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NE\uff08\u30ca\u30a4\u30a2\u30b7\u30f3\u5f53\u91cf\uff09\u306b\u63db\u7b97\u3057\u3066\u8868\u8a18\u3059\u308b\u3002\u52d5\u7269\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u306b1.4%,\u3001\u690d\u7269\u30bf\u30f3\u30d1\u30af\u8cea\u4e2d\u306b1.0%\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u3092\u542b\u3080\u3068\u3057\u3001\u307e\u305f\u3001\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f360 mg\u304b\u3089\u30ca\u30a4\u30a2\u30b7\u30f31 mg\u304c\u751f\u5408\u6210\u3055\u308c\u308b\u3068\u3057\u3001\u98df\u54c1\u4e2d\u306b\u542b\u307e\u308c\u308b\u30ca\u30a4\u30a2\u30b7\u30f3\u542b\u91cf\u306b\u52a0\u3048\u3066\u30ca\u30a4\u30a2\u30b7\u30f3\u5f53\u91cf\u3092\u7b97\u51fa\u3059\u308b\u3002 \u6210\u4eba\u7537\u5b50","datePublished":"2022-03-20","dateModified":"2022-03-20","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/jp\/wiki11\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/jp\/wiki11\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/11\/book.png","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/11\/book.png","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/5f\/Disambig_gray.svg\/25px-Disambig_gray.svg.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/5f\/Disambig_gray.svg\/25px-Disambig_gray.svg.png","height":"19","width":"25"},"url":"https:\/\/wiki.edu.vn\/jp\/wiki11\/archives\/127638","about":["Wiki"],"wordCount":1066,"articleBody":"\u3053\u306e\u9805\u76ee\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3\u7fa4\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u3066\u3044\u307e\u3059\u3002\u30d0\u30f3\u30c9\u306b\u3064\u3044\u3066\u306f\u300c\u30ca\u30a4\u30a2\u30b7\u30f3 (\u30d0\u30f3\u30c9)\u300d\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002  \u30ca\u30a4\u30a2\u30b7\u30f3 (Niacin[\u6ce8\u91c8 1]) \u306f\u3001\u30cb\u30b3\u30c1\u30f3\u9178\u3068\u30cb\u30b3\u30c1\u30f3\u9178\u30a2\u30df\u30c9\uff08\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\uff09\u306e\u7dcf\u79f0\u3067\u3001\u30d3\u30bf\u30df\u30f3B3 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of Contents1\u65e5\u306e\u76ee\u6a19\u6442\u53d6\u91cf[\u7de8\u96c6]\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8[\u7de8\u96c6]\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30a2\u30c7\u30cb\u30f3\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff08NAD\uff09\u7d4c\u8def[\u7de8\u96c6]NAD\u30b5\u30a4\u30af\u30eb[\u7de8\u96c6]\u6ce8\u91c8[\u7de8\u96c6]\u51fa\u5178[\u7de8\u96c6]\u5916\u90e8\u30ea\u30f3\u30af[\u7de8\u96c6]1\u65e5\u306e\u76ee\u6a19\u6442\u53d6\u91cf[\u7de8\u96c6]NE\uff08\u30ca\u30a4\u30a2\u30b7\u30f3\u5f53\u91cf\uff09\u306b\u63db\u7b97\u3057\u3066\u8868\u8a18\u3059\u308b\u3002\u52d5\u7269\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u306b1.4%,\u3001\u690d\u7269\u30bf\u30f3\u30d1\u30af\u8cea\u4e2d\u306b1.0%\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u3092\u542b\u3080\u3068\u3057\u3001\u307e\u305f\u3001\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f360 mg\u304b\u3089\u30ca\u30a4\u30a2\u30b7\u30f31 mg\u304c\u751f\u5408\u6210\u3055\u308c\u308b\u3068\u3057\u3001\u98df\u54c1\u4e2d\u306b\u542b\u307e\u308c\u308b\u30ca\u30a4\u30a2\u30b7\u30f3\u542b\u91cf\u306b\u52a0\u3048\u3066\u30ca\u30a4\u30a2\u30b7\u30f3\u5f53\u91cf\u3092\u7b97\u51fa\u3059\u308b\u3002\u6210\u4eba\u7537\u5b50 14-17 mgNE\u6210\u4eba\u5973\u6027 12-13 mgNE\u8a31\u5bb9\u4e0a\u9650\u6442\u53d6\u91cf\u309230 mgNE\u3068\u3059\u308b\u3002  \u3055\u3089\u306b\u3001\u6442\u53d6\u30a8\u30cd\u30eb\u30ae\u30fc1000 kcal\u306b\u5bfe\u30574.8 mgNE\u3092\u52a0\u3048\u308b\u3002\u30ca\u30a4\u30a2\u30b7\u30f3\u3092\u8c4a\u5bcc\u306b\u542b\u3080\u98df\u54c1\u30ab\u30c4\u30aa\u3001\u30b5\u30d0\u3001\u30d6\u30ea\u3001\u30a4\u30ef\u30b7\u3001\u30ec\u30d0\u30fc\u3001\u9d8f\u3055\u3055\u307f\u3001\u30de\u30b0\u30ed\u3001\u30b7\u30e9\u30b9\u5e72\u3057\u3001\u305f\u3089\u3053\u3001\u8c46\u985e\u3001\u30b3\u30fc\u30d2\u30fc\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8[\u7de8\u96c6]\u4e3b\u3068\u3057\u3066\u4ee5\u4e0b\u306e\u6210\u5206\u304c\u30ca\u30a4\u30a2\u30b7\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u3057\u3066\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u3002\u30da\u30e9\u30b0\u30e9\u53e3\u820c\u708e\u4e0b\u75e2\u306a\u3069\u306e\u80c3\u8178\u969c\u5bb3\u76ae\u819a\u708e\u795e\u7d4c\u75c7\u72b6\u591a\u5f69\u3067\u306f\u3042\u308b\u304c\u81f4\u547d\u7684\u3067\u306a\u3044\u75c7\u72b6\u3092\u793a\u3059\u306e\u304c\u7279\u5fb4\u7684\u3002  \u30ca\u30a4\u30a2\u30b7\u30f3 – 1\u65e5100 mg\u4ee5\u4e0a\u306e\u6442\u53d6\u3067\u76ae\u819a\u304c\u8d64\u304f\u306a\u308a\uff08\u76ae\u819a\u7d05\u6f6e\uff09\u30d2\u30ea\u30d2\u30ea\u3057\u305f\u308a\u3001\u75d2\u307f\u304c\u51fa\u308b\uff08\u63bb\u75d2\u611f\uff09\u304c\u6570\u6642\u9593\u3067\u6cbb\u307e\u308b\u3002 \u56fd\u5185\u5916\u554f\u308f\u305a\u3001\u3053\u308c\u3092\u300c\u30ca\u30a4\u30a2\u30b7\u30f3\u30d5\u30e9\u30c3\u30b7\u30e5\u300d\u3068\u547c\u3076\u3002\u72ec\u7279\u306e\u611f\u899a\u3092\u5f15\u304d\u8d77\u3053\u3059\u305f\u3081\u3001\u3053\u308c\u3092\u6c42\u3081\u3066\u6545\u610f\u306b\u30ca\u30a4\u30a2\u30b7\u30f3\u3092\u904e\u5270\u6442\u53d6\u3059\u308b\u8005\u3082\u591a\u3044\u3002\u30ca\u30a4\u30a2\u30b7\u30f3\u5f90\u653e\u5264 – 1\u65e52000 mg\u4ee5\u4e0a\u3067\u809d\u969c\u5bb3\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9 – 1\u65e53000 mg\u4ee5\u4e0a\u306e\u6442\u53d6\u3067\u809d\u969c\u5bb3\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u6ce8\u610f\u4e8b\u9805\u9ad8\u7528\u91cf\u3067\u306f\u8840\u7cd6\u5024\u3092\u4e0a\u6607\u3055\u305b\u308b\u6050\u308c\u304c\u3042\u308a\u7cd6\u5c3f\u75c5\u3067\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3002\u9ad8\u7528\u91cf\u3067\u306f\u5c3f\u9178\u5024\u3092\u4e0a\u6607\u3055\u305b\u308b\u6050\u308c\u304c\u3042\u308a\u75db\u98a8\u3067\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3002\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u306e\u30ca\u30a4\u30a2\u30b7\u30f3\u3078\u306e\u5909\u63db\u306f\u3001\u52d5\u7269\u306e\u5834\u5408\u809d\u81d3\u306b\u3066\u884c\u308f\u308c\u308b\u3002  \u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30a2\u30c7\u30cb\u30f3\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff08NAD\uff09\u7d4c\u8def[\u7de8\u96c6]\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u306f\u751f\u4f53\u5185\u306b\u304a\u3044\u3066\u3001\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3-2,3-\u30b8\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc (EC 1.13.11.11)\u3001\u30a2\u30ea\u30eb\u30db\u30eb\u30e0\u30a2\u30df\u30c0\u30fc\u30bc(EC 3.5.1.9)\u3001\u30ad\u30cc\u30ec\u30cb\u30f3-3-\u30e2\u30ce\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc (EC 1.14.13.9)\u3001\u30ad\u30cc\u30ec\u30cb\u30ca\u30fc\u30bc (EC 3.7.1.3)\u30013-\u30d2\u30c9\u30ed\u30ad\u30b7\u30a2\u30f3\u30c8\u30e9\u30cb\u30eb\u9178-3,4-\u30b8\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc (EC 1.13.11.6)\u304a\u3088\u3073\u975e\u9175\u7d20\u7684\u53cd\u5fdc\u306b\u3088\u308a\u30ad\u30ce\u30ea\u30f3\u9178(QA)\u306b\u5909\u63db\u3055\u308c\u308b\u3002EC 1.13.11.11 L-tryptophan + O2 = L-formylkynurenineEC 3.5.1.9 N-formyl-L-kynurenine + H2O = formate + L-kynurenineEC 1.14.13.9 L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2OEC 3.7.1.3 3-hydroxy-L-kynurenine + H2O = 3-hydroxy-anthranilate + L-alanineEC 1.13.11.6 3-hydroxy-anthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde\u975e\u9175\u7d20\u7684\u53cd\u5fdc 2-amino-3-carboxymuconate semialdehyde = pyridine-2,3-dicarboxylate(quinolinate;QA)\u30ad\u30ce\u30ea\u30f3\u9178(QA)\u306f\u30ad\u30ce\u30ea\u30f3\u9178\u30db\u30b9\u30db\u30ea\u30dc\u30b7\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u306e\u4f5c\u7528\u306b\u3088\u308aNAD\u30b5\u30a4\u30af\u30eb\u306b\u5c0e\u5165\u3055\u308c\u308b\u3002  EC 2.4.2.19 pyridine-2,3-dicarboxylate(quinolinate;QA) + 5-phospho-a-D-ribose 1-diphosphate(PRPP) = nicotinate D-ribonucleotide(nicotinate mono-nucleotide;NaMN) + diphosphate + CO2\u306a\u304a\u3001\u3053\u308c\u3089\u306f\u30ad\u30cc\u30ec\u30cb\u30f3\u7d4c\u8def\u306e\u4e00\u90e8\u3092\u69cb\u6210\u3057\u3066\u3044\u308b\u3002  NAD\u30b5\u30a4\u30af\u30eb[\u7de8\u96c6]\u751f\u4f53\u5185\u306b\u304a\u3044\u3066\u30cb\u30b3\u30c1\u30f3\u9178\u30e2\u30ce\u30cc\u30af\u30ec\u30aa\u30c1\u30c9(NaMN)\u3001\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30a2\u30c7\u30cb\u30f3\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9(NAD)\u3001\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9(NAm)\u3001\u30cb\u30b3\u30c1\u30f3\u9178(NA)\u306f\u76f8\u4e92\u306b\u5909\u63db\u3055\u308c\u308b\u3002\u3053\u308c\u3089\u306e\u5909\u63db\u306f\u30cb\u30b3\u30c1\u30f3\u9178\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u30a2\u30c7\u30cb\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc (EC 2.7.7.18)\u3001NAD+\u30b7\u30f3\u30c6\u30bf\u30fc\u30bc (EC 6.3.5.1)\u3001NAD+\u30cc\u30af\u30ec\u30aa\u30b7\u30c0\u30fc\u30bc (EC 3.2.2.5)\u3001\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c0\u30fc\u30bc (EC 3.5.1.19)\u3001\u30cb\u30b3\u30c1\u30f3\u9178\u30db\u30b9\u30db\u30ea\u30dc\u30b7\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc (EC 2.4.2.11)\u306b\u3088\u308a\u5f62\u6210\u3055\u308c\u308b\u56de\u8def\u4e0a\u3067\u884c\u308f\u308c\u308b\u3002EC 2.7.7.18 ATP + nicotinate D-ribonucleotide(NaMN) = diphosphate + deamido-NAD+(NaAD)EC 6.3.5.1 ATP + deamido-NAD+(NaAD) + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamateEC 3.2.2.5 NAD+ + H2O = ADP-ribose + nicotinamide(NAm)EC 3.5.1.19 nicotinamide(NAm) + H2O = nicotinate(NA) + NH3EC 2.4.2.11 nicotinate(NA) + 5-phospho-a-D-ribose 1-diphosphate = nicotinate D-ribonucleotide(NaMN) + diphosphate\u30ca\u30a4\u30a2\u30b7\u30f3 (Niacin) \u306f\u30cb\u30b3\u30c1\u30f3\u9178\u30d3\u30bf\u30df\u30f3 (NIcotinic ACid vitamIN) \u306e\u7565\u79f0\u3067\u3042\u308b\u304c\u3001\u3053\u306e\u540d\u79f0\u306f\u5143\u306e\u30cb\u30b3\u30c1\u30f3\u9178\u3068\u3044\u3046\u8a00\u8449\u304c\u6709\u5bb3\u7269\u8cea\u3067\u3042\u308b\u30cb\u30b3\u30c1\u30f3\u3068\u6df7\u540c\u3055\u308c\u308b\u306e\u3092\u907f\u3051\u308b\u305f\u3081\u306b\u4ed8\u3051\u3089\u308c\u305f\u3002\u7d50\u6838\u83cc (Mycobacterium tuberculosis) \u306f\u4ed6\u306e\u6297\u9178\u83cc\u3068\u6bd4\u8f03\u3057\u3066\u591a\u91cf\u306e\u30ca\u30a4\u30a2\u30b7\u30f3\u3092\u7523\u751f\u3059\u308b\u6027\u8cea\u304c\u3042\u308a\u3001\u3053\u306e\u6027\u8cea\u3092\u5229\u7528\u3057\u305f\u7d50\u6838\u83cc\u3068\u305d\u306e\u4ed6\u306e\u6297\u9178\u83cc\u3092\u5224\u5225\u3059\u308b\u8a66\u9a13\u3092\u30ca\u30a4\u30a2\u30b7\u30f3\u8a66\u9a13\u3068\u547c\u3076\u3002\u6ce8\u91c8[\u7de8\u96c6]^ NIcotinic ACid vitamIN (\u30cb\u30b3\u30c1\u30f3\u9178\u30d3\u30bf\u30df\u30f3) \u306e\u7565\u79f0\u3002^ \u4ee3\u8868\u7684\u306a\u7269\u306bInositol hexanicotinate\u304c\u3042\u308b\u3002\u7c73\u56fd\u3067\u306f”No Flush Niacin”\u307e\u305f\u306f”Flush Free Niacin”\u3068\u3057\u3066\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u3002\u51fa\u5178[\u7de8\u96c6]^ Damian D, et al.  \u30d3\u30bf\u30df\u30f3B3\u306b\u3088\u308b\u975e\u30e1\u30e9\u30ce\u30fc\u30de\u76ae\u819a\u304c\u3093\uff08NMSC\uff09\u306e\u518d\u767a\u4e88\u9632\u52b9\u679c\u3092\u691c\u8a0e\u3057\u305f\u81e8\u5e8a\u7b2c\u2162\u76f8\u8a66\u9a13\uff08Australian ONTRAC\uff09.\u7b2c51\u56de\u7c73\u56fd\u81e8\u5e8a\u816b\u760d\u5b66\u4f1a\uff08ASCO\uff09\u767a\u8868\u5916\u90e8\u30ea\u30f3\u30af[\u7de8\u96c6]"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki11\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki11\/archives\/127638#breadcrumbitem","name":"\u30ca\u30a4\u30a2\u30b7\u30f3 – Wikipedia"}}]}]