[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/jp\/wiki3\/archives\/150#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/jp\/wiki3\/archives\/150","headline":"\u30ab\u30eb\u30d1\u30a4\u30f3 (\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9) – Wikipedia","name":"\u30ab\u30eb\u30d1\u30a4\u30f3 (\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9) – Wikipedia","description":"\u30ab\u30eb\u30d1\u30a4\u30f3[1] (1S,11R,13S,14S,24R,26S)-13,26-Dimethyl-2,15-dioxa-12,25-diazatricyclo[22.2.2.211,14]triacontane-3,16-dione \u8b58\u5225\u60c5\u5831 CAS\u767b\u9332\u756a\u53f7 3463-92-1\u00a0 PubChem 442630 ChemSpider 390994\u00a0 UNII VLR223H4QP\u00a0 ChEBI O=C3O[C@H]1CC[C@H](N[C@H]1C)CCCCCCCC(=O)O[C@@H]2[C@@H](N[C@@H](CC2)CCCCCCC3)C InChI=1S\/C28H50N2O4\/c1-21-25-19-17-23(29-21)13-9-5-3-8-12-16-28(32)34-26-20-18-24(30-22(26)2)14-10-6-4-7-11-15-27(31)33-25\/h21-26,29-30H,3-20H2,1-2H3\/t21-,22-,23+,24+,25-,26-\/m0\/s1\u00a0 Key:\u00a0AMSCMASJCYVAIF-QCVMBYIASA-N\u00a0 InChI=1\/C28H50N2O4\/c1-21-25-19-17-23(29-21)13-9-5-3-8-12-16-28(32)34-26-20-18-24(30-22(26)2)14-10-6-4-7-11-15-27(31)33-25\/h21-26,29-30H,3-20H2,1-2H3\/t21-,22-,23+,24+,25-,26-\/m0\/s1 Key:\u00a0AMSCMASJCYVAIF-QCVMBYIABP \u7279\u6027 \u5316\u5b66\u5f0f C28H50N2O4","datePublished":"2020-01-31","dateModified":"2020-01-31","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/jp\/wiki3\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/jp\/wiki3\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/3\/34\/Carpaine.png\/200px-Carpaine.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/3\/34\/Carpaine.png\/200px-Carpaine.png","height":"143","width":"200"},"url":"https:\/\/wiki.edu.vn\/jp\/wiki3\/archives\/150","about":["Wiki"],"wordCount":1550,"articleBody":"\u30ab\u30eb\u30d1\u30a4\u30f3[1](1S,11R,13S,14S,24R,26S)-13,26-Dimethyl-2,15-dioxa-12,25-diazatricyclo[22.2.2.211,14]triacontane-3,16-dione\u8b58\u5225\u60c5\u5831CAS\u767b\u9332\u756a\u53f73463-92-1\u00a0PubChem442630ChemSpider390994\u00a0UNIIVLR223H4QP\u00a0ChEBIO=C3O[C@H]1CC[C@H](N[C@H]1C)CCCCCCCC(=O)O[C@@H]2[C@@H](N[C@@H](CC2)CCCCCCC3)CInChI=1S\/C28H50N2O4\/c1-21-25-19-17-23(29-21)13-9-5-3-8-12-16-28(32)34-26-20-18-24(30-22(26)2)14-10-6-4-7-11-15-27(31)33-25\/h21-26,29-30H,3-20H2,1-2H3\/t21-,22-,23+,24+,25-,26-\/m0\/s1\u00a0Key:\u00a0AMSCMASJCYVAIF-QCVMBYIASA-N\u00a0InChI=1\/C28H50N2O4\/c1-21-25-19-17-23(29-21)13-9-5-3-8-12-16-28(32)34-26-20-18-24(30-22(26)2)14-10-6-4-7-11-15-27(31)33-25\/h21-26,29-30H,3-20H2,1-2H3\/t21-,22-,23+,24+,25-,26-\/m0\/s1Key:\u00a0AMSCMASJCYVAIF-QCVMBYIABP\u7279\u6027\u5316\u5b66\u5f0fC28H50N2O4\u30e2\u30eb\u8cea\u91cf478.70 g\/mol\u878d\u70b9  121 \u00b0C\u7279\u8a18\u306a\u304d\u5834\u5408\u3001\u30c7\u30fc\u30bf\u306f\u5e38\u6e29 (25\u00a0\u00b0C)\u30fb\u5e38\u5727 (100\u00a0kPa) \u306b\u304a\u3051\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u30ab\u30eb\u30d1\u30a4\u30f3 (Carpaine) \u306f\u3001\u5faa\u74b0\u7cfb\u3078\u306e\u4f5c\u7528\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u30d1\u30d1\u30a4\u30e4\u306e\u8449\u306b\u542b\u307e\u308c\u308b\u4e3b\u8981\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u6210\u5206\u306e1\u3064\u3067\u3042\u308b[2]\u3002\u5faa\u74b0\u7cfb\u3078\u306e\u4f5c\u7528\u306e\u7814\u7a76\u306f\u3001\u30da\u30f3\u30bf\u30d0\u30eb\u30d3\u30bf\u30fc\u30eb (30 mg\/kg) \u9ebb\u9154\u4e0b\u306b\u3042\u308b\u3001\u4f53\u91cd314\u00b113 g\u306e\u96c4\u306eWistar\u30e9\u30c3\u30c8\u3092\u7528\u3044\u3066\u884c\u308f\u308c\u305f[3]\u3002\u30ab\u30eb\u30d1\u30a4\u30f3\u306e\u91cf\u30920.5 mg\/kg\u304b\u30892.0 mg\/kg\u306b\u5897\u3084\u3059\u3068\u3001\u53ce\u7e2e\u671f\u8840\u5727\u3001\u62e1\u5f35\u671f\u8840\u5727\u53ca\u3073\u5e73\u5747\u52d5\u8108\u5727\u304c\u5f90\u3005\u306b\u4f4e\u4e0b\u3057\u305f\u3002\u30a2\u30c8\u30ed\u30d4\u30f3\u786b\u9178\u5869\uff081 mg\/kg\uff09\u307e\u305f\u306f\u30d7\u30ed\u30d7\u30e9\u30ce\u30ed\u30fc\u30eb\u5869\u9178\u5869\uff088 mg\/kg\uff09\u306b\u3088\u308b\u9078\u629e\u7684\u81ea\u5f8b\u795e\u7d4c\u7cfb\u906e\u65ad\u306f\u3001\u30ab\u30eb\u30d1\u30a4\u30f3\u306b\u5bfe\u3059\u308b\u5faa\u74b0\u7cfb\u306e\u53cd\u5fdc\u3092\u5909\u5316\u3055\u305b\u306a\u304b\u3063\u305f\u30022 mg\/kg\u306e\u30ab\u30eb\u30d1\u30a4\u30f3\u306b\u3088\u308a\u3001\u5fc3\u62cd\u51fa\u91cf\u30011\u62cd\u5f53\u305f\u308a\u306e\u91cf\u3084\u4ed5\u4e8b\u3001\u307e\u305f\u62cd\u51fa\u529b\u304c\u4f4e\u4e0b\u3057\u305f\u304c\u3001\u305d\u3053\u304b\u3089\u8a08\u7b97\u3055\u308c\u308b\u672b\u68a2\u8840\u7ba1\u62b5\u6297\u306e\u7dcf\u8a08\u306f\u5909\u5316\u3057\u306a\u304b\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u30ab\u30eb\u30d1\u30a4\u30f3\u306f\u5fc3\u7b4b\u306b\u76f4\u63a5\u4f5c\u7528\u3057\u3066\u3044\u308b\u3068\u7d50\u8ad6\u4ed8\u3051\u3089\u308c\u305f\u3002\u30ab\u30eb\u30d1\u30a4\u30f3\u306e\u52b9\u679c\u306f\u3001\u30ab\u30c1\u30aa\u30f3\u3092\u30ad\u30ec\u30fc\u30c8\u3057\u3046\u308b\u5927\u54e1\u74b0\u30b8\u30e9\u30af\u30c8\u30f3\u69cb\u9020\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002^ Merck Index, 11th Edition, 1866.^ Burdick, E.M. (1971). \u201cCarpaine: An alkaloid of Carica papaya\u2014its chemistry and pharmacology\u201d. Econ. Bot. 25:  363\u2013365. doi:10.1007\/BF02985202.\u00a0^ Hornick, C. A.; Sanders, L. I.; Lin, Y. C. (1978). \u201cEffect of carpaine, a papaya alkaloid, on the circulatory function in the rat\u201d. Res. Commun. Chem. Pathol. Pharmacol. 22 (2):  277-289. PMID\u00a0734216.\u00a0"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki3\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki3\/archives\/150#breadcrumbitem","name":"\u30ab\u30eb\u30d1\u30a4\u30f3 (\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9) – Wikipedia"}}]}]