[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/rnd1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki6\/rnd1-wikipedia\/","headline":"Rnd1 &#8211; Wikipedia","name":"Rnd1 &#8211; Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Rnd1 is a small (~21 kDa)","datePublished":"2014-01-24","dateModified":"2014-01-24","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki6\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/9\/96\/PDB_2cls_EBI.png\/180px-PDB_2cls_EBI.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/9\/96\/PDB_2cls_EBI.png\/180px-PDB_2cls_EBI.png","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki6\/rnd1-wikipedia\/","wordCount":5371,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensRnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[5] It is encoded by the gene RND1.[6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][6]Interactions[edit]Rnd1 has been shown to interact with GRB7,[7]PLXNB1,[8]PDE6D,[9][10]ARHGAP5[11] and UBXD5.[12]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000172602 &#8211; Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054855 &#8211; Ensembl, May 2017^ &#8220;Human PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ &#8220;Mouse PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Ridley AJ (Oct 2006). &#8220;Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking&#8221;. Trends in Cell Biology. 16 (10): 522\u20139. doi:10.1016\/j.tcb.2006.08.006. PMID\u00a016949823.^ a b &#8220;Entrez Gene: RND1 Rho family GTPase 1&#8221;.^ Vayssi\u00e8re B, Zalcman G, Mah\u00e9 Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J (Feb 2000). &#8220;Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family&#8221;. FEBS Letters. 467 (1): 91\u20136. doi:10.1016\/S0014-5793(99)01530-6. PMID\u00a010664463. S2CID\u00a04901644.^ Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). &#8220;Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells&#8221;. The Journal of Biological Chemistry. 278 (28): 25671\u20137. doi:10.1074\/jbc.M303047200. PMID\u00a012730235.^ Nancy V, Callebaut I, El Marjou A, de Gunzburg J (Apr 2002). &#8220;The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases&#8221;. The Journal of Biological Chemistry. 277 (17): 15076\u201384. doi:10.1074\/jbc.M109983200. PMID\u00a011786539.^ Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). &#8220;The complex of Arl2-GTP and PDE delta: from structure to function&#8221;. The EMBO Journal. 21 (9): 2095\u2013106. doi:10.1093\/emboj\/21.9.2095. PMC\u00a0125981. PMID\u00a011980706.^ Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH (Jul 2003). &#8220;Rnd proteins function as RhoA antagonists by activating p190 RhoGAP&#8221;. Current Biology. 13 (13): 1106\u201315. doi:10.1016\/S0960-9822(03)00418-4. PMC\u00a06918695. PMID\u00a012842009.^ Katoh H, Harada A, Mori K, Negishi M (May 2002). &#8220;Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers&#8221;. Molecular and Cellular Biology. 22 (9): 2952\u201364. doi:10.1128\/MCB.22.9.2952-2964.2002. PMC\u00a0133765. PMID\u00a011940653.Further reading[edit]Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P (Apr 1998). &#8220;A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion&#8221;. The Journal of Cell Biology. 141 (1): 187\u201397. doi:10.1083\/jcb.141.1.187. PMC\u00a02132722. PMID\u00a09531558.Vayssi\u00e8re B, Zalcman G, Mah\u00e9 Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J (Feb 2000). &#8220;Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family&#8221;. FEBS Letters. 467 (1): 91\u20136. doi:10.1016\/S0014-5793(99)01530-6. PMID\u00a010664463. S2CID\u00a04901644.Aoki J, Katoh H, Mori K, Negishi M (Nov 2000). &#8220;Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells&#8221;. Biochemical and Biophysical Research Communications. 278 (3): 604\u20138. doi:10.1006\/bbrc.2000.3842. PMID\u00a011095956.Rohm B, Rahim B, Kleiber B, Hovatta I, P\u00fcschel AW (Dec 2000). &#8220;The semaphorin 3A receptor may directly regulate the activity of small GTPases&#8221;. FEBS Letters. 486 (1): 68\u201372. doi:10.1016\/S0014-5793(00)02240-7. PMID\u00a011108845. S2CID\u00a07914214.Nancy V, Callebaut I, El Marjou A, de Gunzburg J (Apr 2002). &#8220;The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases&#8221;. The Journal of Biological Chemistry. 277 (17): 15076\u201384. doi:10.1074\/jbc.M109983200. PMID\u00a011786539.Katoh H, Harada A, Mori K, Negishi M (May 2002). &#8220;Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers&#8221;. Molecular and Cellular Biology. 22 (9): 2952\u201364. doi:10.1128\/MCB.22.9.2952-2964.2002. PMC\u00a0133765. PMID\u00a011940653.Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). &#8220;The complex of Arl2-GTP and PDE delta: from structure to function&#8221;. The EMBO Journal. 21 (9): 2095\u2013106. doi:10.1093\/emboj\/21.9.2095. PMC\u00a0125981. PMID\u00a011980706.Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). &#8220;Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells&#8221;. The Journal of Biological Chemistry. 278 (28): 25671\u20137. doi:10.1074\/jbc.M303047200. PMID\u00a012730235.Oinuma I, Ishikawa Y, Katoh H, Negishi M (Aug 2004). &#8220;The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras&#8221;. Science. 305 (5685): 862\u20135. Bibcode:2004Sci&#8230;305..862O. doi:10.1126\/science.1097545. PMID\u00a015297673. S2CID\u00a039544623.Harada A, Katoh H, Negishi M (May 2005). &#8220;Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells&#8221;. The Journal of Biological Chemistry. 280 (18): 18418\u201324. doi:10.1074\/jbc.M411356200. PMID\u00a015738000.Kim YS, Hori M, Yasuda K, Ozaki H (Dec 2005). &#8220;Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria&#8221;. Comparative Biochemistry and Physiology A. 142 (4): 410\u20135. doi:10.1016\/j.cbpa.2005.08.028. PMID\u00a016311049.PDB gallery2cls: THE CRYSTAL STRUCTURE OF THE HUMAN RND1 GTPASE IN THE ACTIVE GTP BOUND STATE       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/rnd1-wikipedia\/#breadcrumbitem","name":"Rnd1 &#8211; Wikipedia"}}]}]