[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/jp\/wiki6\/archives\/1113#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/jp\/wiki6\/archives\/1113","headline":"\u30ab\u30d9\u30aa\u30e9 – Wikipedia","name":"\u30ab\u30d9\u30aa\u30e9 – Wikipedia","description":"\u30ab\u30d9\u30aa\u30e9\uff08\u82f1: caveola, pl. caveolae\u3001\u30e9\u30c6\u30f3\u8a9e\u3067\u300c\u5c0f\u3055\u306a\u6d1e\u7a9f\u300d\u306e\u610f\uff09\u3068\u306f\u3001\u7279\u6b8a\u306a\u30bf\u30a4\u30d7\u306e\u8102\u8cea\u30e9\u30d5\u30c8\u3067\u3042\u308a\u3001\u810a\u690e\u52d5\u7269\u306e\u591a\u304f\u306e\u7d30\u80de\u7a2e\u3001\u7279\u306b\u5185\u76ae\u7d30\u80de\u3001\u8102\u80aa\u7d30\u80de\u3001\u80da\u306e\u810a\u7d22\u7d30\u80de\u306e\u7d30\u80de\u819c\u306b\u5b58\u5728\u3059\u308b\u5c0f\u3055\u306a\uff0850\u2013100 nm\uff09\u9665\u5165\u3067\u3042\u308b[1]\u3002\u30ab\u30d9\u30aa\u30e9\u306f1955\u5e74\u306b\u5c71\u7530\u82f1\u667a\u306b\u3088\u3063\u3066\u767a\u898b\u3055\u308c\u305f[2][3]\u3002 \u30ab\u30d9\u30aa\u30e9\u306f\u30d5\u30e9\u30b9\u30b3\u578b\u306e\u5f62\u72b6\u3067\u3042\u308a\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u307b\u304b\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3084\u30b9\u30d5\u30a3\u30f3\u30b4\u8102\u8cea\u306a\u3069\u306e\u8102\u8cea\u306b\u5bcc\u3080\u3002\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306a\u3069\u3001\u3044\u304f\u3064\u304b\u306e\u6a5f\u80fd\u3092\u6301\u3064[4]\u3002\u307e\u305f\u3001\u6a5f\u68b0\u7684\u523a\u6fc0\u306e\u691c\u77e5\u3068\u4fdd\u8b77\u3001\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3001\u767a\u304c\u3093\uff08\u82f1\u8a9e\u7248\uff09\u3001\u75c5\u539f\u4f53\u3068\u306a\u308b\u7d30\u83cc\u3084\u7279\u5b9a\u306e\u30a6\u30a4\u30eb\u30b9\u306e\u53d6\u308a\u8fbc\u307f\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b[5][6][7][8]\u3002 Table of Contents \u30ab\u30d9\u30aa\u30ea\u30f3[\u7de8\u96c6]\u30ab\u30d9\u30aa\u30e9\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9[\u7de8\u96c6]\u305d\u306e\u4ed6\u306e\u5f79\u5272[\u7de8\u96c6]\u95a2\u9023\u9805\u76ee[\u7de8\u96c6]\u5916\u90e8\u30ea\u30f3\u30af[\u7de8\u96c6] \u30ab\u30d9\u30aa\u30ea\u30f3[\u7de8\u96c6] \u30ab\u30d9\u30aa\u30e9\u306e\u5f62\u6210\u3068\u7dad\u6301\u306f\u3001\u5f53\u521d\u306f\u4e3b\u306b21 kDa\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u30ab\u30d9\u30aa\u30ea\u30f3\uff08\u82f1\u8a9e\u7248\uff09\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u305f[9]\u3002\u54fa\u4e73\u985e\u306e\u7d30\u80de\u306b\u306f\u3001Cav1\u3001Cav2\uff08\u82f1\u8a9e\u7248\uff09\u3001Cav3\uff08\u82f1\u8a9e\u7248\uff09\u3068\u3044\u30463\u3064\u306e\u76f8\u540c\u306a\u30ab\u30d9\u30aa\u30ea\u30f3\u304c\u5b58\u5728\u3059\u308b\u3002\u3053\u308c\u3089\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u8db3\u5834\u30c9\u30e1\u30a4\u30f3\u3092\u542b\u3080\u7d30\u80de\u8cea\u5074\u306eN\u672b\u7aef\u3001\u9577\u3044\u30d8\u30a2\u30d4\u30f3\u578b\u306e\u819c\u8cab\u901a\u30c9\u30e1\u30a4\u30f3\u3001\u7d30\u80de\u8cea\u5074\u306eC\u672b\u7aef\u3068\u3044\u3046\u5171\u901a\u3057\u305f\u30c8\u30dd\u30ed\u30b8\u30fc\u3092\u6301\u3064\u3002\u30ab\u30d9\u30aa\u30ea\u30f3\u306f\u5358\u91cf\u4f53\u3068\u3057\u3066\u5408\u6210\u3055\u308c\u3001\u30b4\u30eb\u30b8\u4f53\u3078\u8f38\u9001\u3055\u308c\u308b\u3002\u305d\u306e\u5f8c\u306e\u5206\u6ccc\u7d4c\u8def\u3092\u4ecb\u3057\u305f\u8f38\u9001\u904e\u7a0b\u3067\u3001\u30ab\u30d9\u30aa\u30ea\u30f3\u306f\u8102\u8cea\u30e9\u30d5\u30c8\u3068\u7d50\u5408\u3057\u306614\u201316\u5206\u5b50\u304b\u3089\u306a\u308b\u30aa\u30ea\u30b4\u30de\u30fc\u3092\u5f62\u6210\u3059\u308b\u3002\u3053\u3046\u3057\u305f\u30aa\u30ea\u30b4\u30de\u30fc\u5316\u3057\u305f\u30ab\u30d9\u30aa\u30ea\u30f3\u304c\u30ab\u30d9\u30aa\u30e9\u3092\u5f62\u6210\u3059\u308b\u3002\u30ab\u30d9\u30aa\u30ea\u30f3\u306e\u5b58\u5728\u306f\u819c\u306e\u5f62\u614b\u306b\u5c40\u6240\u7684\u306a\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059[10]\u3002 Cavin\u306f2000\u5e74\u4ee3\u5f8c\u534a\u3001\u30ab\u30d9\u30aa\u30e9\u306e\u5f62\u6210\u3092\u5236\u5fa1\u3059\u308b\u4e3b\u8981\u306a\u69cb\u9020\u7684\u69cb\u6210\u8981\u7d20\u3068\u3057\u3066\u767a\u898b\u3055\u308c\u305f[11][12][13][14]\u3002Cavin\u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a1\u30df\u30ea\u30fc\u306f\u3001Cavin1\uff08\u82f1\u8a9e\u7248\uff09\uff08PTRF\uff09\u3001Cavin2\uff08\u82f1\u8a9e\u7248\uff09\uff08SDPR\uff09\u3001Cavin3\uff08SRBC\uff09\u3001Cavin4\uff08MURC\uff09\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u3002Cavin1\u306f\u591a\u304f\u306e\u7d44\u7e54\u3067\u30ab\u30d9\u30aa\u30e9\u5f62\u6210\u306e\u4e3b\u8981\u306a\u8abf\u7bc0\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u30ab\u30d9\u30aa\u30e9\u3092\u6b20\u304f\u304cCav1\u306f\u8c4a\u5bcc\u306b\u5b58\u5728\u3059\u308b\u7d30\u80de\u3067\u30ab\u30d9\u30aa\u30e9\u3092\u5f62\u6210\u3055\u305b\u308b\u306b\u306f\u3001Cavin1\u306e\u767a\u73fe\u3060\u3051\u3067\u5341\u5206\u3067\u3042\u308b[11][15]\u3002Cavin4\u306fCav3\u3068\u540c\u69d8\u306b\u7b4b\u7279\u7570\u7684\u306b\u767a\u73fe\u3059\u308b[12]\u3002 \u30ab\u30d9\u30aa\u30e9\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9[\u7de8\u96c6] 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\u3053\u306e\u30bf\u30a4\u30d7\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306f\u3001\u4f8b\u3048\u3070\u3001\u5185\u76ae\u7d30\u80de\u3067\u306e\u30a2\u30eb\u30d6\u30df\u30f3\u306e\u30c8\u30e9\u30f3\u30b9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\uff08\u82f1\u8a9e\u7248\uff09\u3084\u8102\u80aa\u7d30\u80de\u3067\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u306e\u30a4\u30f3\u30bf\u30fc\u30ca\u30ea\u30bc\u30fc\u30b7\u30e7\u30f3\u306b\u5229\u7528\u3055\u308c\u308b[10]\u3002 \u305d\u306e\u4ed6\u306e\u5f79\u5272[\u7de8\u96c6] \u30ab\u30d9\u30aa\u30e9\u306f\u3001\u9aa8\u683c\u7b4b\u3001\u5185\u76ae\u7d30\u80de\u3001\u810a\u7d22\u7d30\u80de\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u7d44\u7e54\u306b\u304a\u3044\u3066\u3001\u6a5f\u68b0\u7684\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u7d30\u80de\u3092\u4fdd\u8b77\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b[17][18][19]\u3002 \u30ab\u30d9\u30aa\u30e9\u306f\u4e00\u90e8\u306e\u75c5\u539f\u4f53\u304c\u7d30\u80de\u5185\u306b\u9032\u5165\u3059\u308b\u969b\u306b\u5229\u7528\u3055\u308c\u3001\u75c5\u539f\u4f53\u306f\u30ea\u30bd\u30bd\u30fc\u30e0\u3067\u306e\u5206\u89e3\u3092\u907f\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u4e00\u90e8\u306e\u7d30\u83cc\u306f\u5178\u578b\u7684\u306a\u30ab\u30d9\u30aa\u30e9\u3067\u306f\u306a\u304f\u3001\u7d30\u80de\u819c\u306e\u30ab\u30d9\u30aa\u30ea\u30f3\u306b\u5bcc\u3080\u9818\u57df\u306e\u307f\u3092\u5229\u7528\u3059\u308b\u3002\u3053\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u3092\u5229\u7528\u3059\u308b\u75c5\u539f\u4f53\u306b\u306f\u3001SV40\uff08\u82f1\u8a9e\u7248\uff09\u3084\u30dd\u30ea\u30aa\u30fc\u30de\u30a6\u30a4\u30eb\u30b9\uff08\u82f1\u8a9e\u7248\uff09\u306a\u3069\u306e\u30a6\u30a4\u30eb\u30b9\u3084\u3001\u5927\u8178\u83ccEscherichia","datePublished":"2020-12-31","dateModified":"2022-09-14","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/jp\/wiki6\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/jp\/wiki6\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/11\/book.png","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/11\/book.png","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/ja.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/ja.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/jp\/wiki6\/archives\/1113","about":["Wiki"],"wordCount":5856,"articleBody":"\u30ab\u30d9\u30aa\u30e9\uff08\u82f1: caveola, pl. caveolae\u3001\u30e9\u30c6\u30f3\u8a9e\u3067\u300c\u5c0f\u3055\u306a\u6d1e\u7a9f\u300d\u306e\u610f\uff09\u3068\u306f\u3001\u7279\u6b8a\u306a\u30bf\u30a4\u30d7\u306e\u8102\u8cea\u30e9\u30d5\u30c8\u3067\u3042\u308a\u3001\u810a\u690e\u52d5\u7269\u306e\u591a\u304f\u306e\u7d30\u80de\u7a2e\u3001\u7279\u306b\u5185\u76ae\u7d30\u80de\u3001\u8102\u80aa\u7d30\u80de\u3001\u80da\u306e\u810a\u7d22\u7d30\u80de\u306e\u7d30\u80de\u819c\u306b\u5b58\u5728\u3059\u308b\u5c0f\u3055\u306a\uff0850\u2013100 nm\uff09\u9665\u5165\u3067\u3042\u308b[1]\u3002\u30ab\u30d9\u30aa\u30e9\u306f1955\u5e74\u306b\u5c71\u7530\u82f1\u667a\u306b\u3088\u3063\u3066\u767a\u898b\u3055\u308c\u305f[2][3]\u3002  \u30ab\u30d9\u30aa\u30e9\u306f\u30d5\u30e9\u30b9\u30b3\u578b\u306e\u5f62\u72b6\u3067\u3042\u308a\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u307b\u304b\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3084\u30b9\u30d5\u30a3\u30f3\u30b4\u8102\u8cea\u306a\u3069\u306e\u8102\u8cea\u306b\u5bcc\u3080\u3002\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306a\u3069\u3001\u3044\u304f\u3064\u304b\u306e\u6a5f\u80fd\u3092\u6301\u3064[4]\u3002\u307e\u305f\u3001\u6a5f\u68b0\u7684\u523a\u6fc0\u306e\u691c\u77e5\u3068\u4fdd\u8b77\u3001\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3001\u767a\u304c\u3093\uff08\u82f1\u8a9e\u7248\uff09\u3001\u75c5\u539f\u4f53\u3068\u306a\u308b\u7d30\u83cc\u3084\u7279\u5b9a\u306e\u30a6\u30a4\u30eb\u30b9\u306e\u53d6\u308a\u8fbc\u307f\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b[5][6][7][8]\u3002Table of Contents\u30ab\u30d9\u30aa\u30ea\u30f3[\u7de8\u96c6]\u30ab\u30d9\u30aa\u30e9\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9[\u7de8\u96c6]\u305d\u306e\u4ed6\u306e\u5f79\u5272[\u7de8\u96c6]\u95a2\u9023\u9805\u76ee[\u7de8\u96c6]\u5916\u90e8\u30ea\u30f3\u30af[\u7de8\u96c6]\u30ab\u30d9\u30aa\u30ea\u30f3[\u7de8\u96c6]\u30ab\u30d9\u30aa\u30e9\u306e\u5f62\u6210\u3068\u7dad\u6301\u306f\u3001\u5f53\u521d\u306f\u4e3b\u306b21 kDa\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u30ab\u30d9\u30aa\u30ea\u30f3\uff08\u82f1\u8a9e\u7248\uff09\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u305f[9]\u3002\u54fa\u4e73\u985e\u306e\u7d30\u80de\u306b\u306f\u3001Cav1\u3001Cav2\uff08\u82f1\u8a9e\u7248\uff09\u3001Cav3\uff08\u82f1\u8a9e\u7248\uff09\u3068\u3044\u30463\u3064\u306e\u76f8\u540c\u306a\u30ab\u30d9\u30aa\u30ea\u30f3\u304c\u5b58\u5728\u3059\u308b\u3002\u3053\u308c\u3089\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u8db3\u5834\u30c9\u30e1\u30a4\u30f3\u3092\u542b\u3080\u7d30\u80de\u8cea\u5074\u306eN\u672b\u7aef\u3001\u9577\u3044\u30d8\u30a2\u30d4\u30f3\u578b\u306e\u819c\u8cab\u901a\u30c9\u30e1\u30a4\u30f3\u3001\u7d30\u80de\u8cea\u5074\u306eC\u672b\u7aef\u3068\u3044\u3046\u5171\u901a\u3057\u305f\u30c8\u30dd\u30ed\u30b8\u30fc\u3092\u6301\u3064\u3002\u30ab\u30d9\u30aa\u30ea\u30f3\u306f\u5358\u91cf\u4f53\u3068\u3057\u3066\u5408\u6210\u3055\u308c\u3001\u30b4\u30eb\u30b8\u4f53\u3078\u8f38\u9001\u3055\u308c\u308b\u3002\u305d\u306e\u5f8c\u306e\u5206\u6ccc\u7d4c\u8def\u3092\u4ecb\u3057\u305f\u8f38\u9001\u904e\u7a0b\u3067\u3001\u30ab\u30d9\u30aa\u30ea\u30f3\u306f\u8102\u8cea\u30e9\u30d5\u30c8\u3068\u7d50\u5408\u3057\u306614\u201316\u5206\u5b50\u304b\u3089\u306a\u308b\u30aa\u30ea\u30b4\u30de\u30fc\u3092\u5f62\u6210\u3059\u308b\u3002\u3053\u3046\u3057\u305f\u30aa\u30ea\u30b4\u30de\u30fc\u5316\u3057\u305f\u30ab\u30d9\u30aa\u30ea\u30f3\u304c\u30ab\u30d9\u30aa\u30e9\u3092\u5f62\u6210\u3059\u308b\u3002\u30ab\u30d9\u30aa\u30ea\u30f3\u306e\u5b58\u5728\u306f\u819c\u306e\u5f62\u614b\u306b\u5c40\u6240\u7684\u306a\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059[10]\u3002  Cavin\u306f2000\u5e74\u4ee3\u5f8c\u534a\u3001\u30ab\u30d9\u30aa\u30e9\u306e\u5f62\u6210\u3092\u5236\u5fa1\u3059\u308b\u4e3b\u8981\u306a\u69cb\u9020\u7684\u69cb\u6210\u8981\u7d20\u3068\u3057\u3066\u767a\u898b\u3055\u308c\u305f[11][12][13][14]\u3002Cavin\u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a1\u30df\u30ea\u30fc\u306f\u3001Cavin1\uff08\u82f1\u8a9e\u7248\uff09\uff08PTRF\uff09\u3001Cavin2\uff08\u82f1\u8a9e\u7248\uff09\uff08SDPR\uff09\u3001Cavin3\uff08SRBC\uff09\u3001Cavin4\uff08MURC\uff09\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u3002Cavin1\u306f\u591a\u304f\u306e\u7d44\u7e54\u3067\u30ab\u30d9\u30aa\u30e9\u5f62\u6210\u306e\u4e3b\u8981\u306a\u8abf\u7bc0\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u30ab\u30d9\u30aa\u30e9\u3092\u6b20\u304f\u304cCav1\u306f\u8c4a\u5bcc\u306b\u5b58\u5728\u3059\u308b\u7d30\u80de\u3067\u30ab\u30d9\u30aa\u30e9\u3092\u5f62\u6210\u3055\u305b\u308b\u306b\u306f\u3001Cavin1\u306e\u767a\u73fe\u3060\u3051\u3067\u5341\u5206\u3067\u3042\u308b[11][15]\u3002Cavin4\u306fCav3\u3068\u540c\u69d8\u306b\u7b4b\u7279\u7570\u7684\u306b\u767a\u73fe\u3059\u308b[12]\u3002\u30ab\u30d9\u30aa\u30e9\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9[\u7de8\u96c6]\u30ab\u30d9\u30aa\u30e9\u306f\u3001\u30af\u30e9\u30b9\u30ea\u30f3\u975e\u4f9d\u5b58\u7684\u3001\u8102\u8cea\u30e9\u30d5\u30c8\u4f9d\u5b58\u7684\u306a\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u304c\u884c\u308f\u308c\u308b\u5834\u6240\u306e1\u3064\u3067\u3042\u308b\u3002\u30ab\u30d9\u30aa\u30e9\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u5c0f\u80de\u306e\u5f62\u6210\u306b\u306f\u30ab\u30d9\u30aa\u30ea\u30f3\u306e\u30aa\u30ea\u30b4\u30de\u30fc\u5316\u304c\u5fc5\u8981\u3067\u3042\u308a\u3001\u30aa\u30ea\u30b4\u30de\u30fc\u5316\u306b\u3088\u3063\u3066\u30ab\u30d9\u30aa\u30ea\u30f3\u306b\u5bcc\u3080\u5fae\u5c0f\u30c9\u30e1\u30a4\u30f3\u304c\u7d30\u80de\u819c\u306b\u5f62\u6210\u3055\u308c\u308b\u3002\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u306e\u5897\u52a0\u3084\u30ab\u30d9\u30aa\u30ea\u30f3\u306e\u8db3\u5834\u30c9\u30e1\u30a4\u30f3\u306e\u7d30\u80de\u819c\u3078\u306e\u633f\u5165\u306b\u3088\u3063\u3066\u3001\u30ab\u30d9\u30aa\u30e9\u306e\u9665\u5165\u306f\u62e1\u5927\u3057\u3001\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u5c0f\u80de\u304c\u5f62\u6210\u3055\u308c\u308b\u3002\u305d\u306e\u5f8c\u306e\u7d30\u80de\u819c\u304b\u3089\u306e\u5c0f\u80de\u306e\u5207\u308a\u96e2\u3057\u306f\u3001\u51fa\u82bd\u3057\u305f\u5c0f\u80de\u306e\u4ed8\u3051\u6839\u90e8\u5206\u306b\u5c40\u5728\u3059\u308bGTP\u30a2\u30fc\u30bc\u3067\u3042\u308b\u30c0\u30a4\u30ca\u30df\u30f32\uff08\u82f1\u8a9e\u7248\uff09\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u308b\u3002\u653e\u51fa\u3055\u308c\u305f\u30ab\u30d9\u30aa\u30e9\u5c0f\u80de\u306f\u521d\u671f\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u307e\u305f\u306f\u30ab\u30d9\u30aa\u30bd\u30fc\u30e0\uff08caveosome\uff09\u306b\u878d\u5408\u3059\u308b\u3002\u30ab\u30d9\u30aa\u30bd\u30fc\u30e0\u306fpH\u304c\u4e2d\u6027\u306e\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u533a\u753b\u3067\u3001\u521d\u671f\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u306e\u30de\u30fc\u30ab\u30fc\u306f\u5b58\u5728\u3057\u306a\u3044\u304c\u3001\u30ab\u30d9\u30aa\u30e9\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306b\u3088\u3063\u3066\u53d6\u308a\u8fbc\u307e\u308c\u305f\u5206\u5b50\u304c\u542b\u307e\u308c\u3066\u3044\u308b[10][16]\u3002\u3053\u306e\u30bf\u30a4\u30d7\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306f\u3001\u4f8b\u3048\u3070\u3001\u5185\u76ae\u7d30\u80de\u3067\u306e\u30a2\u30eb\u30d6\u30df\u30f3\u306e\u30c8\u30e9\u30f3\u30b9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\uff08\u82f1\u8a9e\u7248\uff09\u3084\u8102\u80aa\u7d30\u80de\u3067\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u306e\u30a4\u30f3\u30bf\u30fc\u30ca\u30ea\u30bc\u30fc\u30b7\u30e7\u30f3\u306b\u5229\u7528\u3055\u308c\u308b[10]\u3002\u305d\u306e\u4ed6\u306e\u5f79\u5272[\u7de8\u96c6]\u30ab\u30d9\u30aa\u30e9\u306f\u3001\u9aa8\u683c\u7b4b\u3001\u5185\u76ae\u7d30\u80de\u3001\u810a\u7d22\u7d30\u80de\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u7d44\u7e54\u306b\u304a\u3044\u3066\u3001\u6a5f\u68b0\u7684\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u7d30\u80de\u3092\u4fdd\u8b77\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b[17][18][19]\u3002\u30ab\u30d9\u30aa\u30e9\u306f\u4e00\u90e8\u306e\u75c5\u539f\u4f53\u304c\u7d30\u80de\u5185\u306b\u9032\u5165\u3059\u308b\u969b\u306b\u5229\u7528\u3055\u308c\u3001\u75c5\u539f\u4f53\u306f\u30ea\u30bd\u30bd\u30fc\u30e0\u3067\u306e\u5206\u89e3\u3092\u907f\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u4e00\u90e8\u306e\u7d30\u83cc\u306f\u5178\u578b\u7684\u306a\u30ab\u30d9\u30aa\u30e9\u3067\u306f\u306a\u304f\u3001\u7d30\u80de\u819c\u306e\u30ab\u30d9\u30aa\u30ea\u30f3\u306b\u5bcc\u3080\u9818\u57df\u306e\u307f\u3092\u5229\u7528\u3059\u308b\u3002\u3053\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u3092\u5229\u7528\u3059\u308b\u75c5\u539f\u4f53\u306b\u306f\u3001SV40\uff08\u82f1\u8a9e\u7248\uff09\u3084\u30dd\u30ea\u30aa\u30fc\u30de\u30a6\u30a4\u30eb\u30b9\uff08\u82f1\u8a9e\u7248\uff09\u306a\u3069\u306e\u30a6\u30a4\u30eb\u30b9\u3084\u3001\u5927\u8178\u83ccEscherichia coli\u306e\u4e00\u90e8\u306e\u7cfb\u7d71\u3001\u7dd1\u81bf\u83ccPseudomonas aeruginosa\u3001\u30dd\u30eb\u30d5\u30a3\u30ed\u30e2\u30ca\u30b9\u30fb\u30b8\u30f3\u30b8\u30d0\u30ea\u30b9Porphyromonas gingivalis\u306a\u3069\u306e\u7d30\u83cc\u304c\u3042\u308b[16]\u3002\u30ab\u30d9\u30aa\u30e9\u306f\u7d30\u80de\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u30ab\u30d9\u30aa\u30ea\u30f3\u306f\u8db3\u5834\u30c9\u30e1\u30a4\u30f3\u3092\u4ecb\u3057\u3066\u3044\u304f\u3064\u304b\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u5206\u5b50\uff08eNOS\u306a\u3069\uff09\u3068\u7d50\u5408\u3057\u3001\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u307e\u305f\u3001\u30ab\u30d9\u30aa\u30e9\u306f\u30c1\u30e3\u30cd\u30eb\u306e\u8abf\u7bc0\u3084\u30ab\u30eb\u30b7\u30a6\u30e0\u30b7\u30b0\u30ca\u30eb\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u308b[16]\u3002\u30ab\u30d9\u30aa\u30e9\u306f\u8102\u8cea\u306e\u8abf\u7bc0\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u8102\u80aa\u7d30\u80de\u3067\u306f\u30ab\u30d9\u30aa\u30ea\u30f3Cav1\u304c\u9ad8\u30ec\u30d9\u30eb\u3067\u767a\u73fe\u3057\u3066\u3044\u308b\u3002\u30ab\u30d9\u30aa\u30ea\u30f3\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u8102\u80aa\u9178\u3001\u8102\u80aa\u6ef4\uff08\u82f1\u8a9e\u7248\uff09\u3068\u7d50\u5408\u3057\u3001\u305d\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b[16]\u3002\u30ab\u30d9\u30aa\u30e9\u306f\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u7a2e\u3067\u6a5f\u68b0\u53d7\u5bb9\u5668\u3068\u3057\u3066\u3082\u6a5f\u80fd\u3059\u308b\u3002\u5185\u76ae\u7d30\u80de\u3067\u306f\u3001\u30ab\u30d9\u30aa\u30e9\u306f\u6d41\u308c\u306e\u691c\u77e5\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u6d41\u308c\u523a\u6fc0\u3078\u306e\u6162\u6027\u7684\u306a\u66dd\u9732\u306f\u3001\u7d30\u80de\u819c\u3067\u306eCav1\u306e\u30ec\u30d9\u30eb\u306e\u4e0a\u6607\u3001\u30ea\u30f3\u9178\u5316\u3001eNOS\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u9175\u7d20\u306e\u6d3b\u6027\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u8840\u7ba1\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002\u5e73\u6ed1\u7b4b\u7d30\u80de\u3067\u306f\u3001Cav1\u306f\u7d30\u80de\u5468\u671f\u306e\u9032\u884c\u306e\u5f15\u304d\u91d1\u3068\u306a\u308b\u4f38\u5f35\u306e\u691c\u77e5\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b[16]\u3002\u30d5\u30a3\u30ea\u30d4\u30f3III\u3001\u30b2\u30cb\u30b9\u30c6\u30a4\u30f3\u3001\u30ca\u30a4\u30b9\u30bf\u30c1\u30f3\u306f\u30ab\u30d9\u30aa\u30e9\u7d4c\u8def\u306e\u963b\u5bb3\u5264\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b[10]\u3002 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PMID\u00a018191225. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2265257\/.\u00a0^ a b Bastiani, Michele; Liu, Libin; Hill, Michelle M.; Jedrychowski, Mark P.; Nixon, Susan J.; Lo, Harriet P.; Abankwa, Daniel; Luetterforst, Robert et al. (2009-06-29). \u201cMURC\/Cavin-4 and cavin family members form tissue-specific caveolar complexes\u201d. The Journal of Cell Biology 185 (7):  1259\u20131273. doi:10.1083\/jcb.200903053. ISSN\u00a00021-9525. PMC\u00a02712963. PMID\u00a019546242. https:\/\/open.bu.edu\/bitstream\/2144\/3220\/1\/JCB_200903053.pdf.\u00a0^ Kovtun, Oleksiy; Tillu, Vikas A.; Ariotti, Nicholas; Parton, Robert G.; Collins, Brett M. (2015-04-01). \u201cCavin family proteins and the assembly of caveolae\u201d. Journal of Cell Science 128 (7):  1269\u20131278. doi:10.1242\/jcs.167866. ISSN\u00a00021-9533. PMC\u00a04379724. PMID\u00a025829513. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4379724\/.\u00a0^ Parton, Robert G.; Collins, Brett M. (2016-12-13). \u201cUnraveling the architecture of caveolae\u201d (\u82f1\u8a9e). Proceedings of the National Academy of Sciences 113 (50):  14170\u201314172. doi:10.1073\/pnas.1617954113. ISSN\u00a00027-8424. PMC\u00a05167180. PMID\u00a027911845. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5167180\/.\u00a0^ Liu, Libin; Brown, Dennis; McKee, Mary; LeBrasseur, Nathan K.; Yang, Dan; Albrecht, Kenneth H.; Ravid, Katya; Pilch, Paul F. (2017-05-29). \u201cDeletion of Cavin\/PTRF causes global loss of caveolae, dyslipidemia and glucose intolerance\u201d. Cell Metabolism 8 (4):  310\u2013317. doi:10.1016\/j.cmet.2008.07.008. ISSN\u00a01550-4131. PMC\u00a02581738. PMID\u00a018840361. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2581738\/.\u00a0^ a b c d e Parton, Robert G.; Simons, Kai (2007-03). \u201cThe multiple faces of caveolae\u201d. Nature Reviews. Molecular Cell Biology 8 (3):  185\u2013194. doi:10.1038\/nrm2122. ISSN\u00a01471-0072. PMID\u00a017318224. https:\/\/pubmed.ncbi.nlm.nih.gov\/17318224.\u00a0^ Lo, Harriet P; Hall, Thomas E; Parton, Robert G (2016-01-13). \u201cMechanoprotection by skeletal muscle caveolae\u201d. Bioarchitecture 6 (1):  22\u201327. doi:10.1080\/19490992.2015.1131891. ISSN\u00a01949-0992. PMC\u00a04914031. PMID\u00a026760312. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4914031\/.\u00a0^ Cheng, Jade P.X.; Mendoza-Topaz, Carolina; Howard, Gillian; Chadwick, Jessica; Shvets, Elena; Cowburn, Andrew S.; Dunmore, Benjamin J.; Crosby, Alexi et al. (2015-10-12). \u201cCaveolae protect endothelial cells from membrane rupture during increased cardiac output\u201d. The Journal of Cell Biology 211 (1):  53\u201361. doi:10.1083\/jcb.201504042. ISSN\u00a00021-9525. PMC\u00a04602045. PMID\u00a026459598. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4602045\/.\u00a0^ Lim, Ye-Wheen; Lo, Harriet P.; Ferguson, Charles; Martel, Nick; Giacomotto, Jean; Gomez, Guillermo A.; Yap, Alpha S.; Hall, Thomas E. et al. (2017-07-10). \u201cCaveolae Protect Notochord Cells against Catastrophic Mechanical Failure during Development\u201d (\u82f1\u8a9e). Current Biology 27 (13):  1968\u20131981.e7. doi:10.1016\/j.cub.2017.05.067. ISSN\u00a00960-9822. PMID\u00a028648821.\u00a0\u95a2\u9023\u9805\u76ee[\u7de8\u96c6]\u5916\u90e8\u30ea\u30f3\u30af[\u7de8\u96c6]"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki6\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki6\/archives\/1113#breadcrumbitem","name":"\u30ab\u30d9\u30aa\u30e9 – Wikipedia"}}]}]