[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/jp\/wiki\/archives\/478#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/jp\/wiki\/archives\/478","headline":"\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb – Wikipedia","name":"\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb – Wikipedia","description":"\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb (5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb) (\u82f1\u8a9e 5\u03b2-Coprostanol = 5\u03b2-Cholestan-3\u03b2-ol) \u306f\u3001\u70ad\u7d20\u6570 27\u306e\u30b9\u30bf\u30ce\u30fc\u30eb\u3067\u3042\u308b\u3002\u9ad8\u7b49\u52d5\u7269\u3068\u9ce5\u985e\u306e\u8178\u306e\u4e2d\u3067\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u751f\u5316\u5b66\u7684\u6c34\u7d20\u5316\u3092\u53d7\u3051\u3066\u751f\u6210\u3059\u308b\u3002\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306f\u3001\u74b0\u5883\u4e2d\u306b\u304a\u3051\u308b\u4eba\u7cde\u306e\u5b58\u5728\u306e\u751f\u7269\u5b66\u7684\u6307\u6a19 (\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc) \u3068\u3057\u3066\u3057\u3070\u3057\u3070\u7528\u3044\u3089\u308c\u308b\u3002 \u5316\u5b66\u7684\u6027\u8cea[\u7de8\u96c6] \u6eb6\u89e3\u6027[\u7de8\u96c6] 5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306f\u6c34\u306b\u5bfe\u3059\u308b\u6eb6\u89e3\u5ea6\u304c\u4f4e\u304f\u3001\u305d\u306e\u305f\u3081\u9ad8\u3044\u30aa\u30af\u30bf\u30ce\u30fc\u30eb\/\u6c34\u5206\u914d\u4fc2\u6570\u3092\u793a\u3059 (log Kow = 8.82)\u3002\u3053\u308c\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u74b0\u5883\u3067 5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306f\u56fa\u76f8\u306b\u7d50\u3073\u4ed8\u3044\u3066\u3044\u308b\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u3002 \u5206\u89e3[\u7de8\u96c6] \u5acc\u6c17\u6027\u306e\u6c88\u6bbf\u7269\u3068\u571f\u58cc\u306e\u4e2d\u3067\u306f","datePublished":"2019-12-31","dateModified":"2019-12-31","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/jp\/wiki\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/jp\/wiki\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/11\/book.png","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/11\/book.png","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/3\/36\/Coprostanol_formation.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/3\/36\/Coprostanol_formation.png","height":"652","width":"550"},"url":"https:\/\/wiki.edu.vn\/jp\/wiki\/archives\/478","about":["Wiki"],"wordCount":3543,"articleBody":"\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb (5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb) (\u82f1\u8a9e 5\u03b2-Coprostanol = 5\u03b2-Cholestan-3\u03b2-ol) \u306f\u3001\u70ad\u7d20\u6570 27\u306e\u30b9\u30bf\u30ce\u30fc\u30eb\u3067\u3042\u308b\u3002\u9ad8\u7b49\u52d5\u7269\u3068\u9ce5\u985e\u306e\u8178\u306e\u4e2d\u3067\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u751f\u5316\u5b66\u7684\u6c34\u7d20\u5316\u3092\u53d7\u3051\u3066\u751f\u6210\u3059\u308b\u3002\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306f\u3001\u74b0\u5883\u4e2d\u306b\u304a\u3051\u308b\u4eba\u7cde\u306e\u5b58\u5728\u306e\u751f\u7269\u5b66\u7684\u6307\u6a19 (\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc) \u3068\u3057\u3066\u3057\u3070\u3057\u3070\u7528\u3044\u3089\u308c\u308b\u3002\u5316\u5b66\u7684\u6027\u8cea[\u7de8\u96c6]\u6eb6\u89e3\u6027[\u7de8\u96c6]5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306f\u6c34\u306b\u5bfe\u3059\u308b\u6eb6\u89e3\u5ea6\u304c\u4f4e\u304f\u3001\u305d\u306e\u305f\u3081\u9ad8\u3044\u30aa\u30af\u30bf\u30ce\u30fc\u30eb\/\u6c34\u5206\u914d\u4fc2\u6570\u3092\u793a\u3059 (log Kow = 8.82)\u3002\u3053\u308c\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u74b0\u5883\u3067 5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306f\u56fa\u76f8\u306b\u7d50\u3073\u4ed8\u3044\u3066\u3044\u308b\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u3002\u5206\u89e3[\u7de8\u96c6]\u5acc\u6c17\u6027\u306e\u6c88\u6bbf\u7269\u3068\u571f\u58cc\u306e\u4e2d\u3067\u306f 5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306f\u6570\u767e\u5e74\u306b\u308f\u305f\u3063\u3066\u5b89\u5b9a\u3067\u3042\u308b\u305f\u3081\u3001\u904e\u53bb\u306e\u7cde\u4fbf\u306e\u6392\u51fa\u72b6\u614b\u306e\u6307\u6a19\u3068\u3057\u3066\u4f7f\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u53e4\u74b0\u5883\u306e 5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306e\u8a18\u9332\u306f\u3001\u5730\u57df\u306b\u304a\u3051\u308b\u4eba\u9593\u306e\u5b9a\u4f4f\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3092\u3088\u308a\u7cbe\u78ba\u306b\u7d5e\u308a\u8fbc\u307f\u3001\u6570\u5343\u5e74\u306b\u308f\u305f\u308b\u4eba\u9593\u306e\u4eba\u53e3\u3068\u8fb2\u696d\u6d3b\u52d5\u306e\u76f8\u5bfe\u7684\u306a\u5909\u5316\u3092\u518d\u69cb\u7bc9\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u3066\u304d\u305f[1]\u3002\u5316\u5b66\u7684\u5206\u6790[\u7de8\u96c6]5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306f -OH\u57fa\u3092\u6301\u3063\u3066\u3044\u308b\u306e\u3067\u3001\u3057\u3070\u3057\u3070\u8102\u80aa\u9178\u3092\u542b\u3080\u8102\u8cea\u3068\u7d50\u5408\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u305d\u306e\u305f\u3081\u3001\u30a8\u30b9\u30c6\u30eb\u7d50\u5408\u3092\u9e78\u5316\u3059\u308b\u305f\u3081\u306b\u5f37\u5869\u57fa (NaOH \u307e\u305f\u306fKOH) \u3092\u5229\u7528\u3059\u308b\u3002\u6b21\u306b\u3001\u904a\u96e2\u306e\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u30b9\u30bf\u30ce\u30fc\u30eb\uff08\u98fd\u548c\u30b9\u30c6\u30ed\u30fc\u30eb\uff09\u306f\u3001\u30d8\u30ad\u30b5\u30f3\u306a\u3069\u306e\u6975\u6027\u306e\u4f4e\u3044\u6eb6\u5a92\u306b\u5206\u914d\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u6975\u6027\u8102\u8cea\u304b\u3089\u5206\u96e2\u3055\u308c\u308b\u3002\u5206\u6790\u306b\u5148\u7acb\u3061\u3001\u30d2\u30c9\u30ed\u30ad\u30b7\u30eb\u57fa\u3092BSTFA\uff08\u30d3\u30b9-\u30c8\u30ea\u30e1\u30c1\u30eb\u30b7\u30ea\u30eb\u30c8\u30ea\u30d5\u30eb\u30aa\u30ed\u30a2\u30bb\u30c8\u30a2\u30df\u30c9\uff09\u3067\u8a98\u5c0e\u4f53\u5316\u3057\u3066\u3001\u6c34\u7d20\u3092\u6975\u6027\u306e\u4f4e\u3044\u30c8\u30ea\u30e1\u30c1\u30eb\u30b7\u30ea\u30eb\uff08TMS\uff09\u57fa\u306b\u7f6e\u304d\u63db\u3048\u308b\u3053\u3068\u304c\u3088\u304f\u884c\u308f\u308c\u308b\u3002\u6a5f\u5668\u5206\u6790\u306f\u3001\u30ac\u30b9\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\uff08GC\uff09\u3067\u6c34\u7d20\u708e\u30a4\u30aa\u30f3\u5316\u691c\u51fa\u5668\uff08FID\uff09\u307e\u305f\u306f\u8cea\u91cf\u5206\u6790\u8a08\uff08MS\uff09\u306e\u3044\u305a\u308c\u304b\u3092\u4f7f\u7528\u3057\u3066\u884c\u306a\u308f\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3002\u7570\u6027\u4f53[\u7de8\u96c6]\u7cde\u4fbf\u7531\u6765\u306e\u30b9\u30bf\u30ce\u30fc\u30eb\u3068\u540c\u69d8\u306b\u3001\u4ed6\u306e2\u3064\u306e\u7570\u6027\u4f53\u304c\u74b0\u5883\u4e2d\u3067\u540c\u5b9a\u3055\u308c\u3066\u3044\u308b\u3002 5\u03b1-\u30b3\u30ec\u30b9\u30bf\u30ce\u30fc\u30eb\uff085\u03b1-\u30b3\u30ec\u30b9\u30bf\u30f3-3\u03b2-\u30aa\u30fc\u30eb\uff09\u304a\u3088\u3073 epi-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\uff085\u03b2-\u30b3\u30ec\u30b9\u30bf\u30f3-3\u03b1-\u30aa\u30fc\u30eb\uff09\u3067\u3042\u308b\u3002\u751f\u6210\u3068\u5b58\u5728[\u7de8\u96c6]\u7cde\u4fbf\u7531\u6765[\u7de8\u96c6]5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306f\u3001\u9ad8\u7b49\u52d5\u7269\u3068\u9ce5\u985e\u306e\u8178\u306e\u4e2d\u3067\u3001\u8178\u5185\u7d30\u83cc\u306b\u3088\u308b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u3089\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306e\u5909\u63db\u306b\u3088\u308a\u751f\u6210\u3055\u308c\u308b\u3002\u30b1\u30c8\u30f3\u4e2d\u9593\u4f53\u3092\u7d4c\u7531\u3059\u308b\u751f\u6210\u306e\u4e00\u822c\u7684\u306a\u30b9\u30ad\u30fc\u30e0\u306f\u30011990\u5e74\u306b Grimalt \u3089\u306b\u3088\u308a\u63d0\u6848\u3055\u308c\u305f\u56f3\u3067\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u7cde\u4fbf\u4e2d\u306b5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u304c\u540c\u5b9a\u3055\u308c\u305f\u52d5\u7269\u306e\u30ea\u30b9\u30c8\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u3092\u7523\u751f\u3059\u308b\u52d5\u7269\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u3092\u7523\u751f\u3057\u306a\u3044\u52d5\u7269\u30d2\u30c8\u30a4\u30cc\u30a6\u30b7?\u30d2\u30c4\u30b8?\u9ce5\u985e?5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u3092\u7523\u751f\u3057\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u52d5\u7269\u306f\u5c11\u6570\u3067\u3042\u308a\u3001\u3053\u308c\u3089\u306f\u8868\u306b\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u4e0b\u6c34\u306e\u30c8\u30ec\u30fc\u30b5\u30fc\u3068\u3057\u3066\u306e\u4f7f\u7528[\u7de8\u96c6]\u74b0\u5883\u4e2d\u306e 5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306e\u4e3b\u306a\u767a\u751f\u6e90\u306f\u3001\u30d2\u30c8\u306e\u6392\u6cc4\u7269\u3067\u3042\u308b\u3002\u672a\u51e6\u7406\u4e0b\u6c34\u4e2d\u306e 5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306e\u6fc3\u5ea6\u306f\u3001\u4e7e\u71e5\u56fa\u5f62\u5206\u306e\u7d04 2 – 6%\u3067\u3042\u308b\u3002 \u3053\u306e\u6bd4\u8f03\u7684\u9ad8\u3044\u6fc3\u5ea6\u3068\u305d\u306e\u5b89\u5b9a\u6027\u306b\u3088\u308a\u3001\u30b5\u30f3\u30d7\u30eb\u3001\u7279\u306b\u5806\u7a4d\u7269\u4e2d\u306e\u7cde\u4fbf\u306e\u8a55\u4fa1\u306b\u4f7f\u7528\u3067\u304d\u308b\u30025\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb \/ \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb \u6bd4[\u7de8\u96c6]5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306f\u810a\u690e\u52d5\u7269\u306e\u8178\u306e\u4e2d\u3067\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u3089\u751f\u6210\u3055\u308c\u308b\u305f\u3081\u3001\u53cd\u5fdc\u7269\u306b\u5bfe\u3059\u308b\u751f\u6210\u7269\u306e\u6bd4\u7387\u3092\u4f7f\u7528\u3057\u3066\u3001\u30b5\u30f3\u30d7\u30eb\u4e2d\u306e\u7cde\u4fbf\u306e\u7a0b\u5ea6\u3092\u793a\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u751f\u306e\u672a\u51e6\u7406\u306e\u4e0b\u6c34\u306f\u3001\u901a\u5e38\u30015\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb \/ \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6bd4\u304c\u7d04 10\u3067\u3042\u308a\u3001\u4e0b\u6c34\u51e6\u7406\u30d7\u30e9\u30f3\u30c8 (STP\uff09\u306b\u3088\u3063\u3066\u6e1b\u5c11\u3057\u3001\u6392\u51fa\u3055\u308c\u308b\u5ec3\u6c34\u3067\u306f\u6bd4\u304c\u7d04 2\u306b\u306a\u308b\u3002\u5e0c\u91c8\u3055\u308c\u3066\u3044\u306a\u3044 STP\u5ec3\u6c34\u306f\u3001\u3053\u306e\u9ad8\u3044\u6bd4\u7387\u306b\u3088\u3063\u3066\u8b58\u5225\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u7cde\u4fbf\u7269\u8cea\u304c\u74b0\u5883\u4e2d\u306b\u5206\u6563\u3059\u308b\u306b\u3064\u308c\u3066\u3001\u52d5\u7269\u304b\u3089\u306e\u3088\u308a\u591a\u304f\u306e\uff08\u975e\u7cde\u4fbf\uff09\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u906d\u9047\u3059\u308b\u306b\u3064\u308c\u3066\u3001\u6bd4\u7387\u306f\u6e1b\u5c11\u3059\u308b\u3002Grimalt \u3068 Albaiges\u306f\u30015\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb \/ \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6bd4\u304c 0.2\u3092\u8d85\u3048\u308b\u30b5\u30f3\u30d7\u30eb\u306f\u3001\u7cde\u4fbf\u7269\u8cea\u306b\u3088\u3063\u3066\u6c5a\u67d3\u3055\u308c\u3066\u3044\u308b\u3068\u898b\u306a\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u30025\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb \/( 5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb + 5\u03b1-\u30b3\u30ec\u30b9\u30bf\u30ce\u30fc\u30eb) \u6bd4[\u7de8\u96c6]\u30d2\u30c8\u306e\u7cde\u4fbf\u6c5a\u67d3\u306e\u5225\u306e\u5c3a\u5ea6\u306f\u3001\u98fd\u548c\u30b9\u30c6\u30ed\u30fc\u30eb\u578b\u306e 2\u3064\u306e 3\u03b2-\u30aa\u30fc\u30eb\u7570\u6027\u4f53\u306e\u6bd4\u7387\u3067\u3042\u308b\u30025\u03b1-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306f\u3001\u7d30\u83cc\u306b\u3088\u3063\u3066\u74b0\u5883\u4e2d\u3067\u81ea\u7136\u306b\u5f62\u6210\u3055\u308c\u3001\u4e00\u822c\u306b\u7cde\u4fbf\u8d77\u6e90\u3067\u306f\u306a\u3044\u3002\u6bd4\u7387\u304c 0.7\u4ee5\u4e0a\u306e\u30b5\u30f3\u30d7\u30eb\u306f\u3001\u4eba\u7cde\u306b\u3088\u308b\u6c5a\u67d3\u306e\u53ef\u80fd\u6027\u304c\u3042\u308a\u30010.3\u4ee5\u4e0b\u3067\u306f\u6c5a\u67d3\u304c\u306a\u3044\u3068\u898b\u306a\u305b\u308b\u3002\u3053\u308c\u3089 2\u3064\u306e\u30ab\u30c3\u30c8\u30aa\u30d5\u5024\u306e\u9593\u306e\u6bd4\u7387\u3092\u6301\u3064\u30b5\u30f3\u30d7\u30eb\u306f\u3001\u3053\u306e\u6bd4\u7387\u3060\u3051\u306b\u57fa\u3065\u3044\u3066\u7c21\u5358\u306b\u5206\u985e\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3002(\u30b0\u30e9\u30d5\u306f en:Coprostanol#5\u03b2-Coprostanol \/ (5\u03b2-Coprostanol + 5\u03b1-Cholestanol) Ratio) \u3092\u53c2\u7167(\u30b0\u30e9\u30d5\u306e) \u8d64\u306e\u9818\u57df\u306b\u3042\u308b\u5806\u7a4d\u7269\u306f\u30012\u3064\u306e\u6bd4\u7387\u306e\u4e21\u65b9\u3067\u300c\u6c5a\u67d3\u3055\u308c\u3066\u3044\u308b\u300d\u3068\u5206\u985e\u3055\u308c\u3001\u7dd1\u306e\u9818\u57df\u306b\u3042\u308b\u5806\u7a4d\u7269\u306f\u3001\u540c\u3058\u57fa\u6e96\u3067\u300c\u6c5a\u67d3\u3055\u308c\u3066\u3044\u306a\u3044\u300d\u3068\u5206\u985e\u3055\u308c\u308b\u3002\u9752\u306e\u9818\u57df\u306e\u3082\u306e\u306f\u30015\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb \/ \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6bd4\u3067\u306f\u300c\u6c5a\u67d3\u3055\u308c\u3066\u3044\u306a\u3044\u300d\u30015\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb \/ (5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb + 5\u03b1-\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff09\u6bd4\u3067\u306f\u300c\u4e0d\u78ba\u5b9f\u300d\u3067\u3042\u308b\u30020.3\u304b\u3089 0.7\u306e\u30ab\u30c3\u30c8\u30aa\u30d5\u306e\u9593\u306e\u30b5\u30f3\u30d7\u30eb\u306e\u5927\u90e8\u5206\u306f\u30015\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb \/ \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6bd4\u306b\u5f93\u3063\u3066\u300c\u6c5a\u67d3\u3055\u308c\u3066\u3044\u306a\u3044\u300d\u3068\u898b\u306a\u3055\u308c\u308b\u305f\u3081\u30010.3\u306e\u5024\u306f\u3084\u3084\u63a7\u3048\u3081\u306a\u3082\u306e\u3068\u898b\u306a\u3059\u5fc5\u8981\u304c\u3042\u308b\u30025\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb \/ 24-\u30a8\u30c1\u30eb\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb \u6bd4[\u7de8\u96c6]\u30a6\u30b7\u3084\u30d2\u30c4\u30b8\u306a\u3069\u306e\u8349\u98df\u52d5\u7269\u306f\u3001\u4e3b\u8981\u306a\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u3057\u3066\u03b2-\u30b7\u30c8\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u542b\u3080\u9678\u751f\u690d\u7269\uff08\u8349\uff09\u3092\u6d88\u8cbb\u3059\u308b\u3002 \u03b2-\u30b7\u30c8\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e 24-\u30a8\u30c1\u30eb\u8a98\u5c0e\u4f53\u3067\u3042\u308a\u3001\u9678\u751f\u690d\u7269\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u4f7f\u7528\u3067\u304d\u308b\uff08\u30bb\u30af\u30b7\u30e7\u30f3\u3092\u53c2\u7167\uff09\u3002\u3053\u308c\u3089\u306e\u52d5\u7269\u306e\u8178\u3067\u306f\u3001\u7d30\u83cc\u304c 5\u4f4d\u306e\u4e8c\u91cd\u7d50\u5408\u3092\u751f\u7269\u5b66\u7684\u6c34\u7d20\u5316\u3057\u3066 24-\u30a8\u30c1\u30eb\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u3092\u751f\u6210\u3059\u308b\u305f\u3081\u3001\u3053\u306e\u5316\u5408\u7269\u306f\u8349\u98df\u52d5\u7269\u306e\u7cde\u4fbf\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u4f7f\u7528\u3067\u304d\u308b\u3002 \u3055\u307e\u3056\u307e\u306a\u30bd\u30fc\u30b9\u6750\u6599\u306e\u5178\u578b\u7684\u306a\u5024\u306f\u3001\u5f8c\u306e Gilpin \u306e\u8868\u306b\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002Source5\u03b2-cop \/ 24-ethyl cop\u6d44\u5316\u69fd2.9 \u2013 3.7\u5730\u57df\u306e\u6392\u6c342.6 \u2013 4.1\u98df\u8089\u51e6\u7406\u5de5\u5834-\u30d2\u30c4\u30b8\u3001\u30a6\u30b70.5 \u2013 0.9\u755c\u820e\u306e\u6d17\u6d44\u6c340.2epi-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb \/ \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb[\u7de8\u96c6]\u4e0b\u6c34\u51e6\u7406\u4e2d\u306b\u30015\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306f\u30005\u03b2-\u30b3\u30ec\u30b9\u30bf\u30f3-3\u03b1-\u30aa\u30fc\u30eb\u3001\u3064\u307e\u308a epi-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306b\u5909\u63db\u3055\u308c\u308b\u3002\u307e\u305f\u3001\u74b0\u5883\u4e2d\u3067 5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u304b\u3089 epi-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u3078\u306e\u3086\u3063\u304f\u308a\u3057\u305f\u5909\u63db\u304c\u3042\u308b\u3002\u3053\u306e\u305f\u3081\u3001\u3053\u306e\u6bd4\u7387\u306f\u4e0b\u6c34\u51e6\u7406\u306e\u7a0b\u5ea6\u3001\u307e\u305f\u306f\u74b0\u5883\u4e2d\u3067\u306e\u7d4c\u904e\u6642\u9593\u3092\u793a\u3059\u30025\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb \/ \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb \u6bd4\u3068 epi-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb \/ 5\u03b2-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb \u306e\u30af\u30ed\u30b9\u30d7\u30ed\u30c3\u30c8\u306f\u3001\u7cde\u4fbf\u6c5a\u67d3\u3068\u4e0b\u6c34\u51e6\u7406\u306e\u4e21\u65b9\u3092\u793a\u3059\u3002(\u30b0\u30e9\u30d5\u306f en:Coprostanol#Epi-coprostanol \/ 5\u03b2-coprostanol) \u3092\u53c2\u7167\u95a2\u9023\u3059\u308b\u30de\u30fc\u30ab\u30fc[\u7de8\u96c6]5\u03b1-\u30b3\u30ec\u30b9\u30bf\u30ce\u30fc\u30eb \/ \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb[\u7de8\u96c6]\u74b0\u5883\u4e2d\u3067\u306f\u3001\u30d0\u30af\u30c6\u30ea\u30a2\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u3089 5\u03b2\u7570\u6027\u4f53\u3088\u308a\u3082 5\u03b1-\u30b3\u30ec\u30b9\u30bf\u30f3-3\u03b2-\u30aa\u30fc\u30eb\uff085\u03b1-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\uff09\u3092\u512a\u5148\u7684\u306b\u751f\u6210\u3059\u308b\u3002\u3053\u306e\u53cd\u5fdc\u306f\u4e3b\u306b\u5acc\u6c17\u6027\u9084\u5143\u5806\u7a4d\u7269\u3067\u8d77\u3053\u308a\u30015\u03b1-\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb \/ \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6bd4\u306f\u305d\u306e\u3088\u3046\u306a\u6761\u4ef6\u306e\u4e8c\u6b21\uff08\u30d7\u30ed\u30bb\u30b9\uff09\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u4f7f\u7528\u3067\u304d\u308b\u3002\u3053\u306e\u30de\u30fc\u30ab\u30fc\u306e\u30ab\u30c3\u30c8\u30aa\u30d5\u5024\u306f\u63d0\u6848\u3055\u308c\u3066\u3044\u306a\u3044\u305f\u3081\u3001\u76f8\u5bfe\u7684\u306a\u610f\u5473\u3067\u4f7f\u7528\u3055\u308c\u308b\u3002 \u6bd4\u7387\u304c\u5927\u304d\u3044\u307b\u3069\u3001\u74b0\u5883\u304c\u6e1b\u5c11\u3059\u308b\u3002\u9084\u5143\u74b0\u5883\u306f\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u6709\u6a5f\u7269\u306e\u6295\u5165\u91cf\u304c\u591a\u3044\u5730\u57df\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3002 \u3053\u308c\u306b\u306f\u3001\u4e0b\u6c34\u7531\u6765\u306e\u6392\u51fa\u7269\u304c\u542b\u307e\u308c\u308b\u5834\u5408\u304c\u3042\u308b\u3002\u9084\u5143\u6761\u4ef6\u3068\u6f5c\u5728\u7684\u306a\u767a\u751f\u6e90\u3068\u306e\u95a2\u4fc2\u306f\u3001\u4e0b\u6c34\u6307\u6a19\u3068\u306e\u30af\u30ed\u30b9\u30d7\u30ed\u30c3\u30c8\u3067\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002(\u30b0\u30e9\u30d5\u306f en:Coprostanol#Related markers) \u3092\u53c2\u7167\u3053\u306e\u95a2\u4fc2\u304b\u3089\u3001\u4e0b\u6c34\u6392\u51fa\u304c\u5806\u7a4d\u7269\u306e\u5acc\u6c17\u6027\u9084\u5143\u6761\u4ef6\u306b\u90e8\u5206\u7684\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u8003\u53e4\u5b66\u7814\u7a76\u306b\u304a\u3051\u308b\u4f7f\u7528[\u7de8\u96c6]\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u3068\u305d\u306e\u8a98\u5c0e\u4f53\u30a8\u30d4\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306f\u3001\u8003\u53e4\u5b66\u304a\u3088\u3073\u53e4\u74b0\u5883\u306e\u7814\u7a76\u3067\u3001\u571f\u58cc\u4e2d\u3067\u306e\u5bff\u547d\u3068\u4eba\u9593\u306e\u8178\u3067\u306e\u751f\u7523\u3068\u306e\u5f37\u3044\u95a2\u9023\u6027\u304b\u3089\u3001\u904e\u53bb\u306e\u4eba\u9593\u6d3b\u52d5\u306e\u6307\u6a19\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b[2][3]\u3002 \u7814\u7a76\u8005\u306f\u3001\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306e\u5b58\u5728\u3092\u5229\u7528\u3057\u3066\u3001\u6c5a\u6c34\u3060\u307e\u308a\u3084\u80a5\u6599\u306a\u3069\u306e\u666f\u89b3\u6d3b\u52d5\u306a\u3069\u306e\u8003\u53e4\u5b66\u7684\u7279\u5fb4\u3092\u7279\u5b9a\u3057\u305f[4][5]\u3002\u30b3\u30d7\u30ed\u30b9\u30bf\u30ce\u30fc\u30eb\u306e\u6fc3\u5ea6\u306e\u7d4c\u6642\u5909\u5316\u3092\u4f7f\u7528\u3057\u3066\u3001\u7279\u5b9a\u306e\u5806\u7a4d\u74b0\u5883\u5185\u3067\u4eba\u53e3\u306e\u518d\u69cb\u7bc9\u304c\u4f5c\u6210\u3067\u304d\u308b[1][6]\u3002\u95a2\u9023\u9805\u76ee[\u7de8\u96c6]\u30b3\u30d7\u30ed\u30b9\u30bf\u30f3\uff08\u82f1\u8a9e: Coprostane\uff09\u53c2\u8003\u6587\u732e[\u7de8\u96c6]Mudge, S.M.; Ball, A.S. 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