[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/snd1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki6\/snd1-wikipedia\/","headline":"SND1 – Wikipedia","name":"SND1 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein and coding gene in humans Staphylococcal nuclease domain-containing protein 1 also known","datePublished":"2014-01-08","dateModified":"2014-01-08","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki6\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/b\/b3\/PDB_2hqx_EBI.jpg\/180px-PDB_2hqx_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/b\/b3\/PDB_2hqx_EBI.jpg\/180px-PDB_2hqx_EBI.jpg","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki6\/snd1-wikipedia\/","wordCount":9581,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein and coding gene in humansStaphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene.[5][6][7][8] SND1 is a main component of RISC complex[9] and plays an important role in miRNA function.[10][11] SND1 is Tudor domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster.[12] SND1 is also involved in Autism.[13]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsClinical significance[edit]Interactions[edit]References[edit]Further reading[edit]Clinical significance[edit]SND1 acts as oncogene in many cancers[14][15][16] and in hepatocellular carcinoma progression.[10][11] SND1 promotes tumor angiogenesis in human hepatocellular carcinoma through a novel pathway which involves NF-kappaB and miR-221.[17] SND1 promotes migration and invasion via angiotensin II type 1 receptor and TGF\u03b2 signaling.[18] SND1 expression is regulated by Mir-184 in gliomas.[19]Interactions[edit]SND1 has been shown to interact with MYB,[20]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4SND1 also interacts with G3BP (stress granule protein)[25] and AEG-1.[10][11]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000197157 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001424 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E (Sep 1995). “The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE”. Molecular and Cellular Biology. 15 (9): 4735\u201344. doi:10.1128\/mcb.15.9.4735. PMC\u00a0230717. PMID\u00a07651391.^ Callebaut I, Mornon JP (Jan 1997). “The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development”. The Biochemical Journal. 321 (1): 125\u201332. doi:10.1042\/bj3210125. PMC\u00a01218045. PMID\u00a09003410.^ Paukku K, Yang J, Silvennoinen O (Sep 2003). “Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5”. Molecular Endocrinology. 17 (9): 1805\u201314. doi:10.1210\/me.2002-0256. PMID\u00a012819296.^ “Entrez Gene: SND1 staphylococcal nuclease and tudor domain containing 1”.^ Tsuchiya N, Ochiai M, Nakashima K, Ubagai T, Sugimura T, Nakagama H (Oct 2007). “SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis”. Cancer Research. 67 (19): 9568\u201376. doi:10.1158\/0008-5472.CAN-06-2707. PMID\u00a017909068.^ a b c Yoo BK, Santhekadur PK, Gredler R, Chen D, Emdad L, Bhutia S, Pannell L, Fisher PB, Sarkar D (May 2011). “Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma”. Hepatology. 53 (5): 1538\u201348. doi:10.1002\/hep.24216. PMC\u00a03081619. PMID\u00a021520169.^ a b c Yoo BK, Emdad L, Lee SG, Su ZZ, Santhekadur P, Chen D, Gredler R, Fisher PB, Sarkar D (Apr 2011). “Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology”. Pharmacology & Therapeutics. 130 (1): 1\u20138. doi:10.1016\/j.pharmthera.2011.01.008. PMC\u00a03043119. PMID\u00a021256156.^ Ying, Muying; Chen, Dahua (1 January 2012). “Tudor domain-containing proteins of Drosophila melanogaster”. Development, Growth & Differentiation. 54 (1): 32\u201343. doi:10.1111\/j.1440-169X.2011.01308.x. PMID\u00a023741747. S2CID\u00a023227910.^ Holt R, Barnby G, Maestrini E, Bacchelli E, Brocklebank D, Sousa I, Mulder EJ, Kantoj\u00e4rvi K, J\u00e4rvel\u00e4 I, Klauck SM, Poustka F, Bailey AJ, Monaco AP (Sep 2010). “Linkage and candidate gene studies of autism spectrum disorders in European populations”. European Journal of Human Genetics. 18 (9): 1013\u20139. doi:10.1038\/ejhg.2010.69. PMC\u00a02987412. PMID\u00a020442744.^ Tsuchiya N, Nakagama H (Nov 2010). “MicroRNA, SND1, and alterations in translational regulation in colon carcinogenesis”. Mutation Research. 693 (1\u20132): 94\u2013100. doi:10.1016\/j.mrfmmm.2010.09.001. PMID\u00a020883704.^ Kuruma H, Kamata Y, Takahashi H, Igarashi K, Kimura T, Miki K, Miki J, Sasaki H, Hayashi N, Egawa S (Jun 2009). “Staphylococcal nuclease domain-containing protein 1 as a potential tissue marker for prostate cancer”. The American Journal of Pathology. 174 (6): 2044\u201350. doi:10.2353\/ajpath.2009.080776. PMC\u00a02684170. PMID\u00a019435788.^ Ho J, Kong JW, Choong LY, Loh MC, Toy W, Chong PK, Wong CH, Wong CY, Shah N, Lim YP (Feb 2009). “Novel breast cancer metastasis-associated proteins”. Journal of Proteome Research. 8 (2): 583\u201394. doi:10.1021\/pr8007368. PMID\u00a019086899.^ Santhekadur PK, Das SK, Gredler R, Chen D, Srivastava J, Robertson C, Baldwin AS, Fisher PB, Sarkar D (Apr 2012). “Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor \u03baB and miR-221”. The Journal of Biological Chemistry. 287 (17): 13952\u20138. doi:10.1074\/jbc.M111.321646. PMC\u00a03340184. PMID\u00a022396537.^ Santhekadur PK, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson CL, Mukhopadhyay ND, Fisher PB, Sarkar D (2014). “Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGF\u03b2 signaling”. FEBS Open Bio. 4: 353\u201361. doi:10.1016\/j.fob.2014.03.012. PMC\u00a04050181. PMID\u00a024918049.^ Emdad L, Janjic A, Alzubi MA, Hu B, Santhekadur PK, Menezes ME, Shen XN, Das SK, Sarkar D, Fisher PB (Mar 2015). “Suppression of miR-184 in malignant gliomas upregulates SND1 and promotes tumor aggressiveness”. Neuro-Oncology. 17 (3): 419\u201329. doi:10.1093\/neuonc\/nou220. PMC\u00a04483100. PMID\u00a025216670.^ Dash AB, Orrico FC, Ness SA (Aug 1996). “The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb”. Genes & Development. 10 (15): 1858\u201369. doi:10.1101\/gad.10.15.1858. PMID\u00a08756344.^ Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN, Ness SA (Oct 1998). “Pim-1 kinase and p100 cooperate to enhance c-Myb activity”. Molecular Cell. 2 (4): 417\u201325. doi:10.1016\/S1097-2765(00)80141-0. PMID\u00a09809063.^ a b Yang J, Aittom\u00e4ki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O (Sep 2002). “Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II”. The EMBO Journal. 21 (18): 4950\u20138. doi:10.1093\/emboj\/cdf463. PMC\u00a0126276. PMID\u00a012234934.^ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). “A role for SKIP in EBNA2 activation of CBF1-repressed promoters”. Journal of Virology. 74 (4): 1939\u201347. doi:10.1128\/jvi.74.4.1939-1947.2000. PMC\u00a0111672. PMID\u00a010644367.^ Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). “CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex”. Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23\u20138. Bibcode:1999PNAS…96…23H. doi:10.1073\/pnas.96.1.23. PMC\u00a015086. PMID\u00a09874765.^ Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J (Aug 2010). “Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions”. FEBS Letters. 584 (16): 3525\u201332. doi:10.1016\/j.febslet.2010.07.022. PMC\u00a07127458. PMID\u00a020643132.Further reading[edit]Dash AB, Orrico FC, Ness SA (Aug 1996). “The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb”. Genes & Development. 10 (15): 1858\u201369. doi:10.1101\/gad.10.15.1858. PMID\u00a08756344.Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN, Ness SA (Oct 1998). “Pim-1 kinase and p100 cooperate to enhance c-Myb activity”. Molecular Cell. 2 (4): 417\u201325. doi:10.1016\/S1097-2765(00)80141-0. PMID\u00a09809063.Li\u00e9nard P, Rivi\u00e8re M, Van Vooren P, Szpirer C, Szpirer J (2001). “Assignment of SND1, the gene encoding coactivator p100, to human chromosome 7q31.3 and rat chromosome 4q23 by in situ hybridization”. Cytogenetics and Cell Genetics. 90 (3\u20134): 253\u20134. doi:10.1159\/000056783. PMID\u00a011124528. S2CID\u00a046217878.Rushton JJ, Ness SA (2001). “The conserved DNA binding domain mediates similar regulatory interactions for A-Myb, B-Myb, and c-Myb transcription factors”. Blood Cells, Molecules & Diseases. 27 (2): 459\u201363. doi:10.1006\/bcmd.2001.0405. PMID\u00a011259168.Broadhurst MK, Wheeler TT (Nov 2001). “The p100 coactivator is present in the nuclei of mammary epithelial cells and its abundance is increased in response to prolactin in culture and in mammary tissue during lactation”. The Journal of Endocrinology. 171 (2): 329\u201337. doi:10.1677\/joe.0.1710329. PMID\u00a011691653.Yang J, Aittom\u00e4ki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O (Sep 2002). “Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II”. The EMBO Journal. 21 (18): 4950\u20138. doi:10.1093\/emboj\/cdf463. PMC\u00a0126276. PMID\u00a012234934.Tijms MA, Snijder EJ (Sep 2003). “Equine arteritis virus non-structural protein 1, an essential factor for viral subgenomic mRNA synthesis, interacts with the cellular transcription co-factor p100”. The Journal of General Virology. 84 (Pt 9): 2317\u201322. doi:10.1099\/vir.0.19297-0. PMID\u00a012917451.Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (Jan 2005). “Immunoaffinity profiling of tyrosine phosphorylation in cancer cells”. Nature Biotechnology. 23 (1): 94\u2013101. doi:10.1038\/nbt1046. PMID\u00a015592455. S2CID\u00a07200157.Broadhurst MK, Lee RS, Hawkins S, Wheeler TT (Jan 2005). “The p100 EBNA-2 coactivator: a highly conserved protein found in a range of exocrine and endocrine cells and tissues in cattle”. Biochimica et Biophysica Acta (BBA) – Gene Structure and Expression. 1681 (2\u20133): 126\u201333. doi:10.1016\/j.bbaexp.2004.10.009. PMID\u00a015627504.V\u00e4lineva T, Yang J, Palovuori R, Silvennoinen O (Apr 2005). “The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6”. The Journal of Biological Chemistry. 280 (15): 14989\u201396. doi:10.1074\/jbc.M410465200. PMID\u00a015695802.Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF (Nov 2006). “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes”. Journal of Proteome Research. 5 (11): 3135\u201344. doi:10.1021\/pr060363j. PMID\u00a017081065.Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635\u201348. doi:10.1016\/j.cell.2006.09.026. PMID\u00a017081983. S2CID\u00a07827573.PDB gallery2hqx: Crystal structure of human P100 tudor domain conserved region2o4x: Crystal structure of human P100 tudor domain     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki6\/snd1-wikipedia\/#breadcrumbitem","name":"SND1 – Wikipedia"}}]}]