[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/jp\/wiki4\/2021\/01\/28\/%e8%a3%9c%e4%bd%93%e4%be%9d%e5%ad%98%e6%80%a7%e7%b4%b0%e8%83%9e%e5%82%b7%e5%ae%b3-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/jp\/wiki4\/2021\/01\/28\/%e8%a3%9c%e4%bd%93%e4%be%9d%e5%ad%98%e6%80%a7%e7%b4%b0%e8%83%9e%e5%82%b7%e5%ae%b3-wikipedia\/","headline":"\u88dc\u4f53\u4f9d\u5b58\u6027\u7d30\u80de\u50b7\u5bb3 – Wikipedia","name":"\u88dc\u4f53\u4f9d\u5b58\u6027\u7d30\u80de\u50b7\u5bb3 – Wikipedia","description":"\u88dc\u4f53\u4f9d\u5b58\u6027\u7d30\u80de\u50b7\u5bb3\uff08\u307b\u305f\u3044\u3044\u305d\u3093\u305b\u3044\u3055\u3044\u307c\u3046\u3057\u3087\u3046\u304c\u3044\u3001\u82f1: complement-dependent cytotoxicity\u3001CDC\uff09\u306f\u3001IgG\u6297\u4f53\u304a\u3088\u3073IgM\u6297\u4f53\u306e\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u6a5f\u80fd\u3067\u3042\u308b\u3002\u6297\u4f53\u304c\u6a19\u7684\u7d30\u80de\uff08\u7d30\u83cc\u3084\u30a6\u30a4\u30eb\u30b9\u306b\u611f\u67d3\u3057\u305f\u7d30\u80de\u306a\u3069\uff09\u306e\u8868\u9762\u6297\u539f\u306b\u7d50\u5408\u3059\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u6297\u4f53\u306b\u7d50\u5408\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8ceaC1q\uff08\u82f1\u8a9e\u7248\uff09\u306b\u3088\u3063\u3066\u88dc\u4f53\u7cfb\u306e\u53e4\u5178\u7d4c\u8def\u304c\u4f5c\u52d5\u3057\u3001\u819c\u4fb5\u8972\u8907\u5408\u4f53\uff08MAC\uff09\u304c\u5f62\u6210\u3055\u308c\u3001\u6a19\u7684\u7d30\u80de\u304c\u6eb6\u89e3\u3059\u308b\u3053\u3068\u306b\u306a\u308b\u3002 \u88dc\u4f53\u7cfb\u306f\u3001\u30d2\u30c8\u306eIgG1\u3001IgG3\u3001IgM\u6297\u4f53\u306b\u3088\u3063\u3066\u52b9\u7387\u7684\u306b\u6d3b\u6027\u5316\u3055\u308c\u3001IgG2\u6297\u4f53\u3067\u306f\u5f31\u304f\u3001IgG4\u6297\u4f53\u3067\u306f\u6d3b\u6027\u5316\u3055\u308c\u306a\u3044[1]\u3002 \u6cbb\u7642\u7528\u6297\u4f53[2]\u3084\u6297\u4f53\u65ad\u7247[3]\u304c\u6297\u816b\u760d\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u70ba\u306e\u4f5c\u7528\u6a5f\u5e8f\u306e\u4e00\u3064\u3067\u3042\u308b[4][5]\u3002 Table of Contents CDC\u30a2\u30c3\u30bb\u30a4\u306e\u5229\u7528[\u7de8\u96c6]\u6cbb\u7642\u7528\u6297\u4f53[\u7de8\u96c6]HLA\u578b\u5224\u5b9a\u30fb\u4ea4\u5dee\u9069\u5408\u8a66\u9a13[\u7de8\u96c6]\u95a2\u9023\u9805\u76ee[\u7de8\u96c6]\u53c2\u8003\u8cc7\u6599[\u7de8\u96c6] CDC\u30a2\u30c3\u30bb\u30a4\u306e\u5229\u7528[\u7de8\u96c6] \u6cbb\u7642\u7528\u6297\u4f53[\u7de8\u96c6] \u6297\u816b\u760d\u6027\u306e\u6cbb\u7642\u7528\u6297\u4f53\u3092\u958b\u767a\u3059\u308b\u306b\u306f\u3001\u6a19\u7684\u7d30\u80de\u3092\u6bba\u3059\u70ba\u306eCDC\u8a98\u767a\u80fd\u529b\u3092\u542b\u3080\u3001\u6297\u4f53\u306e\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u6a5f\u80fd\u3092in vitro \u3067\u5206\u6790\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u53e4\u5178\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u6297\u4f53\u3092\u6a19\u7684\u7d30\u80de\u304a\u3088\u3073\u88dc\u4f53\u6e90\uff08\u8840\u6e05\uff09\u3068\u5171\u306b\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3059\u308b\u4e8b\u3067\u3042\u308b\u3002\u305d\u306e\u5f8c\u3001\u3044\u304f\u3064\u304b\u306e\u65b9\u6cd5\u3067\u7d30\u80de\u6b7b\u3092\u6e2c\u5b9a\u3059\u308b\u3002 CDC\u6e2c\u5b9a\u306e\u524d\u306b\u6a19\u7684\u7d30\u80de\u309251Cr\uff08\u82f1\u8a9e\u7248\uff09\u3067\u6a19\u8b58\u3059\u308b\u3068\u3001\u7d30\u80de\u6eb6\u89e3\uff08\u7d30\u80de\u6b7b\uff09\u6642\u306b\u30af\u30ed\u30e0\u304c\u653e\u51fa\u3055\u308c\u3001\u305d\u306e\u653e\u5c04\u80fd\u91cf\u3092\u6e2c\u5b9a\u3059\u308b[6][7]\u3002 \u751f\u7d30\u80de\u306e\u4ee3\u8b1d\u6d3b\u6027\u306e\u6e2c\u5b9a\uff08\u751f\u7d30\u80de\u67d3\u8272\uff09 \u6a19\u7684\u7d30\u80de\u3092\u6297\u4f53\u3084\u88dc\u4f53\u3068\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u305f\u5f8c\u3001\u7d30\u80de\u819c\u3092\u900f\u904e\u3059\u308b\u8272\u7d20\uff08\u30ab\u30eb\u30bb\u30a4\u30f3\uff08\u82f1\u8a9e\u7248\uff09AM[7][8]\u3084\u30ec\u30b5\u30ba\u30ea\u30f3[6][9]\u306a\u3069\uff09\u3092\u6dfb\u52a0\u3059\u308b\u3002\u751f\u304d\u3066\u3044\u308b\u7d30\u80de\u306f\u3053\u308c\u3092\u4ee3\u8b1d\u3057\u3066\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u691c\u51fa\u3067\u304d\u308b\u4e0d\u900f\u904e\u6027\u306e\u86cd\u5149\u751f\u6210\u7269\u3092\u4f5c\u308b\u3002\u3053\u306e\u751f\u6210\u7269\u306f\u3001\u4ee3\u8b1d\u304c\u4e0d\u6d3b\u767a\u306a\u6b7b\u7d30\u80de\u3067\u306f\u5f62\u6210\u3055\u308c\u306a\u3044\u3002 \u653e\u51fa\u3055\u308c\u305f\u7d30\u80de\u5185\u9175\u7d20\u306e\u6d3b\u6027\u6e2c\u5b9a \u6b7b\u7d30\u80de\u304c\u9175\u7d20\uff08LDH\u3084GAPDH\u306a\u3069[6]\uff09\u3092\u653e\u51fa\u3057\u3001\u305d\u306e\u57fa\u8cea\u3092\u52a0\u3048\u308b\u3068\u8272\u306e\u5909\u5316\u304c\u8d77\u3053\u308a\u3001\u901a\u5e38\u306f\u5438\u5149\u5ea6\u3084\u86cd\u5149\u306e\u5909\u5316\u3068\u3057\u3066\u5b9a\u91cf\u3055\u308c\u308b\u3002 \uff08\u86cd\u5149\uff09\u8272\u7d20\u304c\u6b7b\u7d30\u80de\u306e\u640d\u50b7\u3057\u305f\u7d30\u80de\u819c\u3092\u901a\u3057\u3066\u6b7b\u7d30\u80de\u5185\u306b\u5165\u308a\u8fbc\u3080\u3002\u4f8b\u3048\u3070\u3001\u30e8\u30a6\u5316\u30d7\u30ed\u30d4\u30b8\u30a6\u30e0\uff08\u82f1\u8a9e\u7248\uff09\u306f\u6b7b\u7d30\u80de\u306eDNA\u306b\u7d50\u5408\u3057\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u86cd\u5149\u30b7\u30b0\u30ca\u30eb\u304c\u6e2c\u5b9a\u51fa\u6765\u308b[6]\u3002","datePublished":"2021-01-28","dateModified":"2021-01-28","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/jp\/wiki4\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/jp\/wiki4\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/ja.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/ja.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/jp\/wiki4\/2021\/01\/28\/%e8%a3%9c%e4%bd%93%e4%be%9d%e5%ad%98%e6%80%a7%e7%b4%b0%e8%83%9e%e5%82%b7%e5%ae%b3-wikipedia\/","wordCount":3308,"articleBody":"\u88dc\u4f53\u4f9d\u5b58\u6027\u7d30\u80de\u50b7\u5bb3\uff08\u307b\u305f\u3044\u3044\u305d\u3093\u305b\u3044\u3055\u3044\u307c\u3046\u3057\u3087\u3046\u304c\u3044\u3001\u82f1: complement-dependent cytotoxicity\u3001CDC\uff09\u306f\u3001IgG\u6297\u4f53\u304a\u3088\u3073IgM\u6297\u4f53\u306e\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u6a5f\u80fd\u3067\u3042\u308b\u3002\u6297\u4f53\u304c\u6a19\u7684\u7d30\u80de\uff08\u7d30\u83cc\u3084\u30a6\u30a4\u30eb\u30b9\u306b\u611f\u67d3\u3057\u305f\u7d30\u80de\u306a\u3069\uff09\u306e\u8868\u9762\u6297\u539f\u306b\u7d50\u5408\u3059\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u6297\u4f53\u306b\u7d50\u5408\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8ceaC1q\uff08\u82f1\u8a9e\u7248\uff09\u306b\u3088\u3063\u3066\u88dc\u4f53\u7cfb\u306e\u53e4\u5178\u7d4c\u8def\u304c\u4f5c\u52d5\u3057\u3001\u819c\u4fb5\u8972\u8907\u5408\u4f53\uff08MAC\uff09\u304c\u5f62\u6210\u3055\u308c\u3001\u6a19\u7684\u7d30\u80de\u304c\u6eb6\u89e3\u3059\u308b\u3053\u3068\u306b\u306a\u308b\u3002  \u88dc\u4f53\u7cfb\u306f\u3001\u30d2\u30c8\u306eIgG1\u3001IgG3\u3001IgM\u6297\u4f53\u306b\u3088\u3063\u3066\u52b9\u7387\u7684\u306b\u6d3b\u6027\u5316\u3055\u308c\u3001IgG2\u6297\u4f53\u3067\u306f\u5f31\u304f\u3001IgG4\u6297\u4f53\u3067\u306f\u6d3b\u6027\u5316\u3055\u308c\u306a\u3044[1]\u3002\u6cbb\u7642\u7528\u6297\u4f53[2]\u3084\u6297\u4f53\u65ad\u7247[3]\u304c\u6297\u816b\u760d\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u70ba\u306e\u4f5c\u7528\u6a5f\u5e8f\u306e\u4e00\u3064\u3067\u3042\u308b[4][5]\u3002Table of Contents  CDC\u30a2\u30c3\u30bb\u30a4\u306e\u5229\u7528[\u7de8\u96c6]\u6cbb\u7642\u7528\u6297\u4f53[\u7de8\u96c6]HLA\u578b\u5224\u5b9a\u30fb\u4ea4\u5dee\u9069\u5408\u8a66\u9a13[\u7de8\u96c6]\u95a2\u9023\u9805\u76ee[\u7de8\u96c6]\u53c2\u8003\u8cc7\u6599[\u7de8\u96c6]CDC\u30a2\u30c3\u30bb\u30a4\u306e\u5229\u7528[\u7de8\u96c6]\u6cbb\u7642\u7528\u6297\u4f53[\u7de8\u96c6]\u6297\u816b\u760d\u6027\u306e\u6cbb\u7642\u7528\u6297\u4f53\u3092\u958b\u767a\u3059\u308b\u306b\u306f\u3001\u6a19\u7684\u7d30\u80de\u3092\u6bba\u3059\u70ba\u306eCDC\u8a98\u767a\u80fd\u529b\u3092\u542b\u3080\u3001\u6297\u4f53\u306e\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u6a5f\u80fd\u3092in vitro \u3067\u5206\u6790\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u53e4\u5178\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u6297\u4f53\u3092\u6a19\u7684\u7d30\u80de\u304a\u3088\u3073\u88dc\u4f53\u6e90\uff08\u8840\u6e05\uff09\u3068\u5171\u306b\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3059\u308b\u4e8b\u3067\u3042\u308b\u3002\u305d\u306e\u5f8c\u3001\u3044\u304f\u3064\u304b\u306e\u65b9\u6cd5\u3067\u7d30\u80de\u6b7b\u3092\u6e2c\u5b9a\u3059\u308b\u3002CDC\u6e2c\u5b9a\u306e\u524d\u306b\u6a19\u7684\u7d30\u80de\u309251Cr\uff08\u82f1\u8a9e\u7248\uff09\u3067\u6a19\u8b58\u3059\u308b\u3068\u3001\u7d30\u80de\u6eb6\u89e3\uff08\u7d30\u80de\u6b7b\uff09\u6642\u306b\u30af\u30ed\u30e0\u304c\u653e\u51fa\u3055\u308c\u3001\u305d\u306e\u653e\u5c04\u80fd\u91cf\u3092\u6e2c\u5b9a\u3059\u308b[6][7]\u3002\u751f\u7d30\u80de\u306e\u4ee3\u8b1d\u6d3b\u6027\u306e\u6e2c\u5b9a\uff08\u751f\u7d30\u80de\u67d3\u8272\uff09\u6a19\u7684\u7d30\u80de\u3092\u6297\u4f53\u3084\u88dc\u4f53\u3068\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u305f\u5f8c\u3001\u7d30\u80de\u819c\u3092\u900f\u904e\u3059\u308b\u8272\u7d20\uff08\u30ab\u30eb\u30bb\u30a4\u30f3\uff08\u82f1\u8a9e\u7248\uff09AM[7][8]\u3084\u30ec\u30b5\u30ba\u30ea\u30f3[6][9]\u306a\u3069\uff09\u3092\u6dfb\u52a0\u3059\u308b\u3002\u751f\u304d\u3066\u3044\u308b\u7d30\u80de\u306f\u3053\u308c\u3092\u4ee3\u8b1d\u3057\u3066\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u691c\u51fa\u3067\u304d\u308b\u4e0d\u900f\u904e\u6027\u306e\u86cd\u5149\u751f\u6210\u7269\u3092\u4f5c\u308b\u3002\u3053\u306e\u751f\u6210\u7269\u306f\u3001\u4ee3\u8b1d\u304c\u4e0d\u6d3b\u767a\u306a\u6b7b\u7d30\u80de\u3067\u306f\u5f62\u6210\u3055\u308c\u306a\u3044\u3002\u653e\u51fa\u3055\u308c\u305f\u7d30\u80de\u5185\u9175\u7d20\u306e\u6d3b\u6027\u6e2c\u5b9a\u6b7b\u7d30\u80de\u304c\u9175\u7d20\uff08LDH\u3084GAPDH\u306a\u3069[6]\uff09\u3092\u653e\u51fa\u3057\u3001\u305d\u306e\u57fa\u8cea\u3092\u52a0\u3048\u308b\u3068\u8272\u306e\u5909\u5316\u304c\u8d77\u3053\u308a\u3001\u901a\u5e38\u306f\u5438\u5149\u5ea6\u3084\u86cd\u5149\u306e\u5909\u5316\u3068\u3057\u3066\u5b9a\u91cf\u3055\u308c\u308b\u3002\uff08\u86cd\u5149\uff09\u8272\u7d20\u304c\u6b7b\u7d30\u80de\u306e\u640d\u50b7\u3057\u305f\u7d30\u80de\u819c\u3092\u901a\u3057\u3066\u6b7b\u7d30\u80de\u5185\u306b\u5165\u308a\u8fbc\u3080\u3002\u4f8b\u3048\u3070\u3001\u30e8\u30a6\u5316\u30d7\u30ed\u30d4\u30b8\u30a6\u30e0\uff08\u82f1\u8a9e\u7248\uff09\u306f\u6b7b\u7d30\u80de\u306eDNA\u306b\u7d50\u5408\u3057\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u86cd\u5149\u30b7\u30b0\u30ca\u30eb\u304c\u6e2c\u5b9a\u51fa\u6765\u308b[6]\u3002HLA\u578b\u5224\u5b9a\u30fb\u4ea4\u5dee\u9069\u5408\u8a66\u9a13[\u7de8\u96c6]CDC\u691c\u67fb\u306f\u3001\u81d3\u5668\u3084\u9aa8\u9ac4\u306e\u79fb\u690d\u306b\u9069\u3057\u305f\u30c9\u30ca\u30fc\u3001\u3059\u306a\u308f\u3061MHC\u3067\u3042\u308bHLA\u306e\u8868\u73fe\u578b\u304c\u4e00\u81f4\u3059\u308b\u30c9\u30ca\u30fc\u3092\u898b\u3064\u3051\u308b\u305f\u3081\u306b\u884c\u308f\u308c\u308b[10]\u3002\u307e\u305a\u3001\u60a3\u8005\u3068\u30c9\u30ca\u30fc\u306eHLA\u8868\u73fe\u578b\u3092\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001HLA\u578b\u5224\u5b9a\u304c\u884c\u308f\u308c\u308b\u3002\u9069\u5408\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u30da\u30a2\u304c\u898b\u3064\u304b\u308b\u3068\u3001\u60a3\u8005\u304c\u79fb\u690d\u7247\u62d2\u7d76\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u306e\u3042\u308b\u30c9\u30ca\u30fc\u7279\u7570\u7684\u306a\u6297HLA\u6297\u4f53\u3092\u7523\u751f\u3059\u308b\u4e8b\u3092\u6392\u9664\u3059\u308b\u70ba\u306b\u3001\u4ea4\u5dee\u9069\u5408\u8a66\u9a13\u304c\u884c\u308f\u308c\u308b\u3002CDC\u65b9\u5f0f\u306eHLA\u578b\uff08\u8840\u6e05\u578b\uff09\u3067\u306f\u3001\u7279\u5fb4\u4ed8\u3051\u3089\u308c\u305f\u540c\u7a2e\u9593\u30dd\u30ea\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u307e\u305f\u306f\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u304b\u3089\u6210\u308b\u6297HLA\u6297\u4f53\u306e\u30d0\u30c3\u30c1\u3092\u4f7f\u7528\u3059\u308b\u3002\u3053\u308c\u3089\u306e\u6297\u4f53\u306f\u3001\u60a3\u8005\u307e\u305f\u306f\u30c9\u30ca\u30fc\u306e\u30ea\u30f3\u30d1\u7403\u304a\u3088\u3073\u88dc\u4f53\u6e90\u30681\u3064\u305a\u3064\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3055\u308c\u308b\u3002\u6b7b\u7d30\u80de\u306e\u91cf\uff08\u3064\u307e\u308a\u967d\u6027\u7d50\u679c\uff09\u306f\u3001\u6b7b\u7d30\u80de\u307e\u305f\u306f\u751f\u7d30\u80de\u306e\u67d3\u8272\u306b\u3088\u3063\u3066\u6e2c\u5b9a\u3055\u308c\u308b\u3002\u6700\u8fd1\u3067\u306f\u3001CDC\u578b\u5224\u5b9a\u306b\u4ee3\u308f\u3063\u3066\u3001PCR\u306b\u3088\u3063\u3066HLA\u5206\u5b50\u306e\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u914d\u5217\u3092\u7279\u5b9a\u3059\u308b\u5206\u5b50\u578b\u5224\u5b9a\u304c\u884c\u308f\u308c\u3066\u3044\u308b[10]\u3002CDC\u6cd5\u306f\u901a\u5e38\u3001\u4ea4\u5dee\u9069\u5408\u8a66\u9a13\u306b\u7528\u3044\u3089\u308c\u308b\u3002\u57fa\u672c\u7684\u306b\u306f\u3001\u60a3\u8005\u306e\u8840\u6e05\u3092\u30c9\u30ca\u30fc\u306e\u30ea\u30f3\u30d1\u7403\u3068\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u3001\u30a6\u30b5\u30ae\u306e\u88dc\u4f53\u3092\u52a0\u3048\u305f\u5f8c\u306b2\u56de\u76ee\u306e\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3092\u884c\u3046\u3002\u6b7b\u7d30\u80de\u306e\u5b58\u5728\uff08\u967d\u6027\uff09\u306f\u3001\u30c9\u30ca\u30fc\u304c\u3053\u306e\u60a3\u8005\u306b\u9069\u3057\u3066\u3044\u306a\u3044\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u3002\u691c\u67fb\u611f\u5ea6\u3092\u4e0a\u3052\u308b\u70ba\u306b\u306f\u3001\u6700\u5c0f\u57f9\u990a\u6642\u9593\u306e\u5ef6\u9577\u3001\u6297\u30d2\u30c8\u30b0\u30ed\u30d6\u30ea\u30f3\uff08\u82f1\u8a9e\u7248\uff09\uff08AHG\uff09\u306e\u6dfb\u52a0\u3001\u88dc\u4f53\u6dfb\u52a0\u524d\u306e\u672a\u7d50\u5408\u6297\u4f53\u306e\u9664\u53bb\u3001T\u7d30\u80de\u3068B\u7d30\u80de\u306e\u30b5\u30d6\u30bb\u30c3\u30c8\u306e\u5206\u96e2\u306a\u3069\u306e\u6539\u826f\u304c\u53ef\u80fd\u3067\u3042\u308b\u3002CDC\u4ea4\u5dee\u9069\u5408\u8a66\u9a13\u4ee5\u5916\u306b\u3082\u3001\u3088\u308a\u611f\u5ea6\u304c\u9ad8\u304f\u3001\u88dc\u4f53\u975e\u6d3b\u6027\u5316\u6297\u4f53\u3082\u691c\u51fa\u3067\u304d\u308b\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u4ea4\u5dee\u9069\u5408\u8a66\u9a13\u3082\u3042\u308b[11]\u3002  \u95a2\u9023\u9805\u76ee[\u7de8\u96c6]\u53c2\u8003\u8cc7\u6599[\u7de8\u96c6]^ Schroeder, Harry W.; Cavacini, Lisa (2010). \u201cStructure and function of immunoglobulins\u201d. Journal of Allergy and Clinical Immunology. 2010 Primer on Allergic and Immunologic Diseases 125 (2, Supplement 2):  S41\u2013S52. doi:10.1016\/j.jaci.2009.09.046. ISSN\u00a00091-6749. PMC\u00a03670108. PMID\u00a020176268. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3670108\/.\u00a0^ The Role of Complement in the Mechanism of Action of Rituximab for B-Cell Lymphoma: Implications for Therapy. Zhou 2008^ Complement dependent cytotoxicity activity of therapeutic antibody fragments is acquired by immunogenic glycan coupling. Archived 2016-04-09 at the Wayback Machine.^ Meyer, Saskia; Leusen, Jeanette HW; Boross, Peter (2014). \u201cRegulation of complement and modulation of its activity in monoclonal antibody therapy of cancer\u201d. mAbs 6 (5):  1133\u20131144. doi:10.4161\/mabs.29670. ISSN\u00a01942-0862. PMC\u00a04622586. PMID\u00a025517299. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4622586\/.\u00a0^ Wang, Xinhua; Mathieu, Mary; Brezski, Randall J. (2018). \u201cIgG Fc engineering to modulate antibody effector functions\u201d. Protein & Cell 9 (1):  63\u201373. doi:10.1007\/s13238-017-0473-8. ISSN\u00a01674-800X. PMC\u00a05777978. PMID\u00a028986820. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5777978\/.\u00a0^ a b c d Taylor, Ronald P.; Lindorfer, Margaret A. (2014). \u201cThe role of complement in mAb-based therapies of cancer\u201d. Methods 65 (1):  18\u201327. doi:10.1016\/j.ymeth.2013.07.027. ISSN\u00a01095-9130. PMID\u00a023886909.\u00a0^ a b Hernandez, Axel; Parmentier, Julie; Wang, Youzhen; Cheng, Jane; Bornstein, Gadi Gazit (2012). \u201cMonoclonal antibody lead characterization: in vitro and in vivo methods\u201d. Antibody Engineering. Methods in Molecular Biology. 907. pp.\u00a0557\u2013594. doi:10.1007\/978-1-61779-974-7_32. ISBN\u00a0978-1-61779-973-0. ISSN\u00a01940-6029. PMID\u00a022907374\u00a0^ Gillissen, M.A.; Yasuda, E.; de Jong, G.; Levie, S.E.; Go, D.; Spits, H.; van Helden, P.M.; Hazenberg, M.D. (2016). \u201cThe modified FACS calcein AM retention assay: A high throughput flow cytometer based method to measure cytotoxicity\u201d (\u82f1\u8a9e). Journal of Immunological Methods 434:  16\u201323. doi:10.1016\/j.jim.2016.04.002. PMID\u00a027084117.\u00a0^ Gazzano-Santoro, H\u00e9l\u00e8ne; Ralph, Peter; Ryskamp, Thomas C; Chen, Anthony B; Mukku, Venkat R (1997). \u201cA non-radioactive complement-dependent cytotoxicity assay for anti-CD20 monoclonal antibody\u201d (\u82f1\u8a9e). Journal of Immunological Methods 202 (2):  163\u2013171. doi:10.1016\/S0022-1759(97)00002-1. PMID\u00a09107305.\u00a0^ a b Gautreaux, Michael D. (2017), Orlando, Giuseppe; Remuzzi, Giuseppe; Williams, David F., eds., \u201cChapter 17 – Histocompatibility Testing in the Transplant Setting\u201d, Kidney Transplantation, Bioengineering and Regeneration (Academic Press):  223\u2013234, doi:10.1016\/B978-0-12-801734-0.00017-5, ISBN\u00a09780128017340, http:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780128017340000175 2019\u5e748\u670830\u65e5\u95b2\u89a7\u3002\u00a0^ Guillaume, Nicolas (2018). \u201cImproved flow cytometry crossmatching in kidney transplantation\u201d. HLA 92 (6):  375\u2013383. doi:10.1111\/tan.13403. ISSN\u00a02059-2310. PMID\u00a030270577.\u00a0"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki4\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki4\/2021\/01\/28\/%e8%a3%9c%e4%bd%93%e4%be%9d%e5%ad%98%e6%80%a7%e7%b4%b0%e8%83%9e%e5%82%b7%e5%ae%b3-wikipedia\/#breadcrumbitem","name":"\u88dc\u4f53\u4f9d\u5b58\u6027\u7d30\u80de\u50b7\u5bb3 – Wikipedia"}}]}]