.Hong S, Lee MY, Cheong J (2001). “Functional interaction of transcriptional coactivator ASC-2 and C\/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell”. Biochem. Biophys. Res. Commun. 282 (5): 1257\u201362. doi:10.1006\/bbrc.2001.4727. PMID\u00a011302752.Iwasaki T, Chin WW, Ko L (2001). “Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)”. J. Biol. Chem. 276 (36): 33375\u201383. doi:10.1074\/jbc.M101517200. PMID\u00a011443112.Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK (2001). “Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function”. Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10380\u20135. Bibcode:2001PNAS…9810380Z. doi:10.1073\/pnas.181347498. PMC\u00a056969. PMID\u00a011517327.Jung DJ, Na SY, Na DS, Lee JW (2002). “Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors”. J. Biol. Chem. 277 (2): 1229\u201334. doi:10.1074\/jbc.M110417200. PMID\u00a011704680.Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW (2002). “Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs”. Mol. Endocrinol. 16 (1): 128\u201340. doi:10.1210\/mend.16.1.0755. PMID\u00a011773444.Qi C, Chang J, Zhu Y, Yeldandi AV, Rao SM, Zhu YJ (2002). “Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha”. J. Biol. Chem. 277 (32): 28624\u201330. doi:10.1074\/jbc.M201053200. PMID\u00a012039952.Espejo F, Green M, Preece NE, Assa-Munt N (2003). “NMR assignment of human ASC2, a self contained protein interaction domain involved in apoptosis and inflammation”. J. Biomol. NMR. 23 (2): 151\u20132. doi:10.1023\/A:1016398403157. PMID\u00a012153040. S2CID\u00a040822239.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/ncoa6-wikipedia\/#breadcrumbitem","name":"NCOA6 – Wikipedia"}}]}]