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\u306f\u3001\u67d1\u6a58\u985e\u306e\u679c\u76ae\u7b49\u306b\u591a\u304f\u542b\u307e\u308c\u308b\u6709\u6a5f\u5316\u5408\u7269\u3067\u3001\u30d5\u30e9\u30dc\u30f3\u3092\u9aa8\u683c\u306b\u6301\u3064\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\uff08O-\u30e1\u30c1\u30eb\u5316\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\uff09\u306e\u4e00\u7a2e\u3067\u3042\u308b\u3002\u542b\u6709\u98df\u54c1[\u7de8\u96c6]\u4e3b\u306b\u67d1\u6a58\u985e\u306b\u591a\u304f\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u7279\u306b\u30dd\u30f3\u30ab\u30f3\u3001\u30b7\u30fc\u30af\u30ee\u30fc\u30b5\u30fc\u3001\u6a58\u7b49\u306b\u591a\u304f\u542b\u307e\u308c\u3066\u3044\u308b[1]\u3002\u53ef\u98df\u90e8\u5206\u3067\u3042\u308b\u679c\u5b9f\u5c0f\u80de\u81ea\u4f53\u306b\u306f\u3042\u307e\u308a\u542b\u307e\u308c\u3066\u304a\u3089\u305a\u3001\u679c\u76ae\u90e8\u5206\u3067\u3042\u308b\u30d5\u30e9\u30d9\u30c9(\u5916\u679c\u76ae)\u3001\u30a2\u30eb\u30d9\u30c9(\u4e2d\u679c\u76ae)\u306b\u7279\u306b\u591a\u304f\u542b\u6709\u3057\u3066\u3044\u308b\u3002\u67d1\u6a58\u985e\u679c\u5b9f\u5168\u4f53\u679c\u5b9f\u5c0f\u80de\u679c\u76ae\u7d44\u7e54\u30d5\u30e9\u30d9\u30c9\u30a2\u30eb\u30d9\u30c9\u30dd\u30f3\u30ab\u30f330.60.811019833.3\u30b7\u30fc\u30af\u30ee\u30fc\u30b5\u30fc30.32.585.212241.0\u30bf\u30c1\u30d0\u30ca54.3018223346.7\u6e29\u5dde\u307f\u304b\u3093(\u53c2\u8003)1.506.410.81.8\u6ce8\uff1a\u751f\u679c\u306e\u5404\u7d44\u7e54100g\u3042\u305f\u308a\u306e\u542b\u6709\u91cf(mg)\u85ac\u7406\u4f5c\u7528[\u7de8\u96c6]in vitro\u3084\u52d5\u7269\u5b9f\u9a13\u3067\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3084\u816b\u760d\u306e\u6d78\u6f64\u3001\u62e1\u6563\u3001\u8ee2\u79fb\u3092\u9632\u3050\u4f5c\u7528[2][3][4]\u3001\u76ae\u819a\u708e\u6291\u5236\u4f5c\u7528[5]\u3001\u809d\u708e\u6291\u5236\u4f5c\u7528[6]\u7b49\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u8edf\u9aa8\u306e\u5206\u89e3\u3092\u6291\u5236\u3059\u308b\u52b9\u679c\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b[7]\u3002\u307e\u305f\u3001\u57f9\u990a\u6d77\u99ac\u7d30\u80de\u306b\u304a\u3044\u3066AMPA\u578b\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u53d7\u5bb9\u4f53\u3092\u6d3b\u6027\u5316\u3057\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u9577\u671f\u5897\u5f37\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b[8]\u3002^  Nogata Y, Sakamoto K, Shiratsuchi H, Ishii T, Yano M, Ohta H (2006). \u201cFlavonoid composition of fruit tissues of citrus species\u201d. Biosci Biotechnol Biochem 70:  178-192. doi:10.1271\/bbb.70.178. PMID\u00a016428836.\u00a0^  Minagawa A, Otani Y, Kubota T, Wada N, Furukawa T, Kumai K, Kameyama K, Okada Y, Fujii M, Yano M, Sato T, Ito A, Kitajima M (2001). \u201cThe citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice\u201d. Jpn J Cancer Res 92 (12):  1322-1328. PMID\u00a011749698.\u00a0^  Sato T, Koike L, Miyata Y, Hirata M, Mimaki Y, Sashida Y, Yano M, Ito A. (2002). \u201cInhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells\u201d. Cancer Res 62 (4):  1025-1029. PMID\u00a011861377.\u00a0^  Yoshimizu N, Otani Y, Saikawa Y, Kubota T, Yoshida M, Furukawa T, Kumai K, Kameyama K, Fujii M, Yano M, Sato T, Ito A, Kitajima M (2004). \u201cAnti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulation\u201d. Aliment Pharmacol Ther 1:  95-101. doi:10.1111\/j.1365-2036.2004.02082.x. PMID\u00a015298613.\u00a0^  Tanaka S, Sato T, Akimoto N, Yano M, Ito A (2004). \u201cPrevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes in vivo and in vitro\u201d. Biochem Pharmacol 68:  433-439. doi:10.1016\/j.bcp.2004.04.006. PMID\u00a015242810.\u00a0^ Akachi T, Shiina Y, Ohishi Y, Kawaguchi T, Kawagishi H, Morita T, Mori M, Sugiyama K (2010). \u201cHepatoprotective effects of flavonoids from shekwasha (Citrus depressa) against D-galactosamine-induced liver injury in rats\u201d. J Nutr Sci Vitaminol 56 (1):  60-67. doi:10.3177\/jnsv.56.60. PMID\u00a020354348.\u00a0^ Henrotin, Y.; C. Lambert; D. Couchourel; C. Ripoll; E. Chiotelli (January 2011). \u201cNutraceuticals: do they represent a new era in the management of osteoarthritis? \u2013 a narrative review from the lessons taken with five products\u201d. Osteoarthritis and Cartilage 19 (1):  1\u201321. doi:10.1016\/j.joca.2010.10.017. PMID\u00a021035558. http:\/\/www.oarsijournal.com\/article\/S1063-4584%2810%2900358-4\/fulltext#sec3.8 2011\u5e7412\u670827\u65e5\u95b2\u89a7\u3002.\u00a0^  Matsuzaki K, Miyazaki K, Sakai S, Yawo H, Nakata N, Moriguchi S, Fukunaga K, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y (2008). \u201cNobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus\u201d. Eur J Pharmacol 578 (2-3):  194-200. doi:10.1016\/j.ejphar.2007.09.028. PMID\u00a017976577.\u00a0\u5916\u90e8\u30ea\u30f3\u30af[\u7de8\u96c6]"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki4\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki4\/2020\/07\/04\/%e3%83%8e%e3%83%93%e3%83%ac%e3%83%81%e3%83%b3-wikipedia\/#breadcrumbitem","name":"\u30ce\u30d3\u30ec\u30c1\u30f3 – Wikipedia"}}]}]