[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/jp\/wiki16\/archives\/296517#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/jp\/wiki16\/archives\/296517","headline":"\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc\u53cd\u5fdc – Wikipedia","name":"\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc\u53cd\u5fdc – Wikipedia","description":"\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc\u53cd\u5fdc\uff08\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc\u306f\u3093\u306e\u3046\u3001Pictet-Spengler 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\u8907\u7d20\u74b0\u5316\u5408\u7269\u306e\u5408\u6210\u6cd5\u3068\u3057\u3066\u3001\u533b\u85ac\u54c1\u5316\u5b66\u3092\u306f\u3058\u3081\u3068\u3057\u305f\u5206\u91ce\u3067\u73fe\u5728\u3067\u3082\u6c4e\u7528\u3055\u308c\u3066\u3044\u308b\u3002\u91a4\u6cb9\u3084\u30b1\u30c1\u30e3\u30c3\u30d7\u306a\u3069\u306e\u98df\u54c1\u4e2d\u306b\u306f\u3001\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u3068\u30a2\u30eb\u30c9\u30fc\u30b9\u3092\u57fa\u8cea\u3068\u3057\u305f\u672c\u53cd\u5fdc\u306b\u3088\u308b\u751f\u6210\u7269\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u30d5\u30a7\u30cd\u30c1\u30eb\u30a2\u30df\u30f3\u304b\u3089\u306f\u30c6\u30c8\u30e9\u30d2\u30c9\u30ed\u30a4\u30bd\u30ad\u30ce\u30ea\u30f3\u9aa8\u683c\u304c\u3001\u30c8\u30ea\u30d7\u30bf\u30df\u30f3\u304b\u3089\u306f\u03b2-\u30ab\u30eb\u30dc\u30ea\u30f3\u9aa8\u683c\u304c\u751f\u3058\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u9aa8\u683c\u3092\u6301\u3064\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u306f\u672c\u53cd\u5fdc\u3092\u7d4c\u7531\u3057\u3066\u751f\u5408\u6210\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002 \u672c\u53cd\u5fdc\u306f\u3001\u56fa\u76f8\u3092\u7528\u3044\u305f\u30b3\u30f3\u30d3\u30ca\u30c8\u30ea\u30a2\u30eb\u5408\u6210\u306b\u3082\u9069\u7528\u304c\u53ef\u80fd\u3067\u3042\u308b[4][5]\u3002 Table of Contents \u95a2\u9023\u53cd\u5fdc[\u7de8\u96c6]\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc \u30a4\u30bd\u30ad\u30ce\u30ea\u30f3\u5408\u6210\u6cd5[\u7de8\u96c6]\u4e0d\u6589\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc\u53cd\u5fdc[\u7de8\u96c6]\u53c2\u8003\u6587\u732e[\u7de8\u96c6]\u95a2\u9023\u9805\u76ee[\u7de8\u96c6] \u95a2\u9023\u53cd\u5fdc[\u7de8\u96c6] \u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc \u30a4\u30bd\u30ad\u30ce\u30ea\u30f3\u5408\u6210\u6cd5[\u7de8\u96c6] 3,4-\u30b8\u30e1\u30c8\u30ad\u30b7\u30d5\u30a7\u30ce\u30fc\u30eb\u304b\u3089\u672c\u53cd\u5fdc\u306b\u3088\u308a\u30a4\u30bd\u30ad\u30ce\u30ea\u30f3\u3092\u5f97\u308b\u53cd\u5fdc\u306f\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc\u30a4\u30bd\u30ad\u30ce\u30ea\u30f3\u5408\u6210\u6cd5\u3068\u547c\u3070\u308c\u308b\u3002\u30a4\u30f3\u30c9\u30fc\u30eb\u306a\u3069\u3092\u57fa\u8cea\u3068\u3059\u308b\u5834\u5408\u3088\u308a\u3082\u5f37\u3044\u53cd\u5fdc\u6761\u4ef6\u304c\u8981\u6c42\u3055\u308c\u3001\u901a\u5e38\u306f\u5869\u9178\u307e\u305f\u306f\u30c8\u30ea\u30d5\u30eb\u30aa\u30ed\u9162\u9178\u5b58\u5728\u4e0b\u3067\u9084\u6d41\u6761\u4ef6\u3068\u3059\u308b\u3002 \u4e0d\u6589\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc\u53cd\u5fdc[\u7de8\u96c6] \u30db\u30eb\u30e0\u30a2\u30eb\u30c7\u30d2\u30c9\u4ee5\u5916\u306e\u30a2\u30eb\u30c7\u30d2\u30c9\u3092\u7528\u3044\u305f\u5834\u5408\u3001\u751f\u6210\u7269\u306b\u306f\u65b0\u305f\u306a\u4e0d\u6589\u4e2d\u5fc3\u304c\u751f\u3058\u308b\u3002\u57fa\u8cea\u3042\u308b\u3044\u306f\u88dc\u52a9\u5264\u3092\u5de5\u592b\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30b8\u30a2\u30b9\u30c6\u30ec\u30aa\u9078\u629e\u7684\u306a\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc\u53cd\u5fdc\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002[6][7]\u307e\u305f\u3001\u30ad\u30e9\u30eb\u306a\u9178\u3092\u89e6\u5a92\u3068\u3059\u308b\u4f8b\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002[8] \u53c2\u8003\u6587\u732e[\u7de8\u96c6] ^ 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 \u672c\u53cd\u5fdc\u306f\u3001\u56fa\u76f8\u3092\u7528\u3044\u305f\u30b3\u30f3\u30d3\u30ca\u30c8\u30ea\u30a2\u30eb\u5408\u6210\u306b\u3082\u9069\u7528\u304c\u53ef\u80fd\u3067\u3042\u308b[4][5]\u3002Table of Contents\u95a2\u9023\u53cd\u5fdc[\u7de8\u96c6]\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc \u30a4\u30bd\u30ad\u30ce\u30ea\u30f3\u5408\u6210\u6cd5[\u7de8\u96c6]\u4e0d\u6589\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc\u53cd\u5fdc[\u7de8\u96c6]\u53c2\u8003\u6587\u732e[\u7de8\u96c6]\u95a2\u9023\u9805\u76ee[\u7de8\u96c6]\u95a2\u9023\u53cd\u5fdc[\u7de8\u96c6]\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc \u30a4\u30bd\u30ad\u30ce\u30ea\u30f3\u5408\u6210\u6cd5[\u7de8\u96c6]3,4-\u30b8\u30e1\u30c8\u30ad\u30b7\u30d5\u30a7\u30ce\u30fc\u30eb\u304b\u3089\u672c\u53cd\u5fdc\u306b\u3088\u308a\u30a4\u30bd\u30ad\u30ce\u30ea\u30f3\u3092\u5f97\u308b\u53cd\u5fdc\u306f\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc\u30a4\u30bd\u30ad\u30ce\u30ea\u30f3\u5408\u6210\u6cd5\u3068\u547c\u3070\u308c\u308b\u3002\u30a4\u30f3\u30c9\u30fc\u30eb\u306a\u3069\u3092\u57fa\u8cea\u3068\u3059\u308b\u5834\u5408\u3088\u308a\u3082\u5f37\u3044\u53cd\u5fdc\u6761\u4ef6\u304c\u8981\u6c42\u3055\u308c\u3001\u901a\u5e38\u306f\u5869\u9178\u307e\u305f\u306f\u30c8\u30ea\u30d5\u30eb\u30aa\u30ed\u9162\u9178\u5b58\u5728\u4e0b\u3067\u9084\u6d41\u6761\u4ef6\u3068\u3059\u308b\u3002\u4e0d\u6589\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc\u53cd\u5fdc[\u7de8\u96c6]\u30db\u30eb\u30e0\u30a2\u30eb\u30c7\u30d2\u30c9\u4ee5\u5916\u306e\u30a2\u30eb\u30c7\u30d2\u30c9\u3092\u7528\u3044\u305f\u5834\u5408\u3001\u751f\u6210\u7269\u306b\u306f\u65b0\u305f\u306a\u4e0d\u6589\u4e2d\u5fc3\u304c\u751f\u3058\u308b\u3002\u57fa\u8cea\u3042\u308b\u3044\u306f\u88dc\u52a9\u5264\u3092\u5de5\u592b\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30b8\u30a2\u30b9\u30c6\u30ec\u30aa\u9078\u629e\u7684\u306a\u30d4\u30af\u30c6\u30fb\u30b9\u30da\u30f3\u30b0\u30e9\u30fc\u53cd\u5fdc\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002[6][7]\u307e\u305f\u3001\u30ad\u30e9\u30eb\u306a\u9178\u3092\u89e6\u5a92\u3068\u3059\u308b\u4f8b\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002[8]  \u53c2\u8003\u6587\u732e[\u7de8\u96c6]^ Pictet, A.; Spengler, T. Ber. Deutsch. Chem. Ges. 1911, 44, 2030-2036.^ \u7dcf\u8aac: Whaley, W. M.; Govindachari, T. R. Org. React. 1951, 6, 74.^ Hahn, G.; Ludewig, H. Ber. Deutsch. Chem. Ges. 1934, 67, 2031-2035.^ Nielsen, T. E.; Meldal, M. J. Comb. Chem.  2005, 7, 599-610. doi:10.1021\/cc050008a^ \u7dcf\u8aac: Nielsen, T. E.; Diness, F.; Meldal, M. Curr. Opin. Drug Discov. Devel. 2003, 6, 801-814.^ Gremmen, C.; Willemse, B.; Wanner, M. J.; Koomen, G.-J. Org. Lett. 2000, 2, 1955-1958. (doi:10.1021\/ol006034t)^ a) Enrique L. Larghi, Marcela Amongero, Andrea B. J. Bracca, and Teodoro S. Kaufman Arkivoc (RL-1554K) pp 98-153 2005 (Online Review); b) Teodoro S. Kaufman \u201cNew Methods for the Asymmetric Synthesis of Nitrogen Heterocycles\u201d; Ed.: J. L. Vicario. ISBN 81-7736-278-X. Research SignPost, Trivandrum, India. 2005. Chapter 4, pp. 99-147.^ Seayad, J.; Seayad, A. M.; List, B. J. Am. Chem. Soc. 2006, 128, 1086 – 1087. 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