[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en2fr\/wiki28\/pf-4840154-speedy-speedy\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en2fr\/wiki28\/pf-4840154-speedy-speedy\/","headline":"PF-4840154 – Speedy Speedy wiki","name":"PF-4840154 – Speedy Speedy wiki","description":"before-content-x4 Un article de Wikip\u00e9dia, l’encyclop\u00e9die libre after-content-x4 Pyrimidine D\u00e9riv\u00e9e chimique PF-4840154 Des noms Nom IUPAC pr\u00e9f\u00e9r\u00e9 after-content-x4 N -Benzyl-4","datePublished":"2020-11-27","dateModified":"2020-11-27","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en2fr\/wiki28\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en2fr\/wiki28\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/c\/c6\/PF-4840154.svg\/200px-PF-4840154.svg.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/c\/c6\/PF-4840154.svg\/200px-PF-4840154.svg.png","height":"89","width":"200"},"url":"https:\/\/wiki.edu.vn\/en2fr\/wiki28\/pf-4840154-speedy-speedy\/","wordCount":3058,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4Un article de Wikip\u00e9dia, l’encyclop\u00e9die libre        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Pyrimidine D\u00e9riv\u00e9e chimique PF-4840154  Des noms Nom IUPAC pr\u00e9f\u00e9r\u00e9        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4N -Benzyl-4 – [(2-m\u00e9thylpropyl) amino] -2- {4 – [(oxan-3-yl) m\u00e9thyl] pip\u00e9razine-1-yl} pyrimidine-5-carboxamide Identificateurs     Horloge  Chemspider      Inchi = 1S \/ C26H38N6O2 \/ C1-20 (2) 15-27-24-23 (25 (33) 28-16-21-7-4-3-5-8-21) 17-29-26 (30- 24) 32-12-10-31 (11-13-32) 18-22-9-6-14-34-19-22 \/ H3-5,7-8,17,20,22H, 6,9- 16,18-19h2,1-2h3, (h, 28,33) (h, 27,29,30) \u00a0NCl\u00e9: ppanzcqxfybghn-uhfffaoysa-n \u00a0NO = C (NCC1 = CC = CC = C1) C (C = N2) = C (NCC (C) C) N = C2N (CC3) CCN3CC4CCC4 Propri\u00e9t\u00e9s  C 26 H 38 N 6 O 2 Masse molaire 466 630 g \u00b7 mol \u22121  Sauf lorsqu’il est indiqu\u00e9 autrement, des donn\u00e9es sont donn\u00e9es pour les mat\u00e9riaux \u00e0 l’\u00e9tat standard (\u00e0 25 \u00b0 C [77 \u00b0 F], 100 kPa). Compos\u00e9 chimique PF-4840154 est un d\u00e9riv\u00e9 de pyrimidine d\u00e9couvert par Pfizer dans son Sandwich, Kent Research Center. Le compos\u00e9 est un activateur s\u00e9lectif puissant de l’humain (EC 50 = 23 nm) et rat (EC 50 = 97 nm) canaux TRPA1. [d’abord] Ce compos\u00e9 provoque une nociception dans un mod\u00e8le de souris par l’activation de TRPA1. Le PF-4840154 est utilis\u00e9 comme agoniste de r\u00e9f\u00e9rence du canal TRPA1 \u00e0 des fins de d\u00e9pistage \u00e0 haut victime, et est sup\u00e9rieur \u00e0 l’isothiocyanate allyle \u00e0 cette utilisation. [2] Le canal TRPA1 est consid\u00e9r\u00e9 comme une cible de douleur attrayante bas\u00e9e sur le fait que les souris knockout TRPA1 ont montr\u00e9 une att\u00e9nuation presque compl\u00e8te des comportements de douleur dans certains mod\u00e8les de d\u00e9veloppement pr\u00e9clinique. [3] [4]        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Voir \u00e9galement [ modifier ]] Les r\u00e9f\u00e9rences [ modifier ]] ^  Samanta, Amrita; Kislar, Janna; Pumroy, Ruth A.; Han, Seungil; Moiseenkova-Bell, Vera Y. (2018-04-27). “Des informations structurelles sur le m\u00e9canisme mol\u00e9culaire de l’activation et de l’inhibition de la souris TRPA1” . Journal of General Physiology . Rockefeller University Press. 150 (5): 751\u2013762. est ce que je: 10.1085 \/ jgp.201711876 . ISSN 0022-1295 . PMC 5940248 . PMID 29703838 .  ^  Ryckmans T, Aubdool AA, Bodkin JV, Cox P, Brain SD, Dupont T, Fairman E, Hashizume Y, Ishii N, Kato T, Kitching L, Newman J, Omoto K, Rawson D, Strover J (juillet 2011). “Conception et \u00e9valuation pharmacologique de PF-4840154, un agoniste de r\u00e9f\u00e9rence non \u00e9lectrophile du canal TRPA1”. Bioorg. Avec. Chem. Let . 21 (16): 4857\u20134859. est ce que je: 10.1016 \/ j.bmcl.2011.06.035 . PMID 21741838 .  ^  McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM (ao\u00fbt 2007). “TRPA1 intervient dans la douleur induite par le formol” . Proc. Natl. Acad. Sci. ETATS-UNIS . 104 (33): 13525\u201330. est ce que je: 10.1073 \/ pnas.0705924104 . PMC 1941642 . PMID 17686976 .  ^  McMahon SB, Wood JN (mars 2006). “De plus en plus irritable et proche des larmes: TRPA1 dans la douleur inflammatoire” . Cellule . 124 (6): 1123\u20135. est ce que je: 10.1016 \/ j.cell.2006.03.006 . PMID 16564004 .  Trpa Activateurs 4-Hydroxynonenal4-Oxo-2-nonenal4,5-EET12S-HpETE15-Deoxy-\u039412,14-prostaglandin J2\u03b1-Sanshool (ginger, Sichuan and melegueta peppers)AcroleinAllicin (garlic)Allyl isothiocyanate (mustard, radish, horseradish, wasabi)AM404ASP-7663BradykininCannabichromene (cannabis)Cannabidiol (cannabis)Cannabigerol (cannabis)Cinnamaldehyde (cinnamon)CR gas (dibenzoxazepine; DBO)CS gas (2-chlorobenzal malononitrile)Cuminaldehyde (cumin)Curcumin (turmeric)Dehydroligustilide (celery)Diallyl disulfideDicentrine (Lindera spp.)Farnesyl thiosalicylic acidFormalinGingerols (ginger)Hepoxilin A3Hepoxilin B3Hydrogen peroxideIcilinIsothiocyanateJT-010Ligustilide (celery, Angelica acutiloba)Linalool (Sichuan pepper, thyme)MethylglyoxalMethyl salicylate (wintergreen)N-MethylmaleimideNicotine (tobacco)Oleocanthal (olive oil)Paclitaxel (Pacific yew)Paracetamol (acetaminophen)PF-4840154Phenacyl chloridePolygodial (Dorrigo pepper)Shogaols (ginger, Sichuan and melegueta peppers)Tear gasesTetrahydrocannabinol (cannabis)TetrahydrocannabiorcolThiopropanal S-oxide (onion)Umbellulone (Umbellularia californica)WIN 55,212-2Bloqueurs Trpc Trpm Trpml Trppp Trpv Activateurs 2-APB5′,6′-EET9-HODE9-oxoODE12S-HETE12S-HpETE13-HODE13-oxoODE20-HETE\u03b1-Sanshool (ginger, Sichuan and melegueta peppers)Allicin (garlic)AM404AnandamideBisandrographolide (Andrographis paniculata)Camphor (camphor laurel, rosemary, camphorweed, African blue basil, camphor basil)Cannabidiol (cannabis)Cannabidivarin (cannabis)Capsaicin (chili pepper)Carvacrol (oregano, thyme, pepperwort, wild bergamot, others)DHEADiacyl glycerolDihydrocapsaicin (chili pepper)EstradiolEugenol (basil, clove)Evodiamine (Euodia ruticarpa)Gingerols (ginger)GSK1016790AHeatHepoxilin A3Hepoxilin B3Homocapsaicin (chili pepper)Homodihydrocapsaicin (chili pepper)Incensole (incense)Lysophosphatidic acidLow pH (acidic conditions)Menthol (mint)N-Arachidonoyl dopamineN-OleoyldopamineN-OleoylethanolamideNonivamide (PAVA) (PAVA spray)Nordihydrocapsaicin (chili pepper)Paclitaxel (Pacific yew)Paracetamol (acetaminophen)PhenylacetylrinvanilPhorbol esters (e.g., 4\u03b1-PDD)Piperine (black pepper, long pepper)Polygodial (Dorrigo pepper)ProbenecidProtonsRhTxRutamarin (Ruta graveolens)Resiniferatoxin (RTX) (Euphorbia resinifera\/pooissonii)Shogaols (ginger, Sichuan and melegueta peppers)Tetrahydrocannabivarin (cannabis)Thymol (thyme, oregano)Tinyatoxin (Euphorbia resinifera\/pooissonii)TramadolVanillin (vanilla)ZucapsaicinBloqueurs             (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en2fr\/wiki28\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en2fr\/wiki28\/pf-4840154-speedy-speedy\/#breadcrumbitem","name":"PF-4840154 – Speedy Speedy wiki"}}]}]