[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki7\/pclo-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki7\/pclo-wikipedia\/","headline":"PCLO – Wikipedia","name":"PCLO – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Protein piccolo is a protein that","datePublished":"2022-04-25","dateModified":"2022-04-25","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki7\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki7\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki7\/pclo-wikipedia\/","wordCount":5499,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensProtein piccolo is a protein that in humans is encoded by the PCLO gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Interactions[edit]Clinical relevance[edit]References[edit]Further reading[edit]External links[edit]Function[edit]Synaptic vesicles dock and fuse in the active zone of the plasma membrane at chemical synapses. The presynaptic cytoskeletal matrix (PCM), which is associated with the active zone and is situated between synaptic vesicles, is thought to be involved in maintaining the neurotransmitter release site in register with the postsynaptic reception apparatus. The cycling of synaptic vesicles is a multistep process involving a number of proteins (see MIM 603215). Among the components of the PCM that orchestrate these events are Bassoon (BSN; MIM 604020), RIM (RIMS1; MIM 606629), Oboe (RIMS2; MIM 606630), and Piccolo (PCLO).[supplied by OMIM][7]Interactions[edit]The protein product of PCLO called Piccolo has been shown to interact with number of proteins including GIT1,[8]  the F-actin-binding protein Abp1,[9] PRA1,[10] TRIO,[11] DAAM1,[12] and Profilin.[13]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Clinical relevance[edit]Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[14] Recent evidence has shown that a homozygous, nonsense PCLO mutation is the genetic cause of the autosomal recessive neurodegenerative disorder, pontocerebellar hypoplasia type III (PCH3).[15]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000186472 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061601 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Cases-Langhoff C, Voss B, Garner AM, Appeltauer U, Takei K, Kindler S, Veh RW, De Camilli P, Gundelfinger ED, Garner CC (Mar 1996). “Piccolo, a novel 420 kDa protein associated with the presynaptic cytomatrix”. European Journal of Cell Biology. 69 (3): 214\u201323. PMID\u00a08900486.^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). “Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro”. DNA Research. 5 (1): 31\u20139. doi:10.1093\/dnares\/5.1.31. PMID\u00a09628581.^ a b “Entrez Gene: PCLO piccolo (presynaptic cytomatrix protein)”.^ Kim S, Ko J, Shin H, Lee JR, Lim C, Han JH, Altrock WD, Garner CC, Gundelfinger ED, Premont RT, Kaang BK, Kim E (Feb 2003). “The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo”. The Journal of Biological Chemistry. 278 (8): 6291\u2013300. doi:10.1074\/jbc.M212287200. PMID\u00a012473661.^ Fenster, Steven D.; Kessels, Michael M.; Qualmann, Britta; Chung, Wook J.; Nash, Joanne; Gundelfinger, Eckart D.; Garner, Craig C. (2003-05-30). “Interactions between Piccolo and the actin\/dynamin-binding protein Abp1 link vesicle endocytosis to presynaptic active zones”. The Journal of Biological Chemistry. 278 (22): 20268\u201320277. doi:10.1074\/jbc.M210792200. PMID\u00a012654920.^ Fenster, S. D.; Chung, W. J.; Zhai, R.; Cases-Langhoff, C.; Voss, B.; Garner, A. M.; Kaempf, U.; Kindler, S.; Gundelfinger, E. D. (2000-01-01). “Piccolo, a presynaptic zinc finger protein structurally related to bassoon”. Neuron. 25 (1): 203\u2013214. doi:10.1016\/s0896-6273(00)80883-1. PMID\u00a010707984. S2CID\u00a010177138.^ Terry-Lorenzo, Ryan T.; Torres, Viviana I.; Wagh, Dhananjay; Galaz, Jose; Swanson, Selene K.; Florens, Laurence; Washburn, Michael P.; Waites, Clarissa L.; Gundelfinger, Eckart D. (2016-01-01). “Trio, a Rho Family GEF, Interacts with the Presynaptic Active Zone Proteins Piccolo and Bassoon”. PLOS ONE. 11 (12): e0167535. Bibcode:2016PLoSO..1167535T. doi:10.1371\/journal.pone.0167535. PMC\u00a05132261. PMID\u00a027907191.^ Wagh, Dhananjay; Terry-Lorenzo, Ryan; Waites, Clarissa L.; Leal-Ortiz, Sergio A.; Maas, Christoph; Reimer, Richard J.; Garner, Craig C. (2015-01-01). “Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1”. PLOS ONE. 10 (4): e0120093. Bibcode:2015PLoSO..1020093W. doi:10.1371\/journal.pone.0120093. PMC\u00a04405365. PMID\u00a025897839.^ Wang, X.; Kibschull, M.; Laue, M. M.; Lichte, B.; Petrasch-Parwez, E.; Kilimann, M. W. (1999-10-04). “Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin”. The Journal of Cell Biology. 147 (1): 151\u2013162. doi:10.1083\/jcb.147.1.151. PMC\u00a02164979. PMID\u00a010508862.^ Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escare\u00f1o C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hern\u00e1ndez-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR (Mar 2012). “Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing”. Proceedings of the National Academy of Sciences of the United States of America. 109 (10): 3879\u201384. Bibcode:2012PNAS..109.3879L. doi:10.1073\/pnas.1121343109. PMC\u00a03309757. PMID\u00a022343534.^ Ahmed, Mustafa Y.; Chioza, Barry A.; Rajab, Anna; Schmitz-Abe, Klaus; Al-Khayat, Aisha; Al-Turki, Saeed; Baple, Emma L.; Patton, Michael A.; Al-Memar, Ali Y. (2015-04-28). “Loss of PCLO function underlies pontocerebellar hypoplasia type III”. Neurology. 84 (17): 1745\u20131750. doi:10.1212\/WNL.0000000000001523. PMC\u00a04424132. PMID\u00a025832664.Further reading[edit]Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). “Toward a complete human genome sequence”. Genome Research. 8 (11): 1097\u2013108. doi:10.1101\/gr.8.11.1097. PMID\u00a09847074.Wang X, Kibschull M, Laue MM, Lichte B, Petrasch-Parwez E, Kilimann MW (Oct 1999). “Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin”. The Journal of Cell Biology. 147 (1): 151\u201362. doi:10.1083\/jcb.147.1.151. PMC\u00a02164979. PMID\u00a010508862.Fenster SD, Chung WJ, Zhai R, Cases-Langhoff C, Voss B, Garner AM, Kaempf U, Kindler S, Gundelfinger ED, Garner CC (Jan 2000). “Piccolo, a presynaptic zinc finger protein structurally related to bassoon”. Neuron. 25 (1): 203\u201314. doi:10.1016\/S0896-6273(00)80883-1. PMID\u00a010707984. S2CID\u00a010177138.Fenster SD, Garner CC (2002). “Gene structure and genetic localization of the PCLO gene encoding the presynaptic active zone protein Piccolo”. International Journal of Developmental Neuroscience. 20 (3\u20135): 161\u201371. doi:10.1016\/S0736-5748(02)00046-1. PMID\u00a012175852. S2CID\u00a021515091.Takao-Rikitsu E, Mochida S, Inoue E, Deguchi-Tawarada M, Inoue M, Ohtsuka T, Takai Y (Jan 2004). “Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release”. The Journal of Cell Biology. 164 (2): 301\u201311. doi:10.1083\/jcb.200307101. PMC\u00a02172332. PMID\u00a014734538.External links[edit]Overview of all the structural information available in the PDB for UniProt: Q9Y6V0 (Protein piccolo) at the PDBe-KB.     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki7\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki7\/pclo-wikipedia\/#breadcrumbitem","name":"PCLO – Wikipedia"}}]}]