[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/jp\/wiki9\/archives\/291473#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/jp\/wiki9\/archives\/291473","headline":"\u677e\u6751\u4fdd\u5e83 – Wikipedia","name":"\u677e\u6751\u4fdd\u5e83 – Wikipedia","description":"before-content-x4 \u677e\u6751 \u4fdd\u5e83\uff08\u307e\u3064\u3080\u3089 \u3084\u3059\u3072\u308d\u30011955\u5e741\u670820\u65e5 – \uff09\u306f\u3001\u65e5\u672c\u306e\u533b\u5b66\u8005\u3002\u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u5148\u7aef\u533b\u7642\u958b\u767a\u30bb\u30f3\u30bf\u30fc \u65b0\u85ac\u958b\u767a\u5206\u91ce \u5206\u91ce\u9577\u3092\u52d9\u3081\u308b[1]\u3002\u718a\u672c\u770c\u4eba\u5409\u5e02\u51fa\u8eab[2]\u3002 after-content-x4 1986\u5e74\u306b\u9ad8\u5206\u5b50\u85ac\u5264\u304c\u9078\u629e\u7684\u306b\u304c\u3093\u5c40\u6240\u306b\u7559\u307e\u308a\u3084\u3059\u3044\u73fe\u8c61\u3067\u3042\u308b\u300cEPR\u52b9\u679c (Enhanced Permeability and Retention effect)\u300d\u00a0(en)\u00a0\u3092\u3001\u524d\u7530\u6d69\u3068\u5171\u306b\u63d0\u5531\u3057\u305f[3]\u3002\u307e\u305f\u3001\u304c\u3093\u9593\u8cea\u306b\u30c7\u30ea\u30d0\u30ea\u30fc\u3057\u3001\u4e0d\u6eb6\u6027\u30d5\u30a3\u30d6\u30ea\u30f3\u4e0a\u3067\u6297\u304c\u3093\u5264\u3092\u30ea\u30ea\u30fc\u30b9\u3057\u3066\u3001\u304c\u3093\u3068\u816b\u760d\u8840\u7ba1\u4e21\u65b9\u3092\u653b\u6483\u3059\u308b\u304c\u3093\u9593\u8cea\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0 (CAST: CAncer Stromal Targeting) \u7642\u6cd5\u3092\u958b\u767a\u3057\u305f[4][1]\u3002","datePublished":"2022-04-25","dateModified":"2022-04-25","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/jp\/wiki9\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/jp\/wiki9\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/ja.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/ja.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/jp\/wiki9\/archives\/291473","about":["Wiki"],"wordCount":1936,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4\u677e\u6751 \u4fdd\u5e83\uff08\u307e\u3064\u3080\u3089 \u3084\u3059\u3072\u308d\u30011955\u5e741\u670820\u65e5 – \uff09\u306f\u3001\u65e5\u672c\u306e\u533b\u5b66\u8005\u3002\u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u5148\u7aef\u533b\u7642\u958b\u767a\u30bb\u30f3\u30bf\u30fc \u65b0\u85ac\u958b\u767a\u5206\u91ce \u5206\u91ce\u9577\u3092\u52d9\u3081\u308b[1]\u3002\u718a\u672c\u770c\u4eba\u5409\u5e02\u51fa\u8eab[2]\u3002       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x41986\u5e74\u306b\u9ad8\u5206\u5b50\u85ac\u5264\u304c\u9078\u629e\u7684\u306b\u304c\u3093\u5c40\u6240\u306b\u7559\u307e\u308a\u3084\u3059\u3044\u73fe\u8c61\u3067\u3042\u308b\u300cEPR\u52b9\u679c (Enhanced Permeability and Retention effect)\u300d\u00a0(en)\u00a0\u3092\u3001\u524d\u7530\u6d69\u3068\u5171\u306b\u63d0\u5531\u3057\u305f[3]\u3002\u307e\u305f\u3001\u304c\u3093\u9593\u8cea\u306b\u30c7\u30ea\u30d0\u30ea\u30fc\u3057\u3001\u4e0d\u6eb6\u6027\u30d5\u30a3\u30d6\u30ea\u30f3\u4e0a\u3067\u6297\u304c\u3093\u5264\u3092\u30ea\u30ea\u30fc\u30b9\u3057\u3066\u3001\u304c\u3093\u3068\u816b\u760d\u8840\u7ba1\u4e21\u65b9\u3092\u653b\u6483\u3059\u308b\u304c\u3093\u9593\u8cea\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0 (CAST: CAncer Stromal Targeting) \u7642\u6cd5\u3092\u958b\u767a\u3057\u305f[4][1]\u30021981\u5e74 – \u718a\u672c\u5927\u5b66\u533b\u5b66\u90e8\u5352\u696d\u3001\u7b2c\u4e00\u5916\u79d1[1][2]1984\u5e74 – \u540c\u5fae\u751f\u7269\u5b66\u6559\u5ba4\u5927\u5b66\u9662[1][2]1988\u5e74 – \u533b\u5b66\u535a\u58eb\u53f7\u53d6\u5f97[1][2][5]1989\u5e74 – \u7c73\u56fdMt Sinai\u533b\u79d1\u5927\u816b\u760d\u5185\u79d1[1][2]1990\u5e74 – \u82f1\u56fd\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u5927\u5b66Nuffield\u75c5\u7406[1][2]1994\u5e74 – \u56fd\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u4e2d\u592e\u75c5\u9662\u5185\u79d1\u533b\u54e1[1][2]1999\u5e74 – \u540c\u7279\u6b8a\u75c5\u68df\u90e8 \u533b\u9577[1][2]2002\u5e74 – \u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc \u7814\u7a76\u6240\u652f\u6240 \u304c\u3093\u6cbb\u7642\u958b\u767a\u90e8 \u90e8\u9577[1][2]2005\u5e74 – \u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u6771\u75c5\u9662 \u81e8\u5e8a\u958b\u767a\u30bb\u30f3\u30bf\u30fc \u304c\u3093\u6cbb\u7642\u958b\u767a\u90e8 \u90e8\u9577[1][2]2012\u5e74 – \u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u6771\u75c5\u9662 \u81e8\u5e8a\u958b\u767a\u30bb\u30f3\u30bf\u30fc \u65b0\u85ac\u958b\u767a\u5206\u91ce \u5206\u91ce\u9577[1][2]2015\u5e74 – \u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc \u5148\u7aef\u533b\u7642\u958b\u767a\u30bb\u30f3\u30bf\u30fc \u65b0\u85ac\u958b\u767a\u5206\u91ce \u5206\u91ce\u9577[1][2]^ a b c d e f g h i j k l m n o p q cosine (2016\u5e749\u670822\u65e5). \u201c\u677e\u6751 \u4fdd\u5e83 Yasuhiro Matsumura\u201d. \u4e16\u754c\u306e\u5316\u5b66\u8005\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9.   Chem-Station (\u30b1\u30e0\u30b9\u30c6). 2016\u5e749\u670829\u65e5\u95b2\u89a7\u3002^ a b c d e f g h i j k l m n o p \u201c\u677e\u6751\u4fdd\u5e83\u535a\u58eb\u304c\u300c\u30c8\u30e0\u30bd\u30f3\u30fb\u30ed\u30a4\u30bf\u30fc\u5f15\u7528\u6804\u8a89\u8cde\u300d\u53d7\u8cde\u201d (\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9), \u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc,  \u30aa\u30ea\u30b8\u30ca\u30eb\u306e2016\u5e7412\u670821\u65e5\u6642\u70b9\u306b\u304a\u3051\u308b\u30a2\u30fc\u30ab\u30a4\u30d6\u3002, https:\/\/web.archive.org\/web\/20161221123938\/http:\/\/www.ncc.go.jp\/jp\/information\/press_release_20160921.html 2020\u5e742\u670820\u65e5\u95b2\u89a7\u3002\u00a0^ Matsumura, Y; Maeda, H (December 1986). \u201cA new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs\u201d. Cancer research (American Association for Cancer Research) 46 (12):  6387-6392. ISSN\u00a00008-5472. OCLC\u00a070903154. PMID\u00a02946403. http:\/\/cancerres.aacrjournals.org\/content\/46\/12_Part_1\/6387.short.\u00a0^ Matsumura, Y (1 June 2012). \u201cCancer stromal targeting (CAST) therapy\u201d. Advanced drug delivery reviews 64 (8):  710-719. doi:10.1016\/j.addr.2011.12.010. ISSN\u00a00169-409X.\u00a0^ \u677e\u6751 \u4fdd\u5e83\u300c\u9ad8\u5206\u5b50\u5236\u764c\u5264\u306e\u9078\u629e\u7684\u816b\u760d\u96c6\u7a4d\u6a5f\u69cb\u306b\u95a2\u3059\u308b\u7814\u7a76\u300d\u3001\u718a\u672c\u5927\u5b66\u30011988\u5e743\u670825\u65e5\u3001 NAID\u00a0500000054250\u3001 \u56fd\u7acb\u56fd\u4f1a\u56f3\u66f8\u9928\u66f8\u8a8cID:000000218564\u3002^ \u201c\u30ce\u30fc\u30d9\u30eb\u8cde\u6709\u529b\u5019\u88dc\u306b\u672c\u5eb6\u3001\u524d\u7530\u3001\u677e\u6751\u6c0f\u3092\u4e88\u60f3 \u30c8\u30e0\u30bd\u30f3\u30fb\u30ed\u30a4\u30bf\u30fc\u793e\u201d. Science Portal.   \u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb (2016\u5e749\u670823\u65e5). 2016\u5e749\u670829\u65e5\u95b2\u89a7\u3002^ \u201c\u300c\u30c8\u30e0\u30bd\u30f3\u30fb\u30ed\u30a4\u30bf\u30fc\u5f15\u7528\u6804\u8a89\u8cde\u300d\uff08\u30ce\u30fc\u30d9\u30eb\u8cde\u4e88\u6e2c\uff092016\u5e74\u3001\u65e5\u672c\u304b\u3089\u306e\u53d7\u8cde\u8005\u306f3\u540d\u201d (\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9), \u30c8\u30e0\u30bd\u30f3\u30fb\u30ed\u30a4\u30bf\u30fc, (2016\u5e749\u670821\u65e5),  \u30aa\u30ea\u30b8\u30ca\u30eb\u306e2017\u5e743\u670811\u65e5\u6642\u70b9\u306b\u304a\u3051\u308b\u30a2\u30fc\u30ab\u30a4\u30d6\u3002, https:\/\/web.archive.org\/web\/20170311105306\/http:\/\/ip-science.thomsonreuters.jp\/press\/release\/2016\/nobel-laureates\/ 2020\u5e742\u670820\u65e5\u95b2\u89a7\u3002\u00a0\u5916\u90e8\u30ea\u30f3\u30af[\u7de8\u96c6]     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki9\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/jp\/wiki9\/archives\/291473#breadcrumbitem","name":"\u677e\u6751\u4fdd\u5e83 – Wikipedia"}}]}]