[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/jp\/wiki6\/archives\/8209#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/jp\/wiki6\/archives\/8209","headline":"\u30d7\u30ed\u30d1\u30b2\u30eb\u30de\u30cb\u30a6\u30e0 – Wikipedia","name":"\u30d7\u30ed\u30d1\u30b2\u30eb\u30de\u30cb\u30a6\u30e0 – Wikipedia","description":"\u30d7\u30ed\u30d1\u30b2\u30eb\u30de\u30cb\u30a6\u30e0 3-[(2-Carboxyethyl-oxogermyl)oxy-oxogermyl]propanoic acid \u5225\u79f0 proxigermanium, Ge-132, germanium sesquioxide, 2-carboxyethylgermasesquioxane, SK-818, bis(2-carboxyethylgermanium) sesquioxide \u8b58\u5225\u60c5\u5831 CAS\u767b\u9332\u756a\u53f7 12758-40-6 PubChem 83030 C(C[Ge](=O)O[Ge](=O)CCC(=O)O)C(=O)O \u7279\u6027 \u5316\u5b66\u5f0f","datePublished":"2019-06-18","dateModified":"2019-06-18","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/jp\/wiki6\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/jp\/wiki6\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/11\/book.png","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/11\/book.png","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/5f\/Propagermanium_polymeric.png\/120px-Propagermanium_polymeric.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/5f\/Propagermanium_polymeric.png\/120px-Propagermanium_polymeric.png","height":"172","width":"120"},"url":"https:\/\/wiki.edu.vn\/jp\/wiki6\/archives\/8209","about":["Wiki"],"wordCount":1156,"articleBody":"\u30d7\u30ed\u30d1\u30b2\u30eb\u30de\u30cb\u30a6\u30e03-[(2-Carboxyethyl-oxogermyl)oxy-oxogermyl]propanoic acid  \u5225\u79f0proxigermanium, Ge-132, germanium sesquioxide, 2-carboxyethylgermasesquioxane, SK-818, bis(2-carboxyethylgermanium) sesquioxide\u8b58\u5225\u60c5\u5831CAS\u767b\u9332\u756a\u53f712758-40-6PubChem83030C(C[Ge](=O)O[Ge](=O)CCC(=O)O)C(=O)O\u7279\u6027\u5316\u5b66\u5f0fC6H10O7Ge2\u30e2\u30eb\u8cea\u91cf339.4222 g\/mol\u7279\u8a18\u306a\u304d\u5834\u5408\u3001\u30c7\u30fc\u30bf\u306f\u5e38\u6e29 (25\u00a0\u00b0C)\u30fb\u5e38\u5727 (100\u00a0kPa) \u306b\u304a\u3051\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u30d7\u30ed\u30d1\u30b2\u30eb\u30de\u30cb\u30a6\u30e0\uff08Propagermanium\uff09\u306f\u3001\u30b2\u30eb\u30de\u30cb\u30a6\u30e0\u542b\u6709\u6709\u6a5f\u5316\u5408\u7269\u306e\u3072\u3068\u3064\u3067\u3001\u5225\u540d\u306f\u3001\u30d3\u30b9\uff082-\u30ab\u30eb\u30dc\u30ad\u30b7\u30a8\u30c1\u30eb\u30b2\u30eb\u30de\u30cb\u30a6\u30e0\uff09\u4e09\u4e8c\u9178\u5316\u7269\u3001\u307e\u305f\u306f\u30012-\u30ab\u30eb\u30dc\u30ad\u30b7\u30a8\u30c1\u30eb\u30b2\u30eb\u30de\u30f3\u4e09\u4e8c\u9178\u5316\u7269\u3068\u3082\u547c\u3070\u308c\u308b[1]\u3002B\u578b\u6162\u6027\u809d\u708e\u306e\u6cbb\u7642\u306b\u627f\u8a8d\u3055\u308c\u305f\u533b\u85ac\u54c1\u30bb\u30ed\u30b7\u30aa\u30f3\u3002  \u52b9\u80fd\u30fb\u52b9\u679c[\u7de8\u96c6]\u65e5\u672c\u3067\u306e\u52b9\u80fd\u30fb\u52b9\u679c\u306f\u300cHBe\u6297\u539f\u967d\u6027B\u578b\u6162\u6027\u809d\u708e\u306b\u304a\u3051\u308b\u30a6\u30a4\u30eb\u30b9\u30de\u30fc\u30ab\u30fc\u306e\u6539\u5584\u300d\u3067\u3042\u308b\u3002B\u578b\u6162\u6027\u809d\u708e\u306e\u88dc\u5b8c\u4ee3\u66ff\u6cbb\u7642\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u308b\u3002\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u9632\u5fa1\u4f5c\u7528\u304a\u3088\u3073\u514d\u75ab\u8ce6\u6d3b\u4f5c\u7528\u3092\u6709\u3059\u308b[2]\u3002\u7814\u7a76[\u7de8\u96c6]FBXW7\uff08\u82f1\u8a9e\u7248\uff09\u305f\u3093\u3071\u304f\u8cea\u306b\u50cd\u304d\u304b\u3051\u3001\u304c\u3093\u306e\u8ee2\u79fb\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c2015\u5e74\u306b\u4e5d\u5dde\u5927\u5b66\u306e\u52d5\u7269\u5b9f\u9a13\u3067\u78ba\u304b\u3081\u3089\u308c\u3066\u3044\u308b[3][4]\u30022020\u5e74\u306b\u540c\u5927\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u4eba\u9593\u306e\u4e73\u304c\u3093\u306e12\u4eba\u3067\u540c\u69d8\u306e\u52b9\u679c\u304c\u898b\u3089\u308c\u8ee2\u79fb\u6291\u5236\u80fd\u529b\u304c\u78ba\u8a8d\u3055\u308c\u305f[5]\u3002\u9ec4\u75b8\u306e\u3042\u308b\u60a3\u8005\u809d\u786c\u5909\u306e\u60a3\u8005\u3001\u3042\u308b\u3044\u306f\u809d\u786c\u5909\u306e\u7591\u308f\u308c\u308b\u60a3\u8005\u91cd\u5927\u306a\u526f\u4f5c\u7528\u3068\u3057\u3066\u3001B\u578b\u6162\u6027\u809d\u708e\u306e\u6025\u6027\u5897\u60aa\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002^ M.P. Egorov, P.P. Gaspar (1994), Germanium: Organometallic chemistry in Encyclopedia of Inorganic Chemistry. John Wiley & Sons ISBN 0-471-93620-0^ \u201c\u30bb\u30ed\u30b7\u30aa\u30f3\u30ab\u30d7\u30bb\u30eb10 \u6dfb\u4ed8\u6587\u66f8\u201d (2016\u5e7410\u6708). 2016\u5e7411\u67085\u65e5\u95b2\u89a7\u3002^ \u201cF-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner\u201d (2015\u5e741\u67082\u65e5). 2015\u5e741\u67086\u65e5\u95b2\u89a7\u3002^ \u201c\u65e2\u5b58\u85ac\u3067\u304c\u3093\u8ee2\u79fb\u6291\u5236\u3000\u4e5d\u5927\u6559\u6388\u3089\u3001\u30de\u30a6\u30b9\u5b9f\u9a13\u3067\u78ba\u8a8d\u201d (2015\u5e741\u67083\u65e5). 2015\u5e741\u67086\u65e5\u95b2\u89a7\u3002^ Masuda T, Noda M, Kogawa T, Kitagawa D, Hayashi N, Jomori T, Nakanishi Y, Nakayama KI, Ohno S, Mimori K (2020-3). \u201cPhase I dose-escalation trial to repurpose propagermanium, an oral CCL2 inhibitor, in patients with breast cancer\u201d. Cancer Sci. 111 (3):  924\u2013931. doi:10.1111\/cas.14306. PMC\u00a07060487. PMID\u00a031943636. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmid\/31943636\/.\u00a0  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki6\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki6\/archives\/8209#breadcrumbitem","name":"\u30d7\u30ed\u30d1\u30b2\u30eb\u30de\u30cb\u30a6\u30e0 – Wikipedia"}}]}]