[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/jp\/wiki2\/archives\/4002#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/jp\/wiki2\/archives\/4002","headline":"\u5185\u76ae\u578b\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20 – Wikipedia","name":"\u5185\u76ae\u578b\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20 – Wikipedia","description":"NOS3 PDB\u306b\u767b\u9332\u3055\u308c\u3066\u3044\u308b\u69cb\u9020 PDB \u30aa\u30eb\u30bd\u30ed\u30b0\u691c\u7d22: RCSB PDBe PDBj PDB\u306eID\u30b3\u30fc\u30c9\u4e00\u89a7 1M9J, 1M9K, 1M9M, 1M9Q, 1M9R, 1NIW, 2LL7, 3EAH, 3NOS, 2MG5, 4D1O, 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RCSB PDBe PDBj PDB\u306eID\u30b3\u30fc\u30c9\u4e00\u89a71M9J, 1M9K, 1M9M, 1M9Q, 1M9R, 1NIW, 2LL7, 3EAH, 3NOS, 2MG5, 4D1O, 4D1P\u8b58\u5225\u5b50\u8a18\u53f7NOS3, ECNOS, eNOS, nitric oxide synthase 3\u5916\u90e8IDOMIM: 163729 MGI: 97362 HomoloGene: 504 GeneCards: NOS3 \u30aa\u30eb\u30bd\u30ed\u30b0\u7a2e\u30d2\u30c8\u30de\u30a6\u30b9EntrezEnsemblUniProtRefSeq(mRNA)RefSeq(\u30bf\u30f3\u30d1\u30af\u8cea)\u5834\u6240(UCSC)Chr 7: 150.99 \u2013 151.01 MbChr 7: 24.57 \u2013 24.59 MbPubMed\u691c\u7d22[3][4]\u30a6\u30a3\u30ad\u30c7\u30fc\u30bf  \u5185\u76ae\u578b\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20\uff08\u306a\u3044\u3072\u304c\u305f\u3044\u3063\u3055\u3093\u304b\u3061\u3063\u305d\u3054\u3046\u305b\u3044\u3053\u3046\u305d\u3001\u82f1: endothelial nitric oxide synthase\u3001\u7565\u79f0: eNOS\uff09\u307e\u305f\u306f\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d203\uff08nitric oxide synthase 3\u3001NOS3\uff09\u306f\u3001\u30d2\u30c8\u3067\u306f7\u756a\u67d3\u8272\u4f53\uff08\u82f1\u8a9e\u7248\uff09\u306e7q35-7q36\u9818\u57df\u306b\u4f4d\u7f6e\u3059\u308bNOS3\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u30b3\u30fc\u30c9\u3055\u308c\u308b\u9175\u7d20\u3067\u3042\u308b[5]\u3002\u3053\u306e\u9175\u7d20\u306f\u3001\u4e00\u9178\u5316\u7a92\u7d20\uff08NO\uff09\u306e\u5408\u6210\u3092\u884c\u30463\u3064\u306e\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20\u306e\u3046\u3061\u306e1\u3064\u3067\u3042\u308b\u3002NO\u306f\u6c17\u4f53\u306e\u89aa\u6cb9\u6027\u4f4e\u5206\u5b50\u3067\u3001\u3044\u304f\u3064\u304b\u306e\u751f\u7269\u5b66\u7684\u904e\u7a0b\u306b\u95a2\u4e0e\u3059\u308b[6][7]\u3002\u4ed6\u306e2\u3064\u306e\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u306f\u3001\u8133\u306e\u7279\u5b9a\u306e\u795e\u7d4c\u7d30\u80de\u3067\u6052\u5e38\u7684\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u795e\u7d4c\u578b\uff08nNOS\u3001NOS1\uff09[8]\u3068\u3001\u4e00\u822c\u7684\u306b\u306f\u708e\u75c7\u6027\u75be\u60a3\u3067\u767a\u73fe\u304c\u8a98\u5c0e\u3055\u308c\u308b\u8a98\u5c0e\u578b\uff08iNOS\u3001NOS2\uff09[9]\u3067\u3042\u308b\u3002eNOS\u306f\u4e3b\u306b\u8840\u7ba1\u5185\u76ae\u3067\u306eNO\u306e\u7523\u751f\u3092\u62c5\u3046[10]\u3002\u8840\u7ba1\u5185\u76ae\u306f\u8840\u7ba1\u306e\u5185\u5074\u8868\u9762\u306b\u4e26\u3093\u3060\u5358\u5c64\u306e\u6241\u5e73\u7d30\u80de\u304b\u3089\u306a\u308a\u3001\u5185\u8154\u3092\u5faa\u74b0\u3059\u308b\u8840\u6db2\u3068\u8840\u7ba1\u58c1\u306e\u6b8b\u308a\u306e\u90e8\u5206\u3068\u306e\u5883\u754c\u9762\u3068\u306a\u308b[11]\u3002\u8840\u7ba1\u5185\u76ae\u3067eNOS\u306b\u3088\u3063\u3066\u7523\u751f\u3055\u308c\u308bNO\u306f\u3001\u8840\u7ba1\u7dca\u5f35\u3001\u7d30\u80de\u5897\u6b96\u3001\u767d\u8840\u7403\u306e\u63a5\u7740\u3001\u8840\u5c0f\u677f\u306e\u51dd\u96c6\u306e\u8abf\u7bc0\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u5065\u5eb7\u306a\u5fc3\u81d3\u8840\u7ba1\u7cfb\u306b\u306f\u6a5f\u80fd\u7684\u306aeNOS\u304c\u5fc5\u8981\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3002Table of Contents\u69cb\u9020\u3068\u89e6\u5a92\u6d3b\u6027[\u7de8\u96c6]\u81e8\u5e8a\u7684\u610f\u7fa9[\u7de8\u96c6]\u95a2\u9023\u6587\u732e[\u7de8\u96c6]\u95a2\u9023\u9805\u76ee[\u7de8\u96c6]\u69cb\u9020\u3068\u89e6\u5a92\u6d3b\u6027[\u7de8\u96c6]eNOS\u306f\u540c\u4e00\u306a 134 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PMID\u00a020210789.\u00a0^ \u201cT-786\u2192C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm\u201d. Circulation 99 (22):  2864\u201370. (Jun 1999). doi:10.1161\/01.cir.99.22.2864. PMID\u00a010359729.\u00a0^ a b \u201cAn updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension\u201d. PLOS ONE 6 (9):  e24266. (2011). doi:10.1371\/journal.pone.0024266. PMC\u00a03166328. PMID\u00a021912683. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3166328\/.\u00a0^ a b \u201cThe polymorphism for endothelial nitric oxide synthase gene, the level of nitric oxide and the risk for pre-eclampsia: a meta-analysis\u201d. Gene 519 (1):  187\u201393. (Apr 2013). doi:10.1016\/j.gene.2013.01.004. PMID\u00a023375994.\u00a0^ \u201cEndothelial nitric oxide synthase gene polymorphisms and the risk of diabetic nephropathy in type 2 diabetes mellitus\u201d. Genetic Testing and Molecular Biomarkers 16 (6):  574\u20139. (Jun 2012). doi:10.1089\/gtmb.2011.0218. PMID\u00a022313046.\u00a0^ \u201cThe T-786C and C774T endothelial nitric oxide synthase gene polymorphisms independently affect the onset pattern of severe diabetic retinopathy\u201d. Nitric Oxide 13 (1):  88\u201392. (Aug 2005). doi:10.1016\/j.niox.2005.04.004. PMID\u00a015890549.\u00a0^ a b \u201cAssociation of endothelial nitric oxide synthase gene polymorphisms (894G\/T, -786T\/C, G10T) and clinical findings in patients with migraine\u201d. Neuromolecular Medicine 16 (3):  587\u201393. (Sep 2014). doi:10.1007\/s12017-014-8311-0. PMID\u00a024845269.\u00a0^ \u201cAssociation of the T-786C, G894T and 4a\/4b polymorphisms of the endothelial nitric oxide synthase gene with vasculogenic erectile dysfunction in Iranian subjects\u201d. BJU International 107 (12):  1994\u20132001. (Jun 2011). doi:10.1111\/j.1464-410X.2010.09755.x. PMID\u00a020955262.\u00a0^ \u201cBiochemical consequences of the NOS3 Glu298Asp variation in human endothelium: altered caveolar localization and impaired response to shear\u201d. FASEB Journal 21 (11):  2655\u201363. (Sep 2007). doi:10.1096\/fj.06-7088com. PMID\u00a017449720.\u00a0^ \u201cThe association between endothelial nitric oxide synthase gene G894T polymorphism and hypertension in Han Chinese: a case-control study and an updated meta-analysis\u201d. Annals of Human Biology 42 (2):  184\u201394. (Mar 2015). doi:10.3109\/03014460.2014.911958. PMID\u00a024846690.\u00a0^ \u201cThree endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias\u201d. Journal of Hypertension 25 (9):  1763\u201374. (Sep 2007). doi:10.1097\/HJH.0b013e3281de740d. PMID\u00a017762636.\u00a0^ \u201cEndothelial NO synthase genotype and risk of preeclampsia: a multicenter case-control study\u201d. Hypertension 44 (5):  702\u20137. (Nov 2004). doi:10.1161\/01.HYP.0000143483.66701.ec. PMID\u00a015364897.\u00a0^ a b \u201cAssociation of endothelial nitric oxide synthase gene polymorphisms with type 2 diabetes mellitus: a meta-analysis\u201d. Endocrine Journal 60 (7):  893\u2013901. (2013). doi:10.1507\/endocrj.ej12-0463. PMID\u00a023563728.\u00a0^ \u201cThe association of eNOS G894T polymorphism with metabolic syndrome and erectile dysfunction\u201d. The Journal of Sexual Medicine 9 (3):  837\u201343. (Mar 2012). doi:10.1111\/j.1743-6109.2011.02588.x. PMID\u00a022304542.\u00a0^ \u201ceNOS [Glu298Asp] polymorphism, erectile function and ocular pressure in type 2 diabetes\u201d. European Journal of Clinical Investigation 42 (7):  729\u201337. (Jul 2012). doi:10.1111\/j.1365-2362.2011.02638.x. PMID\u00a022224829.\u00a0^ \u201cEffect of 27nt small RNA on endothelial nitric-oxide synthase expression\u201d. Molecular Biology of the Cell 19 (9):  3997\u20134005. (Sep 2008). doi:10.1091\/mbc.E07-11-1186. PMC\u00a02526692. PMID\u00a018614799. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2526692\/.\u00a0^ \u201ceNOS haplotype associated with hypertension in obese children and adolescents\u201d. International Journal of Obesity 35 (3):  387\u201392. (Mar 2011). doi:10.1038\/ijo.2010.146. PMID\u00a020661250.\u00a0^ \u201cDefinition and clinical importance of haplotypes\u201d. Annual Review of Medicine 56:  303\u201320. (2005). doi:10.1146\/annurev.med.56.082103.104540. PMID\u00a015660514.\u00a0^ \u201cSusceptible and protective eNOS haplotypes in hypertensive black and white subjects\u201d. Atherosclerosis 186 (2):  428\u201332. (Jun 2006). doi:10.1016\/j.atherosclerosis.2005.08.003. PMID\u00a016168996.\u00a0^ \u201cEndothelial nitric oxide synthase haplotypes affect the susceptibility to hypertension in patients with type 2 diabetes mellitus\u201d. Atherosclerosis 189 (1):  241\u20136. (Nov 2006). doi:10.1016\/j.atherosclerosis.2005.12.011. PMID\u00a016427644.\u00a0^ \u201cEndothelial nitric oxide synthase haplotypes are related to blood pressure elevation, but not to resistance to antihypertensive drug therapy\u201d. Journal of Hypertension 24 (12):  2393\u20137. (Dec 2006). doi:10.1097\/01.hjh.0000251899.47626.4f. PMID\u00a017082721.\u00a0^ \u201cEndothelial nitric oxide synthase haplotypes associated with hypertension do not predispose to cardiac hypertrophy\u201d. DNA and Cell Biology 29 (4):  171\u20136. (Apr 2010). doi:10.1089\/dna.2009.0955. PMID\u00a020070154.\u00a0^ \u201cEffects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia\u201d. Molecular Human Reproduction 16 (7):  506\u201310. (Jul 2010). doi:10.1093\/molehr\/gaq030. PMID\u00a020457799.\u00a0^ \u201cEndothelial nitric oxide synthase genotype and haplotype are not associated with diabetic retinopathy in diabetes type 2 patients\u201d. Nitric Oxide 15 (4):  417\u201322. (Dec 2006). doi:10.1016\/j.niox.2006.02.002. PMID\u00a016581274.\u00a0^ \u201ceNOS gene T-786C polymorphism modulates atorvastatin-induced increase in blood nitrite\u201d. Free Radical Biology & Medicine 41 (7):  1044\u20139. (Oct 2006). doi:10.1016\/j.freeradbiomed.2006.04.026. PMID\u00a016962929.\u00a0^ \u201cSimvastatin treatment increases nitrite levels in obese women: modulation by T(-786)C polymorphism of eNOS\u201d. Nitric Oxide 33:  83\u20137. (Sep 2013). doi:10.1016\/j.niox.2013.07.005. hdl:11449\/76257. PMID\u00a023876348.\u00a0^ \u201ceNOS and BDKRB2 genotypes affect the antihypertensive responses to enalapril\u201d. European Journal of Clinical Pharmacology 69 (2):  167\u201377. (Feb 2013). doi:10.1007\/s00228-012-1326-2. PMID\u00a022706620.\u00a0^ a b \u201cEndothelial nitric oxide synthase genotypes and haplotypes modify the responses to sildenafil in patients with erectile dysfunction\u201d. The Pharmacogenomics Journal 13 (2):  189\u201396. (Apr 2013). doi:10.1038\/tpj.2011.49. PMID\u00a022064666.\u00a0^ \u201cPharmacogenetics of erectile dysfunction: navigating into uncharted waters\u201d. Pharmacogenomics 15 (11):  1519\u201338. (Aug 2014). doi:10.2217\/pgs.14.110. PMID\u00a025303302.\u00a0\u95a2\u9023\u6587\u732e[\u7de8\u96c6]\u95a2\u9023\u9805\u76ee[\u7de8\u96c6]"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki2\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki2\/archives\/4002#breadcrumbitem","name":"\u5185\u76ae\u578b\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20 – Wikipedia"}}]}]