[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/jp\/wiki3\/archives\/3369#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/jp\/wiki3\/archives\/3369","headline":"\u9577\u9396\u6563\u5728\u53cd\u5fa9\u914d\u5217 – Wikipedia","name":"\u9577\u9396\u6563\u5728\u53cd\u5fa9\u914d\u5217 – Wikipedia","description":"\u3053\u306e\u9805\u76ee\u300c\u9577\u9396\u6563\u5728\u53cd\u5fa9\u914d\u5217\u300d\u306f\u7ffb\u8a33\u3055\u308c\u305f\u3070\u304b\u308a\u306e\u3082\u306e\u3067\u3059\u3002\u4e0d\u81ea\u7136\u3042\u308b\u3044\u306f\u66d6\u6627\u306a\u8868\u73fe\u306a\u3069\u304c\u542b\u307e\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3053\u306e\u307e\u307e\u3067\u306f\u8aad\u307f\u3065\u3089\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\uff08\u539f\u6587\uff1aen:Long interspersed nuclear element\uff09 \u4fee\u6b63\u3001\u52a0\u7b46\u306b\u5354\u529b\u3057\u3001\u73fe\u5728\u306e\u8868\u73fe\u3092\u3088\u308a\u81ea\u7136\u306a\u8868\u73fe\u306b\u3057\u3066\u4e0b\u3055\u308b\u65b9\u3092\u6c42\u3081\u3066\u3044\u307e\u3059\u3002\u30ce\u30fc\u30c8\u30da\u30fc\u30b8\u3084\u5c65\u6b74\u3082\u53c2\u7167\u3057\u3066\u304f\u3060\u3055\u3044\u3002\uff082020\u5e746\u6708\uff09 \u9577\u9396\u6563\u5728\u53cd\u5fa9\u914d\u5217 \u30d2\u30c8 LINE-1 \u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u306e\u6a19\u7684\u30a8\u30f3\u30c9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u7d50\u6676\u69cb\u9020 \u8b58\u5225\u5b50 \u7565\u53f7 LINE \u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u3092\u8868\u793a \u30cd\u30ba\u30df\u79d1\u306b\u304a\u3051\u308b LINE1 \u304a\u3088\u3073 SINE \u306e\u907a\u4f1d\u69cb\u9020\u3002\u4e0b\uff1aL1 RNA-\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306e\u63d0\u6848\u3055\u308c\u305f\u69cb\u9020\u3002ORF1 \u30bf\u30f3\u30d1\u30af\u8cea\u304c3\u91cf\u4f53\u3092\u5f62\u6210\u3057\u3001RNA","datePublished":"2020-07-31","dateModified":"2020-07-31","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/jp\/wiki3\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/jp\/wiki3\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/2\/2a\/Translation_arrow.svg\/50px-Translation_arrow.svg.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/2\/2a\/Translation_arrow.svg\/50px-Translation_arrow.svg.png","height":"17","width":"50"},"url":"https:\/\/wiki.edu.vn\/jp\/wiki3\/archives\/3369","about":["Wiki"],"wordCount":9872,"articleBody":"\u3053\u306e\u9805\u76ee\u300c\u9577\u9396\u6563\u5728\u53cd\u5fa9\u914d\u5217\u300d\u306f\u7ffb\u8a33\u3055\u308c\u305f\u3070\u304b\u308a\u306e\u3082\u306e\u3067\u3059\u3002\u4e0d\u81ea\u7136\u3042\u308b\u3044\u306f\u66d6\u6627\u306a\u8868\u73fe\u306a\u3069\u304c\u542b\u307e\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3053\u306e\u307e\u307e\u3067\u306f\u8aad\u307f\u3065\u3089\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\uff08\u539f\u6587\uff1aen:Long interspersed nuclear element\uff09\u4fee\u6b63\u3001\u52a0\u7b46\u306b\u5354\u529b\u3057\u3001\u73fe\u5728\u306e\u8868\u73fe\u3092\u3088\u308a\u81ea\u7136\u306a\u8868\u73fe\u306b\u3057\u3066\u4e0b\u3055\u308b\u65b9\u3092\u6c42\u3081\u3066\u3044\u307e\u3059\u3002\u30ce\u30fc\u30c8\u30da\u30fc\u30b8\u3084\u5c65\u6b74\u3082\u53c2\u7167\u3057\u3066\u304f\u3060\u3055\u3044\u3002\uff082020\u5e746\u6708\uff09\u9577\u9396\u6563\u5728\u53cd\u5fa9\u914d\u5217\u30d2\u30c8 LINE-1 \u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u306e\u6a19\u7684\u30a8\u30f3\u30c9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u7d50\u6676\u69cb\u9020\u8b58\u5225\u5b50\u7565\u53f7LINE\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u3092\u8868\u793a  \u30cd\u30ba\u30df\u79d1\u306b\u304a\u3051\u308b LINE1 \u304a\u3088\u3073 SINE \u306e\u907a\u4f1d\u69cb\u9020\u3002\u4e0b\uff1aL1 RNA-\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306e\u63d0\u6848\u3055\u308c\u305f\u69cb\u9020\u3002ORF1 \u30bf\u30f3\u30d1\u30af\u8cea\u304c3\u91cf\u4f53\u3092\u5f62\u6210\u3057\u3001RNA \u7d50\u5408\u6d3b\u6027\u304a\u3088\u3073\u6838\u9178\u30b7\u30e3\u30da\u30ed\u30f3\u6d3b\u6027\u3092\u793a\u3057\u3066\u3044\u308b\u3002  \u9577\u9396\u6563\u5728\u53cd\u5fa9\u914d\u5217\uff08\u3061\u3087\u3046\u3055\u3055\u3093\u3056\u3044\u306f\u3093\u3077\u304f\u306f\u3044\u308c\u3064\u3001\u82f1: long interspersed nuclear element, LINE\uff09\u3068\u306f\u3001\u975e LTR \u578b\u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u306e\u4e00\u7fa4\u3067\u3042\u308b\u3002\u591a\u304f\u306e\u771f\u6838\u751f\u7269\u306e\u30b2\u30ce\u30e0\u306b\u5e83\u304f\u898b\u3089\u308c[1][2]\u3001\u30d2\u30c8\u30b2\u30ce\u30e0\u3067\u306f\u5168\u4f53\u306e\u304a\u3088\u305d 21.1% \u3092\u5360\u3081\u308b[3][4][5]\u3002\u305d\u308c\u305e\u308c\u306e\u9577\u3055\u306f\u304a\u304a\u3088\u305d7000\u5869\u57fa\u5bfe\u7a0b\u5ea6\u3067\u3042\u308b\u3002mRNA \u3078\u8ee2\u5199\u3055\u308c\u305f\u306e\u3061\u3001\u9006\u8ee2\u5199\u9175\u7d20\u6d3b\u6027\u3092\u6301\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u3078\u3068\u7ffb\u8a33\u3055\u308c\u308b\u3002\u3053\u306e\u9006\u8ee2\u5199\u9175\u7d20\u306b\u3088\u308a LINE RNA \u304b\u3089\u30b3\u30d4\u30fc\u3055\u308c\u305f DNA \u306e\u30b2\u30ce\u30e0\u4e0a\u306b\u304a\u3051\u308b\u65b0\u3057\u3044\u30b5\u30a4\u30c8\u3078\u306e\u7d44\u307f\u8fbc\u307f\u304c\u53ef\u80fd\u3068\u306a\u308b\u3002  \u30d2\u30c8\u30b2\u30ce\u30e0\u306b\u304a\u3044\u3066\u591a\u91cf\u306b\u307f\u3089\u308c\u308b\u306e\u306f LINE1\uff08\u82f1\u8a9e\u7248\uff09 \u3060\u3051\u3067\u3042\u308b\u3002\u30d2\u30c8\u30b2\u30ce\u30e0\u4e0a\u306b\u306f\u3001\u5207\u308a\u8a70\u3081\u3089\u308c\u305f\u3082\u306e\u3067100000\u500b\u306e\u3001\u5b8c\u5168\u306a\u9577\u3055\u3092\u6301\u3064\u3082\u306e\u30674000\u500b\u306e LINE1 \u8981\u7d20\u304c\u5b58\u5728\u3059\u308b[6]\u3002\u591a\u304f\u306e LINE \u914d\u5217\u306f\u3001\u30e9\u30f3\u30c0\u30e0\u5909\u7570\u306e\u84c4\u7a4d\u306b\u3088\u308a\u3082\u306f\u3084\u8ee2\u5199\u304a\u3088\u3073\u7ffb\u8a33\u304c\u8d77\u3053\u3089\u306a\u3044\u307b\u3069\u52a3\u5316\u3057\u3066\u3044\u308b\u3002LINE DNA \u914d\u5217\u306e\u6bd4\u8f03\u306b\u3088\u308a\u3001\u30b2\u30ce\u30e0\u3078\u306e\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u306e\u633f\u5165\u6642\u671f\u3092\u63a8\u5b9a\u3067\u304d\u308b\u3002Table of Contents\u767a\u898b\u306e\u6b74\u53f2[\u7de8\u96c6]LINE1[\u7de8\u96c6]\u305d\u306e\u4ed6[\u7de8\u96c6]\u30d2\u30c8[\u7de8\u96c6]LINE \u6d3b\u52d5\u306e\u8abf\u7bc0[\u7de8\u96c6]\u75be\u60a3\u3068\u306e\u95a2\u9023[\u7de8\u96c6]\u767a\u898b\u306e\u6b74\u53f2[\u7de8\u96c6]J. Adams et al. 1980 \u306b\u3088\u308a\u3001\u304a\u3088\u305d 6.4 kb \u9577\u306e LINE \u7531\u6765\u914d\u5217\u304c\u521d\u3081\u3066\u8a18\u8f09\u3055\u308c\u305f[7]\u3002\u9375\u3068\u306a\u308b\u9006\u8ee2\u5199\u9175\u7d20 (RT) \u306e\u69cb\u9020\u7684\u7279\u5fb4\u3068\u7cfb\u7d71\u306b\u57fa\u3065\u304d\u3001L1, RTE, R2, I, Jockey \u306e5\u3064\u306e\u4e3b\u8981\u306a\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u985e\u3055\u308c\u3001\u3055\u3089\u306b\u3059\u304f\u306a\u304f\u3068\u308228\u500b\u306e\u4e0b\u4f4d\u5206\u985e\u304c\u3042\u308b[8]\u3002  \u690d\u7269\u30b2\u30ce\u30e0\u3067\u306f\u3001\u3053\u308c\u307e\u3067\u306e\u3068\u3053\u308d\u3001L1 \u304a\u3088\u3073 RTE \u306b\u5206\u985e\u3055\u308c\u308b LINE \u306e\u307f\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b[9][10][11]\u3002L1 \u578b\u306f\u3044\u304f\u3064\u304b\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u4e0b\u4f4d\u5206\u985e\u3055\u308c\u308b\u304c\u3001RTE \u578b LINE \u4fdd\u5b58\u6027\u304c\u9ad8\u304f\u3001\u591a\u304f\u306e\u5834\u5408\u5358\u4e00\u306e\u30d5\u30a1\u30df\u30ea\u30fc\u3092\u69cb\u6210\u3059\u308b[12][13]\u3002\u83cc\u985e\u3067\u306f\u3001Tad, L1, CRE, Deceiver, Inkcap \u3068\u3044\u3063\u305f\u8981\u7d20\u304c\u540c\u5b9a\u3055\u308c\u3066\u304a\u308a[14]\u3001Tad \u985e\u4f3c\u8981\u7d20\u306f\u771f\u83cc\u306e\u30b2\u30ce\u30e0\u306b\u306e\u307f\u898b\u3089\u308c\u308b[15]\u3002\u3059\u3079\u3066\u306e LINE \u306f\u5c11\u306a\u304f\u3068\u30821\u3064\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3001ORF2 \u3092\u30b3\u30fc\u30c9\u3059\u308b\u3002ORF2 \u306f RT \u30c9\u30e1\u30a4\u30f3\u3068\u30a8\u30f3\u30c9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc (EN) \u30c9\u30e1\u30a4\u30f3\u3092\u3042\u308f\u305b\u3082\u3061\u3001EN \u9818\u57df\u306f N \u672b\u7aef APE\uff08\u82f1\u8a9e\u7248\uff09\u304a\u3088\u3073 C \u672b\u7aef RLE \u306e\u3069\u3061\u3089\u304b\u3082\u3057\u304f\u306f\u307e\u308c\u306b\u4e21\u65b9\u306e\u6d3b\u6027\u3092\u3082\u3064\u3002\u30ea\u30dc\u30cc\u30af\u30ec\u30a2\u30fc\u30bc H\uff08\u82f1\u8a9e\u7248\uff09\u30c9\u30e1\u30a4\u30f3\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3082\u3042\u308b\u3002\u9032\u5316\u7684\u306b\u53e4\u3044 R2 \u304a\u3088\u3073 RTE \u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u3092\u9664\u3044\u3066\u3001LINE \u306f\u901a\u5e38 ORF1 \u3068\u547c\u3070\u308c\u308b\u5225\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3059\u308b\u3002ORF1 \u306f Gag-knuckle \u578b\u30b8\u30f3\u30af\u30d5\u30a3\u30f3\u30ac\u30fc\u3001L1-like RRM\uff08\u82f1\u8a9e\u7248\uff09[\u8a33\u8a9e\u7591\u554f\u70b9] (InterPro\uff08\u82f1\u8a9e\u7248\uff09:\u00a0IPR035300)\u3001\u30a8\u30b9\u30c6\u30e9\u30fc\u30bc\u306e\u3044\u305a\u308c\u304b\u3082\u3057\u304f\u306f\u3059\u3079\u3066\u3092\u6301\u3064\u3002\u690d\u7269\u3001\u771f\u83cc\u3001\u6606\u866b\u306b\u304a\u3044\u3066\u306f LTR \u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30dd\u30be\u30f3\uff08\u82f1\u8a9e\u7248\uff09 \u6bd4\u3079\u3066 LINE \u306e\u983b\u5ea6\u306f\u4f4e\u3044\u304c\u3001\u810a\u690e\u52d5\u7269\u306b\u304a\u3044\u3066\u306f\u983b\u5ea6\u304c\u9ad8\u304f\u3001\u7279\u306b\u54fa\u4e73\u52d5\u7269\u306b\u304a\u3044\u3066\u306f\u30b2\u30ce\u30e0\u306e\u7d0420\uff05\u3092\u5360\u3081\u308b[8]\u3002LINE1[\u7de8\u96c6]LINE1\uff08\u82f1\u8a9e\u7248\uff09\uff08L1 \u8981\u7d20\uff09\u306f\u3001\u73fe\u751f\u306e\u30d2\u30c8\u30b2\u30ce\u30e0\u306b\u304a\u3044\u3066\u3082\u3044\u307e\u3060\u6d3b\u52d5\u7684\u306a\u8981\u7d20\u306e1\u3064\u3067\u3042\u308a\u3001\u30aa\u30aa\u30b3\u30a6\u30e2\u30ea\u3092\u9664\u304f\u3059\u3079\u3066\u306e\u54fa\u4e73\u985e\u306b\u898b\u3089\u308c\u308b[16][17]\u3002\u305d\u306e\u4ed6[\u7de8\u96c6]L2 \u304a\u3088\u3073 L3 \u8981\u7d20\u306f\u3001\u30d2\u30c8\u30b2\u30ce\u30e0\u306b\u75d5\u8de1\u306e\u307f\u3092\u6b8b\u3057\u3066\u304a\u308a[5]\u3001\u3053\u308c\u3089\u304c\u6d3b\u52d5\u7684\u3060\u3063\u305f\u306e\u306f\u304a\u3088\u305d2\u301c3\u5104\u5e74\u524d\u3068\u63a8\u5b9a\u3055\u308c\u308b\u3002L1 \u8981\u7d20\u3068\u306f\u7570\u306a\u308a\u3001L2 \u8981\u7d20\u306b\u306f\u96a3\u63a5\u3059\u308b\u6a19\u7684\u90e8\u4f4d\u91cd\u8907\u304c\u307f\u3089\u308c\u306a\u3044[18]\u3002L2 \u304a\u3088\u3073 L3 \u8981\u7d20\u306f\u5171\u306b CR1\u30af\u30ec\u30fc\u30c9 Jockey \u306b\u5206\u985e\u3055\u308c\u308b[19]\u3002\u30d2\u30c8[\u7de8\u96c6]\u6700\u521d\u306e\u30c9\u30e9\u30d5\u30c8\u7248\u30d2\u30c8\u30b2\u30ce\u30e0\u3067\u306f\u3001\u30d2\u30c8\u30b2\u30ce\u30e0\u306b\u5360\u3081\u308b LINE \u306e\u5272\u5408\u306f21\uff05\u3001\u30b3\u30d4\u30fc\u6570\u306f85\u4e07\u3060\u3063\u305f\u3002\u3053\u306e\u5185\u8a33\u306f L1 \u3001L2\u3001L3 \u8981\u7d20\u304c\u305d\u308c\u305e\u308c51\u4e076\u5343\u300131\u4e075\u5343\u30013\u4e077\u5343\u3067\u3042\u3063\u305f\u3002L1 \u8981\u7d20\u306b\u4f9d\u5b58\u3057\u3066\u5897\u6b96\u3059\u308b\u975e\u81ea\u5f8b\u7684\u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u3067\u3042\u308b SINE \u306f\u3001\u30d2\u30c8\u30b2\u30ce\u30e0\u306e13\uff05\u3092\u5360\u3081\u3001\u304a\u3088\u305d150\u4e07\u306e\u30b3\u30d4\u30fc\u6570\u3092\u6301\u3064[5]\u3002SINE \u306e\u8d77\u6e90\u306f  RTE \u306b\u5206\u985e\u3055\u308c\u308b LINE \u306b\u7531\u6765\u3059\u308b\u3053\u3068\u304c\u63a8\u5b9a\u3055\u308c\u3066\u3044\u308b[20]\u3002\u6700\u8fd1\u306e\u63a8\u5b9a\u3067\u306f\u3001\u5178\u578b\u7684\u306a\u4eba\u9593\u306e\u30b2\u30ce\u30e0\u306b\u306f\u6f5c\u5728\u7684\u306b\u53ef\u52d5\u6027\u306e\u3042\u308b L1 \u8981\u7d20\u304c\u5e73\u5747100\u500b\u542b\u307e\u308c\u308b\u3068\u3055\u308c\u308b\u304c\u3001\u5206\u6563\u304c\u5927\u304d\u304f\u591a\u6570\u306e\u6d3b\u52d5\u7684 L1 \u8981\u7d20\u3092\u6301\u3061\u3001L1 \u8a98\u5f15\u5909\u7570\u5c0e\u5165\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u500b\u4f53\u3082\u5b58\u5728\u3059\u308b[21]\u3002L1 \u30b3\u30d4\u30fc\u6570\u306e\u5897\u52a0\u306f\u7d71\u5408\u5931\u8abf\u75c7\u60a3\u8005\u306e\u8133\u306b\u3082\u898b\u3089\u308c\u3001LINE \u304c\u3044\u304f\u3064\u304b\u306e\u795e\u7d4c\u75be\u60a3\u306b\u5f79\u5272\u3092\u679c\u305f\u3059\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b[22]\u3002  \u6a19\u7684\u30d7\u30e9\u30a4\u30e0\u9006\u8ee2\u5199\uff08TPRT\uff09\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\uff1a\u7d44\u307f\u8fbc\u307f\u30b5\u30a4\u30c8\u3067\u76f4\u63a5\uff1aL1 RNP \u306f AAAATT \u30d8\u30ad\u30b5\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3092\u8a8d\u8b58\u3057\u3001ORF2 \u306e\u30a8\u30f3\u30c9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u6d3b\u6027\u306b\u3088\u308a DNA \u306e\u7b2c\u4e00\u9396\u304c\u5207\u65ad\u3055\u308c\u308b\u3002L1 \u30dd\u30ea A \u30c6\u30fc\u30eb\u304c TTTT\u30aa\u30fc\u30d0\u30fc\u30cf\u30f3\u30b0\u306b\u7d50\u5408\u3057\u3001\u30db\u30b9\u30c8 DNA \u3092\u30d7\u30e9\u30a4\u30de\u30fc\u3068\u3057\u3066\u9006\u8ee2\u5199\u304c\u958b\u59cb\u3055\u308c\u308b\u3002\u304a\u305d\u3089\u304f ORF2 \u306f\u7b2c\u4e8c\u9396\u306e\u5207\u65ad\u3092\u4ef2\u4ecb\u3057\u3001\u518d\u3073\u30db\u30b9\u30c8 DNA \u3092\u30d7\u30e9\u30a4\u30de\u30fc\u3068\u3057\u3066\u65b0\u305f\u306b\u5408\u6210\u3055\u308c\u305f cDNA \u306e DNA\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u3078\u306e\u7d50\u5408\u3092\u4ef2\u4ecb\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002LINE \u306f\u3001\u6a19\u7684\u30d7\u30e9\u30a4\u30e0\u9006\u8ee2\u5199 (TPRT) \u3068\u547c\u3070\u308c\u308b\u6a5f\u69cb\u306b\u3088\u308a\u4f1d\u64ad\u3059\u308b\u3002\u3053\u306e\u6a5f\u69cb\u306f\u3001\u30ab\u30a4\u30b3\u306b\u304a\u3051\u308b R2 RNA \u8981\u7d20\uff08\u82f1\u8a9e\u7248\uff09\u306b\u3064\u3044\u3066\u521d\u3081\u3066\u8a18\u8f09\u3055\u308c\u305f\u3002ORF2\uff08\u304a\u3088\u3073\u5b58\u5728\u3059\u308b\u5834\u5408\u306fORF1\uff09\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u305d\u308c\u3089\u3092\u30b3\u30fc\u30c9\u3059\u308b mRNA \u3068\u4e3b\u306b cis \u4f1a\u5408\u3057\u3001\u304a\u305d\u3089\u304f2\u3064\u306e ORF2 \u3068\u672a\u77e5\u306e\u500b\u6570\u306e ORF1 \u30c8\u30e9\u30a4\u30de\u30fc\u304b\u3089\u306a\u308b\u30ea\u30dc\u6838\u30bf\u30f3\u30d1\u30af\u8cea (RNP) \u8907\u5408\u4f53\u3092\u5f62\u6210\u3059\u308b[23]\u3002\u8907\u5408\u4f53\u306f\u6838\u306b\u623b\u3055\u308c\u3001\u305d\u3053\u3067 ORF2 \u306e\u30a8\u30f3\u30c9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u30c9\u30e1\u30a4\u30f3\u306b\u3088\u308a\uff08\u54fa\u4e73\u985e\u3067\u306f TTAAAA \u30d8\u30ad\u30b5\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u30e2\u30c1\u30fc\u30d5\u306b\u304a\u3044\u3066\uff09DNA \u304c\u958b\u88c2\u3059\u308b[24]\u3002\u305d\u3057\u3066 3\u2032OH \u30b0\u30eb\u30fc\u30d7\u304c\u9006\u8ee2\u5199\u9175\u7d20\u306b\u5bfe\u3057\u3066\u958b\u653e\u3055\u308c\u3001LINE RNA \u8ee2\u5199\u7269\u306e\u9006\u8ee2\u5199\u958b\u59cb\u304c\u53ef\u80fd\u3068\u306a\u308b\u3002\u9006\u8ee2\u5199\u5f8c\u3001\u6a19\u7684\u9396\u304c\u5207\u65ad\u3055\u308c\u3001\u65b0\u3057\u304f\u4f5c\u6210\u3055\u308c\u305f cDNA \u304c\u7d44\u307f\u8fbc\u307e\u308c\u308b[25]\u3002\u65b0\u305f\u306a\u633f\u5165\u306b\u3088\u308a\u77ed\u3044\u6a19\u7684\u90e8\u4f4d\u91cd\u8907[\u8a33\u8a9e\u7591\u554f\u70b9]\u304c\u5f62\u6210\u3055\u308c\u308b\u3002\u307e\u305f\u3001\u65b0\u305f\u306a\u633f\u5165\u914d\u5217\u306e\u5927\u90e8\u5206\u306f5\u2032\u304c\u5927\u5e45\u306b\uff08\u30d2\u30c8\u306b\u304a\u3051\u308b\u5e73\u5747\u633f\u5165\u30b5\u30a4\u30ba\u306f 900pb\uff09\u5207\u308a\u8a70\u3081\u3089\u308c\u3001\u3057\u3070\u3057\u3070\u9006\u8ee2\u3057\u3066\u3044\u308b\uff08Szak et al., 2002\uff09\u3002 5\u2032UTR\u3092\u6b20\u304f\u305f\u3081\u3001\u65b0\u3057\u3044\u633f\u5165\u914d\u5217\u306e\u307b\u3068\u3093\u3069\u306f\u6a5f\u80fd\u3057\u306a\u3044\u3002LINE \u6d3b\u52d5\u306e\u8abf\u7bc0[\u7de8\u96c6]\u5bbf\u4e3b\u7d30\u80de\u306f\u3001\u305f\u3068\u3048\u3070\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u3092\u4ecb\u3057\u3066\u3001L1 \u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30b8\u30b7\u30e7\u30f3\u6d3b\u52d5\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u305f\u3068\u3048\u3070\u3001L1 \u914d\u5217\u306b\u7531\u6765\u3059\u308b\u4f4e\u5206\u5b50\u5e72\u6e09RNA\u306eRNA\u5e72\u6e09\u6a5f\u69cb\u306b\u3088\u308a\u3001L1 \u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30b8\u30b7\u30e7\u30f3\u304c\u6291\u5236\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u308b[26]\u3002\u690d\u7269\u30b2\u30ce\u30e0\u3067\u306f\u3001LINE \u306b\u5bfe\u3059\u308b\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u4fee\u98fe[\u8a33\u8a9e\u7591\u554f\u70b9]\u306b\u3088\u308a\u3001\u8fd1\u63a5\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u5909\u5316\u3084\u8868\u73fe\u578b\u306e\u5909\u5316\u3055\u3048\u3082\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3002\u30a2\u30d6\u30e9\u30e4\u30b7\u306e\u5287\u7684\u306a\u53ce\u91cf\u73fe\u8c61\u306b\u3064\u306a\u304c\u308b “mantled” \u30bd\u30de\u30af\u30ed\u30fc\u30ca\u30eb\u5909\u7570\uff08\u82f1\u8a9e\u7248\uff09\u4f53\u306f\u3001\u30a2\u30d6\u30e9\u30e4\u30b7\u30b2\u30ce\u30e0\u306b\u304a\u3051\u308b Karma \u578b LINE \u306b\u5bfe\u3059\u308b\u30e1\u30c1\u30eb\u5316\u306b\u3088\u308a\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b[27]\u3002\u30d2\u30c8 APOBEC3C\uff08\u82f1\u8a9e\u7248\uff09 (A3C) \u3092\u4ecb\u3059\u308b LINE-1 \u306e\u6291\u5236\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u306f\u3001A3C \u3068 ORF1p \u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u308a\u9006\u8ee2\u5199\u9175\u7d20\u6d3b\u6027\u304c\u5f71\u97ff\u3055\u308c\u308b\u3053\u3068\u306b\u3088\u308b[28]\u3002\u75be\u60a3\u3068\u306e\u95a2\u9023[\u7de8\u96c6]L1 \u7531\u6765\u75be\u60a3\u306e\u6b74\u53f2\u7684\u306a\u4f8b\u3068\u3057\u3066\u3001\u633f\u5165\u578b\u907a\u4f1d\u5b50\u5909\u7570\uff08\u82f1\u8a9e\u7248\uff09 \u306b\u3088\u308a\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u8840\u53cb\u75c5 A \u304c\u6319\u3052\u3089\u308c\u308b[29]\u3002\u3044\u304f\u3064\u304b\u306e\u7a2e\u985e\u306e\u764c\u3084\u795e\u7d4c\u969c\u5bb3\u306a\u3069100\u8fd1\u304f\u306e\u75be\u60a3\u304c\u30ec\u30c8\u30ed\u30a8\u30ec\u30e1\u30f3\u30c8\u633f\u5165\u306b\u3088\u308a\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b[30]\u3002\u4e0a\u76ae\u7d30\u80de\u764c\u306b\u304a\u3044\u3066 L1 \u79fb\u52d5\u3068\u767a\u764c\u3068\u306e\u9593\u306e\u76f8\u95a2\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b[31]\u3002LINE \u306e\u4f4e\u30e1\u30c1\u30eb\u5316\u306f\u67d3\u8272\u4f53\u306e\u4e0d\u5b89\u5b9a\u6027\u304a\u3088\u3073\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5909\u5316\u306b\u95a2\u9023\u3057[32]\u3001\u3055\u307e\u3056\u307e\u306a\u7d44\u7e54\u306e\u3055\u307e\u3056\u307e\u306a\u304c\u3093\u7d30\u80de\u306b\u898b\u3089\u308c\u308b[33]\u3002\u764c\u907a\u4f1d\u5b50\u3067\u3042\u308b MET \u907a\u4f1d\u5b50\u5185\u306b\u3042\u308b\u7279\u5b9a\u306e L1 \u306e\u4f4e\u30e1\u30c1\u30eb\u5316\u306f\u3001\u8180\u80f1\u764c\u306e\u816b\u760d\u5f62\u6210\u306b\u95a2\u9023\u3057\u3059\u308b[34]\u3002\u4ea4\u4ee3\u52e4\u52d9\u7761\u7720\u969c\u5bb3\uff08\u82f1\u8a9e\u7248\uff09 [35]\u306f\u764c\u30ea\u30b9\u30af\u306e\u5897\u52a0\u306b\u95a2\u9023\u3059\u308b\u304c\u3001\u3053\u308c\u306f\u591c\u9593\u306b\u5149\u306b\u3055\u3089\u3055\u308c\u308b\u3053\u3068\u306b\u3088\u308a\u3001L1 \u8d77\u56e0\u30b2\u30ce\u30e0\u4e0d\u5b89\u5b9a\u6027\uff08\u82f1\u8a9e\u7248\uff09\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3001\u30e1\u30e9\u30c8\u30cb\u30f3\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u306b\u3088\u308b[36]\u3002^ \u201cSINEs and LINEs: highly repeated short and long interspersed sequences in mammalian genomes\u201d. Cell 28 (3):  433\u20134. (March 1982). doi:10.1016\/0092-8674(82)90194-5. PMID\u00a06280868.\u00a0^ Jurka, J. (1998). \u201cRepeats in genomic DNA: Mining and meaning\u201d. Current Opinion in Structural Biology 8 (3):  333\u2013337. doi:10.1016\/S0959-440X(98)80067-5. PMID\u00a09666329.\u00a0^ \u201cGenome sequence, comparative analysis and haplotype structure of the domestic dog\u201d. Nature 438 (7069):  803\u201319. (December 2005). Bibcode:\u00a02005Natur.438..803L. doi:10.1038\/nature04338. PMID\u00a016341006.\u00a0^  Unique functions of repetitive transcriptomes. International Review of Cell and Molecular Biology. 285. (2010-01-01). pp.\u00a0115\u201388. doi:10.1016\/B978-0-12-381047-2.00003-7. ISBN\u00a09780123810472. PMID\u00a021035099\u00a0^ a b c \u201cInitial sequencing and analysis of the human genome\u201d. Nature 409 (6822):  860\u2013921. (February 2001). Bibcode:\u00a02001Natur.409..860L. doi:10.1038\/35057062. PMID\u00a011237011. https:\/\/deepblue.lib.umich.edu\/bitstream\/2027.42\/62798\/1\/409860a0.pdf.\u00a0^ \u201cReading between the LINEs: human genomic variation induced by LINE-1 retrotransposition\u201d. Genome Research 10 (10):  1496\u2013508. (October 2000). doi:10.1101\/gr.149400. PMC\u00a0310943. PMID\u00a011042149. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC310943\/.\u00a0^ \u201cA family of long reiterated DNA sequences, one copy of which is next to the human beta globin gene\u201d. Nucleic Acids Research 8 (24):  6113\u201328. (December 1980). doi:10.1093\/nar\/8.24.6113. PMC\u00a0328076. PMID\u00a06258162. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC328076\/.\u00a0^ a b \u201cSimple and fast classification of non-LTR retrotransposons based on phylogeny of their RT domain protein sequences\u201d. Gene 448 (2):  207\u201313. (December 2009). doi:10.1016\/j.gene.2009.07.019. PMC\u00a02829327. PMID\u00a019651192. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2829327\/.\u00a0^ \u201cEvolutionary dynamics and evolutionary history in the RTE clade of non-LTR retrotransposons\u201d. Molecular Biology and Evolution 18 (10):  1849\u201363. (October 2001). doi:10.1093\/oxfordjournals.molbev.a003727. PMID\u00a011557792.\u00a0^ \u201cBNR – a LINE family from Beta vulgaris – contains a RRM domain in open reading frame 1 and defines a L1 sub-clade present in diverse plant genomes\u201d. The Plant Journal 59 (6):  872\u201382. (September 2009). doi:10.1111\/j.1365-313x.2009.03923.x. PMID\u00a019473321.\u00a0^ \u201cTwo-step regulation and continuous retrotransposition of the rice LINE-type retrotransposon Karma\u201d. The Plant Cell 15 (8):  1934\u201344. (August 2003). doi:10.1105\/tpc.011809. PMC\u00a0167180. PMID\u00a012897263. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC167180\/.\u00a0^ \u201cProfiling of extensively diversified plant LINEs reveals distinct plant-specific subclades\u201d. The Plant Journal 79 (3):  385\u201397. (August 2014). doi:10.1111\/tpj.12565. PMID\u00a024862340.\u00a0^ \u201cAcquisition of an Archaea-like ribonuclease H domain by plant L1 retrotransposons supports modular evolution\u201d. Proceedings of the National Academy of Sciences of the United States of America 110 (50):  20140\u20135. (December 2013). Bibcode:\u00a02013PNAS..11020140S. doi:10.1073\/pnas.1310958110. PMC\u00a03864347. PMID\u00a024277848. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3864347\/.\u00a0^ \u201cNon-LTR retrotransposons in fungi\u201d. Functional & Integrative Genomics 9 (1):  27\u201342. (February 2009). doi:10.1007\/s10142-008-0093-8. PMID\u00a018677522.\u00a0^ \u201cThe age and evolution of non-LTR retrotransposable elements\u201d. Molecular Biology and Evolution 16 (6):  793\u2013805. (June 1999). doi:10.1093\/oxfordjournals.molbev.a026164. PMID\u00a010368957.\u00a0^ \u201cGenome analysis of the platypus reveals unique signatures of evolution\u201d. Nature 453 (7192):  175\u201383. (May 2008). Bibcode:\u00a02008Natur.453..175W. doi:10.1038\/nature06936. PMC\u00a02803040. PMID\u00a018464734. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2803040\/.\u00a0^ \u201cThe genome sizes of megabats (Chiroptera: Pteropodidae) are remarkably constrained\u201d. Biology Letters 5 (3):  347\u201351. (June 2009). doi:10.1098\/rsbl.2009.0016. PMC\u00a02679926. PMID\u00a019324635. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2679926\/.\u00a0^ Kapitonov, Vladimir V.; Pavlicek, Adam; Jurka, Jerzy (2006-01-01). Anthology of Human Repetitive DNA. Wiley-VCH Verlag GmbH & Co. KGaA. doi:10.1002\/3527600906.mcb.200300166. ISBN\u00a09783527600908\u00a0^ \u201cEvolutionary dynamics in a novel L2 clade of non-LTR retrotransposons in Deuterostomia\u201d. Molecular Biology and Evolution 18 (12):  2213\u201324. (December 2001). doi:10.1093\/oxfordjournals.molbev.a003768. PMID\u00a011719571.\u00a0^ Malik, HS; Eickbush, TH (September 1998). \u201cThe RTE class of non-LTR retrotransposons is widely distributed in animals and is the origin of many SINEs.\u201d. Molecular Biology and Evolution 15 (9):  1123\u201334. doi:10.1093\/oxfordjournals.molbev.a026020. PMID\u00a09729877.\u00a0^ \u201cSequencing, identification and mapping of primed L1 elements (SIMPLE) reveals significant variation in full length L1 elements between individuals\u201d. BMC Genomics 16 (220):  220. (March 2015). doi:10.1186\/s12864-015-1374-y. PMC\u00a04381410. PMID\u00a025887476. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4381410\/.\u00a0^ \u201cIncreased l1 retrotransposition in the neuronal genome in schizophrenia\u201d. Neuron 81 (2):  306\u201313. (January 2014). doi:10.1016\/j.neuron.2013.10.053. PMID\u00a024389010.\u00a0^ \u201cL1 integration in a transgenic mouse model\u201d. Genome Research 16 (2):  240\u201350. (February 2006). doi:10.1101\/gr.4571606. PMC\u00a01361720. PMID\u00a016365384. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1361720\/.\u00a0^ \u201cSequence patterns indicate an enzymatic involvement in integration of mammalian retroposons\u201d. Proceedings of the National Academy of Sciences of the United States of America 94 (5):  1872\u20137. (March 1997). Bibcode:\u00a01997PNAS…94.1872J. doi:10.1073\/pnas.94.5.1872. PMC\u00a020010. PMID\u00a09050872. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC20010\/.\u00a0^ \u201cReverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition\u201d. Cell 72 (4):  595\u2013605. (February 1993). doi:10.1016\/0092-8674(93)90078-5. PMID\u00a07679954.\u00a0^ \u201cL1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells\u201d. Nature Structural & Molecular Biology 13 (9):  763\u201371. (September 2006). doi:10.1038\/nsmb1141. PMID\u00a016936727.\u00a0^ \u201cLoss of Karma transposon methylation underlies the mantled somaclonal variant of oil palm\u201d. Nature 525 (7570):  533\u20137. (September 2015). Bibcode:\u00a02015Natur.525..533O. doi:10.1038\/nature15365. PMC\u00a04857894. PMID\u00a026352475. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4857894\/.\u00a0^ \u201cHuman LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity\u201d. Nucleic Acids Research 42 (1):  396\u2013416. (January 2014). doi:10.1093\/nar\/gkt898. PMC\u00a03874205. PMID\u00a024101588. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3874205\/.\u00a0^ \u201cHaemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man\u201d. Nature 332 (6160):  164\u20136. (March 1988). Bibcode:\u00a01988Natur.332..164K. doi:10.1038\/332164a0. PMID\u00a02831458.\u00a0^ \u201cMobile elements in the human genome: implications for disease\u201d. Genome Medicine 4 (2):  12. (February 2012). doi:10.1186\/gm311. PMC\u00a03392758. PMID\u00a022364178. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3392758\/.\u00a0^ \u201cL1 retrotransposons, cancer stem cells and oncogenesis\u201d. The FEBS Journal 281 (1):  63\u201373. (January 2014). doi:10.1111\/febs.12601. PMC\u00a04160015. PMID\u00a024286172. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4160015\/.\u00a0^ \u201cLong interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications\u201d. Clinical Epigenetics 2 (2):  315\u201330. (August 2011). doi:10.1007\/s13148-011-0032-8. PMC\u00a03365388. PMID\u00a022704344. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3365388\/.\u00a0^ \u201cLINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability\u201d. PLOS ONE 2 (5):  e399. (May 2007). Bibcode:\u00a02007PLoSO…2..399E. doi:10.1371\/journal.pone.0000399. PMC\u00a01851990. PMID\u00a017476321. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1851990\/.\u00a0^ \u201cHypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer\u201d. PLOS Genetics 6 (4):  e1000917. (April 2010). doi:10.1371\/journal.pgen.1000917. PMC\u00a02858672. PMID\u00a020421991. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2858672\/.\u00a0^ \u201cA LINE-1-encoded reverse transcriptase-dependent regulatory mechanism is active in embryogenesis and tumorigenesis\u201d. Annals of the New York Academy of Sciences 1341 (1):  164\u201371. (April 2015). Bibcode:\u00a02015NYASA1341..164S. doi:10.1111\/nyas.12637. PMID\u00a025586649.\u00a0^ \u201cRegulation of L1 expression and retrotransposition by melatonin and its receptor: implications for cancer risk associated with light exposure at night\u201d. Nucleic Acids Research 42 (12):  7694\u2013707. (July 2014). doi:10.1093\/nar\/gku503. PMC\u00a04081101. PMID\u00a024914052. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4081101\/.\u00a0"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki3\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki3\/archives\/3369#breadcrumbitem","name":"\u9577\u9396\u6563\u5728\u53cd\u5fa9\u914d\u5217 – Wikipedia"}}]}]