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RCSB PDBe PDBj PDB\u306eID\u30b3\u30fc\u30c9\u4e00\u89a71HIB, 1I1B, 1IOB, 1ITB, 1L2H, 1S0L, 1T4Q, 1TOO, 1TP0, 1TWE, 1TWM, 21BI, 2I1B, 2KH2, 2NVH, 31BI, 3O4O, 3POK, 41BI, 4DEP, 4G6J, 4G6M, 4GAI, 4I1B, 5I1B, 6I1B, 7I1B, 9ILB, 4GAF, 5BVP\u8b58\u5225\u5b50\u8a18\u53f7IL1B, IL-1, IL1-BETA, IL1F2, interleukin 1 beta, IL1beta\u5916\u90e8IDOMIM: 147720 MGI: 96543 HomoloGene: 481 GeneCards: IL1B \u30aa\u30eb\u30bd\u30ed\u30b0\u7a2e\u30d2\u30c8\u30de\u30a6\u30b9EntrezEnsemblUniProtRefSeq(mRNA)RefSeq(\u30bf\u30f3\u30d1\u30af\u8cea)\u5834\u6240(UCSC)Chr 2: 112.83 \u2013 112.84 MbChr 2: 129.21 \u2013 129.21 MbPubMed\u691c\u7d22[3][4]\u30a6\u30a3\u30ad\u30c7\u30fc\u30bf \u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-1\u03b2\uff08\u82f1: interleukin 1 beta\u3001\u7565\u79f0: IL-1\u03b2\uff09\u306f\u30d2\u30c8\u3067\u306fIL1B\u907a\u4f1d\u5b50\u306b\u30b3\u30fc\u30c9\u3055\u308c\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3001leukocytic pyrogen\u3001leukocytic endogenous 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factor\u306a\u3069\u306e\u540d\u79f0\u3067\u3082\u77e5\u3089\u308c\u3066\u3044\u305f[5][6][7][8]\u3002\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-1\uff08IL-1\uff09\u306b\u306f2\u3064\u306e\u907a\u4f1d\u5b50\u304c\u5b58\u5728\u3057\u3001\u305d\u308c\u305e\u308cIL-1\u03b1\uff08\u82f1\u8a9e\u7248\uff09\u3068IL-1\u03b2\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u308b\u3002IL-1\u03b2\u524d\u99c6\u4f53\u306f\u7d30\u80de\u8cea\u306e\u30ab\u30b9\u30d1\u30fc\u30bc1\u306b\u3088\u3063\u3066\u5207\u65ad\u3055\u308c\u3001\u6210\u719f\u3057\u305fIL-1\u03b2\u304c\u5f62\u6210\u3055\u308c\u308b\u3002\u767a\u71b1\u4f5c\u7528\u3092\u3082\u3064\u30d2\u30c8\u767d\u8840\u7403\u6027\u767a\u71b1\u7269\u8cea\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-1\uff09\u306f\u30011977\u5e74\u306bDinarello\u3089\u306b\u3088\u3063\u3066\u7cbe\u88fd\u3055\u308c\u305f[9]\u30021979\u5e74\u3001Dinarello\u306f\u7cbe\u88fd\u3055\u308c\u305f\u30d2\u30c8\u767d\u8840\u7403\u6027\u767a\u71b1\u7269\u8cea\u304c1972\u5e74\u306bIgal Gery\u306b\u3088\u3063\u3066\u8a18\u8f09\u3055\u308c\u3066\u3044\u305f\u5206\u5b50\u3068\u540c\u4e00\u3067\u3042\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u305f[10][11][12][13]\u3002\u3053\u306e\u7269\u8cea\u306f\u30ea\u30f3\u30d1\u7403\u306e\u5206\u88c2\u4fc3\u9032\u56e0\u5b50\u3067\u3042\u308b\u305f\u3081\u3001lymphocyte-activating 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17.5 kDa\u3067\u3042\u308a\u3001\u6b21\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u6301\u3064\u3002APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS\u30de\u30a6\u30b9D10S\u7d30\u80de\u306b\u5bfe\u3059\u308b\u7528\u91cf\u4f9d\u5b58\u7684\u306a\u7d30\u80de\u5897\u6b96\u52b9\u679c\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u305f\u751f\u7406\u5b66\u7684\u6d3b\u6027\u306f\u30012.5\u20137.1×108 units\/mg\u3067\u3042\u308b\u3002 Table of Contents\u81e8\u5e8a\u7684\u610f\u7fa9[\u7de8\u96c6]\u767a\u304c\u3093\u306b\u304a\u3051\u308b\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3068IL-1\u03b2\u306e\u5f79\u5272[\u7de8\u96c6]\u7db2\u819c\u5909\u6027[\u7de8\u96c6]\u95a2\u9023\u6587\u732e[\u7de8\u96c6]\u95a2\u9023\u9805\u76ee[\u7de8\u96c6]\u5916\u90e8\u30ea\u30f3\u30af[\u7de8\u96c6]\u81e8\u5e8a\u7684\u610f\u7fa9[\u7de8\u96c6]IL-1\u03b2\u306e\u7523\u751f\u306e\u5897\u52a0\u306f\u591a\u6570\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059\u304c\u3001\u6700\u3082\u9855\u8457\u306a\u3082\u306e\u3068\u3057\u3066\u30af\u30ea\u30aa\u30d4\u30ea\u30f3\u95a2\u9023\u5468\u671f\u71b1\u75c7\u5019\u7fa4\uff08\u82f1\u8a9e\u7248\uff09\u3068\u547c\u3070\u308c\u308b\u3001IL-1\u03b2\u306e\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u3092\u958b\u59cb\u3055\u305b\u308b\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u53d7\u5bb9\u4f53NLRP3\u306e\u5909\u7570\u3092\u539f\u56e0\u3068\u3059\u308b\u5358\u4e00\u907a\u4f1d\u5b50\u75be\u60a3\u304c\u6319\u3052\u3089\u308c\u308b[17]\u3002\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u306fIL-1\u03b2\u3092\u6a19\u7684\u3068\u3057\u305f\u30d2\u30c8\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u3042\u308a\u3001\u591a\u304f\u306e\u56fd\u3067\u30af\u30ea\u30aa\u30d4\u30ea\u30f3\u95a2\u9023\u5468\u671f\u71b1\u75c7\u5019\u7fa4\u306e\u6cbb\u7642\u306b\u5bfe\u3057\u3066\u627f\u8a8d\u304c\u884c\u308f\u308c\u3066\u3044\u308b\u3002\u8178\u5185\u7d30\u83cc\u53e2\u306e\u7570\u5e38\uff08dysbiosis\uff09\u306f\u3001IL-1\u03b2\u4f9d\u5b58\u7684\u306b\u9aa8\u9ac4\u708e\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b[18]\u3002IL-1\u03b2\u306f\u591a\u767a\u6027\u786c\u5316\u75c7\u306e\u60a3\u8005\u306e\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u3082\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u3069\u306e\u7d30\u80de\u304cIL-1\u03b2\u3092\u7523\u751f\u3057\u3066\u3044\u308b\u306e\u304b\u306f\u6b63\u78ba\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u30b0\u30e9\u30c1\u30e9\u30de\u30fc\u9162\u9178\u5869\u3084\u30ca\u30bf\u30ea\u30ba\u30de\u30d6\u306b\u3088\u308b\u591a\u767a\u6027\u786c\u5316\u75c7\u306e\u6cbb\u7642\u306b\u3088\u3063\u3066\u3001IL-1\u03b2\u3084\u305d\u306e\u53d7\u5bb9\u4f53\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b[19]\u3002\u767a\u304c\u3093\u306b\u304a\u3051\u308b\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3068IL-1\u03b2\u306e\u5f79\u5272[\u7de8\u96c6]\u3044\u304f\u3064\u304b\u306e\u30bf\u30a4\u30d7\u306e\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306f\u514d\u75ab\u8abf\u7bc0\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u8abf\u6574\u3001\u5206\u5316\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u816b\u760d\u5f62\u6210\u306b\u4f55\u3089\u304b\u306e\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u305fIL-1\u03b2\u306e\u904e\u5270\u767a\u73fe\u306f\u767a\u304c\u3093\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3044\u304f\u3064\u304b\u306e\u30c7\u30fc\u30bf\u306f\u3001NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u591a\u578b\u3068\u7d50\u8178\u304c\u3093\u3084\u60aa\u6027\u9ed2\u8272\u816b\u306a\u3069\u306e\u60aa\u6027\u816b\u760d\u3068\u306e\u95a2\u4fc2\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u80ba\u817a\u304c\u3093\u7d30\u80de\u682aA549\u3067\u306fIL-1\u03b2\u306e\u5206\u6ccc\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u4ed6\u306e\u7814\u7a76\u3067\u306f\u3001\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3068IL-1\u03b2\u306e\u767a\u73fe\u963b\u5bb3\u306b\u3088\u3063\u3066\u60aa\u6027\u9ed2\u8272\u816b\u3067\u306e\u304c\u3093\u7d30\u80de\u306e\u767a\u751f\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b[20]\u3002\u7db2\u819c\u5909\u6027[\u7de8\u96c6]IL-1\u30d5\u30a1\u30df\u30ea\u30fc\u306f\u3001\u52a0\u9f62\u9ec4\u6591\u5909\u6027\u75c7\u3001\u7cd6\u5c3f\u75c5\u7db2\u819c\u75c7\u3001\u7db2\u819c\u8272\u7d20\u5909\u6027\u75c7\u306a\u3069\u3001\u591a\u304f\u306e\u5909\u6027\u75be\u60a3\u306b\u304a\u3051\u308b\u708e\u75c7\u53cd\u5fdc\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u7cd6\u5c3f\u75c5\u7db2\u819c\u75c7\u306e\u60a3\u8005\u306e\u785d\u5b50\u4f53\u3067\u306fIL-1\u03b2\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ec\u30d9\u30eb\u304c\u5927\u304d\u304f\u4e0a\u6607\u3057\u3066\u3044\u308b\u3002IL-1\u03b2\u306e\u5f79\u5272\u306b\u3064\u3044\u3066\u3001\u7cd6\u5c3f\u75c5\u7db2\u819c\u75c7\u306e\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u304c\u7814\u7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vitro\u306e\u7814\u7a76\u304b\u3089\u306f\u3001\u7db2\u819c\u8272\u7d20\u4e0a\u76ae\u7d30\u80de\uff08\u82f1\u8a9e\u7248\uff09\u3084\u5149\u53d7\u5bb9\u7d30\u80de\uff08\u82f1\u8a9e\u7248\uff09\u306e\u640d\u50b7\u306b\u304a\u3051\u308b\u5f79\u5272\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306f\u3001\u7d30\u80de\u8cea\u306eIL-1\u03b2\u524d\u99c6\u4f53\u3092\u6210\u719f\u578b\u3067\u3042\u308bIL-1\u03b2\u3078\u5207\u65ad\u3059\u308b\u30ab\u30b9\u30d1\u30fc\u30bc1\u3092\u6d3b\u6027\u5316\u3059\u308b\u3002\u7db2\u819c\u8272\u7d20\u4e0a\u76ae\u7d30\u80de\u306f\u30d2\u30c8\u306e\u7db2\u819c\u306b\u304a\u3044\u3066\u8840\u6db2\u7db2\u819c\u95a2\u9580\uff08\u82f1\u8a9e\u7248\uff09\u3092\u5f62\u6210\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u7db2\u819c\u306e\u4ee3\u8b1d\u6d3b\u6027\u3001\u5b8c\u5168\u6027\u3001\u514d\u75ab\u7d30\u80de\u306e\u6d78\u6f64\u306e\u963b\u5bb3\u306b\u91cd\u8981\u3067\u3042\u308b\u3002\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3055\u3089\u3055\u308c\u305f\u30d2\u30c8\u306e\u7db2\u819c\u8272\u7d20\u4e0a\u76ae\u7d30\u80de\u306fIL-1\u03b2\u3092\u5206\u6ccc\u3059\u308b\u3002\u708e\u75c7\u53cd\u5fdc\u306f\u7db2\u819c\u7d30\u80de\u306e\u640d\u50b7\u3068\u514d\u75ab\u7cfb\u306e\u7d30\u80de\u306e\u6d78\u6f64\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002NLRP3\u306e\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306a\u3069\u306e\u708e\u75c7\u904e\u7a0b\u306f\u52a0\u9f62\u9ec4\u6591\u5909\u6027\u75c7\u3084\u4ed6\u306e\u7db2\u819c\u75be\u60a3\u306e\u539f\u56e0\u306e1\u3064\u3067\u3042\u308a\u3001\u5931\u660e\u3078\u3068\u3064\u306a\u304c\u308b[21][22][23]\u3002^ a b c GRCh38: Ensembl release 89: ENSG00000125538 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027398 – Ensembl, May 2017^ Human PubMed Reference:^ Mouse PubMed Reference:^ \u201cNucleotide sequence of human monocyte interleukin 1 precursor cDNA\u201d. Proceedings of the National Academy of Sciences of the United States of America 81 (24): 7907\u201311. (December 1984). Bibcode:\u00a01984PNAS…81.7907A. doi:10.1073\/pnas.81.24.7907. PMC\u00a0392262. PMID\u00a06083565. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC392262\/.\u00a0^ a b March, C. J.; Mosley, B.; Larsen, A.; Cerretti, D. P.; Braedt, G.; Price, V.; Gillis, S.; Henney, C. S. et al. (1985 Jun 20-26). \u201cCloning, sequence and expression of two distinct human interleukin-1 complementary DNAs\u201d. Nature 315 (6021): 641\u2013647. doi:10.1038\/315641a0. ISSN\u00a00028-0836. PMID\u00a02989698. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2989698.\u00a0^ \u201cGenomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene\u201d. Nucleic Acids Research 14 (20): 7897\u2013914. (October 1986). doi:10.1093\/nar\/14.20.7897. PMC\u00a0311823. PMID\u00a03490654. http:\/\/nar.oxfordjournals.org\/cgi\/reprint\/14\/20\/7897?view=long&pmid=3490654.\u00a0^ \u201cHuman interleukin-1 beta gene\u201d. Gene 52 (1): 95\u2013101. (1987). doi:10.1016\/0378-1119(87)90398-2. PMID\u00a02954882.\u00a0^ Dinarello, C. A.; Renfer, L.; Wolff, S. M. (1977-10). \u201cHuman leukocytic pyrogen: purification and development of a radioimmunoassay\u201d. Proceedings of the National Academy of Sciences of the United States of America 74 (10): 4624\u20134627. doi:10.1073\/pnas.74.10.4624. ISSN\u00a00027-8424. PMC\u00a0PMC431999. PMID\u00a022079. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22079.\u00a0^ \u201cPotentiation of the T-lymphocyte response to mitogens. I. The responding cell\u201d. The Journal of Experimental Medicine 136 (1): 128\u201342. (July 1972). doi:10.1084\/jem.136.1.128. PMC\u00a02139184. PMID\u00a05033417. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2139184\/.\u00a0^ \u201cPotentiation of the T-lymphocyte response to mitogens. II. 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PMID\u00a0314491. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/314491.\u00a0^ \u201cEntrez Gene: IL1B interleukin 1, beta\u201d. 2020\u5e745\u67082\u65e5\u95b2\u89a7\u3002^ Sutton, Caroline E.; Lalor, Stephen J.; Sweeney, Cheryl M.; Brereton, Corinna F.; Lavelle, Ed C.; Mills, Kingston H. G. (2009-08-21). \u201cInterleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity\u201d. Immunity 31 (2): 331\u2013341. doi:10.1016\/j.immuni.2009.08.001. ISSN\u00a01097-4180. PMID\u00a019682929. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19682929.\u00a0^ \u201cNLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases\u201d. Redox Biology 4: 296\u2013307. (April 2015). doi:10.1016\/j.redox.2015.01.008. PMC\u00a04315937. 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