[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki8\/estradiol-diundecylate-hydroxyprogesterone-heptanoate-testosterone-cyclohexylpropionate-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki8\/estradiol-diundecylate-hydroxyprogesterone-heptanoate-testosterone-cyclohexylpropionate-wikipedia\/","headline":"Estradiol diundecylate\/hydroxyprogesterone heptanoate\/testosterone cyclohexylpropionate – Wikipedia","name":"Estradiol diundecylate\/hydroxyprogesterone heptanoate\/testosterone cyclohexylpropionate – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Combination drug Estradiol diundecylate\/hydroxyprogesterone heptanoate\/testosterone cyclohexylpropionate (EDU\/OHPH\/TCHP), sold under the brand name Trioestrine","datePublished":"2019-07-11","dateModified":"2019-07-11","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki8\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki8\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki8\/estradiol-diundecylate-hydroxyprogesterone-heptanoate-testosterone-cyclohexylpropionate-wikipedia\/","wordCount":3871,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Combination drugEstradiol diundecylate\/hydroxyprogesterone heptanoate\/testosterone cyclohexylpropionate (EDU\/OHPH\/TCHP), sold under the brand name Trioestrine Retard, is an injectable combination medication of estradiol diundecylate (EDU), an estrogen, hydroxyprogesterone heptanoate (OHPH), a progestogen, and testosterone cyclohexylpropionate (TCHP), an androgen\/anabolic steroid.[1][2][3] It contained 2.25\u00a0mg EDU, 100\u00a0mg OHPH, and 67.5\u00a0mg TCHP in oil solution, was provided as ampoules, and was administered by intramuscular injection.[1][2][3][4][5] The medication was manufactured by Roussel and Th\u00e9ramex and was marketed by 1953.[6] It is no longer available.[7][8]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4See also[edit]References[edit]^ a b Herschberg AD (10 October 1960). “[The menopause and the treatment of its disorders by a long-acting multihormone complex: trioestrine lente]”. Gazette M\u00e9dicale de France (in French). 67: 1987\u201396. ISSN\u00a00016-5557. PMID\u00a013713782.^ a b Leszek Kr\u00f3wczy\u0144ski (1987). Extended Release Dosage Forms. CRC Press. p.\u00a013. ISBN\u00a0978-0-8493-4307-0. Hydroxyprogesterone heptanoate + testosterone cyclohexylpropionate + oestradiol undecanoate. Trioestrine-RetardR (Theramex). Oily solution for injection.^ a b Axel Kleemann; J\u00fcrgen Engel (2001). Pharmaceutical substances: syntheses, patents, applications. Thieme. p.\u00a01998. ISBN\u00a0978-3-13-558404-1.^ Bordier, Philippe (1963). “Cure of fifteen osteoporosis cases by a delayed effect of hormonal association”. Semaine des Hopitaux. 39 (2): 81\u20134. ISSN\u00a00037-1777. The patients (females) received intramuscularly, every 10 days for 2-3 months, estradiol diundecyleate 2.25, testosterone cyclohexylpropionate 67.5, and hydroxyprogesterone heptylate 100 mg. (“trioestrine retard”). Their av. calcuria decreased 30.5% (0-69%) and asthenia, anorexia, and muscular activity improved.^ France (1964). Journal officiel de la R\u00e9publique fran\u00e7aise. Sp\u00e9cialit\u00e9 d\u00e9nomm\u00e9e Trioestrine retard Theramex, solut\u00e9 injectable I. M.\u00a0: […] Composition\u00a0: heptylate d’hydroxy-17 alpha-progest\u00e9rone, 10 g\u00a0; cyclohexyl propionate de testost\u00e9rone, 10 g\u00a0; di-und\u00e9cylate d’\u0153stradiol, 0,5 g\u00a0; excipient Q. S. P. 100 ml (en bo\u00eetes de 2 ampoules de 1 ml).^ France (March 1953). Journal officiel de la R\u00e9publique fran\u00e7aise. pp.\u00a02564\u2013.^ “Home”. micromedexsolutions.com.^ [1][dead link]EstrogensER agonistsSteroidal: AlfatradiolCertain androgens\/anabolic steroids (e.g., testosterone, testosterone esters, methyltestosterone, metandienone, nandrolone esters) (via estrogenic metabolites)Certain progestins (e.g., norethisterone, noretynodrel, etynodiol diacetate, tibolone)ClomestroneCloxestradiol acetateConjugated estriolConjugated estrogensEpiestriolEpimestrolEsterified estrogensEstetrol\u2020EstradiolEstradiol esters (e.g., estradiol acetate, estradiol benzoate, estradiol cypionate, estradiol enanthate, estradiol undecylate, estradiol valerate, polyestradiol phosphate, estradiol ester mixtures (Climacteron))Estramustine phosphateEstriolEstriol esters (e.g., estriol succinate, polyestriol phosphate)Estrogenic substancesEstroneEstrone estersEthinylestradiol#Hydroxyestrone diacetateMestranolMethylestradiolMoxestrolNilestriolPrasterone (dehydroepiandrosterone; DHEA)PromestrieneQuinestradolQuinestrolProgonadotropinsAntiestrogensER antagonists(incl. SERMs\/SERDs)Aromatase inhibitorsAntigonadotropinsAndrogens\/anabolic steroids (e.g., testosterone, testosterone esters, nandrolone esters, oxandrolone, fluoxymesterone)D2 receptor antagonists (prolactin releasers) (e.g., domperidone, metoclopramide, risperidone, haloperidol, chlorpromazine, sulpiride)GnRH agonists (e.g., leuprorelin, goserelin)GnRH antagonists (e.g., cetrorelix, elagolix)Progestogens (e.g., chlormadinone acetate, cyproterone acetate, gestonorone caproate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate)OthersAndrogens(incl. AAS)AR agonistsProgonadotropinsAntiandrogensAR antagonistsSteroidogenesisinhibitorsAntigonadotropinsD2 receptor antagonists (prolactin releasers) (e.g., domperidone, metoclopramide, risperidone, haloperidol, chlorpromazine, sulpiride)Estrogens (e.g., bifluranol, diethylstilbestrol, estradiol, estradiol esters, ethinylestradiol, ethinylestradiol sulfonate, paroxypropione)GnRH agonists (e.g., leuprorelin)GnRH antagonists (e.g., cetrorelix)Progestogens (incl., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone caproate, gestonorone caproate, medroxyprogesterone acetate, megestrol acetate)OthersERAgonistsSteroidal: 2-Hydroxyestradiol2-Hydroxyestrone3-Methyl-19-methyleneandrosta-3,5-dien-17\u03b2-ol3\u03b1-Androstanediol3\u03b1,5\u03b1-Dihydrolevonorgestrel3\u03b2,5\u03b1-Dihydrolevonorgestrel3\u03b1-Hydroxytibolone3\u03b2-Hydroxytibolone3\u03b2-Androstanediol4-Androstenediol4-Androstenedione4-Fluoroestradiol4-Hydroxyestradiol4-Hydroxyestrone4-Methoxyestradiol4-Methoxyestrone5-Androstenediol7-Oxo-DHEA7\u03b1-Hydroxy-DHEA7\u03b1-Methylestradiol7\u03b2-Hydroxyepiandrosterone8,9-Dehydroestradiol8,9-Dehydroestrone8\u03b2-VE210\u03b2,17\u03b2-Dihydroxyestra-1,4-dien-3-one (DHED)11\u03b2-Chloromethylestradiol11\u03b2-Methoxyestradiol15\u03b1-Hydroxyestradiol16-Ketoestradiol16-Ketoestrone16\u03b1-Fluoroestradiol16\u03b1-Hydroxy-DHEA16\u03b1-Hydroxyestrone16\u03b1-Iodoestradiol16\u03b1-LE216\u03b2-Hydroxyestrone16\u03b2,17\u03b1-Epiestriol (16\u03b2-hydroxy-17\u03b1-estradiol)17\u03b1-Estradiol (alfatradiol)17\u03b1-Dihydroequilenin17\u03b1-Dihydroequilin17\u03b1-Epiestriol (16\u03b1-hydroxy-17\u03b1-estradiol)17\u03b1-Ethynyl-3\u03b1-androstanediol17\u03b1-Ethynyl-3\u03b2-androstanediol17\u03b2-Dihydroequilenin17\u03b2-Dihydroequilin17\u03b2-Methyl-17\u03b1-dihydroequileninAbirateroneAbiraterone acetateAlestramustineAlmestroneAnabolic steroids (e.g., testosterone and esters, methyltestosterone, metandienone (methandrostenolone), nandrolone and esters, many others; via estrogenic metabolites)AtrimustineBolandiolBolandiol dipropionateButolameClomestroneCloxestradiolConjugated estriolConjugated estrogensCyclodiolCyclotriolDHEADHEA-Sent-EstradiolEpiestriol (16\u03b2-epiestriol, 16\u03b2-hydroxy-17\u03b2-estradiol)EpimestrolEquileninEquilinERA-63 (ORG-37663)Esterified estrogensEstetrolEstradiolEstramustineEstramustine phosphateEstrapronicateEstrazinolEstriolEstrofurateEstrogenic substancesEstromustineEstroneEtamestrol (eptamestrol)EthinylandrostenediolEthinylestradiolEthinylestriolEthylestradiolEtynodiolEtynodiol diacetateHexolameHippulinHydroxyestrone diacetateLynestrenolLynestrenol phenylpropionateMestranolMethylestradiolMoxestrolMytatrienediolNilestriolNorethisteroneNoretynodrelOrestratePentolameProdiameProlamePromestrieneRU-16117QuinestradolQuinestrolTiboloneXenoestrogens: Anise-related (e.g., anethole, anol, dianethole, dianol, photoanethole)Chalconoids (e.g., isoliquiritigenin, phloretin, phlorizin (phloridzin), wedelolactone)Coumestans (e.g., coumestrol, psoralidin)Flavonoids (incl. 7,8-DHF, 8-prenylnaringenin, apigenin, baicalein, baicalin, biochanin A, calycosin, catechin, daidzein, daidzin, ECG, EGCG, epicatechin, equol, formononetin, glabrene, glabridin, genistein, genistin, glycitein, kaempferol, liquiritigenin, mirificin, myricetin, naringenin, penduletin, pinocembrin, prunetin, puerarin, quercetin, tectoridin, tectorigenin)Lavender oilLignans (e.g., enterodiol, enterolactone, nyasol (cis-hinokiresinol))Metalloestrogens (e.g., cadmium)Pesticides (e.g., alternariol, dieldrin, endosulfan, fenarimol, HPTE, methiocarb, methoxychlor, triclocarban, triclosan)Phytosteroids (e.g., digitoxin (digitalis), diosgenin, guggulsterone)Phytosterols (e.g., \u03b2-sitosterol, campesterol, stigmasterol)Resorcylic acid lactones (e.g., zearalanone, \u03b1-zearalenol, \u03b2-zearalenol, zearalenone, zeranol (\u03b1-zearalanol), taleranol (teranol, \u03b2-zearalanol))Steroid-like (e.g., deoxymiroestrol, miroestrol)Stilbenoids (e.g., resveratrol, rhaponticin)Synthetic xenoestrogens (e.g., alkylphenols, bisphenols (e.g., BPA, BPF, BPS), DDT, parabens, PBBs, PHBA, phthalates, PCBs)Others (e.g., agnuside, rotundifuran)Mixed(SERMs)AntagonistsCoregulator-binding modulators: ERX-11GPERPRAgonistsTestosterone derivatives: Progestins: 6,6-Difluoronorethisterone6,6-Difluoronorethisterone acetate17\u03b1-Allyl-19-nortestosteroneAllylestrenolAltrenogestChloroethynylnorgestrelCingestolDanazolDesogestrelDienogestEthinylandrostenediolEthisteroneEthyneroneEtonogestrelEtynodiolEtynodiol diacetateGestodeneGestrinoneLevonorgestrelLevonorgestrel esters (e.g., levonorgestrel butanoate)LynestrenolLynestrenol phenylpropionateMetynodiolMetynodiol diacetateNorelgestrominNorethisterone (norethindrone)Norethisterone esters (e.g., norethisterone acetate, norethisterone enanthate)NoretynodrelNorgesteroneNorgestimateNorgestrelNorgestrienoneNorvinisteroneOxendoloneQuingestanolQuingestanol acetateTiboloneTigestolTosagestin; Anabolic\u2013androgenic steroids: 11\u03b2-Methyl-19-nortestosterone11\u03b2-Methyl-19-nortestosterone dodecylcarbonate19-Nor-5-androstenediol19-Nor-5-androstenedione19-NordehydroepiandrosteroneBolandiolBolandiol dipropionateBolandioneDimethisteroneDienedioneDienoloneDimethandroloneDimethandrolone buciclateDimethandrolone dodecylcarbonateDimethandrolone undecanoateDimethyldienoloneDimethyltrienoloneEthyldienoloneEthylestrenol (ethylnandrol)MethyldienoloneMetribolone (R-1881)Methoxydienone (methoxygonadiene)MiboleroneNandroloneNandrolone esters (e.g., nandrolone decanoate, nandrolone phenylpropionate)NorethandroloneNormethandrone (methylestrenolone, normethandrolone, normethisterone)RU-2309TetrahydrogestrinoneTrenbolone (trienolone)Trenbolone esters (e.g., trenbolone acetate, trenbolone enanthate)TrendioneTrestoloneTrestolone acetateMixed(SPRMs)AntagonistsmPR(PAQR)     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki8\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki8\/estradiol-diundecylate-hydroxyprogesterone-heptanoate-testosterone-cyclohexylpropionate-wikipedia\/#breadcrumbitem","name":"Estradiol diundecylate\/hydroxyprogesterone heptanoate\/testosterone cyclohexylpropionate – Wikipedia"}}]}]