[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/jp\/wiki5\/2022\/08\/23\/%e3%83%96%e3%83%a9%e3%82%bc%e3%82%a4%e3%83%b3-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/jp\/wiki5\/2022\/08\/23\/%e3%83%96%e3%83%a9%e3%82%bc%e3%82%a4%e3%83%b3-wikipedia\/","headline":"\u30d6\u30e9\u30bc\u30a4\u30f3 – Wikipedia","name":"\u30d6\u30e9\u30bc\u30a4\u30f3 – Wikipedia","description":"\u30d6\u30e9\u30bc\u30a4\u30f3\uff08Brazzein\uff09\u306f\u3001\u30a2\u30d5\u30ea\u30ab\u897f\u90e8\u539f\u7523\u306e\u30a2\u30d6\u30e9\u30ca\u76ee\u306e\u6a39\u6728\u30cb\u30b7\u30a2\u30d5\u30ea\u30ab\u30a4\u30c1\u30b4\uff08Pentadiplandra brazzeana\u3001\u30e2\u30ce\u30bf\u30a4\u30d7\uff09\u306e\u679c\u5b9f\u306b\u542b\u307e\u308c\u308b\u7518\u5473\u6210\u5206\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u30021994\u5e74\u306b\u30a6\u30a3\u30b9\u30b3\u30f3\u30b7\u30f3\u5927\u5b66\u30de\u30c7\u30a3\u30bd\u30f3\u6821\u3067\u9175\u7d20\u3068\u3057\u3066\u521d\u3081\u3066\u5358\u96e2\u3055\u308c\u305f[2]\u3002 \u30d6\u30e9\u30bc\u30a4\u30f3\u306f\u3001\u7a2e\u5b50\u306e\u5468\u308a\u306e\u30d1\u30eb\u30d7\u72b6\u7d44\u7e54\u306e\u7d30\u80de\u5916\u9818\u57df\u3067\u898b\u3089\u308c\u308b\u3002 1989\u5e74\u306b\u767a\u898b\u3055\u308c\u305f\u30da\u30f3\u30bf\u30b8\u30f3\u306b\u6b21\u3044\u3067\u3001\u30d6\u30e9\u30bc\u30a4\u30f3\u306f\u3001\u3053\u306e\u30a2\u30d5\u30ea\u30ab\u306e\u679c\u5b9f\u304b\u3089\u767a\u898b\u3055\u308c\u305f2\u3064\u3081\u306e\u7518\u5473\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u306a\u3063\u305f[3]\u3002 \u30e2\u30cd\u30ea\u30f3\u3084\u30bd\u30fc\u30de\u30c1\u30f3\u306e\u3088\u3046\u306a\u4ed6\u306e\u5929\u7136\u306e\u7518\u5473\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u540c\u69d8\u306b\u3001\u975e\u5e38\u306b\u7518\u3044\uff08\u30b9\u30af\u30ed\u30fc\u30b9\u306e500\u500d\u304b\u30892000\u500d\uff09[4]\u3002 \u679c\u5b9f\u306f\u30d2\u30c8\u3001\u30b5\u30eb\u3001\u30dc\u30ce\u30dc\u306b\u3068\u3063\u3066\u306f\u7518\u304f\u611f\u3058\u308b\u304c\u3001\u30b4\u30ea\u30e9\u306f\u7518\u5473\u53d7\u5bb9\u4f53\u306b\u5909\u7570\u304c\u751f\u3058\u3066\u3044\u308b\u305f\u3081\u30d6\u30e9\u30bc\u30a4\u30f3\u3092\u7518\u304f\u611f\u3058\u308b\u3053\u3068\u306f\u306a\u304f\u3001\u679c\u5b9f\u3092\u98df\u7528\u306b\u3059\u308b\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u3044\u306a\u3044[5][6]\u3002 Table of Contents \u4f1d\u7d71\u7684\u306a\u5229\u7528[\u7de8\u96c6]\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020[\u7de8\u96c6]\u7518\u3055\u306e\u6027\u8cea[\u7de8\u96c6]\u7518\u5473\u6599\u3068\u3057\u3066[\u7de8\u96c6]\u95a2\u9023\u9805\u76ee[\u7de8\u96c6] \u4f1d\u7d71\u7684\u306a\u5229\u7528[\u7de8\u96c6] \u3053\u306e\u690d\u7269\u306f\u30ac\u30dc\u30f3\u3084\u30ab\u30e1\u30eb\u30fc\u30f3\u306b\u751f\u80b2\u3057\u3001\u985e\u4eba\u733f\u3084\u73fe\u5730\u306e\u4eba\u9593\u306b\u9577\u3044\u9593\u6d88\u8cbb\u3055\u308c\u3066\u304d\u305f\u3002\u679c\u5b9f\u306f\u975e\u5e38\u306b\u7518\u304f\u3001\u5e7c\u5150\u304c\u6bcd\u4e73\u3092\u5fd8\u308c\u3066\u3057\u307e\u3046\u3088\u3046\u306a\u5473\u3067\u3042\u308b\u305f\u3081\u3001\u73fe\u5730\u306e\u4eba\u306f\u3001\u73fe\u5730\u306e\u8a00\u8449\u3067\u201dOubli\u201d\uff08\u30d5\u30e9\u30f3\u30b9\u8a9e\u3067\u300c\u5fd8\u308c\u305f\u300d\u306e\u610f\u5473\uff09\u3068\u547c\u3076[7]\u3002\u4e00\u5ea6\u305d\u306e\u5b9f\u3092\u98df\u3079\u308b\u3068\u3001\u6bcd\u89aa\u306b\u4f1a\u3046\u305f\u3081\u306b\u6751\u306b\u5e30\u308b\u306e\u3092\u5fd8\u308c\u3066\u3057\u307e\u3046\u3068\u8a00\u308f\u308c\u308b[8]\u3002 \u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020[\u7de8\u96c6] 54\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u30e2\u30ce\u30de\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u7518\u5473\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e2d\u3067\u6700\u5c0f\u306e\u3001\u5206\u5b50\u91cf6.5 kDa\u3067\u3042\u308b[2]\u3002Swiss-Prot\u306b\u3088\u308b\u30d6\u30e9\u30bc\u30a4\u30f3\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u306f\u3001\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\u3002 QDKCKKVYEN YPVSKCQLAN QCNYDCKLDK HARSGECFYD EKRNLQCICD","datePublished":"2022-08-23","dateModified":"2022-08-23","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/jp\/wiki5\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/jp\/wiki5\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/ja.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/ja.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/jp\/wiki5\/2022\/08\/23\/%e3%83%96%e3%83%a9%e3%82%bc%e3%82%a4%e3%83%b3-wikipedia\/","about":["Wiki"],"wordCount":3986,"articleBody":"\u30d6\u30e9\u30bc\u30a4\u30f3\uff08Brazzein\uff09\u306f\u3001\u30a2\u30d5\u30ea\u30ab\u897f\u90e8\u539f\u7523\u306e\u30a2\u30d6\u30e9\u30ca\u76ee\u306e\u6a39\u6728\u30cb\u30b7\u30a2\u30d5\u30ea\u30ab\u30a4\u30c1\u30b4\uff08Pentadiplandra brazzeana\u3001\u30e2\u30ce\u30bf\u30a4\u30d7\uff09\u306e\u679c\u5b9f\u306b\u542b\u307e\u308c\u308b\u7518\u5473\u6210\u5206\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u30021994\u5e74\u306b\u30a6\u30a3\u30b9\u30b3\u30f3\u30b7\u30f3\u5927\u5b66\u30de\u30c7\u30a3\u30bd\u30f3\u6821\u3067\u9175\u7d20\u3068\u3057\u3066\u521d\u3081\u3066\u5358\u96e2\u3055\u308c\u305f[2]\u3002  \u30d6\u30e9\u30bc\u30a4\u30f3\u306f\u3001\u7a2e\u5b50\u306e\u5468\u308a\u306e\u30d1\u30eb\u30d7\u72b6\u7d44\u7e54\u306e\u7d30\u80de\u5916\u9818\u57df\u3067\u898b\u3089\u308c\u308b\u30021989\u5e74\u306b\u767a\u898b\u3055\u308c\u305f\u30da\u30f3\u30bf\u30b8\u30f3\u306b\u6b21\u3044\u3067\u3001\u30d6\u30e9\u30bc\u30a4\u30f3\u306f\u3001\u3053\u306e\u30a2\u30d5\u30ea\u30ab\u306e\u679c\u5b9f\u304b\u3089\u767a\u898b\u3055\u308c\u305f2\u3064\u3081\u306e\u7518\u5473\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u306a\u3063\u305f[3]\u3002\u30e2\u30cd\u30ea\u30f3\u3084\u30bd\u30fc\u30de\u30c1\u30f3\u306e\u3088\u3046\u306a\u4ed6\u306e\u5929\u7136\u306e\u7518\u5473\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u540c\u69d8\u306b\u3001\u975e\u5e38\u306b\u7518\u3044\uff08\u30b9\u30af\u30ed\u30fc\u30b9\u306e500\u500d\u304b\u30892000\u500d\uff09[4]\u3002 \u679c\u5b9f\u306f\u30d2\u30c8\u3001\u30b5\u30eb\u3001\u30dc\u30ce\u30dc\u306b\u3068\u3063\u3066\u306f\u7518\u304f\u611f\u3058\u308b\u304c\u3001\u30b4\u30ea\u30e9\u306f\u7518\u5473\u53d7\u5bb9\u4f53\u306b\u5909\u7570\u304c\u751f\u3058\u3066\u3044\u308b\u305f\u3081\u30d6\u30e9\u30bc\u30a4\u30f3\u3092\u7518\u304f\u611f\u3058\u308b\u3053\u3068\u306f\u306a\u304f\u3001\u679c\u5b9f\u3092\u98df\u7528\u306b\u3059\u308b\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u3044\u306a\u3044[5][6]\u3002  Table of Contents\u4f1d\u7d71\u7684\u306a\u5229\u7528[\u7de8\u96c6]\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020[\u7de8\u96c6]\u7518\u3055\u306e\u6027\u8cea[\u7de8\u96c6]\u7518\u5473\u6599\u3068\u3057\u3066[\u7de8\u96c6]\u95a2\u9023\u9805\u76ee[\u7de8\u96c6]\u4f1d\u7d71\u7684\u306a\u5229\u7528[\u7de8\u96c6]\u3053\u306e\u690d\u7269\u306f\u30ac\u30dc\u30f3\u3084\u30ab\u30e1\u30eb\u30fc\u30f3\u306b\u751f\u80b2\u3057\u3001\u985e\u4eba\u733f\u3084\u73fe\u5730\u306e\u4eba\u9593\u306b\u9577\u3044\u9593\u6d88\u8cbb\u3055\u308c\u3066\u304d\u305f\u3002\u679c\u5b9f\u306f\u975e\u5e38\u306b\u7518\u304f\u3001\u5e7c\u5150\u304c\u6bcd\u4e73\u3092\u5fd8\u308c\u3066\u3057\u307e\u3046\u3088\u3046\u306a\u5473\u3067\u3042\u308b\u305f\u3081\u3001\u73fe\u5730\u306e\u4eba\u306f\u3001\u73fe\u5730\u306e\u8a00\u8449\u3067\u201dOubli\u201d\uff08\u30d5\u30e9\u30f3\u30b9\u8a9e\u3067\u300c\u5fd8\u308c\u305f\u300d\u306e\u610f\u5473\uff09\u3068\u547c\u3076[7]\u3002\u4e00\u5ea6\u305d\u306e\u5b9f\u3092\u98df\u3079\u308b\u3068\u3001\u6bcd\u89aa\u306b\u4f1a\u3046\u305f\u3081\u306b\u6751\u306b\u5e30\u308b\u306e\u3092\u5fd8\u308c\u3066\u3057\u307e\u3046\u3068\u8a00\u308f\u308c\u308b[8]\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020[\u7de8\u96c6]54\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u30e2\u30ce\u30de\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u7518\u5473\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e2d\u3067\u6700\u5c0f\u306e\u3001\u5206\u5b50\u91cf6.5 kDa\u3067\u3042\u308b[2]\u3002Swiss-Prot\u306b\u3088\u308b\u30d6\u30e9\u30bc\u30a4\u30f3\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u306f\u3001\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\u3002QDKCKKVYEN YPVSKCQLAN QCNYDCKLDK HARSGECFYD EKRNLQCICD YCEY[9]\u30d6\u30e9\u30bc\u30a4\u30f3\u306e\u69cb\u9020\u306f\u3001pH 5.2\u300122\u2103\u306e\u6761\u4ef6\u4e0b\u3067\u3001\u6838\u78c1\u6c17\u5171\u9cf4\u3067\u6c7a\u5b9a\u3055\u308c\u305f\u3002\u30d6\u30e9\u30bc\u30a4\u30f3\u306f\u3001\u7b49\u9593\u9694\u306b\u914d\u7f6e\u3055\u308c\u305f4\u3064\u306e\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u3092\u6301\u3061\u3001\u30b9\u30eb\u30d5\u30d2\u30c9\u30ea\u30eb\u57fa\u306f\u6301\u305f\u306a\u3044\u3002  \u30d6\u30e9\u30bc\u30a4\u30f3\u306e\u7acb\u4f53\u69cb\u9020\u89e3\u6790\u3067\u306f\u30011\u3064\u306e\u03b1\u30d8\u30ea\u30c3\u30af\u30b9\u30683\u3064\u306e\u9006\u5e73\u884c\u03b2\u30b7\u30fc\u30c8\u3067\u3067\u304d\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u4e00\u898b\u3057\u305f\u3068\u3053\u308d\u30e2\u30cd\u30ea\u30f3\u3068\u3082\u30bd\u30fc\u30de\u30c1\u30f3\u3068\u306e\u985e\u4f3c\u6027\u306f\u307f\u3089\u308c\u306a\u3044\u304c[10]\u3001\u6700\u8fd1\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u3053\u308c\u30893\u3064\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u7518\u5473\u3092\u751f\u3058\u3055\u305b\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u985e\u4f3c\u3057\u305f\u69cb\u9020\uff08”sweet finger”\uff09\u3092\u6301\u3064\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f[11]\u300229\u756a\u304b\u308933\u756a\u6b8b\u57fa\u306839\u304b\u308943\u756a\u6b8b\u57fa\u3001\u305d\u308c\u306b36\u756a\u6b8b\u57fa\u304c\u3001C\u672b\u7aef\u3068\u3068\u3082\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7518\u5473\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u767a\u898b\u3055\u308c\u305f\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u96fb\u8377\u3082\u3001\u7518\u5473\u53d7\u5bb9\u4f53\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u5927\u304d\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b[2]\u3002\u3053\u306e\u77e5\u8b58\u306b\u57fa\u3065\u3044\u3066\u5408\u6210\u3055\u308c\u305f\u3001pGul-1-\u30d6\u30e9\u30bc\u30a4\u30f3\u3068\u547c\u3070\u308c\u308b\u5408\u6210\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u5929\u7136\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e2\u500d\u306e\u7518\u5473\u3092\u6301\u3064\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u308b[12]\u3002\u7518\u3055\u306e\u6027\u8cea[\u7de8\u96c6]\u91cd\u91cf\u57fa\u6e96\u3067\u3001\u30d6\u30e9\u30bc\u30a4\u30f3\u306f\u7802\u7cd6\u3088\u308a\u3082500\u500d\u304b\u30892000\u500d\u7518\u3044[10]\u3002\u7518\u3055\u306e\u77e5\u899a\u306f\u3001\u30bd\u30fc\u30de\u30c1\u30f3\u3088\u308a\u3082\u30b9\u30af\u30ed\u30fc\u30b9\u306b\u8fd1\u304f\u3001\u96d1\u5473\u306e\u306a\u3044\u7518\u3044\u5473\u3067\u3001\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u3088\u308a\u3082\u5f8c\u5473\u304c\u9577\u304f\u7d9a\u304f[13]\u3002\u30d6\u30e9\u30bc\u30a4\u30f3\u306f\u30012.5\u304b\u30898\u307e\u3067\u306e\u5e83\u3044pH\u7bc4\u56f2\u3067\u5b89\u5b9a\u3067\u3042\u308a[14]\u3001\u307e\u305f98\u2103\u30672\u6642\u9593\u7f6e\u3044\u3066\u3082\u5b89\u5b9a\u3067\u3042\u308b[2]\u3002\u7518\u5473\u6599\u3068\u3057\u3066[\u7de8\u96c6]\u30d6\u30e9\u30bc\u30a4\u30f3\u306f\u3001\u4f4e\u30ab\u30ed\u30ea\u30fc\u306e\u4ee3\u66ff\u7518\u5473\u6599\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u3002\u7cd6\u5c3f\u75c5\u306e\u4eba\u306b\u3082\u5b89\u5168\u3067\u3042\u308a\u3001\u6c34\u306b\u3082\u975e\u5e38\u306b\u6eb6\u3051\u3084\u3059\u3044(>50 mg\/mL)[14]\u3002\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u3084\u30b9\u30c6\u30d3\u30a2\u7b49\u306e\u4ed6\u306e\u7518\u5473\u6599\u3068\u6df7\u305c\u308b\u3068\u3001\u5f8c\u5473\u306e\u96d1\u5473\u304c\u6e1b\u308a\u3001\u5404\u3005\u306e\u30d5\u30ec\u30fc\u30d0\u30fc\u304c\u88dc\u5b8c\u3055\u308c\u308b[15]\u3002\u30bd\u30fc\u30de\u30c1\u30f3\u3068\u306f\u7570\u306a\u308a\u3001\u7518\u3055\u306e\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306f\u4ed6\u306e\u5929\u7136\u7518\u5473\u6599\u3088\u308a\u306f\u30b9\u30af\u30ed\u30fc\u30b9\u306b\u8fd1\u3044\u3002\u4ed6\u306e\u7518\u5473\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7570\u306a\u3063\u3066\u71b1\u306b\u8010\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u98df\u54c1\u5de5\u696d\u306b\u9069\u3057\u3066\u3044\u308b[16]\u3002\u30d6\u30e9\u30bc\u30a4\u30f3\u3078\u306e\u95a2\u5fc3\u304c\u9ad8\u307e\u308b\u3053\u3068\u3067\u3001\u30ac\u30dc\u30f3\u3067\u5929\u7136\u306e\u539f\u6599\u3092\u5f97\u308b\u3053\u3068\u304c\u56f0\u96e3\u306b\u306a\u3063\u3066\u304d\u305f\u304c\u3001\u56fa\u76f8\u53cd\u5fdc\u3067\u306e\u5408\u6210\u304c\u53ef\u80fd\u3068\u306a\u3063\u305f[10]\u3002\u5927\u8178\u83cc\u306b\u3088\u308b\u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4f5c\u88fd\u3082\u6210\u529f\u3057\u3066\u3044\u308b[17]\u3002\u30c6\u30ad\u30b5\u30b9\u5dde\u306e\u4f01\u696d\u3067\u3042\u308bProdigene\u3068Nectar Worldwide\u306f\u3001Wisconsin Alumni Research Foundation\u306e\u6301\u3064\u30d6\u30e9\u30bc\u30a4\u30f3\u306b\u95a2\u3059\u308b\u7279\u8a31\u306e\u4f7f\u7528\u30e9\u30a4\u30bb\u30f3\u30b9\u3092\u6301\u3063\u3066\u304a\u308a\u3001\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u30c0\u30a4\u30ba\u3092\u4f5c\u88fd\u3057\u3066\u3044\u308b\u3002\u7d041\u30c8\u30f3\u306e\u30c0\u30a4\u30ba\u304b\u3089\u30011-2kg\u306e\u30d6\u30e9\u30bc\u30a4\u30f3\u304c\u5f97\u3089\u308c\u308b\u3002\u30b3\u30e0\u30ae\u306b\u7d44\u307f\u8fbc\u3093\u3067\u3001\u4f8b\u3048\u3070\u30b7\u30ea\u30a2\u30eb\u7528\u306b\u6700\u521d\u304b\u3089\u7518\u3044\u30b3\u30e0\u30ae\u3092\u4f5c\u88fd\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u308b[16]\u30022009\u5e74\u304b\u3089\u3001Natur Research Ingredients\u304cCweet\u306e\u5546\u6a19\u540d\u3067\u5e02\u8ca9\u3057\u3066\u3044\u308b[18][19]\u3002\u3053\u306e\u679c\u5b9f\u306e\u7518\u5473\u306b\u3064\u3044\u3066\u306f\u3001\u897f\u30a2\u30d5\u30ea\u30ab\u3067\u306f\u53e4\u304f\u304b\u3089\u77e5\u3089\u308c\u3066\u3044\u305f\u304c\u3001\u5927\u5b66\u306f\u3001\u30d6\u30e9\u30bc\u30a4\u30f3\u306f\u81ea\u3089\u306e\u767a\u660e\u3067\u3042\u308a\u3001\u30ac\u30dc\u30f3\u3068\u306f\u4f55\u306e\u95a2\u4fc2\u3082\u306a\u3044\u3053\u3068\u3092\u8a8d\u3081\u308b\u3088\u3046\u4e3b\u5f35\u3057\u3066\u3044\u308b[20]\u3002\u73fe\u5730\u306e\u4f4f\u6c11\u3078\u306e\u88dc\u511f\u91d1\u3092\u652f\u6255\u3046\u3053\u3068\u306a\u3057\u306b\u3001\u73fe\u5730\u306e\u4f4f\u6c11\u306e\u751f\u7269\u533b\u5b66\u77e5\u8b58\u306b\u57fa\u3065\u304f\u6cd5\u7684\u6a29\u5229\u3092\u4e3b\u5f35\u3059\u308b\u3053\u3068\u306f\u3001GRAIN\uff08\u82f1\u8a9e\u7248\uff09\u3084\u30b0\u30ea\u30fc\u30f3\u30d4\u30fc\u30b9 (NGO)\u304b\u3089\u3001\u30d0\u30a4\u30aa\u30d1\u30a4\u30e9\u30b7\u30fc\uff08\u82f1\u8a9e\u7248\uff09\uff08\u751f\u7269\u8cc7\u6e90\u306e\u76d7\u8cca\u884c\u70ba\uff09\u3067\u3042\u308b\u3068\u898b\u306a\u3055\u308c\u3066\u3044\u308b[21]\u3002\u95a2\u9023\u9805\u76ee[\u7de8\u96c6]^ PDB 2brz; Caldwell JE, Abildgaard F, Dzakula Z, Ming D, Hellekant G, Markley JL (June 1998). \u201cSolution structure of the thermostable sweet-tasting protein brazzein\u201d. Nat. Struct. Biol. 5 (6):  427\u201331. doi:10.1038\/nsb0698-427. PMID\u00a09628478.\u00a0^ a b c d Ming D, Hellekant G (November 1994). \u201cBrazzein, a new high-potency thermostable sweet protein from Pentadiplandra brazzeana B\u201d. FEBS Lett. 355 (1):  106\u20138. doi:10.1016\/0014-5793(94)01184-2. PMID\u00a07957951.\u00a0^ van der Wel H, Larson G, Hladik A, Hladik CM, Hellekant G, Glaser D (1989). \u201cIsolation and characterization of pentadin, the sweet principle of Pentadiplandra brazzeana Baillon\u201d. Chem. Senses 14 (1):  75\u201379. doi:10.1093\/chemse\/14.1.75.\u00a0^ Faus I, Sisniega H (2004). \u201cSweet-tasting Proteins\u201d. In Hofrichter M, Steinb\u00fcchel A. Biopolymers: Polyamides and Complex Proteinaceous Materials II (8 ed.). Weinheim: Wiley-VCH. pp.\u00a0203\u2013209. ISBN\u00a03-527-30223-9. http:\/\/www.wiley-vch.de\/books\/biopoly\/pdf_v08\/vol08_08.pdf\u00a0^ Guevara, Elaine E.; Veilleux, Carrie C.; Saltonstall, Kristin; Caccone, Adalgisa; Mundy, Nicholas I.; Bradley, Brenda J. (09 2016). \u201cPotential arms race in the coevolution of primates and angiosperms: brazzein sweet proteins and gorilla taste receptors\u201d. American Journal of Physical Anthropology 161 (1):  181\u2013185. doi:10.1002\/ajpa.23046. ISSN\u00a01096-8644. PMID\u00a027393125. https:\/\/pubmed.ncbi.nlm.nih.gov\/27393125.\u00a0^ Gruber, Karl. \u201cGorillas may have evolved a way to beat a cheating berry plant\u201d (\u82f1\u8a9e). New Scientist. 2021\u5e741\u67083\u65e5\u95b2\u89a7\u3002^ Stein J (2002\u5e7411\u67084\u65e5). \u201cUW\u2013Madison professor makes a sweet discovery\u201d.   Wisconsin State Journal. 10\/2\/2010\u6642\u70b9\u306e\u30aa\u30ea\u30b8\u30ca\u30eb\u3088\u308a\u30a2\u30fc\u30ab\u30a4\u30d6\u30022007\u5e749\u670828\u65e5\u95b2\u89a7\u3002^ Hladik CM, Hladik A (1988). \u201cSucres et “faux sucres” de la for\u00eat \u00e9quatoriale\u00a0: \u00e9volution et perception des produits sucr\u00e9s par les populations foresti\u00e8res d’Afrique\u201d. Journal d’Agriculture Tropicale et de Botanique Appliqu\u00e9e (FRA) 35:  51\u201366.  \u30aa\u30ea\u30b8\u30ca\u30eb\u306e2011\u5e747\u670826\u65e5\u6642\u70b9\u306b\u304a\u3051\u308b\u30a2\u30fc\u30ab\u30a4\u30d6\u3002. https:\/\/web.archive.org\/web\/20110726061539\/http:\/\/www.forafri.org\/_fiche.php?resource_id=1889.\u00a0^ UniProtKB\/Swiss-Prot database entry #PP56552^ a b c Izawa H, Ota M, Kohmura M, Ariyoshi Y (July 1996). \u201cSynthesis and characterization of the sweet protein brazzein\u201d. Biopolymers 39 (1):  95\u2013101. doi:10.1002\/(SICI)1097-0282(199607)39:13.0.CO;2-B. PMID\u00a08924630.\u00a0^ Tancredi T, Pastore A, Salvadori S, Esposito V, Temussi PA (June 2004). \u201cInteraction of sweet proteins with their receptor. A conformational study of peptides corresponding to loops of brazzein, monellin and thaumatin\u201d. Eur. J. Biochem. 271 (11):  2231\u201340. doi:10.1111\/j.1432-1033.2004.04154.x. PMID\u00a015153113.\u00a0^ Assadi-Porter FM, Aceti DJ, Markley JL (April 2000). \u201cSweetness determinant sites of brazzein, a small, heat-stable, sweet-tasting protein\u201d. Arch. Biochem. Biophys. 376 (2):  259\u201365. doi:10.1006\/abbi.2000.1726. PMID\u00a010775411.\u00a0^ Pfeiffer JF, Boulton RB, Noble AC (2000). \u201cModelling the sweetness response using time-intensity data\u201d. Food Quality and Preference 11 (1):  129\u2013138. doi:10.1016\/S0950-3293(99)00036-1.\u00a0^ a b Birch, Gordon Gerard (2000). Ingredients Handbook – Sweeteners (Ingredients Handbook Series). Leatherhead Food Research Association. ISBN\u00a00-905748-90-5\u00a0^ Hellekant G, Danilova V (2005). \u201cBrazzein a Small, Sweet Protein: Discovery and Physiological Overview\u201d. Chem. Senses 30 (Supplement 1):  i88\u2013i89. doi:10.1093\/chemse\/bjh127. PMID\u00a015738210.\u00a0^ a b US patent 5326580, Hellekant BG, Ming D, “Brazzein sweetener”, issued 1994-07-05\u00a0^ Assadi-Porter FM, Aceti DJ, Cheng H, Markley JL (April 2000). \u201cEfficient production of recombinant brazzein, a small, heat-stable, sweet-tasting protein of plant origin\u201d. Arch. Biochem. Biophys. 376 (2):  252\u20138. doi:10.1006\/abbi.2000.1725. PMID\u00a010775410.\u00a0^ Halliday  J (2008\u5e746\u670827\u65e5). \u201cNatural sweetener race hots up with Nutrinova break-through\u201d.   www.foodnavigator.com. 2008\u5e7411\u670818\u65e5\u95b2\u89a7\u3002^ Hills S (2008\u5e746\u670824\u65e5). \u201cNew sweetener to hit market hungry for alternatives\u201d.   www.foodnavigator.com. 2008\u5e7411\u670818\u65e5\u95b2\u89a7\u3002^ Select Committee on Environmental Audit (1999\u5e7411\u670825\u65e5). \u201cTrade Related Intellectual Property Rights (TRIPs) and Farmers’ Rights\u201d.   House of Commons, www.parliament.uk. 2008\u5e749\u670813\u65e5\u95b2\u89a7\u3002^ \u201cThe European Patent Directive: License to Plunder\u201d.   Genetic Resources Action International (GRAIN) (1998\u5e745\u67081\u65e5). 2008\u5e749\u670813\u65e5\u95b2\u89a7\u3002"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki5\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki5\/2022\/08\/23\/%e3%83%96%e3%83%a9%e3%82%bc%e3%82%a4%e3%83%b3-wikipedia\/#breadcrumbitem","name":"\u30d6\u30e9\u30bc\u30a4\u30f3 – Wikipedia"}}]}]