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acid\u85ac\u7269\u52d5\u614b\u30c7\u30fc\u30bf\u534a\u6e1b\u671f42 seconds\u8b58\u5225CAS\u756a\u53f735121-78-9\u00a0PubChemCID: 5282411IUPHAR\/BPS1915ChemSpider102770\u00a0UNIIDCR9Z582X0\u00a0KEGGD00106 ChEMBLCHEMBL1139\u00a0\u5316\u5b66\u7684\u30c7\u30fc\u30bf\u5316\u5b66\u5f0fC20H32O5\u5206\u5b50\u91cf352.47\u00a0g\u00b7mol\u22121OC(=O)CCCC=C1C[C@@H]2[C@@H](\/C=C\/[C@@H](O)CCCCC)[C@H](O)C[C@@H]2O1InChI=1S\/C20H32O5\/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22\/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)\/b11-10+,15-8-\/t14-,16+,17+,18+,19-\/m0\/s1\u00a0Key:KAQKFAOMNZTLHT-OZUDYXHBSA-N\u00a0\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u3092\u8868\u793a\u30d7\u30ed\u30b9\u30bf\u30b5\u30a4\u30af\u30ea\u30f3\uff08Prostacyclin\uff09\u307e\u305f\u306f\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3I2\uff08Prostaglandin I2\u3001PGI2\uff09\u306f\u3001\u30a8\u30a4\u30b3\u30b5\u30ce\u30a4\u30c9\u7cfb\u306e\u8102\u8cea\u5206\u5b50\u3067\u3042\u308b\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3\u306e\u4e00\u7a2e\u3067\u3042\u308b\u3002\u8840\u5c0f\u677f\u306e\u6d3b\u6027\u5316\u6291\u5236\u4f5c\u7528\u3068\u3001\u8840\u7ba1\u62e1\u5f35\u4f5c\u7528\u304c\u3042\u308b\u3002  \u30d7\u30ed\u30b9\u30bf\u30b5\u30a4\u30af\u30ea\u30f3\uff08PGI2\uff09\u306f\u3001\u4e3b\u306b\u4e00\u6b21\u6b62\u8840\uff08\u8840\u6813\u5f62\u6210\u306e\u4e00\u90e8\uff09\u306b\u95a2\u4e0e\u3059\u308b\u8840\u5c0f\u677f\u306e\u6813\u5f62\u6210\u3092\u9632\u3050\u3002\u3053\u308c\u306f\u3001\u8840\u5c0f\u677f\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3059\u308b\u4e8b\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u308b\u3002\u307e\u305f\u3001\u8840\u7ba1\u62e1\u5f35\u5264\u3068\u3057\u3066\u3082\u6709\u52b9\u3067\u3042\u308b\u3002\u30d7\u30ed\u30b9\u30bf\u30b5\u30a4\u30af\u30ea\u30f3\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u3001\u540c\u3058\u304f\u30a8\u30a4\u30b3\u30b5\u30ce\u30a4\u30c9\u3067\u3042\u308b\u30c8\u30ed\u30f3\u30dc\u30ad\u30b5\u30f3\uff08TXA2\uff09\u306e\u76f8\u4e92\u4f5c\u7528\u3068\u306f\u5bfe\u7167\u7684\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u4e8b\u306f\u3001\u8840\u7ba1\u969c\u5bb3\u306b\u95a2\u9023\u3057\u305f\u3053\u306e2\u3064\u306e\u751f\u7406\u6d3b\u6027\u7269\u8cea\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u6052\u5e38\u6027\u7dad\u6301\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u5f37\u304f\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u4f5c\u7528\u6a5f\u5e8f[\u7de8\u96c6]\u524d\u8ff0\u306e\u69d8\u306b\u3001\u30d7\u30ed\u30b9\u30bf\u30b5\u30a4\u30af\u30ea\u30f3\uff08PGI2\uff09\u306f\u5065\u5eb7\u306a\u5185\u76ae\u7d30\u80de\u304b\u3089\u653e\u51fa\u3055\u308c\u3001\u8fd1\u508d\u306e\u8840\u5c0f\u677f\u3084\u5185\u76ae\u7d30\u80de\u306eG\u30bf\u30f3\u30d1\u30af\u8cea\u5171\u5f79\u53d7\u5bb9\u4f53\u304c\u95a2\u4e0e\u3059\u308b\u30d1\u30e9\u30af\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb\u30ab\u30b9\u30b1\u30fc\u30c9\u306b\u3088\u3063\u3066\u305d\u306e\u6a5f\u80fd\u3092\u767a\u63ee\u3059\u308b\u3002\u8840\u5c0f\u677f\u306eGs\u30bf\u30f3\u30d1\u30af\u8cea\u5171\u5f79\u53d7\u5bb9\u4f53\uff08\u30d7\u30ed\u30b9\u30bf\u30b5\u30a4\u30af\u30ea\u30f3\u53d7\u5bb9\u4f53\uff09\u306f\u3001PGI2\u3068\u7d50\u5408\u3059\u308b\u3068\u6d3b\u6027\u5316\u3055\u308c\u308b\u3002cAMP\u306f\u3001\u8840\u5c0f\u677f\u306e\u904e\u5ea6\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3057\uff08\u8840\u6db2\u5faa\u74b0\u3092\u4fc3\u9032\uff09\u3001\u30c8\u30ed\u30f3\u30dc\u30ad\u30b5\u30f3A2\uff08TXA2\uff09\u306e\u7d50\u5408\u306b\u3088\u308b\u7d30\u80de\u8cea\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u306e\u4e0a\u6607\uff08\u8840\u5c0f\u677f\u306e\u6d3b\u6027\u5316\u3068\u305d\u308c\u306b\u7d9a\u304f\u51dd\u56fa\u3092\u5f15\u304d\u8d77\u3053\u3059\uff09\u3092\u6253\u3061\u6d88\u3059\u50cd\u304d\u3092\u3059\u308b\u3002PGI2\u306f\u3001\u5185\u76ae\u306e\u30d7\u30ed\u30b9\u30bf\u30b5\u30a4\u30af\u30ea\u30f3\u53d7\u5bb9\u4f53\u306b\u3082\u7d50\u5408\u3057\u3001\u540c\u69d8\u306b\u7d30\u80de\u8cea\u5185\u306ecAMP\u6fc3\u5ea6\u3092\u4e0a\u6607\u3055\u305b\u308b\u3002\u3053\u306ecAMP\u306f\u3001\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bcA\uff08PKA\uff09\u3092\u6d3b\u6027\u5316\u3059\u308b\u3002\u305d\u3057\u3066\u3001PKA\u306f\u30df\u30aa\u30b7\u30f3\u8efd\u9396\u30ad\u30ca\u30fc\u30bc\u306e\u30ea\u30f3\u9178\u5316\u3092\u4fc3\u9032\u3057\u3066\u30ab\u30b9\u30b1\u30fc\u30c9\u3092\u7d99\u7d9a\u3057\u3001\u305d\u308c[\u8a33\u8a9e\u7591\u554f\u70b9]\u3092\u963b\u5bb3\u3057\u3001\u5e73\u6ed1\u7b4b\u306e\u5f1b\u7de9\u3068\u8840\u7ba1\u62e1\u5f35\u3092\u9f4e\u3059\u3002\u306a\u304a\u3001PGI2\u3068TXA2\u306f\u751f\u7406\u7684\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8\u3068\u3057\u3066\u50cd\u304f\u3002    Ball-and-stick model of prostacyclin\u30d7\u30ed\u30b9\u30bf\u30b5\u30a4\u30af\u30ea\u30f3\u306e\u7523\u751f\u306f\u3001NSAID\u304c\u30b7\u30af\u30ed\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc\u9175\u7d20COX1\u304a\u3088\u3073COX2\u306b\u4f5c\u7528\u3059\u308b\u3053\u3068\u3067\u963b\u5bb3\u3055\u308c\u308b\u3002\u3053\u308c\u3089\u306e\u9175\u7d20\u306f\u30a2\u30e9\u30ad\u30c9\u30f3\u9178\u3092\u30d7\u30ed\u30b9\u30bf\u30b5\u30a4\u30af\u30ea\u30f3\u306e\u76f4\u63a5\u306e\u524d\u99c6\u4f53\u3067\u3042\u308b\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3H2\uff08PGH2\uff09\u306b\u5909\u63db\u3059\u308b\u3002\u30c8\u30ed\u30f3\u30dc\u30ad\u30b5\u30f3\uff08\u8840\u5c0f\u677f\u51dd\u96c6\u3092\u4fc3\u9032\u3059\u308b\u30a8\u30a4\u30b3\u30b5\u30ce\u30a4\u30c9\uff09\u3082COX\u9175\u7d20\u306e\u4e0b\u6d41\u306b\u3042\u308b\u306e\u3067\u3001NSAID\u306e\u52b9\u679c\u306f\u30d0\u30e9\u30f3\u30b9\u3092\u3068\u308b\u3088\u3046\u306b\u4f5c\u7528\u3059\u308b\u3068\u601d\u308f\u308c\u308b\u304b\u3082\u77e5\u308c\u306a\u3044\u3002\u3057\u304b\u3057\u3001\u30d7\u30ed\u30b9\u30bf\u30b5\u30a4\u30af\u30ea\u30f3\u6fc3\u5ea6\u306f\u30c8\u30ed\u30f3\u30dc\u30ad\u30b5\u30f3\u6fc3\u5ea6\u3088\u308a\u3082\u9065\u304b\u306b\u65e9\u304f\u56de\u5fa9\u3059\u308b\u305f\u3081\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\u6295\u4e0e\u3067\u306f\u6700\u521d\u306f\u6b86\u3069\u52b9\u679c\u304c\u306a\u3044\u304c\u3001\u6700\u7d42\u7684\u306b\u306f\u8840\u5c0f\u677f\u51dd\u96c6\u3092\u9632\u3050\u4e8b\u304c\u51fa\u6765\u308b\uff08\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3\u304c\u518d\u751f\u7523\u3055\u308c\u308b\u70ba\u3001\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3\u306e\u52b9\u679c\u304c\u512a\u52e2\u306b\u306a\u308b\uff09\u3002\u3053\u306e\u4e8b\u306f\u3001TXA2\u3068PGI2\u3068\u3044\u3046\u305d\u308c\u305e\u308c\u306e\u5206\u5b50\u3092\u7523\u751f\u3059\u308b\u7d30\u80de\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u8aac\u660e\u3067\u304d\u308b\u3002PGI2\u306f\u4e3b\u306b\u6709\u6838\u306e\u5185\u76ae\u7d30\u80de\u3067\u7523\u751f\u3055\u308c\u308b\u305f\u3081\u3001NSAID\u306b\u3088\u308bCOX\u963b\u5bb3\u306f\u3001COX\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u5316\u304c\u9032\u307f\u3001\u305d\u306e\u5f8c\u3001PGI2\u306e\u751f\u6210\u3092\u89e6\u5a92\u3059\u308bCOX\u9175\u7d20\u304c\u591a\u304f\u7523\u751f\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u6642\u9593\u306e\u7d4c\u904e\u3068\u5171\u306b\u514b\u670d\u3055\u308c\u308b\u3002\u4e00\u65b9\u3001TXA2\u306f\u4e3b\u306b\u7121\u6838\u8840\u5c0f\u677f\u304b\u3089\u653e\u51fa\u3055\u308c\u308b\u3002\u7121\u6838\u8840\u5c0f\u677f\u306f\u3001NSAID\u306b\u3088\u308bCOX\u963b\u5bb3\u306b\u5bfe\u5fdc\u3057\u3066COX\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u5897\u3084\u3059\u4e8b\u304c\u51fa\u6765\u306a\u3044\u3002\u306a\u305c\u306a\u3089\u3001\u305d\u306e\u3088\u3046\u306a\u4f5c\u696d\u3092\u884c\u3046\u306e\u306b\u5fc5\u8981\u306aDNA\u6750\u6599\u304c\u7121\u3044\u304b\u3089\u3067\u3042\u308b\u3002\u3053\u306e\u70ba\u3001NSAID\u306f\u8840\u6db2\u5faa\u74b0\u3092\u4fc3\u9032\u3057\u3001\u8840\u6813\u75c7\u3092\u6291\u5236\u3059\u308bPGI2\u3092\u512a\u4f4d\u306b\u4f5c\u7528\u3055\u305b\u308b\u4e8b\u304c\u51fa\u6765\u308b\u3002  Eicosanoid synthesis. (Prostacyclin near bottom 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Kirkby, Nicholas S.; Lundberg, Martina H.; Harrington, Louise S.; Leadbeater, Philip D. M.; Milne, Ginger L.; Potter, Claire M. F.; Al-Yamani, Malak; Adeyemi, Oladipupo et al. (2012-10-23). \u201cCyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system\u201d. Proceedings of the National Academy of Sciences of the United States of America 109 (43):  17597\u201317602. Bibcode:\u00a02012PNAS..10917597K. doi:10.1073\/pnas.1209192109. ISSN\u00a00027-8424. PMC\u00a03491520. PMID\u00a023045674. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3491520\/.\u00a0^ \u201cThromboxane (TX)A3 and prostaglandin (PG)I3 are formed in man after dietary eicosapentaenoic acid: identification and quantification by capillary gas chromatography-electron impact mass spectrometry\u201d. Biomed. Mass Spectrom. 12 (9):  470\u20136. (1985). doi:10.1002\/bms.1200120905. PMID\u00a02996649.\u00a0^ Moncada, S.; Gryglewski, R.; Bunting, S.; Vane, J. R. (21 October 1976). \u201cAn enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation\u201d. Nature 263 (5579):  663\u2013665. Bibcode:\u00a01976Natur.263..663M. doi:10.1038\/263663a0. PMID\u00a0802670.\u00a0\u5916\u90e8\u30ea\u30f3\u30af[\u7de8\u96c6]\u201cEpoprostenol\u201d. Drug Information Portal.   U.S. National Library of Medicine. 2021\u5e748\u670826\u65e5\u95b2\u89a7\u3002\u201cEpoprostenol sodium\u201d. Drug Information Portal.   U.S. National Library of Medicine. 2021\u5e748\u670826\u65e5\u95b2\u89a7\u3002"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki5\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki5\/2021\/12\/29\/%e3%83%97%e3%83%ad%e3%82%b9%e3%82%bf%e3%82%b5%e3%82%a4%e3%82%af%e3%83%aa%e3%83%b3-wikipedia\/#breadcrumbitem","name":"\u30d7\u30ed\u30b9\u30bf\u30b5\u30a4\u30af\u30ea\u30f3 – Wikipedia"}}]}]