[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki8\/nrl-gene-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki8\/nrl-gene-wikipedia\/","headline":"NRL (gene) &#8211; Wikipedia","name":"NRL (gene) &#8211; Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Neural retina-specific leucine zipper protein is a protein","datePublished":"2020-12-28","dateModified":"2020-12-28","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki8\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki8\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/11\/book.png","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/11\/book.png","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/www.wikimedia.org\/static\/images\/wmf-logo.png","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-logo.png","height":"101","width":"135"},"url":"https:\/\/wiki.edu.vn\/en\/wiki8\/nrl-gene-wikipedia\/","wordCount":6752,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensNeural retina-specific leucine zipper protein is a protein that in humans is encoded by the NRL gene.[5][6][7]Function[edit]This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoreceptor cell development and function. Mutations in this gene have been associated with retinitis pigmentosa and degenerative diseases of the retina.[7]See also[edit]References[edit]^ a b c ENSG00000285493 GRCh38: Ensembl release 89: ENSG00000129535, ENSG00000285493 &#8211; Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040632 &#8211; Ensembl, May 2017^ &#8220;Human PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ &#8220;Mouse PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Yang-Feng TL, Swaroop A (Oct 1992). &#8220;Neural retina-specific leucine zipper gene NRL (D14S46E) maps to human chromosome 14q11.1-q11.2&#8221; (PDF). Genomics. 14 (2): 491\u20132. doi:10.1016\/S0888-7543(05)80248-4. hdl:2027.42\/29820. PMID\u00a01427865.^ Bessant DA, Payne AM, Mitton KP, Wang QL, Swain PK, Plant C, Bird AC, Zack DJ, Swaroop A, Bhattacharya SS (Apr 1999). &#8220;A mutation in NRL is associated with autosomal dominant retinitis pigmentosa&#8221;. Nature Genetics. 21 (4): 355\u20136. doi:10.1038\/7678. PMID\u00a010192380. S2CID\u00a028621258.^ a b &#8220;Entrez Gene: NRL neural retina leucine zipper&#8221;.Further reading[edit]ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}]]>Swaroop A, Xu JZ, Pawar H, Jackson A, Skolnick C, Agarwal N (Jan 1992). &#8220;A conserved retina-specific gene encodes a basic motif\/leucine zipper domain&#8221;. Proceedings of the National Academy of Sciences of the United States of America. 89 (1): 266\u201370. Bibcode:1992PNAS&#8230;89..266S. doi:10.1073\/pnas.89.1.266. PMC\u00a048217. PMID\u00a01729696.Kumar R, Chen S, Scheurer D, Wang QL, Duh E, Sung CH, Rehemtulla A, Swaroop A, Adler R, Zack DJ (Nov 1996). &#8220;The bZIP transcription factor Nrl stimulates rhodopsin promoter activity in primary retinal cell cultures&#8221;. The Journal of Biological Chemistry. 271 (47): 29612\u20138. doi:10.1074\/jbc.271.47.29612. PMID\u00a08939891.Farjo Q, Jackson A, Pieke-Dahl S, Scott K, Kimberling WJ, Sieving PA, Richards JE, Swaroop A (Oct 1997). &#8220;Human bZIP transcription factor gene NRL: structure, genomic sequence, and fine linkage mapping at 14q11.2 and negative mutation analysis in patients with retinal degeneration&#8221;. Genomics. 45 (2): 395\u2013401. doi:10.1006\/geno.1997.4964. PMID\u00a09344665.Chen S, Wang QL, Nie Z, Sun H, Lennon G, Copeland NG, Gilbert DJ, Jenkins NA, Zack DJ (Nov 1997). &#8220;Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes&#8221;. Neuron. 19 (5): 1017\u201330. doi:10.1016\/S0896-6273(00)80394-3. PMID\u00a09390516. S2CID\u00a018485264.Mitton KP, Swain PK, Chen S, Xu S, Zack DJ, Swaroop A (Sep 2000). &#8220;The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation&#8221;. The Journal of Biological Chemistry. 275 (38): 29794\u20139. doi:10.1074\/jbc.M003658200. PMID\u00a010887186.Swain PK, Hicks D, Mears AJ, Apel IJ, Smith JE, John SK, Hendrickson A, Milam AH, Swaroop A (Sep 2001). &#8220;Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors&#8221;. The Journal of Biological Chemistry. 276 (39): 36824\u201330. doi:10.1074\/jbc.M105855200. PMID\u00a011477108.DeAngelis MM, Grimsby JL, Sandberg MA, Berson EL, Dryja TP (Mar 2002). &#8220;Novel mutations in the NRL gene and associated clinical findings in patients with dominant retinitis pigmentosa&#8221;. Archives of Ophthalmology. 120 (3): 369\u201375. doi:10.1001\/archopht.120.3.369. PMID\u00a011879142.Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). &#8220;Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts&#8221;. Molecular Vision. 8: 196\u2013204. PMID\u00a012107411.Acar C, Mears AJ, Yashar BM, Maheshwary AS, Andreasson S, Baldi A, Sieving PA, Iannaccone A, Musarella MA, Jacobson SG, Swaroop A (Jan 2003). &#8220;Mutation screening of patients with Leber Congenital Amaurosis or the enhanced S-Cone Syndrome reveals a lack of sequence variations in the NRL gene&#8221;. Molecular Vision. 9: 14\u20137. PMID\u00a012552256.Mitton KP, Swain PK, Khanna H, Dowd M, Apel IJ, Swaroop A (Feb 2003). &#8220;Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor&#8221;. Human Molecular Genetics. 12 (4): 365\u201373. doi:10.1093\/hmg\/ddg035. PMID\u00a012566383.Bessant DA, Holder GE, Fitzke FW, Payne AM, Bhattacharya SS, Bird AC (Jun 2003). &#8220;Phenotype of retinitis pigmentosa associated with the Ser50Thr mutation in the NRL gene&#8221;. Archives of Ophthalmology. 121 (6): 793\u2013802. doi:10.1001\/archopht.121.6.793. PMID\u00a012796249.Pittler SJ, Zhang Y, Chen S, Mears AJ, Zack DJ, Ren Z, Swain PK, Yao S, Swaroop A, White JB (May 2004). &#8220;Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity&#8221;. The Journal of Biological Chemistry. 279 (19): 19800\u20137. doi:10.1074\/jbc.M401864200. PMID\u00a015001570.Friedman JS, Khanna H, Swain PK, Denicola R, Cheng H, Mitton KP, Weber CH, Hicks D, Swaroop A (Nov 2004). &#8220;The minimal transactivation domain of the basic motif-leucine zipper transcription factor NRL interacts with TATA-binding protein&#8221;. The Journal of Biological Chemistry. 279 (45): 47233\u201341. doi:10.1074\/jbc.M408298200. PMID\u00a015328344.Wright AF, Reddick AC, Schwartz SB, Ferguson JS, Aleman TS, Kellner U, Jurklies B, Schuster A, Zrenner E, Wissinger B, Lennon A, Shu X, Cideciyan AV, Stone EM, Jacobson SG, Swaroop A (Nov 2004). &#8220;Mutation analysis of NR2E3 and NRL genes in Enhanced S Cone Syndrome&#8221;. Human Mutation. 24 (5): 439. doi:10.1002\/humu.9285. PMID\u00a015459973.Nishiguchi KM, Friedman JS, Sandberg MA, Swaroop A, Berson EL, Dryja TP (Dec 2004). &#8220;Recessive NRL mutations in patients with clumped pigmentary retinal degeneration and relative preservation of blue cone function&#8221;. Proceedings of the National Academy of Sciences of the United States of America. 101 (51): 17819\u201324. Bibcode:2004PNAS..10117819N. doi:10.1073\/pnas.0408183101. PMC\u00a0535407. PMID\u00a015591106.Khanna H, Akimoto M, Siffroi-Fernandez S, Friedman JS, Hicks D, Swaroop A (Sep 2006). &#8220;Retinoic acid regulates the expression of photoreceptor transcription factor NRL&#8221;. The Journal of Biological Chemistry. 281 (37): 27327\u201334. doi:10.1074\/jbc.M605500200. PMC\u00a01592579. PMID\u00a016854989.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:\" \"counter(listitem)\"a0 \"}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:\" (\"counter(listitem)\"a0 \"}]]>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}]]>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}]]>(4) \u03b2-Scaffold factors with minor groove contacts (0) Other transcription factorsWikimedia ErrorOur servers are currently under maintenance or experiencing a technical problem.Please try again in a few\u00a0minutes.See the error message at the bottom of this page for more\u00a0information. 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