[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/jp\/wiki22\/archives\/108361#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/jp\/wiki22\/archives\/108361","headline":"\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20 – Wikipedia","name":"\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20 – Wikipedia","description":"ACE PDB\u306b\u767b\u9332\u3055\u308c\u3066\u3044\u308b\u69cb\u9020 PDB \u30aa\u30eb\u30bd\u30ed\u30b0\u691c\u7d22: RCSB PDBe PDBj PDB\u306eID\u30b3\u30fc\u30c9\u4e00\u89a7 1O86, 1O8A, 1UZE, 1UZF, 2C6F, 2C6N, 2IUL, 2IUX, 2OC2, 2XY9, 2XYD, 2YDM,","datePublished":"2022-03-23","dateModified":"2022-03-23","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/jp\/wiki22\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/jp\/wiki22\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/7\/73\/PDB_1o86_EBI.jpg\/250px-PDB_1o86_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/7\/73\/PDB_1o86_EBI.jpg\/250px-PDB_1o86_EBI.jpg","height":"188","width":"250"},"url":"https:\/\/wiki.edu.vn\/jp\/wiki22\/archives\/108361","about":["Wiki"],"wordCount":1904,"articleBody":"ACEPDB\u306b\u767b\u9332\u3055\u308c\u3066\u3044\u308b\u69cb\u9020PDB\u30aa\u30eb\u30bd\u30ed\u30b0\u691c\u7d22: RCSB PDBe PDBj PDB\u306eID\u30b3\u30fc\u30c9\u4e00\u89a71O86, 1O8A, 1UZE, 1UZF, 2C6F, 2C6N, 2IUL, 2IUX, 2OC2, 2XY9, 2XYD, 2YDM, 3BKK, 3BKL, 3NXQ, 4APH, 4APJ, 3L3N, 4BXK, 4BZR, 4BZS, 4C2N, 4C2O, 4C2P, 4C2Q, 4C2R, 4CA5, 4CA6, 4UFA, 4UFB, 5AMB, 5AM9, 5AM8, 5AMC, 5AMA\u8b58\u5225\u5b50\u8a18\u53f7ACE, angiotensin I converting enzyme, ACE1, CD143, DCP, DCP1, ICH, MVCD3, Angiotensin-converting enzyme\u5916\u90e8IDOMIM: 106180 MGI: 87874 HomoloGene: 37351 GeneCards: ACE \u30aa\u30eb\u30bd\u30ed\u30b0\u7a2e\u30d2\u30c8\u30de\u30a6\u30b9EntrezEnsemblUniProtRefSeq(mRNA)RefSeq(\u30bf\u30f3\u30d1\u30af\u8cea)\u5834\u6240(UCSC)Chr 17: 63.48 \u2013 63.5 MbChr 17: 105.86 \u2013 105.88 MbPubMed\u691c\u7d22[3][4]\u30a6\u30a3\u30ad\u30c7\u30fc\u30bf  \u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\uff08\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u3078\u3093\u304b\u3093\u3053\u3046\u305d\u3001\u82f1: angiotensin-converting enzyme\u3001ACE\u3001EC 3.4.15.1\uff09\u3068\u306f\u4e0d\u6d3b\u6027\u4f53\u3067\u3042\u308b\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3I (\u82f1: angiotensin I\u3001Ang I) \u3092\u3001\u751f\u7406\u6d3b\u6027\u3092\u6301\u3064\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3II (\u82f1: angiotensin II\u3001Ang II) \u306b\u5909\u63db\u3059\u308b\u53cd\u5fdc\u3092\u89e6\u5a92\u3059\u308b\u9175\u7d20\uff08\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff09\u3067\u3042\u308b\u3002\u69cb\u9020\u30fb\u767a\u73fe[\u7de8\u96c6]\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\uff08\u4ee5\u4e0b\u300cACE\u300d\uff09\u306f\u305d\u306e\u6d3b\u6027\u4e2d\u5fc3(HExxH)\u306b\u4e9c\u925b\u3092\u6709\u3059\u308b\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306e\u4e00\u7a2e\u3067\u3042\u308a\u3001\u7d30\u80de\u819c\u4e0a\u306b\u5b58\u5728\u3059\u308b\u3002ACE\u306b\u306f2\u3064\u306e\u7570\u306a\u308b\u30bf\u30a4\u30d7\u304c\u5b58\u5728\u3057\u3001\u305d\u308c\u305e\u308c somatic ACE (sACE) \u3068 germinal ACE (gACE) \u3068\u547c\u3070\u308c\u308b\u3002sACE\u306f\u5168\u8eab\u306e\u7d30\u80de\u306b\u5e83\u304f\u5206\u5e03\u3059\u308b\u306e\u306b\u5bfe\u3057\u3066\u3001gACE\u306f\u767a\u73fe\u3057\u3066\u3044\u308b\u7d44\u7e54\u304c\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u7cbe\u5de3\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001sACE\u306f\u6d3b\u6027\u90e8\u4f4d\u3092N\u672b\u7aef\u5074\u3068C\u672b\u7aef\u5074\u306b2\u3064\u6301\u3064\u306e\u306b\u5bfe\u3057\u3001gACE\u306f\u6d3b\u6027\u90e8\u4f4d\u30921\u3064\u3057\u304b\u6301\u305f\u306a\u3044\u3002sACE\u306eN\u672b\u7aef\u53ca\u3073C\u672b\u7aef\u306e\u6d3b\u6027\u4e2d\u5fc3\u90e8\u4f4d\u306f\u305d\u308c\u305e\u308c\u30a2\u30df\u30ce\u9178\u914d\u5217\u306f\u540c\u3058\u3067\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u57fa\u8cea\u306b\u5bfe\u3059\u308b\u53cd\u5fdc\u6027\u306a\u3069\u6027\u8cea\u304c\u7570\u306a\u308b\u70b9\u304c\u5b58\u5728\u3059\u308b\u3002    \u30ec\u30cb\u30f3-\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\u306b\u304a\u3051\u308bACE\u306e\u5f79\u5272\u3002ACE\u306e\u57fa\u672c\u7684\u306a\u50cd\u304d\u306f\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3I\u3092\u6d3b\u6027\u4f53\u306e\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3II\u3078\u5909\u63db\u3057\u3001\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u518d\u5438\u53ce\u3092\u4fc3\u3057\u3066\u8840\u5727\u306e\u8abf\u6574\u3092\u884c\u3046\u3053\u3068\u306b\u3042\u308b\u3002\u307e\u305f\u3001ACE\u306f\u30d6\u30e9\u30b8\u30ad\u30cb\u30f3\u306e\u5206\u89e3\u306b\u95a2\u4e0e\u3059\u308b\u30ad\u30cb\u30ca\u30fc\u30bcII\u3068\u540c\u7b49\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u3064\u307e\u308a\u3001ACE\u306f\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3I\u306e\u5909\u63db\u3068\u30ad\u30cb\u30ca\u30fc\u30bcII\u306e\u5206\u89e3\u306e\u4e21\u65b9\u306b\u50cd\u304f\u9175\u7d20\u3067\u3042\u308b\u3002\u305d\u306e\u4ed6\u306b\u3082\u30b5\u30d6\u30b9\u30bf\u30f3\u30b9P\u3084\u9ec4\u4f53\u5f62\u6210\u30db\u30eb\u30e2\u30f3\u653e\u51fa\u30db\u30eb\u30e2\u30f3 (LH-RH) \u7b49\u3092\u57fa\u8cea\u3068\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u57fa\u8cea\u7279\u7570\u6027\u306f\u4f4e\u3044\u3002\u8fd1\u5e74\u3067\u306f\u30ec\u30cb\u30f3\u30fb\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u30fb\u30a2\u30eb\u30c9\u30b9\u30c6\u30ed\u30f3\u7cfb (\u82f1: renin-angiotensin system\u3001RAS) \u4ee5\u5916\u306b\u5bfe\u3059\u308bACE\u306e\u6a5f\u80fd\u3082\u89e3\u660e\u3055\u308c\u3064\u3064\u3042\u308b\u3002ACE\u306fACE\u963b\u5bb3\u85ac\u306b\u3088\u3063\u3066\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u305f\u3060\u3057\u3001\u30d2\u30c8\u306b\u304a\u3044\u3066\u306fACE\u3092\u4ecb\u3055\u306a\u3044\u30ad\u30de\u30fc\u30bc\u30fb\u30a2\u30f3\u30ae\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\u306b\u3088\u3063\u3066\u3082\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3II\u304c\u751f\u6210\u3055\u308c\u3066\u3044\u308b[5][6] (\u901a\u5e38\u306e\u30e9\u30c3\u30c8\u306b\u306f\u30ad\u30de\u30fc\u30bc\u30fb\u30a2\u30f3\u30ae\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\u304c\u7121\u3044[5])\u3002\u30ca\u30c8\u30ea\u30a6\u30e0\u518d\u53d6\u308a\u8fbc\u307f\u304c\u4e0d\u8981\u306a\u9ad8\u5869\u98df\u3067\u306f\u30ec\u30cb\u30f3\u5206\u6ccc\u3084ACE\u6d3b\u6027\u304c\u4f4e\u4e0b\u3057\u3066\u30ec\u30cb\u30f3\u30fb\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\u304c\u6291\u5236\u3055\u308c\u308b\u3002\u3057\u304b\u3057\u81ea\u7136\u767a\u75c7\u9ad8\u8840\u5727\u30e9\u30c3\u30c8 (SHR)\u306b\u304a\u3044\u3066\u306f\u9ad8\u5869\u98df\u306b\u3088\u3063\u3066\u8840\u6f3f\u4e2d\u306e\u30ec\u30cb\u30f3\u3084ACE\u6d3b\u6027\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u306e\u306b\u3082\u95a2\u308f\u3089\u305a\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3II\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u308b[7]\u3002\u95a2\u9023\u9805\u76ee[\u7de8\u96c6]  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