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NAP\u30b9\u30b3\u30a2\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u306e\u304c\u7279\u5fb4\u3067\u3042\u308b\u3002 Philadelphia\u67d3\u8272\u4f53\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u305f\u7279\u52b9\u85ac\u30a4\u30de\u30c1\u30cb\u30d6\u30e1\u30b7\u30eb\u9178\u5869\uff08\u5546\u54c1\u540d\u30b0\u30ea\u30d9\u30c3\u30af\uff09\u304c2001\u5e74\u627f\u8a8d\u3055\u308c: \u73fe\u5728\u7b2c\u4e00\u9078\u629e\u85ac\u306b\u306a\u3063\u3066\u3044\u308b\u3002\u672a\u6cbb\u7642\u306e\u81ea\u7136\u7d4c\u904e\u3067\u306f\u6570\u5e74\u306e\u5f8c\u306b100\uff05\u6025\u6027\u8ee2\u5316\u3092\u8d77\u3053\u3057\u3001\u6025\u6027\u767d\u8840\u75c5\u3068\u306a\u308b\u3002 \u771f\u6027\u591a\u8840\u75c7\uff08\u771f\u6027\u8d64\u8840\u7403\u5897\u52a0\u75c7\uff09Polycythemia Vera\uff1aPV 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\u672c\u614b\u6027\u8840\u5c0f\u677f\u8840\u75c7Essential Thrombocythemia\uff1aET \u8840\u5c0f\u677f\u306e\u5897\u52a0\u304c\u8457\u3057\u3044\u3002\u81ea\u7136\u7d4c\u904e\u3067\u306f\u6025\u6027\u8ee2\u5316\u306f\u307e\u308c\u3067\u3042\u308b\u3002 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\u5c1a\u3001\u9aa8\u9ac4\u5897\u6b96\u6027\u816b\u760d\u306fWHO\u5206\u985e\u3067\u306f\u3001\u9aa8\u9ac4\u5897\u6b96\u6027\u75be\u60a3\uff08\u3053\u3064\u305a\u3044\u305e\u3046\u3057\u3087\u304f\u305b\u3044\u3057\u3063\u304b\u3093\u3001\u82f1\u540d\uff1aMyeloproliferative disease\u3001\u7565\u79f0\uff1aMPD\uff09\u304b\u30892008\u5e74\u6539\u8a02\u306eWHO\u5206\u985e\u7b2c4\u7248\u306b\u3066\u6539\u540d\u3055\u308c\u305f\u3082\u306e\u3067\u3042\u308b\u3002\u9aa8\u9ac4\u5897\u6b96\u6027\u75be\u60a3(MPD)\u306e\u540d\u79f0\u30822010\u5e74\u73fe\u5728\u3001\u4e00\u822c\u7684\u306b\u4f7f\u308f\u308c\u3066\u3044\u308b\u304c\u3001\u4e21\u8005\u306f\u540c\u3058\u75be\u60a3\u7fa4\u306e\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u6162\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5Chronic Myelogenous Leukemia\uff1aCMLCML\u306fPhiladelphia\u67d3\u8272\u4f53\u304c\u539f\u56e0\u3067\u9846\u7c92\u7403\u7cfb\u306e\u5897\u52a0\u304c\u8457\u3057\u3044\u3002NAP\u30b9\u30b3\u30a2\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u306e\u304c\u7279\u5fb4\u3067\u3042\u308b\u3002Philadelphia\u67d3\u8272\u4f53\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u305f\u7279\u52b9\u85ac\u30a4\u30de\u30c1\u30cb\u30d6\u30e1\u30b7\u30eb\u9178\u5869\uff08\u5546\u54c1\u540d\u30b0\u30ea\u30d9\u30c3\u30af\uff09\u304c2001\u5e74\u627f\u8a8d\u3055\u308c: \u73fe\u5728\u7b2c\u4e00\u9078\u629e\u85ac\u306b\u306a\u3063\u3066\u3044\u308b\u3002\u672a\u6cbb\u7642\u306e\u81ea\u7136\u7d4c\u904e\u3067\u306f\u6570\u5e74\u306e\u5f8c\u306b100\uff05\u6025\u6027\u8ee2\u5316\u3092\u8d77\u3053\u3057\u3001\u6025\u6027\u767d\u8840\u75c5\u3068\u306a\u308b\u3002\u771f\u6027\u591a\u8840\u75c7\uff08\u771f\u6027\u8d64\u8840\u7403\u5897\u52a0\u75c7\uff09Polycythemia Vera\uff1aPV\u8d64\u8840\u7403\u7cfb\u306e\u5897\u52a0\u304c\u8457\u3057\u3044\u3000\u307b\u307c\u5168\u4f8b\u3067V617F\u5909\u7570JAK2\u907a\u4f1d\u5b50\u304c\u307f\u3064\u304b\u3063\u3066\u3044\u308b\u3002\u81ea\u7136\u7d4c\u904e\u3067\u306f\u6025\u6027\u8ee2\u5316\u306f\u307e\u308c\u3067\u3042\u308b\u3002\u539f\u767a\u6027\u9aa8\u9ac4\u7dda\u7dad\u75c7Myelofibrosis\uff1aMF\u9aa8\u9ac4\u9593\u8cea\u7d30\u80de\u306e\u5897\u52a0\u304c\u8457\u3057\u3044\u3002\u9aa8\u9ac4\u7dda\u7dad\u75c7\u306e\u4e88\u5f8c\u306f\u60aa\u304f\u3001\u5e73\u5747\u751f\u5b58\u671f\u9593\u306f5\u5e74\u307b\u3069\u3067\u3042\u308b\u300220\uff05\u304b\u308930\uff05\u306f\u672b\u671f\u306b\u6025\u6027\u767d\u8840\u75c5\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u7121\u75c7\u72b6\u3067\u3042\u308c\u3070\u6cbb\u7642\u306f\u7d4c\u904e\u89b3\u5bdf\u3067\u3042\u308a\u3001\u8ca7\u8840\u306b\u5bfe\u3057\u3066\u306f\u30bf\u30f3\u30d1\u30af\u540c\u5316\u30db\u30eb\u30e2\u30f3\u3001\u5de8\u813e\u3068\u767d\u8840\u7403\u6570\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306b\u306f\u30d2\u30c9\u30ed\u30ad\u30b7\u5c3f\u7d20\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u884c\u308f\u308c\u308b\u3002\u3053\u308c\u3089\u306f\u652f\u6301\u7642\u6cd5\u3067\u3042\u308a\u3001\u540c\u7a2e\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u304c\u552f\u4e00\u306e\u6cbb\u7652\u7684\u6cbb\u7642\u6cd5\u3067\u3042\u308b\u3002\u9aa8\u9ac4\u7dda\u7dad\u75c7\u306e\u4e09\u5fb4\u3068\u3057\u3066\u306f\u3001\u9aa8\u9ac4\u306e\u5e83\u7bc4\u306a\u7dda\u7dad\u5316\u304a\u3088\u3073\u3001\u9ac4\u5916\u9020\u8840\u306b\u3088\u308b\u8457\u3057\u3044\u809d\u813e\u816b\u3001\u672b\u68a2\u8840\u306e\u767d\u8d64\u82bd\u7403\u75c7\u304c\u6709\u540d\u3067\u3042\u308b\u3002\u767d\u8d64\u82bd\u7403\u75c7\u306f\u8d64\u82bd\u7403\u3068\u9846\u7c92\u7403\u306e\u5e7c\u82e5\u7d30\u80de\u304c\u672b\u68a2\u8840\u4e2d\u306b\u307f\u3089\u308c\u308b\u3053\u3068\u3067\u3001leukoerythoroblastosis\u3068\u3044\u3044\u3001\u9aa8\u9ac4\u7dda\u7dad\u75c7\u3001\u764c\u306e\u9aa8\u9ac4\u6d78\u6f64\u3001\u7c9f\u7c92\u7d50\u6838\u3067\u6709\u540d\u3067\u3042\u308b\u3002\u672c\u614b\u6027\u8840\u5c0f\u677f\u8840\u75c7Essential Thrombocythemia\uff1aET\u8840\u5c0f\u677f\u306e\u5897\u52a0\u304c\u8457\u3057\u3044\u3002\u81ea\u7136\u7d4c\u904e\u3067\u306f\u6025\u6027\u8ee2\u5316\u306f\u307e\u308c\u3067\u3042\u308b\u3002\u6162\u6027\u597d\u4e2d\u7403\u6027\u767d\u8840\u75c5 Chronic Neutrophilic Leukemia\uff1aCNL\u767d\u8840\u7403\u306e\u4e00\u7a2e\u985e\u3001\u597d\u4e2d\u7403\u304c\u9855\u8457\u306b\u5897\u52a0\u3059\u308b\u3002CML\u306b\u4f3c\u308b\u304cPhiladelphia\u67d3\u8272\u4f53\u306f\u5b58\u5728\u305b\u305a\u3001NAP\u30b9\u30b3\u30a2\u306f\u4f4e\u4e0b\u3057\u306a\u3044\u3002\u975e\u5e38\u306b\u5e0c\u3067\u3042\u308b\u3002\u6162\u6027\u597d\u9178\u7403\u6027\u767d\u8840\u75c5\/\u7279\u767a\u6027\u597d\u9178\u7403\u5897\u52a0\u75c7\u5019\u7fa4\uff08CEL\/HES\uff09\u767d\u8840\u7403\u306e\u4e00\u7a2e\u597d\u9178\u7403\u304c\u5897\u52a0\u3057\u3001\u591a\u304f\u306e\u81d3\u5668\u306b\u597d\u9178\u7403\u304c\u6e7f\u6f64\u3057\u50b7\u5bb3\u3059\u308b\u3002\u5206\u985e\u4e0d\u53ef\u80fd\u578bPV\u306e\u307b\u307c\u5168\u4f8b\u3001MF\u3001ET\u306e\u304a\u304a\u3088\u305d\u534a\u6570\u306b\u304a\u3044\u3066\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bcJak2\u907a\u4f1d\u5b50\u306e\u70b9\u7a81\u7136\u5909\u7570\u304c\u767a\u898b\u3055\u308c\u3001JAK2V617F\u5909\u7570\u878d\u5408\u907a\u4f1d\u5b50\u3068\u547c\u3070\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u305f\u5275\u85ac\u304c\u7814\u7a76\u3055\u308c\u3001JAK1\/JAK2\u3092\u6a19\u7684\u3068\u3059\u308b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u5264\u3067\u3042\u308b\u30eb\u30ad\u30bd\u30ea\u30c1\u30cb\u30d6\u304c\u3001\u539f\u767a\u6027\u9aa8\u9ac4\u7dda\u7dad\u75c7\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u85ac\u3068\u3057\u3066\u627f\u8a8d\u7533\u8acb\u4e2d\u3067\u3042\u308b[1]\u3002\u30c9\u30e9\u30a4\u30bf\u30c3\u30d7\u306b\u95a2\u3057\u3066[\u7de8\u96c6]\u30c9\u30e9\u30a4\u30bf\u30c3\u30d7\u3092\u8d77\u3053\u3059\u75be\u60a3\u3068\u3057\u3066\u306f\u3001\u6162\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306e\u6025\u6027\u8ee2\u5316\u3001\u9aa8\u9ac4\u7dda\u7dad\u75c7\u3001\u764c\u306e\u9aa8\u9ac4\u6d78\u6f64\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u9aa8\u9ac4\u7dda\u7dad\u75c7\u306b\u95a2\u3057\u3066\u306f\u5c11\u3005\u5b9a\u7fa9\u304c\u8907\u96d1\u3067\u3042\u308b\u3002\u9aa8\u9ac4\u5897\u6b96\u6027\u75be\u60a3\u3068\u3057\u3066\u306f\u6162\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306f\u9846\u7c92\u7403\u7cfb\u306e\u5897\u52a0\u304c\u8457\u3057\u304f\u3001\u771f\u6027\u591a\u8840\u75c7\u3067\u306f\u8d64\u8840\u7403\u7cfb\u306e\u5897\u52a0\u304c\u8457\u3057\u304f\u3001\u672c\u614b\u6027\u8840\u5c0f\u677f\u8840\u75c7\u3067\u306f\u8840\u5c0f\u677f\u306e\u5897\u52a0\u304c\u8457\u3057\u304f\u3001\u9aa8\u9ac4\u7dda\u7dad\u75c7\u3067\u306f\u9aa8\u9ac4\u9593\u8cea\u7d30\u80de\u306e\u5897\u52a0\u304c\u8457\u3057\u3044\u306e\u304c\u7279\u5fb4\u3068\u3055\u308c\u3066\u3044\u308b\u3002\u3068\u3053\u308d\u304c\u9aa8\u9ac4\u306e\u9593\u8cea\u7d30\u80de\u304c\u30af\u30ed\u30fc\u30ca\u30eb\u306b\u5897\u6b96\u3057\u305f\u3068\u3044\u3046\u5831\u544a\u306f\u5b58\u5728\u3057\u306a\u3044\u3002\u5de8\u6838\u7403\u306e\u7570\u5e38\u30af\u30ed\u30fc\u30f3\u304c\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u5206\u6ccc\u3057\u305f\u4e8c\u6b21\u7684\u306a\u7d50\u679c\u306a\u306e\u3067\u306f\u306a\u3044\u306e\u304b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u9aa8\u9ac4\u7dda\u7dad\u75c7\u306f\u7279\u767a\u6027\u3068\u4e8c\u6b21\u6027\u306b\u5206\u304b\u308c\u308b\u3002\u4e8c\u6b21\u6027\u306b\u767a\u751f\u3059\u308b\u3082\u306e\u3068\u3057\u3066\u672a\u6cbb\u7642\u306e\u767d\u8840\u75c5\u3084MDS\u306f\u542b\u307e\u306a\u3044\u3002 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